{ "uniprot_canonical_ac": "A0A0G2K2S9-1", "uniprot_ac": "A0A0G2K2S9", "uniprot_id": "A0A0G2K2S9_RAT", "mass": { "chemical_mass": 51551.0, "monoisotopic_mass": 51551.0 }, "refseq": { "ac": "NP_001100982", "name": "transcriptional enhancer factor TEF-4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100982" }, "gene_names": [ { "name": "Tead2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9", "id": "A0A0G2K2S9" }, { "name": "Tead2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100982", "id": "NP_001100982" } ], "protein_names": [ { "name": "Embryonic TEA domain containing factor; TEA domain family member 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100982", "id": "NP_001100982" }, { "name": "TEA domain transcription factor 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K2S9" }, { "name": "transcriptional enhancer factor TEF-4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100982", "id": "NP_001100982" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "common_name": "Rat" } ], "gene": [ { "name": "Tead2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9", "locus": { "chromosome": "1", "start_pos": 95719186, "end_pos": 95703005, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000020695", "url": "https://www.ensembl.org/id/ENSRNOG00000020695" } ] } } ], "crossref": [ { "id": "ENSRNOG00000020695", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020695", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "308582", "url": "https://www.ncbi.nlm.nih.gov/gene/308582", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041086", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041086", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:308582", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:308582", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WQTRALG", "url": "https://omabrowser.org/oma/group/WQTRALG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1408493at2759", "url": "http://www.orthodb.org/?query=1408493at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11834", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11834", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11834:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11834:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01285", "url": "http://pfam.xfam.org/family/PF01285", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17725", "url": "http://pfam.xfam.org/family/PF17725", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "1593252", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1593252", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K2S9-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6JAZ6", "url": "https://www.uniprot.org/uniprot/A6JAZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6JAZ6-1", "url": "https://www.uniprot.org/uniprot/A6JAZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLRTLGSWESSGSHKTSREEAQMGDPRTGAPLDDGGGWTGSEEGSEEGTGGSEGVGGDGSPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPSGPQATELFQFWSGSSGPTWNVPDVKPFSQAPFSMSLTPPATDLPGYEPPPALSPLPPPAPSPPAWQARALGTARLQLVEFSAFVEPPDAVDSFQRHLFVHISQQCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSAEEAGNSGGAGGFYGVSSQYESRELMTLTCSSKVCSFGKQVVEKVETERAQLEGGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD", "length": 468, "header": "tr|A0A0G2K2S9-1|A0A0G2K2S9_RAT Isoform 1 of TEA domain transcription factor 2 OS=Rattus norvegicus OX=10116 GN=Tead2 PE=4 SV=1 CANONICAL=A0A0G2K2S9-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K2S9-1", "url": "", "sequence": { "sequence": "MGLRTLGSWESSGSHKTSREEAQMGDPRTGAPLDDGGGWTGSEEGSEEGTGGSEGVGGDGSPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPSGPQATELFQFWSGSSGPTWNVPDVKPFSQAPFSMSLTPPATDLPGYEPPPALSPLPPPAPSPPAWQARALGTARLQLVEFSAFVEPPDAVDSFQRHLFVHISQQCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSAEEAGNSGGAGGFYGVSSQYESRELMTLTCSSKVCSFGKQVVEKVETERAQLEGGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD", "length": 468, "header": "tr|A0A0G2K2S9-1|A0A0G2K2S9_RAT Isoform 1 of TEA domain transcription factor 2 OS=Rattus norvegicus OX=10116 GN=Tead2 PE=4 SV=1 CANONICAL=A0A0G2K2S9-1" }, "locus": { "chromosome": "1", "start_pos": 95718496, "end_pos": 95703065, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000090838.2", "url": "https://www.ensembl.org/id/ENSRNOT00000090838.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072360.2", "url": "https://www.ensembl.org/id/ENSRNOP00000072360.2" } ] } }, { "isoform_ac": "A6JAZ6-1", "url": "", "sequence": { "sequence": "MGDPRTGAPLDDGGGWTGSEEGSEEGTGGSEGVGGDGSPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPSGPQATELFQFWSGSSGPTWNVPDVKPFSQAPFSMSLTPPATDLPGYEPPPALSPLPPPAPSPPAWQARALGTARLQLVEFSAFVEPPDAVDSFQRHLFVHISQQCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSAEEAGNSGGAGGFYGVSSQYESRELMTLTCSSKVCSFGKQVVEKVETERAQLEGGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD", "length": 445, "header": "tr|A6JAZ6-1|A0A0G2K2S9_RAT Computationally mapped isoform of TEA domain transcription factor 2 OS=Rattus norvegicus OX=10116 GN=Tead2 PE=4 SV=1 CANONICAL=A0A0G2K2S9-1" }, "locus": { "chromosome": "1", "start_pos": 95718496, "end_pos": 95703871, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000028086.5", "url": "https://www.ensembl.org/id/ENSRNOT00000028086.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000028086.4", "url": "https://www.ensembl.org/id/ENSRNOP00000028086.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:308582", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:308582", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P48301-1", "protein_name": "Transcriptional enhancer factor TEF-4", "gene_name": "Tead2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGDPRTGAPLDDGGGWTGSEEGSEEGTGGSEGVGGDGSPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPSGPQATELFQFWSGSSGPPWNVPDVKPFSQAPFSVSLTPPASDLPGYEPPPALSPLPPPAPSPPAWQARALGTARLQLIEFSAFVEPPDAVDSFQRHLFVHISQQCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSAEEAGSSGGGGGFYGVSSQYESRELMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQYHIYRLVRD", "length": 445 }, "evidence": [ { "id": "45243963", "url": "http://www.informatics.jax.org/homology/45243963", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q15562-1", "protein_name": "Transcriptional enhancer factor TEF-4", "gene_name": "TEAD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD", "length": 447 }, "evidence": [ { "id": "45243963", "url": "http://www.informatics.jax.org/homology/45243963", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 15, "go_terms": [ { "name": "vasculogenesis", "id": "GO:0001570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001570", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "cellular response to retinoic acid", "id": "GO:0071300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071300", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "hippo signaling", "id": "GO:0035329", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035329", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "neural tube closure", "id": "GO:0001843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "embryonic heart tube morphogenesis", "id": "GO:0003143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003143", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "embryonic organ development", "id": "GO:0048568", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048568", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "notochord development", "id": "GO:0030903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030903", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "lateral mesoderm development", "id": "GO:0048368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048368", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "paraxial mesoderm development", "id": "GO:0048339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048339", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "regulation of stem cell differentiation", "id": "GO:2000736", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000736", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "protein-containing complex assembly", "id": "GO:0065003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "transcription coactivator binding", "id": "GO:0001223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001223", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "disordered domain specific binding", "id": "GO:0097718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097718", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "TEAD-YAP complex", "id": "GO:0140552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140552", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2S9", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 426, "end_pos": 428, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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