{ "uniprot_canonical_ac": "A0A0G2K320-1", "uniprot_ac": "A0A0G2K320", "uniprot_id": "A0A0G2K320_RAT", "mass": { "chemical_mass": 183373.0, "monoisotopic_mass": 183373.0 }, "refseq": { "ac": "NP_001101247", "name": "sialoadhesin precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101247" }, "gene_names": [ { "name": "Siglec1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K320", "id": "A0A0G2K320" }, { "name": "Siglec1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101247", "id": "NP_001101247" }, { "name": "Sn", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101247", "id": "NP_001101247" } ], "protein_names": [ { "name": "Sialic acid binding Ig like lectin 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K320" }, { "name": "sialic acid binding Ig-like lectin 1, sialoadhesin", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101247", "id": "NP_001101247" }, { "name": "sialoadhesin precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101247", "id": "NP_001101247" } ], "function": [ { "annotation": "Sialoadhesin is a macrophage-restricted adhesion molecule that recognizes N-acetylneuraminylalpha2-3galactose structure. Macrophages in lymph nodes express high levels of unmasked sialoadhesin.", "evidence": [ { "database": "RefSeq", "id": "NP_001101247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101247" }, { "database": "PubMed", "id": "11971865", "url": "https://glygen.org/publication/PubMed/11971865" } ] }, { "annotation": "Sialoadhesin-positive macrophages were increased during the late stage of diabetes concomitantly with the increase of alpha-smooth muscle actin-positive mesangial cells, mesangial matrix area and type IV collagen.", "evidence": [ { "database": "RefSeq", "id": "NP_001101247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101247" }, { "database": "PubMed", "id": "22526486", "url": "https://glygen.org/publication/PubMed/22526486" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K320", "url": "https://www.uniprot.org/uniprot/A0A0G2K320" } ], "common_name": "Rat" } ], "gene": [ { "name": "Siglec1", "url": "https://www.uniprot.org/uniprot/A0A0G2K320", "locus": { "chromosome": "3", "start_pos": 118287988, "end_pos": 118306850, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000021243", "url": "https://www.ensembl.org/id/ENSRNOG00000021243" } ] } } ], "crossref": [ { "id": "ENSRNOG00000021243", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000021243", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "311426", "url": "https://www.ncbi.nlm.nih.gov/gene/311426", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:311426", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:311426", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FNSQKFE", "url": "https://omabrowser.org/oma/group/FNSQKFE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5360480at2759", "url": "http://www.orthodb.org/?query=5360480at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47243", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47243", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47243:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47243:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "http://pfam.xfam.org/family/PF07679", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "http://pfam.xfam.org/family/PF07686", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08205", "url": "http://pfam.xfam.org/family/PF08205", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13895", "url": "http://pfam.xfam.org/family/PF13895", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13927", "url": "http://pfam.xfam.org/family/PF13927", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-198933", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198933", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1311953", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311953", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K320", "url": "https://www.uniprot.org/uniprot/A0A0G2K320", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K320-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K320-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZVM6", "url": "https://www.uniprot.org/uniprot/D3ZVM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZVM6-1", "url": "https://www.uniprot.org/uniprot/D3ZVM6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "HLRTRMCALLSLLLLASVFTPGQTTWGVSSPKDVQGLTGSCLLIPCIFSFPADVSVPNGITAIWYYDYSGKRQVVIHSGDPKLVDERFRGRAELTGNMDHKVCNLLLKDLKLEDSGTYNFRFEISDGNRWSDVRGTTVTVTKDPSPPTITIPHELREGVEVNVNCSTPYLCLQEKQVSLHWQGQDPTRSVISNFQSLEPTGVYHQTTLHMAPSWQDHRRTLRCQLSLATHSSQKEVYLQVQHAPKGVEILLSSSGRNILPGNLVTLTCRVNSSYPAVSSVDWVKDGVNLTAKGHVLQLSSATWNDSGVYTCQATNNVGSLASPPLSLHVFMAEVKINPAGPILENETVTLLCSTPKEAPQELRYSWYKNNILLEDAHAPTLHLPAVTRADTGFYFCEVQNTQGSERSGPVSVVVRYPPLTPDLTTFLETQAGLVGIFHCSVISEPLATVVLSHGGLTLASSSGENDFNPRFSISSAPNSVRLEIRDLQPADSGEYTCSATNSLGKSMSSLDFHANVARLLISPSKEVVEGQAVTLSCRSGLNPAPDTRFSWYLNGALLLEGSSSNFLLPAASSTDSGSYYCRARAGPHTSGPSLPTVLTVFYPPRKLTFTARLDLDTSGDGDGRRGILLCQVDSDPPAQLQLLHKGHVVATSLPSMCGSCSRRMKVSRASNSLQVEIQKPVLEDEGMYLCEASNTLGNSSVSASFNAKATVVVITPSDTLLEGTEASLTCNVTQEVAVSPANFSWFRNGVLWTQGPLETVRLQPLARTDAAVYACRLLTDDGAQLSAPVVLSVQYAPDPPKLSALLDVGQGHMAVFICTVDSYPLAHLSLFRGERLLATSLEPQRLSHGRIQAKATANSLQLEVRELGLEDSGNYHCEATNVLGSANSSLFFQVRGAWVQVSPSPELREGQAVVLSCQVPTGVPEGTSYRWFQDGRPLQESTSSILRIAAISLRQAGAYHCQAQAPDTAAASLAAPVSLHVSYTPRHVTLSALLSTGPGRYGHLVCSAQSDPPALLRLFHQNRLVASTLQGPEELASSNPRLHVAVSSNELRLEIQFTELEDGGTYTCEATNTLGQASATADFDAQAVRVAVWPNATVQEGQQVNLSCLAWSTHQDSLSYTWYKGGQQLLGVRSISLPSVTVSDATSYRCGVGLPGHTPHLSRPVTLDVLYAPRSLQLTYLLESQGRRLALVLCTVDSRPPAQLTLSHGGQLLASSTEASVPNTLRLELQDPKPSDEGLYSCSAQSPLGKVNTSLALRLEGVRVRMNPSATVPEGEPVTVTCEDPAALSPALYAWFHNGHWLQEGPASSLQFPVTTQAHAGAYFCQVHDTQGTRSSRPASLQILYAPRDAVLSSFRDSRTRHMVVIQCTVDSEPPAELVLSRNSKVLAASRELHSSAPGISHVQAARNALRLQVQDTTFGDGNTYVCTARNTLGSISTTHKLLRETDIHVTAEPGLDVPEGTALNLSCHLPGGSQPVGNSSFTWFWNRHLLHSAPVPTLSFTPVVRAQAGSYHCRAELSTGVTTSPPVMLRVLYPPKTPTLTVFVEPQGGHQGILDCRVDSEPLASLTLQLGSQLVASNQPHSAPTQPHIRVTAPPNALRLDIEELGPNNQGEYVCTASNALGSASASAYFGTRALQQLQLFQRLLWVLGFLAGFLGLLLGLGACYSWRKKNSSKLNVNENSAEMTTQKDNIQEETVAAV", "length": 1700, "header": "tr|A0A0G2K320-1|A0A0G2K320_RAT Isoform 1 of Sialic acid binding Ig like lectin 1 OS=Rattus norvegicus OX=10116 GN=Siglec1 PE=1 SV=2 CANONICAL=A0A0G2K320-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K320-1", "url": "", "sequence": { "sequence": "HLRTRMCALLSLLLLASVFTPGQTTWGVSSPKDVQGLTGSCLLIPCIFSFPADVSVPNGITAIWYYDYSGKRQVVIHSGDPKLVDERFRGRAELTGNMDHKVCNLLLKDLKLEDSGTYNFRFEISDGNRWSDVRGTTVTVTKDPSPPTITIPHELREGVEVNVNCSTPYLCLQEKQVSLHWQGQDPTRSVISNFQSLEPTGVYHQTTLHMAPSWQDHRRTLRCQLSLATHSSQKEVYLQVQHAPKGVEILLSSSGRNILPGNLVTLTCRVNSSYPAVSSVDWVKDGVNLTAKGHVLQLSSATWNDSGVYTCQATNNVGSLASPPLSLHVFMAEVKINPAGPILENETVTLLCSTPKEAPQELRYSWYKNNILLEDAHAPTLHLPAVTRADTGFYFCEVQNTQGSERSGPVSVVVRYPPLTPDLTTFLETQAGLVGIFHCSVISEPLATVVLSHGGLTLASSSGENDFNPRFSISSAPNSVRLEIRDLQPADSGEYTCSATNSLGKSMSSLDFHANVARLLISPSKEVVEGQAVTLSCRSGLNPAPDTRFSWYLNGALLLEGSSSNFLLPAASSTDSGSYYCRARAGPHTSGPSLPTVLTVFYPPRKLTFTARLDLDTSGDGDGRRGILLCQVDSDPPAQLQLLHKGHVVATSLPSMCGSCSRRMKVSRASNSLQVEIQKPVLEDEGMYLCEASNTLGNSSVSASFNAKATVVVITPSDTLLEGTEASLTCNVTQEVAVSPANFSWFRNGVLWTQGPLETVRLQPLARTDAAVYACRLLTDDGAQLSAPVVLSVQYAPDPPKLSALLDVGQGHMAVFICTVDSYPLAHLSLFRGERLLATSLEPQRLSHGRIQAKATANSLQLEVRELGLEDSGNYHCEATNVLGSANSSLFFQVRGAWVQVSPSPELREGQAVVLSCQVPTGVPEGTSYRWFQDGRPLQESTSSILRIAAISLRQAGAYHCQAQAPDTAAASLAAPVSLHVSYTPRHVTLSALLSTGPGRYGHLVCSAQSDPPALLRLFHQNRLVASTLQGPEELASSNPRLHVAVSSNELRLEIQFTELEDGGTYTCEATNTLGQASATADFDAQAVRVAVWPNATVQEGQQVNLSCLAWSTHQDSLSYTWYKGGQQLLGVRSISLPSVTVSDATSYRCGVGLPGHTPHLSRPVTLDVLYAPRSLQLTYLLESQGRRLALVLCTVDSRPPAQLTLSHGGQLLASSTEASVPNTLRLELQDPKPSDEGLYSCSAQSPLGKVNTSLALRLEGVRVRMNPSATVPEGEPVTVTCEDPAALSPALYAWFHNGHWLQEGPASSLQFPVTTQAHAGAYFCQVHDTQGTRSSRPASLQILYAPRDAVLSSFRDSRTRHMVVIQCTVDSEPPAELVLSRNSKVLAASRELHSSAPGISHVQAARNALRLQVQDTTFGDGNTYVCTARNTLGSISTTHKLLRETDIHVTAEPGLDVPEGTALNLSCHLPGGSQPVGNSSFTWFWNRHLLHSAPVPTLSFTPVVRAQAGSYHCRAELSTGVTTSPPVMLRVLYPPKTPTLTVFVEPQGGHQGILDCRVDSEPLASLTLQLGSQLVASNQPHSAPTQPHIRVTAPPNALRLDIEELGPNNQGEYVCTASNALGSASASAYFGTRALQQLQLFQRLLWVLGFLAGFLGLLLGLGACYSWRKKNSSKLNVNENSAEMTTQKDNIQEETVAAV", "length": 1700, "header": "tr|A0A0G2K320-1|A0A0G2K320_RAT Isoform 1 of Sialic acid binding Ig like lectin 1 OS=Rattus norvegicus OX=10116 GN=Siglec1 PE=1 SV=2 CANONICAL=A0A0G2K320-1" }, "locus": { "chromosome": "3", "start_pos": 118306153, "end_pos": 118289120, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000091493.2", "url": "https://www.ensembl.org/id/ENSRNOT00000091493.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072470.2", "url": "https://www.ensembl.org/id/ENSRNOP00000072470.2" } ] } }, { "isoform_ac": "D3ZVM6-1", "url": "", "sequence": { "sequence": "MCALLSLLLLASVFTPGQTTWGVSSPKDVQGLTGSCLLIPCIFSFPADVSVPNGITAIWYYDYSGKRQVVIHSGDPKLVDERFRGRAELTGNMDHKVCNLLLKDLKLEDSGTYNFRFEISDGNRWSDVRGTTVTVTKDPSPPTITIPHELREGVEVNVNCSTPYLCLQEKQVSLHWQGQDPTRSVISNFQSLEPTGVYHQTTLHMAPSWQDHRRTLRCQLSLATHSSQKEVYLQVQHAPKGVEILLSSSGRNILPGNLVTLTCRVNSSYPAVSSVDWVKDGVNLTAKGHVLQLSSATWNDSGVYTCQATNNVGSLASPPLSLHVFMAEVKINPAGPILENETVTLLCSTPKEAPQELRYSWYKNNILLEDAHAPTLHLPAVTRADTGFYFCEVQNTQGSERSGPVSVVVRYPPLTPDLTTFLETQAGLVGIFHCSVISEPLATVVLSHGGLTLASSSGENDFNPRFSISSAPNSVRLEIRDLQPADSGEYTCSATNSLGKSMSSLDFHANDPPRKLTFTARLDLDTSGDGDGRRGILLCQVDSDPPAQLQLLHKGHVVATSLPSMCGSCSRRMKVSRASNSLQVEIQKPVLEDEGMYLCEASNTLGNSSVSASFNAKATVVVITPSDTLLEGTEASLTCNVTQEVAVSPANFSWFRNGVLWTQGPLETVRLQPLARTDAAVYACRLLTDDGAQLSAPVVLSVQYAPDPPKLSALLDVGQGHMAVFICTVDSYPLAHLSLFRGERLLATSLEPQRLSHGRIQAKATANSLQLEVRELGLEDSGNYHCEATNVLGSANSSLFFQVRGAWVQVSPSPELREGQAVVLSCQVPTGVPEGTSYRWFQDGRPLQESTSSILRIAAISLRQAGAYHCQAQAPDTAAASLAAPVSLHVSYTPRHVTLSALLSTGPGRYGHLVCSAQSDPPALLRLFHQNRLVASTLQGPEELASSNPRLHVAVSSNELRLEIQFTELEDGGTYTCEATNTLGQASATADFDAQAVRVAVWPNATVQEGQQVNLSCLAWSTHQDSLSYTWYKGGQQLLGVRSISLPSVTVSDATSYRCGVGLPGHTPHLSRPVTLDVLYAPRSLQLTYLLESQGRRLALVLCTVDSRPPAQLTLSHGGQLLASSTEASVPNTLRLELQDPKPSDEGLYSCSAQSPLGKVNTSLALRLEGVRVRMNPSATVPEGEPVTVTCEDPAALSPALYAWFHNGHWLQEGPASSLQFPVTTQAHAGAYFCQVHDTQGTRSSRPASLQILYAPRDAVLSSFRDSRTRHMVVIQCTVDSEPPAELVLSRNSKVLAASRELHSSAPGISHVQAARNALRLQVQDTTFGDGNTYVCTARNTLGSISTTHKLLRETDIHVTAEPGLDVPEGTALNLSCHLPGGSQPVGNSSFTWFWNRHLLHSAPVPTLSFTPVVRAQAGSYHCRAELSTGVTTSPPVMLRVLYPPKTPTLTVFVEPQGGHQGILDCRVDSEPLASLTLQLGSQLVASNQPHSAPTQPHIRVTAPPNALRLDIEELGPNNQGEYVCTASNALGSASASAYFGTRALQQLQLFQRLLWVLGFLAGFLGLLLGLGACYSWRKKNSSKLNVNENSAEMTTQKDNIQEETVAAV", "length": 1609, "header": "tr|D3ZVM6-1|D3ZVM6_RAT Computationally mapped isoform of Sialic acid binding Ig like lectin 1 OS=Rattus norvegicus OX=10116 GN=Siglec1 PE=1 SV=2 CANONICAL=A0A0G2K320-1" }, "locus": { "chromosome": "3", "start_pos": 118306138, "end_pos": 118289120, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000028855.8", "url": "https://www.ensembl.org/id/ENSRNOT00000028855.8" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000028855.6", "url": "https://www.ensembl.org/id/ENSRNOP00000028855.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Lymph node macrophages, but not spleen macrophages, express high levels of unmasked sialoadhesin: implication for the adhesive properties of macrophages in vivo.", "journal": "Glycobiology", "date": "2002", "authors": "Nakamura K, Yamaji T, Crocker PR, Suzuki A, Hashimoto Y", "evidence": [ { "database": "RefSeq", "id": "NP_001101247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101247" } ], "reference": [ { "type": "PubMed", "id": "11971865", "url": "https://glygen.org/publication/PubMed/11971865" } ] }, { "title": "Phenotypic change of macrophages in the progression of diabetic nephropathy; sialoadhesin-positive activated macrophages are increased in diabetic kidney.", "journal": "Clinical and experimental nephrology", "date": "2012", "authors": "Nagase R, Kajitani N, Shikata K, Ogawa D, Kodera R, Okada S, Kido Y, Makino H", "evidence": [ { "database": "RefSeq", "id": "NP_001101247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101247" } ], "reference": [ { "type": "PubMed", "id": "22526486", "url": "https://glygen.org/publication/PubMed/22526486" } ] } ], "pathway": [ { "id": "rno:311426", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:311426", "resource": "KEGG Pathway" }, { "id": "R-RNO-198933", "name": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198933", "resource": "Reactome", "description": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" } ], "orthologs": [ { "uniprot_canonical_ac": "Q62230-1", "protein_name": "Sialoadhesin", "gene_name": "Siglec1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCVLFSLLLLASVFSLGQTTWGVSSPKNVQGLSGSCLLIPCIFSYPADVPVSNGITAIWYYDYSGKRQVVIHSGDPKLVDKRFRGRAELMGNMDHKVCNLLLKDLKPEDSGTYNFRFEISDSNRWLDVKGTTVTVTTDPSPPTITIPEELREGMERNFNCSTPYLCLQEKQVSLQWRGQDPTHSVTSSFQSLEPTGVYHQTTLHMALSWQDHGRTLLCQFSLGAHSSRKEVYLQVPHAPKGVEILLSSSGRNILPGDPVTLTCRVNSSYPAVSAVQWARDGVNLGVTGHVLRLFSAAWNDSGAYTCQATNDMGSLVSSPLSLHVFMAEVKMNPAGPVLENETVTLLCSTPKEAPQELRYSWYKNHILLEDAHASTLHLPAVTRADTGFYFCEVQNAQGSERSSPLSVVVRYPPLTPDLTTFLETQAGLVGILHCSVVSEPLATVVLSHGGLTLASNSGENDFNPRFRISSAPNSLRLEIRDLQPADSGEYTCLAVNSLGNSTSSLDFYANVARLLINPSAEVVEGQAVTLSCRSGLSPAPDTRFSWYLNGALLLEGSSSSLLLPAASSTDAGSYYCRTQAGPNTSGPSLPTVLTVFYPPRKPTFTARLDLDTSGVGDGRRGILLCHVDSDPPAQLRLLHKGHVVATSLPSRCGSCSQRTKVSRTSNSLHVEIQKPVLEDEGVYLCEASNTLGNSSAAASFNAKATVLVITPSNTLREGTEANLTCNVNQEVAVSPANFSWFRNGVLWTQGSLETVRLQPVARTDAAVYACRLLTEDGAQLSAPVVLSVLYAPDPPKLSALLDVGQGHMAVFICTVDSYPLAHLSLFRGDHLLATNLEPQRPSHGRIQAKATANSLQLEVRELGLVDSGNYHCEATNILGSANSSLFFQVRGAWVQVSPSPELREGQAVVLSCQVPTGVSEGTSYSWYQDGRPLQESTSSTLRIAAISLRQAGAYHCQAQAPDTAIASLAAPVSLHVSYTPRHVTLSALLSTDPERLGHLVCSVQSDPPAQLQLFHRNRLVASTLQGADELAGSNPRLHVTVLPNELRLQIHFPELEDDGTYTCEASNTLGQASAAADFDAQAVRVTVWPNATVQEGQQVNLTCLVWSTHQDSLSYTWYKGGQQLLGARSITLPSVKVLDATSYRCGVGLPGHAPHLSRPVTLDVLHAPRNLRLTYLLETQGRQLALVLCTVDSRPPAQLTLSHGDQLVASSTEASVPNTLRLELQDPRPSNEGLYSCSAHSPLGKANTSLELLLEGVRVKMNPSGSVPEGEPVTVTCEDPAALSSALYAWFHNGHWLQEGPASSLQFLVTTRAHAGAYFCQVHDTQGTRSSRPASLQILYAPRDAVLSSFRDSRTRLMVVIQCTVDSEPPAEMVLSHNGKVLAASHERHSSASGIGHIQVARNALRLQVQDVTLGDGNTYVCTAQNTLGSISTTQRLLTETDIRVTAEPGLDVPEGTALNLSCLLPGGSGPTGNSSFTWFWNRHRLHSAPVPTLSFTPVVRAQAGLYHCRADLPTGATTSAPVMLRVLYPPKTPTLIVFVEPQGGHQGILDCRVDSEPLAILTLHRGSQLVASNQLHDAPTKPHIRVTAPPNALRVDIEELGPSNQGEYVCTASNTLGSASASAYFGTRALHQLQLFQRLLWVLGFLAGFLCLLLGLVAYHTWRKKSSTKLNEDENSAEMATKKNTIQEEVVAAL", "length": 1695 }, "evidence": [ { "id": "45243648", "url": "http://www.informatics.jax.org/homology/45243648", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BZZ2-1", "protein_name": "Sialoadhesin", "gene_name": "SIGLEC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"length": 1709 }, "evidence": [ { "id": "45243648", "url": "http://www.informatics.jax.org/homology/45243648", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K320", "url": "https://www.uniprot.org/uniprot/A0A0G2K320" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K320", "url": "https://www.uniprot.org/uniprot/A0A0G2K320" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K320", "url": "https://www.uniprot.org/uniprot/A0A0G2K320" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001238", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001238", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K320", "url": "https://www.uniprot.org/uniprot/A0A0G2K320" } ], "pmid": "" }, { "name": "positive regulation of T cell apoptotic process", "id": "GO:0070234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070234", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K320", "url": "https://www.uniprot.org/uniprot/A0A0G2K320" } ], "pmid": "" }, { "name": "clathrin-dependent endocytosis of virus by host cell", "id": "GO:0075512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0075512", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K320", "url": "https://www.uniprot.org/uniprot/A0A0G2K320" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "virion binding", "id": "GO:0046790", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046790", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K320", "url": "https://www.uniprot.org/uniprot/A0A0G2K320" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1095, "end_pos": 1097, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1105, "end_pos": 1107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1252, "end_pos": 1254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1465, "end_pos": 1467, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1479, "end_pos": 1481, "annotation": "n_glycosylation_sequon" }, { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1672, "end_pos": 1674, "annotation": "n_glycosylation_sequon" }, { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 288, "end_pos": 290, "annotation": "n_glycosylation_sequon" }, { "start_pos": 304, "end_pos": 306, "annotation": 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