{ "uniprot_canonical_ac": "A0A0G2K2X2-1", "uniprot_ac": "A0A0G2K2X2", "uniprot_id": "A0A0G2K2X2_RAT", "mass": { "chemical_mass": 71058.0, "monoisotopic_mass": 71058.0 }, "refseq": {}, "gene_names": [ { "name": "Alkbh8", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K2X2", "id": "A0A0G2K2X2" } ], "protein_names": [ { "name": "Alkylated DNA repair protein alkB homolog 8", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A0G2K2X2" }, { "name": "2.1.1.229", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K2X2" }, { "name": "Probable alpha-ketoglutarate-dependent dioxygenase ABH8", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K2X2" }, { "name": "S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K2X2" }, { "name": "tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K2X2" } ], "function": [], "disease": [ { "disease_id": "DOID:0081232", "recommended_name": { "id": "DOID:0081232", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0081232", "name": "autosomal recessive intellectual developmental disorder 71", "description": "An autosomal recessive intellectual developmental disorder that has_material_basis_in homozygous mutation in the ALKBH8 gene on chromosome 11q22." }, "synonyms": [ { "id": "MONDO:0032789", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032789", "name": "intellectual developmental disorder, autosomal recessive 71", "description": "" }, { "id": "MONDO:0032789", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032789", "name": "INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 71", "description": "" }, { "id": "MONDO:0032789", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032789", "name": "MRT71", "description": "" }, { "id": "MONDO:0032789", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032789", "name": "Mental Retardation, Autosomal Recessive 71", "description": "" }, { "id": "MIM:618504", "resource": "MIM", "url": "https://www.omim.org/entry/618504", "name": "Intellectual developmental disorder, autosomal recessive 71", "description": "Intellectual developmental disorder, autosomal recessive 71" } ], "evidence": [ { "id": "0081232", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0081232" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2X2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2X2" } ], "common_name": "Rat" } ], "gene": [ { "name": "Alkbh8", "url": 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"categories": [ "Protein Classification" ] }, { "id": "IPR013216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027450", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027450", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034256", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034256", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PWKTKDE", "url": "https://omabrowser.org/oma/group/PWKTKDE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR13069", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13069", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13069:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13069:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "http://pfam.xfam.org/family/PF00076", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08241", "url": "http://pfam.xfam.org/family/PF08241", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF09004", "url": "http://pfam.xfam.org/family/PF09004", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13532", "url": "http://pfam.xfam.org/family/PF13532", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "1304687", 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"MNINHEGVLKLTKMEKKFLRKQSKARHVLLKHEGIQAVSYPTQSLVIANGGLGNAVSRKQLLLTLEKCGPVEALLMPPNKPYAFVIFQTIEESKKAYSILNGKEIIDDLGQKIFLYLNFVEKAQWKKLGLQALPPGLLVVEEIISSEEEKMLLESVNWTEDTGNQHFQRSLKHRRVKHFGYEFHYENNTVDKDKPLPGGLPEICSSILEKLLKEGYIKHKPDQLTINQYEPGHGIPAHIDSHSAFEHEIVSLSLGSAIVMDFKHPEGVTVQVMLPRRSLLVMTGESRYLWTHGITPRKFDTIQASEQFKGGIINSDIGDLTLSKRGMRTSFTFRKVRRIPCNCSYSSVCDRQRKATPPSLLESSKEALELEQKHVHHVYDEIASHFSSTRHSPWPRIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIGCDRSRNLVDICRERQFQALVCDALAVPVRSGSCDACISIAVIHHFATAERRVEALQEIARLLRSGGQALIYVWAMEQEYRDQKSKYLKGNRISQGDKGELNSATSMEQLLVNQMPEGVSEDPGLSVHSSNNTKDEECKSRKVLNSELPIHTNRTCFHSQDVLVPWHLKGKPGKDKAVEQSGLARCPDPRPVFQSLLPCFL", "length": 631, "header": "tr|A0A0G2K2X2-1|A0A0G2K2X2_RAT Isoform 1 of Alkylated DNA repair protein alkB homolog 8 OS=Rattus norvegicus OX=10116 GN=Alkbh8 PE=3 SV=1 CANONICAL=A0A0G2K2X2-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K2X2-1", "url": "", "sequence": { "sequence": 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"https://www.ensembl.org/id/ENSRNOT00000084222.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072411.2", "url": "https://www.ensembl.org/id/ENSRNOP00000072411.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2X2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2X2" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2X2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2X2" } ], "pmid": "" }, { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2X2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2X2" } ], "pmid": "" }, { "name": "2-oxoglutarate-dependent dioxygenase activity", "id": "GO:0016706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016706", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2X2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2X2" } ], "pmid": "" }, { "name": "tRNA (uracil) methyltransferase activity", "id": "GO:0016300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016300", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2X2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2X2" } ], "pmid": "" }, { "name": "tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity", "id": "GO:0106335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106335", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2X2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2X2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2X2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2X2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2X2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2X2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2X2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2X2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2X2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2X2" } ], "pmid": "" }, { "name": "tRNA wobble uridine modification", "id": "GO:0002098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002098", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2X2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2X2" } ], "pmid": "" }, { "name": "tRNA methylation", "id": "GO:0030488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030488", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2X2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2X2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 342, "end_pos": 344, "annotation": "n_glycosylation_sequon" }, { "start_pos": 561, "end_pos": 563, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { 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