{
    "uniprot_canonical_ac": "A0A0G2K1L5-1",
    "uniprot_ac": "A0A0G2K1L5",
    "uniprot_id": "A0A0G2K1L5_RAT",
    "mass": {
        "chemical_mass": 29261.0,
        "monoisotopic_mass": 29261.0
    },
    "refseq": {
        "ac": "NP_001041512",
        "name": "receptor expression-enhancing protein 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041512"
    },
    "gene_names": [
        {
            "name": "Reep2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K1L5",
            "id": "A0A0G2K1L5"
        },
        {
            "name": "LOC682105",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K1L5",
            "id": "A0A0G2K1L5"
        },
        {
            "name": "Reep2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041512",
            "id": "NP_001041512"
        }
    ],
    "protein_names": [
        {
            "name": "Receptor expression-enhancing protein",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A0A0G2K1L5"
        },
        {
            "name": "receptor expression-enhancing protein 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041512",
            "id": "NP_001041512"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0110782",
            "recommended_name": {
                "id": "DOID:0110782",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0110782",
                "name": "hereditary spastic paraplegia 31",
                "description": "A hereditary spastic paraplegia that has_material_basis_in mutation in the REEP1 gene on chromosome 2p11."
            },
            "synonyms": [
                {
                    "id": "DOID:0110782",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110782",
                    "name": "SPG31",
                    "description": ""
                },
                {
                    "id": "DOID:0110782",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110782",
                    "name": "autosomal dominant spastic paraplegia 31",
                    "description": ""
                },
                {
                    "id": "DOID:0110782",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110782",
                    "name": "autosomal dominant spastic paraplegia type 31",
                    "description": ""
                },
                {
                    "id": "MONDO:0012453",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012453",
                    "name": "hereditary spastic paraplegia 31",
                    "description": "A rare type of hereditary spastic paraplegia usually characterized by a pure phenotype of proximal weakness of the lower extremities with spastic gait and brisk reflexes, with a bimodal age of onset of either childhood or adulthood (>30 years). In some cases, it can present as a complex phenotype with additional associated manifestations including peripheral neuropathy, bulbar palsy (with dysarthria and dysphagia), distal amyotrophy, and impaired distal vibration sense."
                },
                {
                    "id": "MONDO:0012453",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012453",
                    "name": "REEP1 hereditary spastic paraplegia",
                    "description": ""
                },
                {
                    "id": "MONDO:0012453",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012453",
                    "name": "SPG31",
                    "description": ""
                },
                {
                    "id": "MONDO:0012453",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012453",
                    "name": "autosomal dominant spastic paraplegia 31",
                    "description": ""
                },
                {
                    "id": "MONDO:0012453",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012453",
                    "name": "autosomal dominant spastic paraplegia type 31",
                    "description": ""
                },
                {
                    "id": "MONDO:0012453",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012453",
                    "name": "hereditary spastic paraplegia caused by mutation in REEP1",
                    "description": ""
                },
                {
                    "id": "MONDO:0012453",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012453",
                    "name": "hereditary spastic paraplegia type 31",
                    "description": ""
                },
                {
                    "id": "MONDO:0012453",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012453",
                    "name": "spastic paraplegia 31",
                    "description": ""
                },
                {
                    "id": "MONDO:0012453",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012453",
                    "name": "spastic paraplegia 31, autosomal dominant",
                    "description": ""
                },
                {
                    "id": "MIM:610250",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/610250",
                    "name": "Spastic paraplegia 31, autosomal dominant",
                    "description": "Spastic paraplegia 31, autosomal dominant"
                }
            ],
            "evidence": [
                {
                    "id": "0110782",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110782"
                }
            ]
        },
        {
            "disease_id": "DOID:0110817",
            "recommended_name": {
                "id": "DOID:0110817",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0110817",
                "name": "hereditary spastic paraplegia 72A",
                "description": "A hereditary spastic paraplegia that has_material_basis_in a heterozygous mutation in the REEP2 gene on chromosome 5q31.2."
            },
            "synonyms": [
                {
                    "id": "DOID:0110817",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110817",
                    "name": "SPG72",
                    "description": ""
                },
                {
                    "id": "DOID:0110817",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110817",
                    "name": "autosomal spastic paraplegia type 72",
                    "description": ""
                },
                {
                    "id": "MONDO:0014282",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014282",
                    "name": "hereditary spastic paraplegia 72",
                    "description": "Any pure hereditary spastic paraplegia in which the cause of the disease is a mutation in the REEP2 gene."
                },
                {
                    "id": "MONDO:0014282",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014282",
                    "name": "REEP2 pure hereditary spastic paraplegia",
                    "description": ""
                },
                {
                    "id": "MONDO:0014282",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014282",
                    "name": "SPG72",
                    "description": ""
                },
                {
                    "id": "MONDO:0014282",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014282",
                    "name": "autosomal spastic paraplegia type 72",
                    "description": ""
                },
                {
                    "id": "MONDO:0014282",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014282",
                    "name": "hereditary spastic paraplegia type 72",
                    "description": ""
                },
                {
                    "id": "MONDO:0014282",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014282",
                    "name": "pure hereditary spastic paraplegia caused by mutation in REEP2",
                    "description": ""
                },
                {
                    "id": "MONDO:0014282",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014282",
                    "name": "spastic paraplegia 72, autosomal dominant",
                    "description": ""
                },
                {
                    "id": "MONDO:0014282",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014282",
                    "name": "spastic paraplegia 72, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MIM:615625",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/615625",
                    "name": "Spastic paraplegia 72",
                    "description": "Spastic paraplegia 72"
                }
            ],
            "evidence": [
                {
                    "id": "0110817",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110817"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2K1L5",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K1L5"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Reep2",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K1L5",
            "locus": {
                "chromosome": "18",
                "start_pos": 26447161,
                "end_pos": 26438346,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000049629",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000049629"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000049629",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000049629",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "682105",
            "url": "https://www.ncbi.nlm.nih.gov/gene/682105",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR004345",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004345",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:682105",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:682105",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "SWAERCP",
            "url": "https://omabrowser.org/oma/group/SWAERCP/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5482465at2759",
            "url": "http://www.orthodb.org/?query=5482465at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12300",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12300",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12300:SF29",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12300:SF29",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF03134",
            "url": "http://pfam.xfam.org/family/PF03134",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1586980",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1586980",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2K1L5",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K1L5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2K1L5-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K1L5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q0VGJ9",
            "url": "https://www.uniprot.org/uniprot/Q0VGJ9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q0VGJ9-1",
            "url": "https://www.uniprot.org/uniprot/Q0VGJ9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAQNWEEDWPSNHACLPRLIFGTLYPAYSSYKAVKTKNVKEYVKWMMYWIVFAFFTTAETLTDIILSWFPFYFELKIAFVIWLLSPYTKGSSVLYRKFVHPTLSNKEKEIDEYITQARDKSYETMMRVGKRGLNLAANAAVTAAAKGQGVLSEKLRSFSMQDLTLIRDEDALPLQGPDGRLQPGPVGLLDTIEDLGDEPALSLRSSSSQADPRTETSEDDLGDKAPKRTKPIKKVPKAEPPASKTLKTRPKKKSPGGGDSA",
        "length": 261,
        "header": "tr|A0A0G2K1L5-1|A0A0G2K1L5_RAT Isoform 1 of Receptor expression-enhancing protein  OS=Rattus norvegicus OX=10116 GN=Reep2 PE=3 SV=2 CANONICAL=A0A0G2K1L5-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2K1L5-1",
            "url": "",
            "sequence": {
                "sequence": "MAQNWEEDWPSNHACLPRLIFGTLYPAYSSYKAVKTKNVKEYVKWMMYWIVFAFFTTAETLTDIILSWFPFYFELKIAFVIWLLSPYTKGSSVLYRKFVHPTLSNKEKEIDEYITQARDKSYETMMRVGKRGLNLAANAAVTAAAKGQGVLSEKLRSFSMQDLTLIRDEDALPLQGPDGRLQPGPVGLLDTIEDLGDEPALSLRSSSSQADPRTETSEDDLGDKAPKRTKPIKKVPKAEPPASKTLKTRPKKKSPGGGDSA",
                "length": 261,
                "header": "tr|A0A0G2K1L5-1|A0A0G2K1L5_RAT Isoform 1 of Receptor expression-enhancing protein  OS=Rattus norvegicus OX=10116 GN=Reep2 PE=3 SV=2 CANONICAL=A0A0G2K1L5-1"
            },
            "locus": {
                "chromosome": "18",
                "start_pos": 26446140,
                "end_pos": 26440120,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000078969.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000078969.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000071891.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000071891.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q0VGJ9-1",
            "url": "",
            "sequence": {
                "sequence": "MVSWIISRLVVLIFGTLYPAYSSYKAVKTKNVKEYVKWMMYWIVFAFFTTAETLTDIILSWFPFYFELKIAFVIWLLSPYTKGSSVLYRKFVHPTLSNKEKEIDEYITQARDKSYETMMRVGKRGLNLAANAAVTAAAKGQGVLSEKLRSFSMQDLTLIRDEDALPLQGPDGRLQPGPVGLLDTIEDLGDEPALSLRSSSSQADPRTETSEDDLGDKAPKRTKPIKKVPKAEPPASKTLKTRPKKKSPGGGDSA",
                "length": 254,
                "header": "tr|Q0VGJ9-1|A0A0G2K1L5_RAT Computationally mapped isoform of Receptor expression-enhancing protein  OS=Rattus norvegicus OX=10116 GN=Reep2 PE=3 SV=1 CANONICAL=A0A0G2K1L5-1"
            },
            "locus": {
                "chromosome": "18",
                "start_pos": 26446140,
                "end_pos": 26438461,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000073564.3",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000073564.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000065717.3",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000065717.3"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:682105",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:682105",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8VCD6-1",
            "protein_name": "Receptor expression-enhancing protein 2",
            "gene_name": "Reep2",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MVSWIISRLVVLIFGTLYPAYSSYKAVKTKNVKEYVKWMMYWIVFAFFTTAETLTDIILSWFPFYFELKIAFVIWLLSPYTKGSSVLYRKFVHPTLSNKEKEIDEYITQARDKSYETMMRVGKRGLNLAANAAVTAAAKGQGVLSEKLRSFSMQDLTLIRDEDALPLQGPDGRLQPGPVGLLDTIEDLGDEPALSLRSSTSQPDPRTETSEDDLGDKAPKRTKPIKKVPRAEPPASKTLKTRPKKKSSGGGDSA",
                "length": 254
            },
            "evidence": [
                {
                    "id": "45238009",
                    "url": "http://www.informatics.jax.org/homology/45238009",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9BRK0-1",
            "protein_name": "Receptor expression-enhancing protein 2",
            "gene_name": "REEP2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MVSWIISRLVVLIFGTLYPAYSSYKAVKTKNVKEYVKWMMYWIVFAFFTTAETLTDIVLSWFPFYFELKIAFVIWLLSPYTKGSSVLYRKFVHPTLSNKEKEIDEYITQARDKSYETMMRVGKRGLNLAANAAVTAAAKGVLSEKLRSFSMQDLTLIRDEDALPLQRPDGRLRPSPGSLLDTIEDLGDDPALSLRSSTNPADSRTEASEDDMGDKAPKRAKPIKKAPKAEPLASKTLKTRPKKKTSGGGDSA",
                "length": 252
            },
            "evidence": [
                {
                    "id": "45238009",
                    "url": "http://www.informatics.jax.org/homology/45238009",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "regulation of intracellular transport",
                        "id": "GO:0032386",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032386",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K1L5",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1L5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum tubular network organization",
                        "id": "GO:0071786",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071786",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K1L5",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1L5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein transport into membrane raft",
                        "id": "GO:0032596",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032596",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K1L5",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1L5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sensory perception of bitter taste",
                        "id": "GO:0050913",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050913",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K1L5",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1L5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sensory perception of sweet taste",
                        "id": "GO:0050916",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050916",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K1L5",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1L5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 5,
                "go_terms": [
                    {
                        "name": "endoplasmic reticulum",
                        "id": "GO:0005783",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K1L5",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1L5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K1L5",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1L5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K1L5",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K1L5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum membrane",
                        "id": "GO:0005789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K1L5",
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