{
    "uniprot_canonical_ac": "A0A0G2K2W1-1",
    "uniprot_ac": "A0A0G2K2W1",
    "uniprot_id": "A0A0G2K2W1_RAT",
    "mass": {
        "chemical_mass": 444289.0,
        "monoisotopic_mass": 444289.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Pkhd1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1",
            "id": "A0A0G2K2W1"
        }
    ],
    "protein_names": [
        {
            "name": "PKHD1 ciliary IPT domain containing fibrocystin/polyductin",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A0G2K2W1"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0080212",
            "recommended_name": {
                "id": "DOID:0080212",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080212",
                "name": "polycystic kidney disease 4",
                "description": "A autosomal recessive polycystic kidney disease that has_material_basis_in mutation in the PKD4 gene."
            },
            "synonyms": [],
            "evidence": [
                {
                    "id": "0080212",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080212"
                }
            ]
        },
        {
            "disease_id": "DOID:0110861",
            "recommended_name": {
                "id": "DOID:0110861",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0110861",
                "name": "autosomal recessive polycystic kidney disease",
                "description": "A polycystic kidney disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium, inherited in an autosomal recessive fashion."
            },
            "synonyms": [
                {
                    "id": "DOID:0110861",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110861",
                    "name": "Arpkd",
                    "description": ""
                },
                {
                    "id": "DOID:0110861",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110861",
                    "name": "Pkhd1",
                    "description": ""
                },
                {
                    "id": "DOID:0110861",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110861",
                    "name": "Polycystic Kidney Disease, Infantile, Type I",
                    "description": ""
                },
                {
                    "id": "DOID:0110861",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110861",
                    "name": "Polycystic Kidney and Hepatic Disease 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0033004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0033004",
                    "name": "polycystic kidney disease 4",
                    "description": "A autosomal dominant polycystic kidney disease that has material basis in mutation in the PKD4 gene."
                },
                {
                    "id": "MONDO:0033004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0033004",
                    "name": "polycystic kidney disease 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0033004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0033004",
                    "name": "polycystic kidney disease 4, with or without hepatic disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0033004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0033004",
                    "name": "PKD3",
                    "description": ""
                },
                {
                    "id": "MONDO:0033004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0033004",
                    "name": "PKD3, formerly",
                    "description": ""
                },
                {
                    "id": "MONDO:0033004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0033004",
                    "name": "PKD4",
                    "description": ""
                },
                {
                    "id": "MONDO:0033004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0033004",
                    "name": "hepatic fibrosis, congenital",
                    "description": ""
                },
                {
                    "id": "MONDO:0033004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0033004",
                    "name": "polycystic kidney and hepatic disease 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0033004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0033004",
                    "name": "polycystic kidney disease 4 with or without hepatic disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0033004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0033004",
                    "name": "polycystic kidney disease 4 with or without polycystic liver disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0033004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0033004",
                    "name": "polycystic kidney disease, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0033004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0033004",
                    "name": "polycystic kidney disease, infantile, type 1",
                    "description": ""
                },
                {
                    "id": "MIM:263200",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/263200",
                    "name": "Polycystic kidney disease 4, with or without polycystic liver disease",
                    "description": "Polycystic kidney disease 4, with or without polycystic liver disease"
                }
            ],
            "evidence": [
                {
                    "id": "0110861",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110861"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2K2W1",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Pkhd1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1",
            "locus": {
                "chromosome": "9",
                "start_pos": 22549513,
                "end_pos": 23037381,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000058742",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000058742"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000058742",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000058742",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00603",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00603",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002909",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002909",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR006626",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006626",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011050",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011050",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR012334",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012334",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013783",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR014756",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019316",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019316",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR037524",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037524",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR039448",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039448",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "FMVWGSA",
            "url": "https://omabrowser.org/oma/group/FMVWGSA/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR46769",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46769",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR46769:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46769:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01833",
            "url": "http://pfam.xfam.org/family/PF01833",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF10162",
            "url": "http://pfam.xfam.org/family/PF10162",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13229",
            "url": "http://pfam.xfam.org/family/PF13229",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1308476",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308476",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2K2W1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2K2W1-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "VMPAWRISLLSVELLLLANAYSSFRIEPTEGSLAGGTWITLVFDGLETSILYPNNGSQLAIDLVNVATPALKIPCDISPLFVDLPVVTCQTRSLPSEAPEGLYSLEIRSGDQLLGSPCARLLDNCTFKFSKEQTPVLYQVNPSSGVPGEVVHVYGWVITDRMEIFDPDVDYMESPLILEAGGDKWLTPCSLINRKTGICFPIQEEHGLGTVQCRVEGSYIGSQNVSFSVFNKGRSMVHKEAWLISAKQELFLYQTYPEIHSVFPKVGSLGGRTDITITGDFFDPSARVTIAGIPCDIRHVSPRKIECTTRAPGNGARLTAPQAGNRGLLFEVGNAVKDEELTEATPGYRWQIVPNASSPSGFWSKEGRPFRARLSGFFVAPETNNYTFWIQADSQAFLRFSSSEEPRMKVEVASIAVGTADWFDSWEQNGNEGSWQQKTNKLELQGGAKYYLEAEQHGIAPSRGMRIAVQIHNTWLNPDVVNTYLLEKHQIRAQAQRLPEIQVLNMSGKGNFFLTWGNVSSQPVPANATAQQIQTIIEELLVVKCNLVPLSARVLLWLGFEQGLDGSRSDGVLTSSTEPFCGRFSLGQLRHLILSPGAVSKGYQLDRYPYLCFAYRGHMNRTLDMTVSFLFGFQNVMKNITCDWSLMEPHPESWHFTCNNLWDTCVRHSEELQSSLANTPLLVHRIDIFPVVPEADLLYVDEIILADTNVTVSQADSGVARPGGNVVESVSVVGVPPVYSIASWMAGCGSELPLITACYVPTQGTGEGSELIEVTAKRLQRTSPPLGGHFSLHLSDTVIPDVPVHVSARQLHKLLQDNADESTSGYLNADDFIVTKDQNSCYEHVWTLSWTTQIGDLPNFIRVSDQNLTGLNPTITARVVYDGGVFLGPILGDTLATANQQTQVTVQVNDIPAHCSGSCSFQYQRASTPSVDCVWYSLGSDVNLLVHFTGNGFPRDAQFLQVTVINTSCEVIFSNETNVACELALLPVGVHRVFMLVRPSGLALNASGEGLFLRVEPRLDAVEPSTGAEIGGWWVTLRGSSLEGVSLVLFGTRSCVIDVIRSNSQQIQCKVPPRGKDGYTVNVTVINGDHSTVLARAFTYVSSLNPVIVSLSRNRSNIAGGEILFLGMTLMVNYTDLNVQIYIQNTSAQVLAKTAWGLEVLLPPLLPGIYVISAFINGISIRSQGVDLHIQYLTEVFSMEPCSGSLLGGTILRLSGAGLGRDPALIRVLVDNRPCDTVKLTEVNIWCETPRVLLPPRADVLTVPASVEIWAGNTSFVGKAFIFTYEAAATPVVTAMWGELMNNSVRFYVEGNNLSDSVILLGSLKCDLQVQLFGDNMNLSGCSLLLHSLEAGVYALQVRHKRMGFANMSAVPQKFELSPQIIDIFPTHGSIYGGTVLTVKGTAFRSRRRSVHVDLSGPFTCVILSLGDHTVLCQTKFVGDQFSETSLALNITVLVNGLTSKCEGNCTLFLEEAATPIVDALTISISGSLTTVLMRGQRLGSAGEPTAFVDGQLLCHTTFFNTSYVACQMRDLAPGFHYLSAVRTSAGYACLNSVSRNFFVVPQVFDYFPKDFSIHGGSLLTIKGTTLRGWKTTFVYVGQQACLTVNISSEFIQCIVPAGNGSAALEIDVDGVLYHMGFVDYSSIFTPELLSVSRSHDILTFTVARISGAANVDILIGTSPCLDVAGNRTILRCMVPLLPAGEYAVTGYDHSRGWVSSTLILVLRATVTSVTENYGCLGGRLLHVLGAGFSPGNISAAVCGAPCQVLANATVSAFSCLVLPLDASLAFLCNLRHAEDSCGVSRPTYLQCDLTVSVGMERLPGSWPYVYLCEESSQGLFVPDHQIFLSFSGLFLSPKVERDEVLIYNSSCNITMETEAEMECGTPNQPITAKITEIQKSRGQNTQGNFSFQFCRRWSRPHSWFPHRVPQDGDNVTVETSHLLLLDANTSLLNSLHIKGGKLIFMEPGPIDLRAHSILITDGGELHIGSEDKPFQGKARIKLYGSVHSTSFFPYGVKFLAVRNGTLSLHGSVPEVTFTYLRAAACAGDTVLALEEAVAWHPGDEAVISSGATVEGAEATEEVVVVETVHDADLHLRNPLRYSYNFTENWVTGVNHILKATVALLSRNIIVQGNLTLERVKLLDSCQEAGAAEGNLKHCLYSKSEKMLGARNLGARVIIQSFPEEPSLVKLKGVQFRDLGQAFHKHLSSLTLVGAMRGSYLHSCSMWGSFSRGLSIHRTWGLKVENNIFYKIVGHALLVGSYMDRSFSTSEAVIGRKNGWWEEGSMIRNNVIINVSGAEGLSSSEMLAPAGIYTFSPTSAIEGNRVCAAGYGYVLHLVTSQTVQAPLLSFNWNTAHSCTRYGLLVYPEFQPPWNNDTGFTLFQNFMVWGSAGGAQIFRSNNLHLRNFQVYACRDFGIDILESDTNTLVTDSFLLGHFTHEGSLCMSVGIKTPKRWGLTISNTTFVNFDLNCVAIRTCSGCSQGQGGFPVKTRQLKFVNSSNLVAFPFPHAAVLQDLDGSLSGKNGSHVLASMETLSDTCLTNASFSQIVSGSVCGEAVLFHRMSIGLAKSLDVPKNLTMTDIRNRTITINYVDDTLSNSYGWMALLLDQETYLLQFEGPWTDGSLQYSATFDNFAPGNYLLLMHRDLLPYPDILLRCGSRVGQSLPSHPLPSRDGACDWFFHRQLRQLTYLVSGEGQVHVFLQVKHGAPPTVSASTSVSESALKWSLPETWQDVEKGWGGYNHTIPGPGDDVLILPNKTVLVDTDLPVLRCLYVMGTLEFPVDRSNVLSVACLLIAGGELKVGTLENPLGKDQRLLILLRASEEIFCDRFDGIRVDPGTIGVYGKLRLHSAYPKKSWVHLGADIAPGNERIIVHNAVDWQPHDKIVLSSSSYEPHEAEVLTVKEVKDHHIRIYERLKHRHIGSAHTLEDSRQICLAAEVGLLTRNIRIQSDSSCRGRLLVGSFRKSSGEEFSGILQLLNVEIQNMGSPLYASIEFTGVSAGSWVISSTVHQSCTVGIHASSSRGMVLNDNIVFGTKGHGIDVEGQNYSLTNNLVILSMQSANSLPWVAGIKVNYAEDIILHGNVVAGSERLGFHVRGHGCSSEVLWSDNVVHSSLHGIHLYKKREPNNCTGVSGFLAFKNFDYGAMVQTENSVDIQNITLVDNTVGLLAISYVSSAPLRSGSTLQITLRNSVIVATSSSFDCIQDRKAPQSANWTSTDRAPSNPRGGRIGILWPVSASEPNGWPQEPWHKVRGGHSVPGIMKLQDVTFSSFVKSCYSDDLDVCILTNEHSTGIMYPITAERTRMLKIKDKNKFYFLPLQSGKDLVGTICPASSDCEIPRKYLFTDLDGRTLGLSPPVSVFPRIEEGWTGSFFNTGIFREEQKCTFRAMIQGFFCKQTEHAVLILDNVDVTWTIPKFYPLVSITNGFVDTFSIVKDSGLCFPTSSPSTFYSILPTRQMTKVCFPERTPPFLHFFLLANRRASKLILAVFYNEIQSPYVFLDKSFIPPTPVESAFSLLDEPVGANYFDIMNNLLYVVLQGEEAVEIRSSVSIHLALTVTFSVLEKGWEKAVLESLRGFFQIDQNQIRLTLEMPGNKETLKAIANSEGKRKRSCPTVTCAVPSSRYVQRRPLMAEMASFTITPATTLETFSKVIVFEIGDLPNARDSEFIQSLPSNRLQKLAHQVITAQQTGVLENVLGMTVGALLVAQSEGVTGYRNASSLITGNQIYTRPSVVSILVQPSDGEVGIELPIQPRLIFLDEKNERVEALGLPSEPWIISVSLEGTSESMLKGCTQAETQDGYVTFSRLAVLTSGSNWHLVFTVTFPPGTNLTARSKTFAVLPVAGKERSTIILALSLCSVASWVALSCLICCWFKKSKTRKIKPEDISESQAKEQKKNTHISSKPRELQVKTAKEDAMMGEDMRMKVMEGRQNQFSQHSMDGVSKRKVSRRAVPEERTATPALKIPRTTCVPGALPQQLTLPEPGNWQEAQQQLLRYQLAGRDQLLLLCPDLRQERQQGQEPSQLNKGSGRCMGLSQEKATCVPTETFCLHTAPPETIQ",
        "length": 4052,
        "header": "tr|A0A0G2K2W1-1|A0A0G2K2W1_RAT Isoform 1 of PKHD1 ciliary IPT domain containing fibrocystin/polyductin  OS=Rattus norvegicus OX=10116 GN=Pkhd1 PE=1 SV=2 CANONICAL=A0A0G2K2W1-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2K2W1-1",
            "url": "",
            "sequence": {
                "sequence": "VMPAWRISLLSVELLLLANAYSSFRIEPTEGSLAGGTWITLVFDGLETSILYPNNGSQLAIDLVNVATPALKIPCDISPLFVDLPVVTCQTRSLPSEAPEGLYSLEIRSGDQLLGSPCARLLDNCTFKFSKEQTPVLYQVNPSSGVPGEVVHVYGWVITDRMEIFDPDVDYMESPLILEAGGDKWLTPCSLINRKTGICFPIQEEHGLGTVQCRVEGSYIGSQNVSFSVFNKGRSMVHKEAWLISAKQELFLYQTYPEIHSVFPKVGSLGGRTDITITGDFFDPSARVTIAGIPCDIRHVSPRKIECTTRAPGNGARLTAPQAGNRGLLFEVGNAVKDEELTEATPGYRWQIVPNASSPSGFWSKEGRPFRARLSGFFVAPETNNYTFWIQADSQAFLRFSSSEEPRMKVEVASIAVGTADWFDSWEQNGNEGSWQQKTNKLELQGGAKYYLEAEQHGIAPSRGMRIAVQIHNTWLNPDVVNTYLLEKHQIRAQAQRLPEIQVLNMSGKGNFFLTWGNVSSQPVPANATAQQIQTIIEELLVVKCNLVPLSARVLLWLGFEQGLDGSRSDGVLTSSTEPFCGRFSLGQLRHLILSPGAVSKGYQLDRYPYLCFAYRGHMNRTLDMTVSFLFGFQNVMKNITCDWSLMEPHPESWHFTCNNLWDTCVRHSEELQSSLANTPLLVHRIDIFPVVPEADLLYVDEIILADTNVTVSQADSGVARPGGNVVESVSVVGVPPVYSIASWMAGCGSELPLITACYVPTQGTGEGSELIEVTAKRLQRTSPPLGGHFSLHLSDTVIPDVPVHVSARQLHKLLQDNADESTSGYLNADDFIVTKDQNSCYEHVWTLSWTTQIGDLPNFIRVSDQNLTGLNPTITARVVYDGGVFLGPILGDTLATANQQTQVTVQVNDIPAHCSGSCSFQYQRASTPSVDCVWYSLGSDVNLLVHFTGNGFPRDAQFLQVTVINTSCEVIFSNETNVACELALLPVGVHRVFMLVRPSGLALNASGEGLFLRVEPRLDAVEPSTGAEIGGWWVTLRGSSLEGVSLVLFGTRSCVIDVIRSNSQQIQCKVPPRGKDGYTVNVTVINGDHSTVLARAFTYVSSLNPVIVSLSRNRSNIAGGEILFLGMTLMVNYTDLNVQIYIQNTSAQVLAKTAWGLEVLLPPLLPGIYVISAFINGISIRSQGVDLHIQYLTEVFSMEPCSGSLLGGTILRLSGAGLGRDPALIRVLVDNRPCDTVKLTEVNIWCETPRVLLPPRADVLTVPASVEIWAGNTSFVGKAFIFTYEAAATPVVTAMWGELMNNSVRFYVEGNNLSDSVILLGSLKCDLQVQLFGDNMNLSGCSLLLHSLEAGVYALQVRHKRMGFANMSAVPQKFELSPQIIDIFPTHGSIYGGTVLTVKGTAFRSRRRSVHVDLSGPFTCVILSLGDHTVLCQTKFVGDQFSETSLALNITVLVNGLTSKCEGNCTLFLEEAATPIVDALTISISGSLTTVLMRGQRLGSAGEPTAFVDGQLLCHTTFFNTSYVACQMRDLAPGFHYLSAVRTSAGYACLNSVSRNFFVVPQVFDYFPKDFSIHGGSLLTIKGTTLRGWKTTFVYVGQQACLTVNISSEFIQCIVPAGNGSAALEIDVDGVLYHMGFVDYSSIFTPELLSVSRSHDILTFTVARISGAANVDILIGTSPCLDVAGNRTILRCMVPLLPAGEYAVTGYDHSRGWVSSTLILVLRATVTSVTENYGCLGGRLLHVLGAGFSPGNISAAVCGAPCQVLANATVSAFSCLVLPLDASLAFLCNLRHAEDSCGVSRPTYLQCDLTVSVGMERLPGSWPYVYLCEESSQGLFVPDHQIFLSFSGLFLSPKVERDEVLIYNSSCNITMETEAEMECGTPNQPITAKITEIQKSRGQNTQGNFSFQFCRRWSRPHSWFPHRVPQDGDNVTVETSHLLLLDANTSLLNSLHIKGGKLIFMEPGPIDLRAHSILITDGGELHIGSEDKPFQGKARIKLYGSVHSTSFFPYGVKFLAVRNGTLSLHGSVPEVTFTYLRAAACAGDTVLALEEAVAWHPGDEAVISSGATVEGAEATEEVVVVETVHDADLHLRNPLRYSYNFTENWVTGVNHILKATVALLSRNIIVQGNLTLERVKLLDSCQEAGAAEGNLKHCLYSKSEKMLGARNLGARVIIQSFPEEPSLVKLKGVQFRDLGQAFHKHLSSLTLVGAMRGSYLHSCSMWGSFSRGLSIHRTWGLKVENNIFYKIVGHALLVGSYMDRSFSTSEAVIGRKNGWWEEGSMIRNNVIINVSGAEGLSSSEMLAPAGIYTFSPTSAIEGNRVCAAGYGYVLHLVTSQTVQAPLLSFNWNTAHSCTRYGLLVYPEFQPPWNNDTGFTLFQNFMVWGSAGGAQIFRSNNLHLRNFQVYACRDFGIDILESDTNTLVTDSFLLGHFTHEGSLCMSVGIKTPKRWGLTISNTTFVNFDLNCVAIRTCSGCSQGQGGFPVKTRQLKFVNSSNLVAFPFPHAAVLQDLDGSLSGKNGSHVLASMETLSDTCLTNASFSQIVSGSVCGEAVLFHRMSIGLAKSLDVPKNLTMTDIRNRTITINYVDDTLSNSYGWMALLLDQETYLLQFEGPWTDGSLQYSATFDNFAPGNYLLLMHRDLLPYPDILLRCGSRVGQSLPSHPLPSRDGACDWFFHRQLRQLTYLVSGEGQVHVFLQVKHGAPPTVSASTSVSESALKWSLPETWQDVEKGWGGYNHTIPGPGDDVLILPNKTVLVDTDLPVLRCLYVMGTLEFPVDRSNVLSVACLLIAGGELKVGTLENPLGKDQRLLILLRASEEIFCDRFDGIRVDPGTIGVYGKLRLHSAYPKKSWVHLGADIAPGNERIIVHNAVDWQPHDKIVLSSSSYEPHEAEVLTVKEVKDHHIRIYERLKHRHIGSAHTLEDSRQICLAAEVGLLTRNIRIQSDSSCRGRLLVGSFRKSSGEEFSGILQLLNVEIQNMGSPLYASIEFTGVSAGSWVISSTVHQSCTVGIHASSSRGMVLNDNIVFGTKGHGIDVEGQNYSLTNNLVILSMQSANSLPWVAGIKVNYAEDIILHGNVVAGSERLGFHVRGHGCSSEVLWSDNVVHSSLHGIHLYKKREPNNCTGVSGFLAFKNFDYGAMVQTENSVDIQNITLVDNTVGLLAISYVSSAPLRSGSTLQITLRNSVIVATSSSFDCIQDRKAPQSANWTSTDRAPSNPRGGRIGILWPVSASEPNGWPQEPWHKVRGGHSVPGIMKLQDVTFSSFVKSCYSDDLDVCILTNEHSTGIMYPITAERTRMLKIKDKNKFYFLPLQSGKDLVGTICPASSDCEIPRKYLFTDLDGRTLGLSPPVSVFPRIEEGWTGSFFNTGIFREEQKCTFRAMIQGFFCKQTEHAVLILDNVDVTWTIPKFYPLVSITNGFVDTFSIVKDSGLCFPTSSPSTFYSILPTRQMTKVCFPERTPPFLHFFLLANRRASKLILAVFYNEIQSPYVFLDKSFIPPTPVESAFSLLDEPVGANYFDIMNNLLYVVLQGEEAVEIRSSVSIHLALTVTFSVLEKGWEKAVLESLRGFFQIDQNQIRLTLEMPGNKETLKAIANSEGKRKRSCPTVTCAVPSSRYVQRRPLMAEMASFTITPATTLETFSKVIVFEIGDLPNARDSEFIQSLPSNRLQKLAHQVITAQQTGVLENVLGMTVGALLVAQSEGVTGYRNASSLITGNQIYTRPSVVSILVQPSDGEVGIELPIQPRLIFLDEKNERVEALGLPSEPWIISVSLEGTSESMLKGCTQAETQDGYVTFSRLAVLTSGSNWHLVFTVTFPPGTNLTARSKTFAVLPVAGKERSTIILALSLCSVASWVALSCLICCWFKKSKTRKIKPEDISESQAKEQKKNTHISSKPRELQVKTAKEDAMMGEDMRMKVMEGRQNQFSQHSMDGVSKRKVSRRAVPEERTATPALKIPRTTCVPGALPQQLTLPEPGNWQEAQQQLLRYQLAGRDQLLLLCPDLRQERQQGQEPSQLNKGSGRCMGLSQEKATCVPTETFCLHTAPPETIQ",
                "length": 4052,
                "header": "tr|A0A0G2K2W1-1|A0A0G2K2W1_RAT Isoform 1 of PKHD1 ciliary IPT domain containing fibrocystin/polyductin  OS=Rattus norvegicus OX=10116 GN=Pkhd1 PE=1 SV=2 CANONICAL=A0A0G2K2W1-1"
            },
            "locus": {
                "chromosome": "9",
                "start_pos": 23035484,
                "end_pos": 22550573,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000080948.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000080948.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000072399.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000072399.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 17,
                "go_terms": [
                    {
                        "name": "regulation of centrosome duplication",
                        "id": "GO:0010824",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010824",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of epithelial cell apoptotic process",
                        "id": "GO:1904036",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904036",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of cell population proliferation",
                        "id": "GO:0008284",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of apoptotic process",
                        "id": "GO:0043066",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "kidney development",
                        "id": "GO:0001822",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001822",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "intracellular calcium ion homeostasis",
                        "id": "GO:0006874",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006874",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of NF-kappaB transcription factor activity",
                        "id": "GO:0032088",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032088",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cilium assembly",
                        "id": "GO:0060271",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of protein kinase B signaling",
                        "id": "GO:0051898",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051898",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of ERK1 and ERK2 cascade",
                        "id": "GO:0070372",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070372",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "establishment of mitotic spindle orientation",
                        "id": "GO:0000132",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000132",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of TOR signaling",
                        "id": "GO:0032006",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032006",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of epithelial cell proliferation",
                        "id": "GO:0050679",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050679",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of establishment of planar polarity",
                        "id": "GO:0090175",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090175",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "branching morphogenesis of an epithelial tube",
                        "id": "GO:0048754",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048754",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell-cell junction organization",
                        "id": "GO:0045216",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045216",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of cholangiocyte proliferation",
                        "id": "GO:1904054",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904054",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 11,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum",
                        "id": "GO:0005783",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi apparatus",
                        "id": "GO:0005794",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "centrosome",
                        "id": "GO:0005813",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cilium",
                        "id": "GO:0005929",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "perinuclear region of cytoplasm",
                        "id": "GO:0048471",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "extracellular exosome",
                        "id": "GO:0070062",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "apical plasma membrane",
                        "id": "GO:0016324",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ciliary basal body",
                        "id": "GO:0036064",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitotic spindle",
                        "id": "GO:0072686",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "9+0 non-motile cilium",
                        "id": "GO:0097731",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097731",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K2W1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 1005,
            "end_pos": 1007,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1082,
            "end_pos": 1084,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1114,
            "end_pos": 1116,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1133,
            "end_pos": 1135,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1145,
            "end_pos": 1147,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 124,
            "end_pos": 126,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1273,
            "end_pos": 1275,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1302,
            "end_pos": 1304,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1313,
            "end_pos": 1315,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1338,
            "end_pos": 1340,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1367,
            "end_pos": 1369,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1450,
            "end_pos": 1452,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1465,
            "end_pos": 1467,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1521,
            "end_pos": 1523,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1606,
            "end_pos": 1608,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1620,
            "end_pos": 1622,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1687,
            "end_pos": 1689,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1753,
            "end_pos": 1755,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1768,
            "end_pos": 1770,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1865,
            "end_pos": 1867,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1869,
            "end_pos": 1871,
            "annotation": "n_glycosylation_sequon"
        },
        {
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