{ "uniprot_canonical_ac": "A0A0G2K2H4-1", "uniprot_ac": "A0A0G2K2H4", "uniprot_id": "A0A0G2K2H4_RAT", "mass": { "chemical_mass": 110151.0, "monoisotopic_mass": 110151.0 }, "refseq": { "ac": "NP_001178855", "name": "serine/threonine-protein kinase/endoribonuclease IRE1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178855" }, "gene_names": [ { "name": "Ern1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4", "id": "A0A0G2K2H4" }, { "name": "Ern1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006247696", "id": "XP_006247696" }, { "name": "RGD1559716", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006247696", "id": "XP_006247696" } ], "protein_names": [ { "name": "non-specific serine/threonine protein kinase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A0G2K2H4" }, { "name": "2.7.11.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K2H4" }, { "name": "endoplasmic reticulum (ER) to nucleus signalling 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178855", "id": "NP_001178855" }, { "name": "serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006247696", "id": "XP_006247696" }, { "name": "serine/threonine-protein kinase/endoribonuclease IRE1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178855", "id": "NP_001178855" } ], "function": [ { "annotation": "Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001178855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178855" }, { "database": "PubMed", "id": "32272965", "url": "https://glygen.org/publication/PubMed/32272965" } ] }, { "annotation": "Endoplasmic reticulum stress related factor IRE1alpha regulates TXNIP/NLRP3-mediated pyroptosis in diabetic nephropathy.", "evidence": [ { "database": "RefSeq", "id": "NP_001178855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178855" }, { "database": "PubMed", "id": "32950473", "url": "https://glygen.org/publication/PubMed/32950473" } ] }, { "annotation": "Hyperoxia induces endoplasmic reticulum stressassociated apoptosis via the IRE1α pathway in rats with bronchopulmonary dysplasia.", "evidence": [ { "database": "RefSeq", "id": "NP_001178855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178855" }, { "database": "PubMed", "id": "33179109", "url": "https://glygen.org/publication/PubMed/33179109" } ] }, { "annotation": "Inhibition of IRE1 suppresses the catabolic effect of IL-1beta on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.", "evidence": [ { "database": "RefSeq", "id": "NP_001178855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178855" }, { "database": "PubMed", "id": "35085541", "url": "https://glygen.org/publication/PubMed/35085541" } ] }, { "annotation": "Palmitate induces cardiomyocyte death via inositol requiring enzyme-1 (IRE1)-mediated signaling independent of X-box binding protein 1 (XBP1).", "evidence": [ { "database": "RefSeq", "id": "NP_001178855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178855" }, { "database": "PubMed", "id": "32199617", "url": "https://glygen.org/publication/PubMed/32199617" } ] } ], "disease": [ { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. 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The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. 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The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. 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"name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AJE4-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AJE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LSY7", "url": "https://www.uniprot.org/uniprot/F1LSY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LSY7-1", "url": "https://www.uniprot.org/uniprot/F1LSY7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPARWLLLLLALLLLPPGPGSFGRASTVTLPEALLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYIWQREGLRKVVHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKRSFEEVINLVGQTSENTPTTVSQDVEEKLPRAPAKPEAPVDSMLKDMATIILSTFLLVGWVAFIITYPLSMHQQRQLQHQQFQKELEKIQLLQQQQLPFHPHGDLTQDPDFLDSSGLFSESSGTSSPSPSPRASNHSLNSSSSASKAGTSPSLEPDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQANILLGACSLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVRQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKRHHYRELPLEVQETLGSIPDDFVRYFTSRFPHLLSHTYRAMELCRHERLFQTYYWHEPTEAQPPGIPDAL", "length": 977, "header": "tr|A0A0G2K2H4-1|A0A0G2K2H4_RAT Isoform 1 of non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Ern1 PE=2 SV=1 CANONICAL=A0A0G2K2H4-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K2H4-1", "url": "", "sequence": { "sequence": "MPARWLLLLLALLLLPPGPGSFGRASTVTLPEALLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYIWQREGLRKVVHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKRSFEEVINLVGQTSENTPTTVSQDVEEKLPRAPAKPEAPVDSMLKDMATIILSTFLLVGWVAFIITYPLSMHQQRQLQHQQFQKELEKIQLLQQQQLPFHPHGDLTQDPDFLDSSGLFSESSGTSSPSPSPRASNHSLNSSSSASKAGTSPSLEPDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQANILLGACSLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVRQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKRHHYRELPLEVQETLGSIPDDFVRYFTSRFPHLLSHTYRAMELCRHERLFQTYYWHEPTEAQPPGIPDAL", "length": 977, "header": "tr|A0A0G2K2H4-1|A0A0G2K2H4_RAT Isoform 1 of non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Ern1 PE=2 SV=1 CANONICAL=A0A0G2K2H4-1" }, "locus": { "chromosome": "10", "start_pos": 91421005, "end_pos": 91330713, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000085736.2", "url": "https://www.ensembl.org/id/ENSRNOT00000085736.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072244.1", "url": "https://www.ensembl.org/id/ENSRNOP00000072244.1" } ] } }, { "isoform_ac": "A0A8I5ZPE4-1", "url": "", "sequence": { "sequence": "MPARWLLLLLALLLLPPGPGSFGRASTVTLPEALLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTVRIFNSLVLTCF", "length": 108, "header": "tr|A0A8I5ZPE4-1|A0A8I5ZPE4_RAT Computationally mapped isoform of Endoplasmic reticulum to nucleus signaling 1 OS=Rattus norvegicus OX=10116 GN=Ern1 PE=4 SV=1 CANONICAL=A0A0G2K2H4-1" }, "locus": { "chromosome": "10", "start_pos": 91421005, "end_pos": 91366229, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000107730.1", "url": "https://www.ensembl.org/id/ENSRNOT00000107730.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000079836.1", "url": "https://www.ensembl.org/id/ENSRNOP00000079836.1" } ] } }, { "isoform_ac": "A0A8I6A2F5-1", "url": "", "sequence": { "sequence": "MPARWLLLLLALLLLPPGPGSFGRASTVTLPEALLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTVGSPGPRRQKERTDSSKLFSGLHTCAAPCIQSPSQHTEINKCHKKFFKKSLHPSHIREICFSFRESMW", "length": 164, "header": "tr|A0A8I6A2F5-1|A0A8I6A2F5_RAT Computationally mapped isoform of Endoplasmic reticulum to nucleus signaling 1 OS=Rattus norvegicus OX=10116 GN=Ern1 PE=4 SV=1 CANONICAL=A0A0G2K2H4-1" }, "locus": { "chromosome": "10", "start_pos": 91421005, "end_pos": 91365338, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000108922.1", "url": "https://www.ensembl.org/id/ENSRNOT00000108922.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000086547.1", "url": "https://www.ensembl.org/id/ENSRNOP00000086547.1" } ] } }, { "isoform_ac": "A0A8I6AJE4-1", "url": "", "sequence": { "sequence": "MSLQSFGRASTVTLPEALLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGISGLPPMNLSTTIPGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYIWQREGLRKVVHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKRSFEEVINLVGQTSENTPTTVSQDVEEKLPRAPAKPEAPVDSMLKDMATIILSTFLLVGWVAFIITYPLSMHQQRQLQHQQFQKELEKIQLLQQQQLPFHPHGDLTQDPDFLDSSGLFSESSGTSSPSPSPRASNHSLNSSSSASKAGTSPSLEPDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPPLTSVYMHTQTCTHMYNGSTQLCHLAMEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVRQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKRHHYRELPLEVQETLGSIPDDFVRYFTSRFPHLLSHTYRAMELCRHERLFQTYYWHEPTEAQPPGIPDAL", "length": 927, "header": "tr|A0A8I6AJE4-1|A0A8I6AJE4_RAT Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Ern1 PE=4 SV=1 CANONICAL=A0A0G2K2H4-1" }, "locus": { "chromosome": "10", "start_pos": 91389792, "end_pos": 91330713, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000116974.1", "url": "https://www.ensembl.org/id/ENSRNOT00000116974.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000093755.1", "url": "https://www.ensembl.org/id/ENSRNOP00000093755.1" } ] } }, { "isoform_ac": "F1LSY7-1", "url": "", "sequence": { "sequence": "MRRCNDIQSFGRASTVTLPEALLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYIWQREGLRKVVHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKRSFEEVINLVGQTSENTPTTVSQDVEEKLPRAPAKPEAPVDSMLKDMATIILSTFLLVGWVAFIITYPLSMHQQRQLQHQQFQKELEKIQLLQQQQLPFHPHGDLTQDPDFLDSSGLFSESSGTSSPSPSPRASNHSLNSSSSASKAGTSPSLEPDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQANILLGACSLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVRQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKRHHYRELPLEVQETLGSIPDDFVRYFTSRFPHLLSHTYRAMELCRHERLFQTYYWHEPTEAQPPGIPDAL", "length": 965, "header": "tr|F1LSY7-1|F1LSY7_RAT Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Ern1 PE=4 SV=2 CANONICAL=A0A0G2K2H4-1" }, "locus": { "chromosome": "10", "start_pos": 91391879, "end_pos": 91330713, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000017371.6", "url": "https://www.ensembl.org/id/ENSRNOT00000017371.6" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000017371.4", "url": "https://www.ensembl.org/id/ENSRNOP00000017371.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Palmitate induces cardiomyocyte death via inositol requiring enzyme-1 (IRE1)-mediated signaling independent of X-box binding protein 1 (XBP1).", "journal": "Biochemical and biophysical research communications", "date": "2020", "authors": "Yamamoto T, Endo J, Kataoka M, Matsuhashi T, Katsumata Y, Shirakawa K, Isobe S, Moriyama H, Goto S, Shimanaka Y, Kono N, Arai H, Shinmura K, Fukuda K, Sano M", "evidence": [ { "database": "RefSeq", "id": "NP_001178855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178855" } ], "reference": [ { "type": "PubMed", "id": "32199617", "url": "https://glygen.org/publication/PubMed/32199617" } ] }, { "title": "Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization.", "journal": "Arthritis research & therapy", "date": "2020", "authors": "Li R, Zhao K, Ruan Q, Meng C, Yin F", "evidence": [ { "database": "RefSeq", "id": "NP_001178855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178855" } ], "reference": [ { "type": "PubMed", "id": "32272965", "url": "https://glygen.org/publication/PubMed/32272965" } ] }, { "title": "Endoplasmic reticulum stress related factor IRE1alpha regulates TXNIP/NLRP3-mediated pyroptosis in diabetic nephropathy.", "journal": "Experimental cell research", "date": "2020", "authors": "Ke R, Wang Y, Hong S, Xiao L", "evidence": [ { "database": "RefSeq", "id": "NP_001178855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178855" } ], "reference": [ { "type": "PubMed", "id": "32950473", "url": "https://glygen.org/publication/PubMed/32950473" } ] }, { "title": "Hyperoxia induces endoplasmic reticulum stressassociated apoptosis via the IRE1α pathway in rats with bronchopulmonary dysplasia.", "journal": "Molecular medicine reports", "date": "2021", "authors": "Tong X, Li M, Liu N, Huang W, Xue X, Fu J", "evidence": [ { "database": "RefSeq", "id": "NP_001178855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178855" } ], "reference": [ { "type": "PubMed", "id": "33179109", "url": "https://glygen.org/publication/PubMed/33179109" } ] }, { "title": "Inhibition of IRE1 suppresses the catabolic effect of IL-1beta on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.", "journal": "Biochemical pharmacology", "date": "2022", "authors": "Kang H, Dong Y, Peng R, Liu H, Guo Q, Song K, Zhu M, Yu K, Wu W, Li F", "evidence": [ { "database": "RefSeq", "id": "NP_001178855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178855" } ], "reference": [ { "type": "PubMed", "id": "35085541", "url": "https://glygen.org/publication/PubMed/35085541" } ] } ], "pathway": [ { "id": "rno:498013", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:498013", "resource": "KEGG Pathway" }, { "id": "R-RNO-381070", "name": "IRE1alpha activates chaperones", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-381070", "resource": "Reactome", "description": "IRE1alpha activates chaperones" } ], "orthologs": [ { "uniprot_canonical_ac": "O75460-1", "protein_name": "Serine/threonine-protein kinase/endoribonuclease IRE1", "gene_name": "ERN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPPVTPDAL", "length": 977 }, "evidence": [ { "id": "45233791", "url": "http://www.informatics.jax.org/homology/45233791", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9EQY0-1", "protein_name": "Serine/threonine-protein kinase/endoribonuclease IRE1", "gene_name": "Ern1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPARWLLLLLALLLPPPGPGSFGRTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQGEVLRKVVHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKRSFEEVINIVGQTSDNTPTTVSQDVEEKLARAPAKPEAPVDSMLKDMATIILSTFLLVGWVAFIITYPLSVHQQRQLQHQQFQKELEKIQLLQQQQLPFHPHGDLTQDPEFLDSSGPFSESSGTSSPSPSPRASNHSLHPSSSASRAGTSPSLEQDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQANILLGACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKEALDGPIVRQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPVEVQETLGSIPDDFVRYFTSRFPHLLSHTYQAMELCRHERLFQTYYWHEPTEPQPPVIPYAL", "length": 977 }, "evidence": [ { "id": "45233791", "url": "http://www.informatics.jax.org/homology/45233791", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 13, "go_terms": [ { "name": "platelet-derived growth factor receptor binding", "id": "GO:0005161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005161", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "ADP binding", "id": "GO:0043531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043531", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "endonuclease activity", "id": "GO:0004519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004519", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "RNA endonuclease activity", "id": "GO:0004521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004521", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "Hsp90 protein binding", "id": "GO:0051879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051879", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "Hsp70 protein binding", "id": "GO:0030544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030544", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 20, "go_terms": [ { "name": "positive regulation of RNA splicing", "id": "GO:0033120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033120", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "mRNA splicing, via endonucleolytic cleavage and ligation", "id": "GO:0070054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070054", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "insulin metabolic process", "id": "GO:1901142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901142", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "peptidyl-serine trans-autophosphorylation", "id": "GO:1990579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990579", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "protein phosphorylation", "id": "GO:0006468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "IRE1-mediated unfolded protein response", "id": "GO:0036498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036498", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "cellular response to glucose stimulus", "id": "GO:0071333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071333", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "protein autophosphorylation", "id": "GO:0046777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046777", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "cellular response to hydrogen peroxide", "id": "GO:0070301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070301", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "positive regulation of vascular associated smooth muscle cell proliferation", "id": "GO:1904707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904707", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "endothelial cell proliferation", "id": "GO:0001935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001935", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "endoplasmic reticulum unfolded protein response", "id": "GO:0030968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "cellular response to vascular endothelial growth factor stimulus", "id": "GO:0035924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035924", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "id": "GO:0070059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070059", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "response to endoplasmic reticulum stress", "id": "GO:0034976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034976", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "positive regulation of JUN kinase activity", "id": "GO:0043507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043507", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "positive regulation of endoplasmic reticulum unfolded protein response", "id": "GO:1900103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900103", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "peptidyl-serine autophosphorylation", "id": "GO:0036289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036289", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "cellular response to unfolded protein", "id": "GO:0034620", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034620", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "cellular response to manganese ion", "id": "GO:0071287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071287", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "IRE1-TRAF2-ASK1 complex", "id": "GO:1990604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990604", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "IRE1-RACK1-PP2A complex", "id": "GO:1990630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990630", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2H4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": 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180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 534, "end_pos": 536, "annotation": "n_glycosylation_sequon" }, { "start_pos": 538, "end_pos": 540, "annotation": "n_glycosylation_sequon" }, { "start_pos": 877, "end_pos": 879, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-RNO-381091", "name": "IRE1 dimer autophosphorylates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K2H4-1" ], "evidence": [ { "id": "R-RNO-381091", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-381091" } ] }, { "id": "R-RNO-381109", "name": "IRE1 binds IRE1 forming dimer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K2H4-1" ], "evidence": [ { "id": "R-RNO-381109", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-381109" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K2H4", "gene_name": "Ern1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A0G2K2H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A0G2K2H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }