{
    "uniprot_canonical_ac": "A0A0G2K229-1",
    "uniprot_ac": "A0A0G2K229",
    "uniprot_id": "A0A0G2K229_RAT",
    "mass": {
        "chemical_mass": 121015.0,
        "monoisotopic_mass": 121015.0
    },
    "refseq": {
        "ac": "NP_001258374",
        "name": "A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258374"
    },
    "gene_names": [
        {
            "name": "Adamts10",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K229",
            "id": "A0A0G2K229"
        },
        {
            "name": "Adamts10",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258374",
            "id": "NP_001258374"
        }
    ],
    "protein_names": [
        {
            "name": "A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258374",
            "id": "NP_001258374"
        },
        {
            "name": "ADAM metallopeptidase with thrombospondin type 1 motif, 10",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A0G2K229"
        },
        {
            "name": "a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10; a disintegrin-like and metalloprotease with thrombospondin type 1 motif, 10; A disintegrin and metalloproteinase with thrombospondin motifs 10",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258374",
            "id": "NP_001258374"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0050475",
            "recommended_name": {
                "id": "DOID:0050475",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050475",
                "name": "Weill-Marchesani syndrome",
                "description": "A syndrome characterized by short stature, brachycephaly and other facial abnormalities, brachydactyly, joint stiffness and distinctive ocular abnormalities."
            },
            "synonyms": [
                {
                    "id": "DOID:0050475",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050475",
                    "name": "GEMSS syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:0050475",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050475",
                    "name": "Marchesani-Weill Syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:0050475",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050475",
                    "name": "Mesodermal Dysmorphodystrophy, Congenital",
                    "description": ""
                },
                {
                    "id": "DOID:0050475",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050475",
                    "name": "Spherophakia Brachymorphia Syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:0050475",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050475",
                    "name": "congenital mesodermal dystrophy",
                    "description": ""
                },
                {
                    "id": "MONDO:0012013",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012013",
                    "name": "Weill-Marchesani syndrome 2, dominant",
                    "description": "A Weill-Marchesani syndrome characterized by progressive joint stiffness, glaucoma, short stature and lens dislocation. It has been described in three members of a family (the grandfather, his daughter and grandson). It is likely to be transmitted as an autosomal dominant trait. The acronym GEMSS (Glaucoma, Ectopia, Microspherophakia, Stiff joints, Short stature) was proposed as a name for the syndrome. This syndrome shows similarities to Moore-Federman syndrome."
                },
                {
                    "id": "MONDO:0012013",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012013",
                    "name": "mesodermal Dysmorphodystrophy, congenital",
                    "description": ""
                },
                {
                    "id": "MONDO:0012013",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012013",
                    "name": "spherophakia-brachymorphia syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0012013",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012013",
                    "name": "GEMSS",
                    "description": ""
                },
                {
                    "id": "MONDO:0012013",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012013",
                    "name": "GEMSS syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0012013",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012013",
                    "name": "WMS2",
                    "description": ""
                },
                {
                    "id": "MONDO:0012013",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012013",
                    "name": "Weill-Marchesani syndrome 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0012013",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012013",
                    "name": "Weill-Marchesani syndrome type 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0012013",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012013",
                    "name": "Weill-Marchesani syndrome, autosomal dominant",
                    "description": ""
                },
                {
                    "id": "MONDO:0012013",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012013",
                    "name": "glaucoma, ectopia, microspherophakia, Stiff joints and short stature syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0012013",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012013",
                    "name": "glaucoma-lens ectopia-microspherophakia-stiffness-shortness syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0010194",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010194",
                    "name": "Weill-Marchesani syndrome 1",
                    "description": "Any Weill-Marchesani syndrome in which the cause of the disease is a mutation in the ADAMTS10 gene."
                },
                {
                    "id": "MONDO:0010194",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010194",
                    "name": "ADAMTS10 Weill-Marchesani syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0010194",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010194",
                    "name": "Weill-Marchesani syndrome 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010194",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010194",
                    "name": "Weill-Marchesani syndrome 1, recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010194",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010194",
                    "name": "Weill-Marchesani syndrome caused by mutation in ADAMTS10",
                    "description": ""
                },
                {
                    "id": "MONDO:0010194",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010194",
                    "name": "Weill-Marchesani syndrome type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010194",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010194",
                    "name": "WMS1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010194",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010194",
                    "name": "Weill-Marchesani syndrome, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010194",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010194",
                    "name": "mesodermal Dysmorphodystrophy, congenital",
                    "description": ""
                },
                {
                    "id": "MONDO:0010194",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010194",
                    "name": "spherophakia-brachymorphia syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0013176",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013176",
                    "name": "Weill-Marchesani 4 syndrome, recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0013176",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013176",
                    "name": "15q26.3 microdeletion syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0013176",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013176",
                    "name": "WMS4",
                    "description": ""
                },
                {
                    "id": "MONDO:0013176",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013176",
                    "name": "Weill-Marchesani syndrome 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0013176",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013176",
                    "name": "Weill-Marchesani-like syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0013176",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013176",
                    "name": "ichthyosis-short stature-brachydactyly-microspherophakia syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0013899",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013899",
                    "name": "Weill-Marchesani syndrome 3",
                    "description": "Any Weill-Marchesani syndrome in which the cause of the disease is a mutation in the LTBP2 gene."
                },
                {
                    "id": "MONDO:0013899",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013899",
                    "name": "LTBP2 Weill-Marchesani syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0013899",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013899",
                    "name": "Weill-Marchesani syndrome 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0013899",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013899",
                    "name": "Weill-Marchesani syndrome 3, recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0013899",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013899",
                    "name": "Weill-Marchesani syndrome caused by mutation in LTBP2",
                    "description": ""
                },
                {
                    "id": "MONDO:0013899",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013899",
                    "name": "Weill-Marchesani syndrome type 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0013899",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013899",
                    "name": "WMS3",
                    "description": ""
                },
                {
                    "id": "MIM:608328",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/608328",
                    "name": "Weill-Marchesani syndrome 2",
                    "description": "Weill-Marchesani syndrome 2"
                },
                {
                    "id": "MIM:277600",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/277600",
                    "name": "Weill-Marchesani syndrome 1",
                    "description": "Weill-Marchesani syndrome 1"
                },
                {
                    "id": "MIM:613195",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/613195",
                    "name": "Weill-Marchesani syndrome 4",
                    "description": "Weill-Marchesani syndrome 4"
                },
                {
                    "id": "MIM:614819",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/614819",
                    "name": "Weill-Marchesani syndrome 3",
                    "description": "Weill-Marchesani syndrome 3"
                }
            ],
            "evidence": [
                {
                    "id": "0050475",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050475"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2K229",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K229"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Adamts10",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K229",
            "locus": {
                "chromosome": "7",
                "start_pos": 14361620,
                "end_pos": 14331745,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000008857",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000008857"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000008857",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000008857",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd04273",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04273",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "314655",
            "url": "https://www.ncbi.nlm.nih.gov/gene/314655",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000884",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001590",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001590",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002870",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002870",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR010294",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR010294",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR010909",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR010909",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013273",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013273",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR024079",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036383",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR041645",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041645",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR045371",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR045371",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:314655",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314655",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "SWWTGEW",
            "url": "https://omabrowser.org/oma/group/SWWTGEW/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2910701at2759",
            "url": "http://www.orthodb.org/?query=2910701at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11905",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11905",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11905:SF159",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11905:SF159",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13723",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13723",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13723:SF26",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13723:SF26",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00090",
            "url": "http://pfam.xfam.org/family/PF00090",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01421",
            "url": "http://pfam.xfam.org/family/PF01421",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01562",
            "url": "http://pfam.xfam.org/family/PF01562",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF05986",
            "url": "http://pfam.xfam.org/family/PF05986",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF08686",
            "url": "http://pfam.xfam.org/family/PF08686",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF17771",
            "url": "http://pfam.xfam.org/family/PF17771",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF19030",
            "url": "http://pfam.xfam.org/family/PF19030",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF19236",
            "url": "http://pfam.xfam.org/family/PF19236",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-5173214",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5173214",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001258374",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258374",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1598320",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1598320",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2K229",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K229",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2K229-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K229-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "E9PT70",
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            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "E9PT70-1",
            "url": "https://www.uniprot.org/uniprot/E9PT70-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MASACQILRWALALGLGLTFKVTHAFRSQDELLSSLESYEIAFPTRVDHNGAMLAFSPPALRRQRRGVGAAAESRLFYKVAAPSTHFLLNLTRSPRLLAGHVSVEYWTREGLAWQRAARAHCLYAGHLQGQAGSSHVAISTCGGLHGLIVADDEEYLIEPLQGGPKGRRGPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPQGNETERGQLGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGNIVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVSHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSINEDIGLATAFTIAHEIGHTFGMNHDGVGNGCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRSCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTNDCPPGSQDFREMQCSEFDSVPFRGKFYTWKTYRGGGVKACSLTCLADGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPALPGTGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTSQPHRLPLAGTTFHLRQGPDQAQSLEALGPINASLIIMVLAQAELPALRYRFNAPIARDALPPYSWHYAPWTKCSAQCAGGSQVQVVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSRCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACQGPMCPPEWAALDWSECTPSCGPGLRHRVVLCKSADQRSTLPPGHCPPAAKPPSTMRCNLRRCPPARWVASEWGECSTQCGLGQQQRTVRCTSHTGQPSRECTEALRPSTMQQCEAKCDSVVPPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQGR",
        "length": 1104,
        "header": "tr|A0A0G2K229-1|A0A0G2K229_RAT Isoform 1 of ADAM metallopeptidase with thrombospondin type 1 motif, 10  OS=Rattus norvegicus OX=10116 GN=Adamts10 PE=4 SV=1 CANONICAL=A0A0G2K229-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2K229-1",
            "url": "",
            "sequence": {
                "sequence": "MASACQILRWALALGLGLTFKVTHAFRSQDELLSSLESYEIAFPTRVDHNGAMLAFSPPALRRQRRGVGAAAESRLFYKVAAPSTHFLLNLTRSPRLLAGHVSVEYWTREGLAWQRAARAHCLYAGHLQGQAGSSHVAISTCGGLHGLIVADDEEYLIEPLQGGPKGRRGPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPQGNETERGQLGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGNIVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVSHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSINEDIGLATAFTIAHEIGHTFGMNHDGVGNGCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRSCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTNDCPPGSQDFREMQCSEFDSVPFRGKFYTWKTYRGGGVKACSLTCLADGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPALPGTGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTSQPHRLPLAGTTFHLRQGPDQAQSLEALGPINASLIIMVLAQAELPALRYRFNAPIARDALPPYSWHYAPWTKCSAQCAGGSQVQVVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSRCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACQGPMCPPEWAALDWSECTPSCGPGLRHRVVLCKSADQRSTLPPGHCPPAAKPPSTMRCNLRRCPPARWVASEWGECSTQCGLGQQQRTVRCTSHTGQPSRECTEALRPSTMQQCEAKCDSVVPPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQGR",
                "length": 1104,
                "header": "tr|A0A0G2K229-1|A0A0G2K229_RAT Isoform 1 of ADAM metallopeptidase with thrombospondin type 1 motif, 10  OS=Rattus norvegicus OX=10116 GN=Adamts10 PE=4 SV=1 CANONICAL=A0A0G2K229-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 14361022,
                "end_pos": 14337157,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000086336.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000086336.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000072082.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000072082.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "E9PT70-1",
            "url": "",
            "sequence": {
                "sequence": "MASACQILRWALALGLGLTFKVTHAFRSQDELLSSLESYEIAFPTRVDHNGAMLAFSPPALRRQRRGVGAAAESRLFYKVAAPSTHFLLNLTRSPRLLAGHVSVEYWTREGLAWQRAARAHCLYAGHLQGQAGSSHVAISTCGGLHGLIVADDEEYLIEPLQGGPKGRRGPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPQGNETERGQLGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGNIVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVSHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSINEDIGLATAFTIAHEIGHTFGMNHDGVGNGCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQWSQLSWNLLCRPGWPHPHRDPLSGISHLCHCALPDIFTLVPPQL",
                "length": 533,
                "header": "tr|E9PT70-1|E9PT70_RAT Computationally mapped isoform of ADAM metallopeptidase with thrombospondin type 1 motif, 10  OS=Rattus norvegicus OX=10116 GN=Adamts10 PE=4 SV=2 CANONICAL=A0A0G2K229-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 14348113,
                "end_pos": 14337157,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000011849.6",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000011849.6"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000011849.6",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000011849.6"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:314655",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314655",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-5173214",
            "name": "O-glycosylation of TSR domain-containing proteins",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5173214",
            "resource": "Reactome",
            "description": "O-glycosylation of TSR domain-containing proteins"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P58459-1",
            "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 10",
            "gene_name": "Adamts10",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MASACQILRWALALGLGLTFKVTHAFRSQDELLSSLESYEIAFPTRVDHNGAMLAFSPPAFRRQRRGAGATTESRLFYKVAAPSTHFLLNLTRSPRLLAGHVSVEYWTREGLAWQRAARAHCLYAGHLQGQAGSSHVAVSTCGGLHGLIVADDEEYLIEPLQGGPKGHRGPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNESERGQLGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGNIVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVSHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSINEDIGLATAFTIAHEIGHTFGMNHDGVGNGCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRSCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTNDCPPGSQDFREMQCSEFDSVPFRGKFYTWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPALPGTGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFHLRQGPDQAQSLEALGPINASLIIMVLAQAELPALHYRFNAPIARDALPPYSWHYAPWTKCSAQCAGGSQVQVVECRNQLDSSAVAPHYCSGHSKLPKRQRACNTEPCPPDWVVGNWSRCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACQGPMCPPEWATLDWSECTPSCGPGLRHRVVLCKSADQRSTLPPGHCLPAAKPPSTMRCNLRRCPPARWVTSEWGECSTQCGLGQQQRTVRCTSHTGQPSRECTEALRPSTMQQCEAKCDSVVPPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQGR",
                "length": 1104
            },
            "evidence": [
                {
                    "id": "45235425",
                    "url": "http://www.informatics.jax.org/homology/45235425",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9H324-1",
            "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 10",
            "gene_name": "ADAMTS10",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCHGH",
                "length": 1103
            },
            "evidence": [
                {
                    "id": "45235425",
                    "url": "http://www.informatics.jax.org/homology/45235425",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "metalloendopeptidase activity",
                        "id": "GO:0004222",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K229",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K229"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K229",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K229"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "extracellular region",
                        "id": "GO:0005576",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K229",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K229"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "extracellular matrix",
                        "id": "GO:0031012",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K229",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K229"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "microfibril",
                        "id": "GO:0001527",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001527",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K229",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K229"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "collagen-containing extracellular matrix",
                        "id": "GO:0062023",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K229",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K229"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "proteolysis",
                        "id": "GO:0006508",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K229",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K229"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "extracellular matrix organization",
                        "id": "GO:0030198",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K229",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K229"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 222,
            "end_pos": 224,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 740,
            "end_pos": 742,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 795,
            "end_pos": 797,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 892,
            "end_pos": 894,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 90,
            "end_pos": 92,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}