{ "uniprot_canonical_ac": "A0A0G2JZC4-1", "uniprot_ac": "A0A0G2JZC4", "uniprot_id": "A0A0G2JZC4_RAT", "mass": { "chemical_mass": 119884.0, "monoisotopic_mass": 119884.0 }, "refseq": { "ac": "NP_001101238", "name": "semaphorin-6D precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101238" }, "gene_names": [ { "name": "Sema6d", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "id": "A0A0G2JZC4" }, { "name": "Sema6d", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101238", "id": "NP_001101238" } ], "protein_names": [ { "name": "Semaphorin 6D", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2JZC4" }, { "name": "sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101238", "id": "NP_001101238" }, { "name": "semaphorin-6D precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101238", "id": "NP_001101238" } ], "function": [ { "annotation": "SEMA6D, Negatively Regulated by miR-7, Contributes to C28/I2 chondrocyte's Catabolic and Anabolic Activities via p38 Signaling Pathway. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001101238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101238" }, { "database": "PubMed", "id": "35757507", "url": "https://glygen.org/publication/PubMed/35757507" } ] }, { "annotation": "The spatio-temporal expression of Decorin, Semaphorin6D, SPARC, Spry-1 and Tsukushi in developing prostate is described and observed similar mesenchymal expression patterns in rat and human.", "evidence": [ { "database": "RefSeq", "id": "NP_001101238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101238" }, { "database": "PubMed", "id": "22880013", "url": "https://glygen.org/publication/PubMed/22880013" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "common_name": "Rat" } ], "gene": [ { "name": "Sema6d", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "locus": { "chromosome": "3", "start_pos": 111941094, "end_pos": 111883872, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000004812", "url": "https://www.ensembl.org/id/ENSRNOG00000004812" } ] } } ], "crossref": [ { "id": "ENSRNOG00000004812", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000004812", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "311384", "url": "https://www.ncbi.nlm.nih.gov/gene/311384", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:311384", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:311384", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IAEEPWF", "url": "https://omabrowser.org/oma/group/IAEEPWF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5399685at2759", "url": "http://www.orthodb.org/?query=5399685at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11036", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11036:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "7Y4O", "url": "https://www.rcsb.org/structure/7Y4O", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7Y4Q", "url": "https://www.rcsb.org/structure/7Y4Q", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF01403", "url": "http://pfam.xfam.org/family/PF01403", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01437", "url": "http://pfam.xfam.org/family/PF01437", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-416700", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416700", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1310910", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310910", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JZC4-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZVU9", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZVU9-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZWU1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZWU1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZWU1-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZWU1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AKL1", "url": "https://www.uniprot.org/uniprot/A0A8I6AKL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AKL1-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AKL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GKS5", "url": "https://www.uniprot.org/uniprot/A0A8I6GKS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GKS5-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GKS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZDA2", "url": "https://www.uniprot.org/uniprot/D3ZDA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZDA2-1", "url": "https://www.uniprot.org/uniprot/D3ZDA2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRFFLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNDIPQTEVIPSKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVIGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDRDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGWLSQGVCERVTLGMLAGGYEQDTEYGNTAHLGDCHESLPTSTTPDYKIFGGPTSDMEVPSSSVTTVASSPEITSKVIDTWRPKLTSSRKFVVQDDPNTSDFTDTISGIPKGVRWEVQSGDSNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDPKSMAMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSDKAHGHGASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNVDHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNAKAIMGEIHMAHQTLMLDPVGPMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTTSVRPLNKYTY", "length": 1073, "header": "tr|A0A0G2JZC4-1|A0A0G2JZC4_RAT Isoform 1 of Semaphorin 6D OS=Rattus norvegicus OX=10116 GN=Sema6d PE=1 SV=2 CANONICAL=A0A0G2JZC4-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JZC4-1", "url": "", "sequence": { "sequence": "MRFFLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNDIPQTEVIPSKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVIGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDRDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGWLSQGVCERVTLGMLAGGYEQDTEYGNTAHLGDCHESLPTSTTPDYKIFGGPTSDMEVPSSSVTTVASSPEITSKVIDTWRPKLTSSRKFVVQDDPNTSDFTDTISGIPKGVRWEVQSGDSNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDPKSMAMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSDKAHGHGASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNVDHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNAKAIMGEIHMAHQTLMLDPVGPMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTTSVRPLNKYTY", "length": 1073, "header": "tr|A0A0G2JZC4-1|A0A0G2JZC4_RAT Isoform 1 of Semaphorin 6D OS=Rattus norvegicus OX=10116 GN=Sema6d PE=1 SV=2 CANONICAL=A0A0G2JZC4-1" }, "locus": { "chromosome": "3", "start_pos": 111938676, "end_pos": 111927002, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000090802.2", "url": "https://www.ensembl.org/id/ENSRNOT00000090802.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000070994.2", "url": "https://www.ensembl.org/id/ENSRNOP00000070994.2" } ] } }, { "isoform_ac": "A0A8I5ZVU9-1", "url": "", "sequence": { "sequence": "MRFFLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNDIPQTEVIPSKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVIGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDRDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGWLSQGVCERVTLGMLLLTEDFFAFHNHSAGGYEQDTEYGNTAHLGDCHGVRWEVQSGDSNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDPKSMAMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSDKAHGHGASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNVDHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNAKAIMGEIHMAHQTLMLDPVGPMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTTSVRPLNKYTY", "length": 1011, "header": "tr|A0A8I5ZVU9-1|A0A8I5ZVU9_RAT Computationally mapped isoform of Semaphorin 6D OS=Rattus norvegicus OX=10116 GN=Sema6d PE=4 SV=1 CANONICAL=A0A0G2JZC4-1" }, "locus": { "chromosome": "3", "start_pos": 111938676, "end_pos": 111927002, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000098848.1", "url": "https://www.ensembl.org/id/ENSRNOT00000098848.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000082908.1", "url": "https://www.ensembl.org/id/ENSRNOP00000082908.1" } ] } }, { "isoform_ac": "A0A8I5ZWU1-1", "url": "", "sequence": { "sequence": "MRFFLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNDIPQTEVIPSKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVIGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDRDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGWLSQGVCERVTLGMLNQESLLDASHVNGHLFATTDMEVPSSSVTTVASSPEITSKVIDTWRPKLTSSRKFVVQDDPNTSDFTDTISGVRWEVQSGDSNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDPKSMAMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSDKAHGHGASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNVDHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNAKAIMGEIHMAHQTLMLDPVGPMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTTSVRPLNKYTY", "length": 1049, "header": "tr|A0A8I5ZWU1-1|A0A8I5ZWU1_RAT Computationally mapped isoform of Semaphorin 6D OS=Rattus norvegicus OX=10116 GN=Sema6d PE=4 SV=1 CANONICAL=A0A0G2JZC4-1" }, "locus": { "chromosome": "3", "start_pos": 111938676, "end_pos": 111927002, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000113650.1", "url": "https://www.ensembl.org/id/ENSRNOT00000113650.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000083343.1", "url": "https://www.ensembl.org/id/ENSRNOP00000083343.1" } ] } }, { "isoform_ac": "A0A8I6AKL1-1", "url": "", "sequence": { "sequence": "MRFFLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNDIPQTEVIPSKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVIGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDRDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGWLSQGVCERVTLGMLLLTEDFFAFHNHSAGGYEQDTEYGNTAHLGDCHESLPTSTTPDYKIFGGPTSGVRWEVQSGDSNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDPKSMAMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSDKAHGHGASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNVDHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNAKAIMGEIHMAHQTLMLDPVGPMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTTSVRPLNKYTY", "length": 1030, "header": "tr|A0A8I6AKL1-1|A0A8I6AKL1_RAT Computationally mapped isoform of Semaphorin 6D OS=Rattus norvegicus OX=10116 GN=Sema6d PE=4 SV=1 CANONICAL=A0A0G2JZC4-1" }, "locus": { "chromosome": "3", "start_pos": 111938676, "end_pos": 111927002, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000102426.1", "url": "https://www.ensembl.org/id/ENSRNOT00000102426.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000094338.1", "url": "https://www.ensembl.org/id/ENSRNOP00000094338.1" } ] } }, { "isoform_ac": "A0A8I6GKS5-1", "url": "", "sequence": { "sequence": "MRFFLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNDIPQTEVIPSKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVIGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDRDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGWLSQGVCERVTLGMLAGGYEQDTEYGNTAHLGDCHDMEVPSSSVTTVASSPEITSKVIDTWRPKLTSSRKFVVQDDPNTSDFTDTISGIPKGVRWEVQSGDSNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDPKSMAMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSDKAHGHGASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNVDHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNAKAIMGEIHMAHQTLMLDPVGPMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTTSVRPLNKYTY", "length": 1054, "header": "tr|A0A8I6GKS5-1|A0A8I6GKS5_RAT Computationally mapped isoform of Semaphorin 6D OS=Rattus norvegicus OX=10116 GN=Sema6d PE=4 SV=1 CANONICAL=A0A0G2JZC4-1" }, "locus": { "chromosome": "3", "start_pos": 111938676, "end_pos": 111927002, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000109949.1", "url": "https://www.ensembl.org/id/ENSRNOT00000109949.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000093722.1", "url": "https://www.ensembl.org/id/ENSRNOP00000093722.1" } ] } }, { "isoform_ac": "D3ZDA2-1", "url": "", "sequence": { "sequence": "MRFFLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNDIPQTEVIPSKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVIGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDRDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGWLSQGVCERVTLGMLLLTEDFFAFHNHSAGGYEQDTEYGNTAHLGDCHGVRWEVQSGDSNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDPKSMAMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSDKAHGHGASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNVDHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNAKAIMGEIHMAHQTLMLDPVGPMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTTSVRPLNKYTY", "length": 990, "header": "tr|D3ZDA2-1|D3ZDA2_RAT Computationally mapped isoform of Semaphorin 6D OS=Rattus norvegicus OX=10116 GN=Sema6d PE=1 SV=1 CANONICAL=A0A0G2JZC4-1" }, "locus": { "chromosome": "3", "start_pos": 111938676, "end_pos": 111927002, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000066101.2", "url": "https://www.ensembl.org/id/ENSRNOT00000066101.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000062577.1", "url": "https://www.ensembl.org/id/ENSRNOP00000062577.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer.", "journal": "PloS one", "date": "2012", "authors": "Henke A, Grace OC, Ashley GR, Stewart GD, Riddick AC, Yeun H, O'Donnell M, Anderson RA, Thomson AA", "evidence": [ { "database": "RefSeq", "id": "NP_001101238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101238" } ], "reference": [ { "type": "PubMed", "id": "22880013", "url": "https://glygen.org/publication/PubMed/22880013" } ] }, { "title": "SEMA6D, Negatively Regulated by miR-7, Contributes to C28/I2 chondrocyte's Catabolic and Anabolic Activities via p38 Signaling Pathway.", "journal": "Oxidative medicine and cellular longevity", "date": "2022", "authors": "Yang H, Yang Z, Yu Z, Xiong C, Zhang Y, Zhang J, Huang Y, Zhou X, Li J, Xu N", "evidence": [ { "database": "RefSeq", "id": "NP_001101238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101238" } ], "reference": [ { "type": "PubMed", "id": "35757507", "url": "https://glygen.org/publication/PubMed/35757507" } ] }, { "title": "Hybrid in vitro/in silico analysis of low-affinity protein-protein interactions that regulate signal transduction by Sema6D.", "journal": "Protein Sci.", "date": "2022", "authors": "Tanaka Tsubasa, Ekimoto Toru, Nagatomo Meri, Neyazaki Makiko, Shimoji Erena, Yamane Tsutomu, Kanagawa Sakura, Oi Rika, Mihara Emiko, Takagi Junichi, Akashi Satoko, Ikeguchi Mitsunori, Nogi Terukazu", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "reference": [ { "type": "PubMed", "id": "36156831", "url": "https://glygen.org/publication/PubMed/36156831" } ] } ], "pathway": [ { "id": "rno:311384", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:311384", "resource": "KEGG Pathway" }, { "id": "R-RNO-416700", "name": "Other semaphorin interactions", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416700", "resource": "Reactome", "description": "Other semaphorin interactions" } ], "orthologs": [ { "uniprot_canonical_ac": "Q76KF0-1", "protein_name": "Semaphorin-6D", "gene_name": "Sema6d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGFLLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEIPQTEVIPSKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLRTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLAFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDKDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGWLSQGVCERVTLGMLPGGYEQDTEYGNTAHLGDCHESLPPSTTPDYKIFGGPTSDMEVSSSSVTTVASSPEITSKVIDTWRPKLTSSRKFVVQDDPNTSDFTDTISGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDTKSMAVDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHSHGASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQSMDHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNPKAILGEIHMAHQTLMLDPVGPMAEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTTSVRPLNKYTY", "length": 1073 }, "evidence": [ { "id": "45230470", "url": "http://www.informatics.jax.org/homology/45230470", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NFY4-1", "protein_name": "Semaphorin-6D", "gene_name": "SEMA6D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPTSDMEVSSSSVTTMASIPEITPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY", "length": 1073 }, "evidence": [ { "id": "45230470", "url": "http://www.informatics.jax.org/homology/45230470", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "semaphorin receptor binding", "id": "GO:0030215", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030215", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" }, { "name": "chemorepellent activity", "id": "GO:0045499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045499", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" }, { "name": "semaphorin-plexin signaling pathway", "id": "GO:0071526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071526", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" }, { "name": "smooth muscle cell migration", "id": "GO:0014909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014909", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" }, { "name": "neural crest cell migration", "id": "GO:0001755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001755", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" }, { "name": "negative regulation of smooth muscle cell migration", "id": "GO:0014912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014912", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" }, { "name": "ventricular system development", "id": "GO:0021591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021591", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" }, { "name": "negative chemotaxis", "id": "GO:0050919", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050919", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" }, { "name": "positive regulation of smooth muscle cell migration", "id": "GO:0014911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014911", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" }, { "name": "negative regulation of axon extension involved in axon guidance", "id": "GO:0048843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048843", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZC4", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1034, "end_pos": 1036, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 435, "end_pos": 437, "annotation": "n_glycosylation_sequon" }, { "start_pos": 461, "end_pos": 463, "annotation": "n_glycosylation_sequon" }, { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" }, { "start_pos": 631, "end_pos": 633, "annotation": "n_glycosylation_sequon" }, { "start_pos": 832, "end_pos": 834, "annotation": "n_glycosylation_sequon" }, { "start_pos": 838, "end_pos": 840, "annotation": "n_glycosylation_sequon" }, { "start_pos": 967, "end_pos": 969, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", 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