{ "uniprot_canonical_ac": "A0A0G2K254-1", "uniprot_ac": "A0A0G2K254", "uniprot_id": "A0A0G2K254_RAT", "mass": { "chemical_mass": 73605.0, "monoisotopic_mass": 73605.0 }, "refseq": {}, "gene_names": [ { "name": "Ndc80", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K254", "id": "A0A0G2K254" } ], "protein_names": [ { "name": "Kinetochore protein NDC80", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A0G2K254" } ], "function": [ { "annotation": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprot/A0A0G2K254#function" }, { "database": "UniProtKB", "id": "RU368072", "url": "https://www.uniprot.org/uniprot/RU368072#function" } ] } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ], "evidence": [ { "id": "9256", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprot/A0A0G2K254" } ], "common_name": "Rat" } ], "gene": [ { "name": "Ndc80", "url": "https://www.uniprot.org/uniprot/A0A0G2K254", "locus": { "chromosome": "9", "start_pos": 111407191, "end_pos": 111440924, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000013727", "url": "https://www.ensembl.org/id/ENSRNOG00000013727" } ] } } ], "crossref": [ { "id": "IPR005550", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005550", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PSHKFQK", "url": "https://omabrowser.org/oma/group/PSHKFQK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10643", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10643", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10643:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10643:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03801", "url": "http://pfam.xfam.org/family/PF03801", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18077", "url": "http://pfam.xfam.org/family/PF18077", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "1310154", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310154", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprot/A0A0G2K254", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K254-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K254-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRSSVSSCGAGRLSMQELRSLDLNKPGLHTPQTERSTFGKLSTHKPTSERKVSIFGKRTSEHGSRNSQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLYEFLTENGYVYSVSMKSLQAPSTKDFLKIFAFLYGFLCPSYELPDTKCEEEVPRIFKELGYPFALSKSSMYTVGAPHTWPHIVAALVWLTDCIKIHDAMKQSSPLFDDGQAWGEETEDGIKHNKLFLDYTKKCYEKFMTGADTFEDVDAELQAKLKDLYKVDASKLESLVEENKALNEQIARLEQEREKEPNRLISLRKLKASLQADVQNYKAYMSNLESHSSILEQKLSSLDEEIGRLELECETVKQENTRLQSVVDNQKYSIADIERINHEKNELQQTINKLTKDLEAEQQQMWNEELKYARGKEAIEAQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRTQVYAPLKELLNEIEEEINKALNKKMGLEDTLEQLNTVKTESKRAVRMLKEEVQKLDDLYQQKVKEAEEEDKKCASELDSLEKHKHLLESAVNEGLSEAMGELDAVQREYQLAVQTTTEERRKVGNNLQRLLEMVATHVGSLEKHLEEQIVKADREYEECTSEDLLENIRRIAEKYKSNAAQLKAPDK", "length": 641, "header": "tr|A0A0G2K254-1|A0A0G2K254_RAT Isoform 1 of Kinetochore protein NDC80 OS=Rattus norvegicus OX=10116 GN=Ndc80 PE=3 SV=1 CANONICAL=A0A0G2K254-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K254-1", "url": "", "sequence": { "sequence": 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"https://www.ensembl.org/id/ENSRNOT00000080498.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072111.2", "url": "https://www.ensembl.org/id/ENSRNOP00000072111.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "metaphase plate congression", "id": "GO:0051310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051310", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprot/A0A0G2K254" } ], "pmid": "" }, { "name": "attachment of mitotic spindle microtubules to kinetochore", "id": "GO:0051315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051315", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprot/A0A0G2K254" } ], "pmid": "" }, { "name": "kinetochore organization", "id": "GO:0051383", "url": 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meiosis I", "id": "GO:0007057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007057", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprot/A0A0G2K254" } ], "pmid": "" }, { "name": "positive regulation of mitotic cell cycle spindle assembly checkpoint", "id": "GO:0090267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090267", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprot/A0A0G2K254" } ], "pmid": "" }, { "name": "skeletal muscle satellite cell proliferation", "id": "GO:0014841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014841", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprot/A0A0G2K254" } ], "pmid": "" }, { "name": "G2/MI transition of meiotic cell cycle", "id": "GO:0008315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008315", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprot/A0A0G2K254" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "Ndc80 complex", "id": "GO:0031262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031262", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprot/A0A0G2K254" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprot/A0A0G2K254" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprot/A0A0G2K254" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": 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