{ "uniprot_canonical_ac": "A0A0G2K3D7-1", "uniprot_ac": "A0A0G2K3D7", "uniprot_id": "A0A0G2K3D7_RAT", "mass": { "chemical_mass": 73070.0, "monoisotopic_mass": 73070.0 }, "refseq": { "ac": "NP_001004444", "name": "zinc finger and BTB domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004444" }, "gene_names": [ { "name": "Zbtb1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7", "id": "A0A0G2K3D7" } ], "protein_names": [ { "name": "Zinc finger and BTB domain containing 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K3D7" }, { "name": "zinc finger and BTB domain-containing protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004444", "id": "NP_001004444" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "common_name": "Rat" } ], "gene": [ { "name": "Zbtb1", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7", "locus": { "chromosome": "6", "start_pos": 95118996, "end_pos": 95096387, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000058593", "url": "https://www.ensembl.org/id/ENSRNOG00000058593" } ] } } ], "crossref": [ { "id": "ENSRNOG00000058593", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000058593", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18192", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18192", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "314246", "url": "https://www.ncbi.nlm.nih.gov/gene/314246", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:314246", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314246", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EGGEPDH", "url": "https://omabrowser.org/oma/group/EGGEPDH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4018144at2759", "url": "http://www.orthodb.org/?query=4018144at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "http://pfam.xfam.org/family/PF00651", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_008762991", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008762991", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1303095", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1303095", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K3D7-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q672J3", "url": "https://www.uniprot.org/uniprot/Q672J3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q672J3-1", "url": "https://www.uniprot.org/uniprot/Q672J3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKILTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDSDCSSSKCSSSASSKHNSKMIFGVRMYEDTVARNGSEANRWSAEPSSTVNTPHNREPEEESLPLANFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHSYQSTARAYHRVVDARDGKDSAIKAELGDKGSPTAFSAHTDKYREDASQAPDDSASPTGSRKSTVESGTAGEEKSRAAETKRVVIKMEPEDVPADDMKDFTIVKVTEKDCNESTDNDELEDEPEEPFYRYYVEEDVGIKKSGRKTLKPRMSVGVDERGGLENMRPPNNSSPRQEDAENASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNTDEKMDMEENPDEQSEIRDMFVEMLDDFRDNHYQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDMFKGAVMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMASGAVGPSKPLEK", "length": 644, "header": "tr|A0A0G2K3D7-1|A0A0G2K3D7_RAT Isoform 1 of Zinc finger and BTB domain containing 1 OS=Rattus norvegicus OX=10116 GN=Zbtb1 PE=1 SV=1 CANONICAL=A0A0G2K3D7-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K3D7-1", "url": "", "sequence": { "sequence": "MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKILTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDSDCSSSKCSSSASSKHNSKMIFGVRMYEDTVARNGSEANRWSAEPSSTVNTPHNREPEEESLPLANFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHSYQSTARAYHRVVDARDGKDSAIKAELGDKGSPTAFSAHTDKYREDASQAPDDSASPTGSRKSTVESGTAGEEKSRAAETKRVVIKMEPEDVPADDMKDFTIVKVTEKDCNESTDNDELEDEPEEPFYRYYVEEDVGIKKSGRKTLKPRMSVGVDERGGLENMRPPNNSSPRQEDAENASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNTDEKMDMEENPDEQSEIRDMFVEMLDDFRDNHYQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDMFKGAVMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMASGAVGPSKPLEK", "length": 644, "header": "tr|A0A0G2K3D7-1|A0A0G2K3D7_RAT Isoform 1 of Zinc finger and BTB domain containing 1 OS=Rattus norvegicus OX=10116 GN=Zbtb1 PE=1 SV=1 CANONICAL=A0A0G2K3D7-1" }, "locus": { "chromosome": "6", "start_pos": 95118810, "end_pos": 95109430, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000078498.2", "url": "https://www.ensembl.org/id/ENSRNOT00000078498.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072596.1", "url": "https://www.ensembl.org/id/ENSRNOP00000072596.1" } ] } }, { "isoform_ac": "Q672J3-1", "url": "", "sequence": { "sequence": "MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKILTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDSDCSSSKCSSSASSKHNSKMIFGVRMYEDTVARNGSEANRWSAEPSSTVNTPHNREPEEESLPLANFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHSYQSTARAYHRVVDARDGKDSAIKAELGDKGSPTAFSAHTDKYREDASQAPDDSASPTGSRKSTVESGTAGEEKSRAAETKRVVIKMEPEDVPADDMKDFTIVKVTEKDCNESTDNDELEDEPEEPFYRYYVEEDVGIKKSGRKTLKPRMSVGVDERGGLENMRPPNNSSPRQEDAENASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNTDEKMDMEENPDEQSEIRDMFVEMLDDFRDNHYQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDMFKGAVMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSGGETICQVCFQIFPNNEQLEQHMDVHLYTCGICGAKFNLRKDMRSHYNAKHLKRT", "length": 713, "header": "tr|Q672J3-1|Q672J3_RAT Computationally mapped isoform of Zinc finger and BTB domain containing 1 OS=Rattus norvegicus OX=10116 GN=Zbtb1 PE=4 SV=1 CANONICAL=A0A0G2K3D7-1" }, "locus": { "chromosome": "6", "start_pos": 95111568, "end_pos": 95109430, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000110356.1", "url": "https://www.ensembl.org/id/ENSRNOT00000110356.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000097406.1", "url": "https://www.ensembl.org/id/ENSRNOP00000097406.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:314246", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314246", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q91VL9-1", "protein_name": "Zinc finger and BTB domain-containing protein 1", "gene_name": "Zbtb1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDADCSSSKCSSSASSRQSSKMIFGVRMYEDTVARNGNEANRWCAEPSSTVNTPHHREPEEESLQLANFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHSYQNTTRAYHRIVDIRDGKDSNIKAELAEKDSSKTFSAQPDKYREDANQAPDDSASTTGSRKSTVEAGIAGEEKSRATETKRIIIKMEPEDIPADDMKDFNIIKVTEKDCNESTDNDELEDEPEEPFYRYYVEEDVGIKKSGRKTLKPRMSISVDERGGLENMRPPNNTSPIQEDAENASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNADEKMDMEENPDEQSEIRDMFVEMLDDFRDNHYQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDMFKGAIMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSGGETICQVCFQIFPNNEQLEQHMDVHLYTCGICGAKFNLRKDMRSHYNAKHLKRT", "length": 713 }, "evidence": [ { "id": "45227812", "url": "http://www.informatics.jax.org/homology/45227812", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y2K1-1", "protein_name": "Zinc finger and BTB domain-containing protein 1", "gene_name": "ZBTB1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDADCSSSKCSSSASSKQNSKMIFGVRMYEDTVARNGNEANRWCAEPSSTVNTPHNREADEESLQLGNFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHLYQNTRSYHRIVDIRDGKDSNIKAEFGEKDSSKTFSAQTDKYRGDTSQAADDSASTTGSRKSSTVESEIASEEKSRAAERKRIIIKMEPEDIPTDELKDFNIIKVTDKDCNESTDNDELEDEPEEPFYRYYVEEDVSIKKSGRKTLKPRMSVSADERGGLENMRPPNNSSPVQEDAENASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNTEEKMDLEENPDEQSEIRDMFVEMLDDFRDNHYQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDMFKSAIMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSAGETICQVCFQIFPNNEQLEQHMDVHLYTCGICGAKFNLRKDMRSHYNAKHLKRT", "length": 713 }, "evidence": [ { "id": "45227812", "url": "http://www.informatics.jax.org/homology/45227812", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 17, "go_terms": [ { "name": "positive regulation of T cell mediated immunity", "id": "GO:0002711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002711", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "regulation of immune system process", "id": "GO:0002682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002682", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "thymus development", "id": "GO:0048538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048538", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "B cell differentiation", "id": "GO:0030183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030183", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "regulation of cytokine production", "id": "GO:0001817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "T cell differentiation in thymus", "id": "GO:0033077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033077", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "cellular response to UV", "id": "GO:0034644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034644", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "mRNA transcription by RNA polymerase II", "id": "GO:0042789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042789", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "translesion synthesis", "id": "GO:0019985", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019985", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "positive regulation of pro-T cell differentiation", "id": "GO:2000176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000176", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "positive regulation of T cell differentiation", "id": "GO:0045582", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045582", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "positive regulation of natural killer cell differentiation", "id": "GO:0032825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032825", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3D7", "url": "https://www.uniprot.org/uniprot/A0A0G2K3D7" } ], "pmid": "" }, { 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