{
    "uniprot_canonical_ac": "A0A0G2K516-1",
    "uniprot_ac": "A0A0G2K516",
    "uniprot_id": "A0A0G2K516_RAT",
    "mass": {
        "chemical_mass": 33251.0,
        "monoisotopic_mass": 33251.0
    },
    "refseq": {
        "ac": "NP_001020809",
        "name": "syntaxin-11",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020809"
    },
    "gene_names": [
        {
            "name": "Stx11",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K516",
            "id": "A0A0G2K516"
        },
        {
            "name": "Stx11",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020809",
            "id": "NP_001020809"
        }
    ],
    "protein_names": [
        {
            "name": "Syntaxin 11",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A0G2K516"
        },
        {
            "name": "syntaxin-11",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020809",
            "id": "NP_001020809"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0110924",
            "recommended_name": {
                "id": "DOID:0110924",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0110924",
                "name": "familial hemophagocytic lymphohistiocytosis 4",
                "description": "A hemophagocytic lymphohistiocytosis that has_material_basis_in an autosomal recessive mutation of the STX11 gene on chromosome 6q24.2."
            },
            "synonyms": [
                {
                    "id": "DOID:0110924",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110924",
                    "name": "FHL4",
                    "description": ""
                },
                {
                    "id": "DOID:0110924",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110924",
                    "name": "HLH4",
                    "description": ""
                },
                {
                    "id": "DOID:0110924",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110924",
                    "name": "HPLH4",
                    "description": ""
                },
                {
                    "id": "MONDO:0011336",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011336",
                    "name": "familial hemophagocytic lymphohistiocytosis 4",
                    "description": "Any genetic hemophagocytic lymphohistiocytosis in which the cause of the disease is a mutation in the STX11 gene."
                },
                {
                    "id": "MONDO:0011336",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011336",
                    "name": "FHL4",
                    "description": ""
                },
                {
                    "id": "MONDO:0011336",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011336",
                    "name": "HLH4",
                    "description": ""
                },
                {
                    "id": "MONDO:0011336",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011336",
                    "name": "HPLH4",
                    "description": ""
                },
                {
                    "id": "MONDO:0011336",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011336",
                    "name": "STX11 genetic hemophagocytic lymphohistiocytosis",
                    "description": ""
                },
                {
                    "id": "MONDO:0011336",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011336",
                    "name": "familial hemophagocytic lymphohistiocytosis 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0011336",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011336",
                    "name": "familial hemophagocytic lymphohistiocytosis type 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0011336",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011336",
                    "name": "genetic hemophagocytic lymphohistiocytosis caused by mutation in STX11",
                    "description": ""
                },
                {
                    "id": "MONDO:0011336",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011336",
                    "name": "hemophagocytic lymphohistiocytosis, familial, type 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0011336",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011336",
                    "name": "Hlh4",
                    "description": ""
                },
                {
                    "id": "MONDO:0011336",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011336",
                    "name": "Hplh4",
                    "description": ""
                },
                {
                    "id": "MONDO:0011336",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011336",
                    "name": "hemophagocytic lymphohistiocytosis, familial, 4",
                    "description": ""
                },
                {
                    "id": "MIM:603552",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/603552",
                    "name": "Hemophagocytic lymphohistiocytosis, familial, 4",
                    "description": "Hemophagocytic lymphohistiocytosis, familial, 4"
                }
            ],
            "evidence": [
                {
                    "id": "0110924",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110924"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2K516",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Stx11",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K516",
            "locus": {
                "chromosome": "1",
                "start_pos": 7289976,
                "end_pos": 7320164,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000014902",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000014902"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000014902",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000014902",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00179",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00179",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd15878",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15878",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "292483",
            "url": "https://www.ncbi.nlm.nih.gov/gene/292483",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000727",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000727",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR006011",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006011",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR006012",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006012",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR010989",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR010989",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR042781",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042781",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR045242",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR045242",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:292483",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:292483",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "TEMNQRE",
            "url": "https://omabrowser.org/oma/group/TEMNQRE/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2879355at2759",
            "url": "http://www.orthodb.org/?query=2879355at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR19957",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19957",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR19957:SF30",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19957:SF30",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00804",
            "url": "http://pfam.xfam.org/family/PF00804",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001020809",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020809",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1304744",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1304744",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2K516",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K516",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2K516-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K516-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MKDRLAELQELSRSYDQQFPDGDDDFDAPQEDIVFETDHILESLYRVIQDIQDENQLLLIDVRRLGRQNVRFLTSMRRLSSIKRDTNSIAKAIKTRGEGIHQKLRSMKEMSEQAEAQHGAHSAVARISHAQYSALARAFQQAMYEYNQAEMKQRDNCKIRIQRQLEIMGKDVSGEQIEDMFEQGKWDVFSENLLADVKGARAALNEIESRHRELLRLEGRIRDVHELFLQMAVLVEKQADTLNVIELNVQKTLDYTGEAKAQVRKAVQYKKKNPCRTICCFCCPCVN",
        "length": 287,
        "header": "tr|A0A0G2K516-1|A0A0G2K516_RAT Isoform 1 of Syntaxin 11  OS=Rattus norvegicus OX=10116 GN=Stx11 PE=3 SV=1 CANONICAL=A0A0G2K516-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2K516-1",
            "url": "",
            "sequence": {
                "sequence": "MKDRLAELQELSRSYDQQFPDGDDDFDAPQEDIVFETDHILESLYRVIQDIQDENQLLLIDVRRLGRQNVRFLTSMRRLSSIKRDTNSIAKAIKTRGEGIHQKLRSMKEMSEQAEAQHGAHSAVARISHAQYSALARAFQQAMYEYNQAEMKQRDNCKIRIQRQLEIMGKDVSGEQIEDMFEQGKWDVFSENLLADVKGARAALNEIESRHRELLRLEGRIRDVHELFLQMAVLVEKQADTLNVIELNVQKTLDYTGEAKAQVRKAVQYKKKNPCRTICCFCCPCVN",
                "length": 287,
                "header": "tr|A0A0G2K516-1|A0A0G2K516_RAT Isoform 1 of Syntaxin 11  OS=Rattus norvegicus OX=10116 GN=Stx11 PE=3 SV=1 CANONICAL=A0A0G2K516-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 7295305,
                "end_pos": 7294445,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000019983.5",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000019983.5"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000073255.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000073255.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:292483",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:292483",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "O75558-1",
            "protein_name": "Syntaxin-11",
            "gene_name": "STX11",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MKDRLAELLDLSKQYDQQFPDGDDEFDSPHEDIVFETDHILESLYRDIRDIQDENQLLVADVKRLGKQNARFLTSMRRLSSIKRDTNSIAKAIKARGEVIHCKLRAMKELSEAAEAQHGPHSAVARISRAQYNALTLTFQRAMHDYNQAEMKQRDNCKIRIQRQLEIMGKEVSGDQIEDMFEQGKWDVFSENLLADVKGARAALNEIESRHRELLRLESRIRDVHELFLQMAVLVEKQADTLNVIELNVQKTVDYTGQAKAQVRKAVQYEEKNPCRTLCCFCCPCLK",
                "length": 287
            },
            "evidence": [
                {
                    "id": "45232487",
                    "url": "http://www.informatics.jax.org/homology/45232487",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9D3G5-1",
            "protein_name": "Syntaxin-11",
            "gene_name": "Stx11",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MKDRLAELQELSRSYDQQFPDGDNDFDAPREDIVFETDNILESLYRVIQDIQDENQLLLIDVRRLGRQNVRFLTSMRRLSSIKRDTNSIAKAIKTRGEGIHQKLRSMKELSEQAEARHGAHSAVARISHAQYSALARAFQQAMYEYNQAEMKQRDNCKIRIQRQLEIMGKDMSGEQIEDMFEQGKWDVFSENLLADLKGARAALNEIESRHRELLRLEGRIRDVHELFLQMAVLVEKQEDTLNVIELNVQKTLDYTGEAKAQVRKAVQYKKKNPCRTICCFCCPCVN",
                "length": 287
            },
            "evidence": [
                {
                    "id": "45232487",
                    "url": "http://www.informatics.jax.org/homology/45232487",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 6,
                "go_terms": [
                    {
                        "name": "presynaptic active zone membrane",
                        "id": "GO:0048787",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048787",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endomembrane system",
                        "id": "GO:0012505",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phagocytic vesicle",
                        "id": "GO:0045335",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synaptic vesicle",
                        "id": "GO:0008021",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "SNARE complex",
                        "id": "GO:0031201",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031201",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 10,
                "go_terms": [
                    {
                        "name": "intracellular protein transport",
                        "id": "GO:0006886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "neutrophil degranulation",
                        "id": "GO:0043312",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043312",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to type II interferon",
                        "id": "GO:0071346",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071346",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "exocytosis",
                        "id": "GO:0006887",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "T cell mediated cytotoxicity",
                        "id": "GO:0001913",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001913",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytotoxic T cell degranulation",
                        "id": "GO:0043316",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043316",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synaptic vesicle fusion to presynaptic active zone membrane",
                        "id": "GO:0031629",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031629",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "vesicle docking",
                        "id": "GO:0048278",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048278",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "natural killer cell mediated cytotoxicity",
                        "id": "GO:0042267",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042267",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "natural killer cell degranulation",
                        "id": "GO:0043320",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043320",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K516",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K516"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
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