{ "uniprot_canonical_ac": "A0A0G2JXG7-1", "uniprot_ac": "A0A0G2JXG7", "uniprot_id": "A0A0G2JXG7_RAT", "mass": { "chemical_mass": 152159.0, "monoisotopic_mass": 152159.0 }, "refseq": { "ac": "NP_001178621", "name": "F-actin-uncapping protein LRRC16A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178621" }, "gene_names": [ { "name": "Carmil1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7", "id": "A0A0G2JXG7" }, { "name": "Carmil1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178621", "id": "NP_001178621" }, { "name": "Lrrc16; Lrrc16a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178621", "id": "NP_001178621" } ], "protein_names": [ { "name": "Capping protein regulator and myosin 1 linker 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2JXG7" }, { "name": "F-actin-uncapping protein LRRC16A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178621", "id": "NP_001178621" }, { "name": "leucine rich repeat containing 16; leucine-rich repeat-containing protein 16A; leucine rich repeat containing 16A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178621", "id": "NP_001178621" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "common_name": "Rat" } ], "gene": [ { "name": "Carmil1", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7", "locus": { "chromosome": "17", "start_pos": 41088326, "end_pos": 40808389, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000016576", "url": "https://www.ensembl.org/id/ENSRNOG00000016576" } ] } } ], "crossref": [ { "id": "ENSRNOG00000016576", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000016576", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "306941", "url": "https://www.ncbi.nlm.nih.gov/gene/306941", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:306941", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:306941", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DKQENRV", "url": "https://omabrowser.org/oma/group/DKQENRV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5476233at2759", "url": "http://www.orthodb.org/?query=5476233at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24112", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24112", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24112:SF39", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24112:SF39", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13516", "url": "http://pfam.xfam.org/family/PF13516", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16000", "url": "http://pfam.xfam.org/family/PF16000", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17888", "url": "http://pfam.xfam.org/family/PF17888", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983231", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001178621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178621", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1306623", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306623", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JXG7-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A2B1", "url": "https://www.uniprot.org/uniprot/A0A8I6A2B1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A2B1-1", "url": "https://www.uniprot.org/uniprot/A0A8I6A2B1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AJW0", "url": "https://www.uniprot.org/uniprot/A0A8I6AJW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AJW0-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AJW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6G5R0", "url": "https://www.uniprot.org/uniprot/A0A8I6G5R0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6G5R0-1", "url": "https://www.uniprot.org/uniprot/A0A8I6G5R0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1M0N7", "url": "https://www.uniprot.org/uniprot/F1M0N7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1M0N7-1", "url": "https://www.uniprot.org/uniprot/F1M0N7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTDESSDVPRELMESIKDVIGRKIKISVKKKVKLEVKGDRVENKVLVLTSCRAFLLSARIPTKLELTFSYLEIHGVICHKPTQMVVETEKCNVSMKMASLEDASDVLAHIGTCLRRIFPGLSPLRIMKKVSMEPSERLASLQALWDSQTLAEPGPCGGFSQMYACVCDWLGFSYREEVQWDVDTIYLTQDTRELNLQDFSHLEHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNLLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNVLRGDDLSHMYNFLAQPNTIVHLDLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQINLSGTKLSPEPLKALLLGLACNHSLKGVSLDLSNCELGHCLRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSRNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEDSPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNSMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTSPEKTEEALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRACGGDAIQEDLKAAERLMRDAKNSKTLLPNLYHVGGASWAGASGLSSSPIQEILESMAGEVTRVVDEQLKGLLESMVDAAENLCPNVMRKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDSLSNSHRKLANHFSRLSKSLPQREDLEVELVEEKPVKRAILTVEDLTEVEKLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPSVRQEKRSSGLISELPSEEGRRLEHFTKLRPKRNKKQQPTQAAVCSINIIPHDGEQNGLMGRVDEGVDEFFTKKVTKMDCKRSSTRCSDTHDLVEGDEKKKRDSRRSGFLNLIKSRSRSERPPTVLMTEELSSPKGAVRSPPVDTARKEIKAAEHNGAPERTEEMRTPEPLEEGLAEEAGRAERSDSRGSPQGGRRYVQVMGSGLLAEMKAKQERRAACAQKKLGNDVISQDPSSPVMSNTERLDGGATVPKLQPGLPEARFGLGTPEKNAKAEPRVDGGCRSRNSSSMPTSPKPLLQSPKPSPAARPSIPQKPRTASKPEDTPDSPSGPSSPKVALLPPILKKVSLDKERDDQSSSQSSPRTFSQEVSRRSWGPAQEYQEQKQRNLGKDGHQGSKSSDSGEEAEKEFIFV", "length": 1374, "header": "tr|A0A0G2JXG7-1|A0A0G2JXG7_RAT Isoform 1 of Capping protein regulator and myosin 1 linker 1 OS=Rattus norvegicus OX=10116 GN=Carmil1 PE=1 SV=2 CANONICAL=A0A0G2JXG7-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JXG7-1", "url": "", "sequence": { "sequence": "MTDESSDVPRELMESIKDVIGRKIKISVKKKVKLEVKGDRVENKVLVLTSCRAFLLSARIPTKLELTFSYLEIHGVICHKPTQMVVETEKCNVSMKMASLEDASDVLAHIGTCLRRIFPGLSPLRIMKKVSMEPSERLASLQALWDSQTLAEPGPCGGFSQMYACVCDWLGFSYREEVQWDVDTIYLTQDTRELNLQDFSHLEHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNLLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNVLRGDDLSHMYNFLAQPNTIVHLDLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQINLSGTKLSPEPLKALLLGLACNHSLKGVSLDLSNCELGHCLRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSRNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEDSPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNSMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTSPEKTEEALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRACGGDAIQEDLKAAERLMRDAKNSKTLLPNLYHVGGASWAGASGLSSSPIQEILESMAGEVTRVVDEQLKGLLESMVDAAENLCPNVMRKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDSLSNSHRKLANHFSRLSKSLPQREDLEVELVEEKPVKRAILTVEDLTEVEKLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPSVRQEKRSSGLISELPSEEGRRLEHFTKLRPKRNKKQQPTQAAVCSINIIPHDGEQNGLMGRVDEGVDEFFTKKVTKMDCKRSSTRCSDTHDLVEGDEKKKRDSRRSGFLNLIKSRSRSERPPTVLMTEELSSPKGAVRSPPVDTARKEIKAAEHNGAPERTEEMRTPEPLEEGLAEEAGRAERSDSRGSPQGGRRYVQVMGSGLLAEMKAKQERRAACAQKKLGNDVISQDPSSPVMSNTERLDGGATVPKLQPGLPEARFGLGTPEKNAKAEPRVDGGCRSRNSSSMPTSPKPLLQSPKPSPAARPSIPQKPRTASKPEDTPDSPSGPSSPKVALLPPILKKVSLDKERDDQSSSQSSPRTFSQEVSRRSWGPAQEYQEQKQRNLGKDGHQGSKSSDSGEEAEKEFIFV", "length": 1374, "header": "tr|A0A0G2JXG7-1|A0A0G2JXG7_RAT Isoform 1 of Capping protein regulator and myosin 1 linker 1 OS=Rattus norvegicus OX=10116 GN=Carmil1 PE=1 SV=2 CANONICAL=A0A0G2JXG7-1" }, "locus": { "chromosome": "17", "start_pos": 41087441, "end_pos": 40808575, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000080745.2", "url": "https://www.ensembl.org/id/ENSRNOT00000080745.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000070264.2", "url": "https://www.ensembl.org/id/ENSRNOP00000070264.2" } ] } }, { "isoform_ac": "A0A8I6A2B1-1", "url": "", "sequence": { "sequence": "MTDESSDVPRELMESIKDVIGRKIKISVKKKVKLEVKGDRVENKVLVLTSCRAFLLSARIPTKLELTFSYLEIHGVICHKPTQMVVETEKCNVSMKMASLEDASDVLAHIGTCLRRIFPGLSPLRIMKKVSMEPSERLASLQALWDSQTLAEPGPCGGFSQMYACVCDWLGFSYREEVQWDVDTIYLTQDTRELNLQDFSHLEHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNLLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNVLRGDDLSHMYNFLAQPNTIVHLDLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQINLSGTKLSPEPLKALLLGLACNHSLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSRNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEDSPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNSMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTSPEKTEEALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRACGGDAIQEDLKAAERLMRDAKNSKTLLPNLYHVGGASWAGASGLSSSPIQEILESMAGEVTRVVDEQLKGLLESMVDAAENLCPNVMRKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDSLSNSHRKLANHFSRLSKSLPQREDLEVELVEEKPVKRAILTVEDLTEVEKLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPSVRQEKRSSGLISELPSEEGRRLEHFTKLRPKRNKKQQPTQAAVCSINIIPHDGEQNGLMGRVDEGVDEFFTKKVTKMDCKRSSTRCSDTHDLVEGDEKKKRDSRRSGFLNLIKSRSRSERPPTVLMTEELSSPKGAVRSPPVDTARKEIKAAEHNGAPERTEEMRTPEPLEEGLAEEAGRAERSDSRGSPQGGRRYVQVMGSGLLAEMKAKQERRAACAQKKLGNDVISQDPSSPVMSNTERLDGGATVPKLQPGLPEARFGLGTPEKNAKAEPRVDGGCRSRNSSSMPTSPKPLLQSPKPSPAARPSIPQKPRTASKPEDTPDSPSGPSSPKVALLPPILKKVSLDKERDDQSSSQSSPRTFSQEACPTNF", "length": 1332, "header": "tr|A0A8I6A2B1-1|A0A8I6A2B1_RAT Computationally mapped isoform of Capping protein regulator and myosin 1 linker 1 OS=Rattus norvegicus OX=10116 GN=Carmil1 PE=3 SV=1 CANONICAL=A0A0G2JXG7-1" }, "locus": { "chromosome": "17", "start_pos": 41080822, "end_pos": 40808575, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000108358.1", "url": "https://www.ensembl.org/id/ENSRNOT00000108358.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000085444.1", "url": "https://www.ensembl.org/id/ENSRNOP00000085444.1" } ] } }, { "isoform_ac": "A0A8I6AJW0-1", "url": "", "sequence": { "sequence": "MTDESSDVPRELMESIKDVIGRKIKISVKKKVKLEVKGDRVENKVLVLTSCRAFLLSARIPTKLELTFSYLEIHGVICHKPTQMVVETEKCNVSMKMASLEDASDVLAHIGTCLRRIFPGLSPLRIMKKVSMEPSERLASLQALWDSQTLAEPGPCGGFSQMYACVCDWLGFSYREEVQWDVDTIYLTQDTRELNLQDFSHLEHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNLLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNVLRGDDLSHMYNFLAQPNTIVHLDLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQINLSGTKLSPEPLKALLLGLACNHSLKGVSLDLSNCELGHCLRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSRNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEDSPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNSMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTSPEKTEEALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRACGGDAIQEDLKAAERLMRDAKNSKTLLPNLYHVGGASWAGASGLSSSPIQEILESMAGEVTRVVDEQLKGLLESMVDAAENLCPNVMRKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDSLSNSHRKLANHFSRLSKSLPQREDLEVELVEEKPVKRAILTVEDLTEVEKLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPSVRQEKRSSGLISELPSEEGRRLEHFTKLRPKRNKKQQPTQAAVCSINIIPHDGEQNGLMGRVDEGVDEFFTKKVTKMDCKRSSTRCSDTHDLVEGDEKKKRDSRRSGFLNLIKSRSRSERPPTVLMTEELSSPKGAVRSPPVDTARKEIKAAEHNGAPERTEEMRTPEPLEEGLAEEAGRAERSDSRGSPQGGRRYVQVMGSGLLAEMKAKQERRAACAQKKLGNDVISQDPSSPVMSNTERLDGGATVPKLQPGLPEARFGLGTPEKNAKAEPRVDGGCRSRNSSSMPTSPKPLLQSPKPSPAARPSIPQKPRTASKPEDTPDSPSGPSSPKVALLPPILKKVSLDKERDDQSSSQSSPRTFSQEVQRGDHFKRHSDHDKPSSRGKRSSKLCFAIAEEEVNAPGYRKSQPTNVSRRSWGPAQEYQEQKQRNLGKDGHQGSKSSDSGEEAEKEFIFV", "length": 1421, "header": "tr|A0A8I6AJW0-1|A0A0G2JXG7_RAT Computationally mapped isoform of Capping protein regulator and myosin 1 linker 1 OS=Rattus norvegicus OX=10116 GN=Carmil1 PE=1 SV=1 CANONICAL=A0A0G2JXG7-1" }, "locus": { "chromosome": "17", "start_pos": 41087441, "end_pos": 40808575, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000104932.1", "url": "https://www.ensembl.org/id/ENSRNOT00000104932.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000095539.1", "url": "https://www.ensembl.org/id/ENSRNOP00000095539.1" } ] } }, { "isoform_ac": "A0A8I6G5R0-1", "url": "", "sequence": { "sequence": "MTDESSDVPRELMESIKDVIGRKIKISVKKKVKLEVKGDRVENKVLVLTSCRAFLLSARIPTKLELTFSYLEIHGVICHKPTQMVVETEKCNVSMKMASLEDASDVLAHIGTCLRRIFPGLSPLRIMKKVSMEPSERLASLQALWDSQTLAEPGPCGGFSQMYACVCDWLGFSYREEVQWDVDTIYLTQDTRELNLQDFSHLEHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNLLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNVLRGDDLSHMYNFLAQPNTIVHLDLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQINLSGTKLSPEPLKALLLGLACNHSLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSRNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEDSPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNSMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTSPEKTEEALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRACGGDAIQEDLKAAERLMRDAKNSKTLLPNLYHVGGASWAGASGLSSSPIQEILESMAGEVTRVVDEQLKGLLESMVDAAENLCPNVMRKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDSLSNSHRKLANHFSRLSKSLPQREDLEVELVEEKPVKRAILTVEDLTEVEKLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPSVRQEKRSSGLISELPSEEGRRLEHFTKLRPKRNKKQQPTQAAVCSINIIPHDGEQNGLMGRVDEGVDEFFTKKVTKMDCKRSSTRCSDTHDLVEGDEKKKRDSRRSGFLNLIKSRSRSERPPTVLMTEELSSPKGAVRSPPVDTARKEIKAAEHNGAPERTEEMRTPEPLEEGLAEEAGRAERSDSRGSPQGGRRYVQVMGSGLLAEMKAKQERRAACAQKKLGNDVISQDPSSPVMSNTERLDGGATVPKLQPGLPEARFGLGTPEKNAKAEPRVDGGCRSRNSSSMPTSPKPLLQSPKPSPAARPSIPQKPRTASKPEDTPDSPSGPSSPKVALLPPILKKVSLDKERDDQSSSQSSPRTFSQEGKNIFPFILPKECHFKRK", "length": 1344, "header": "tr|A0A8I6G5R0-1|A0A8I6G5R0_RAT Computationally mapped isoform of Capping protein regulator and myosin 1 linker 1 OS=Rattus norvegicus OX=10116 GN=Carmil1 PE=3 SV=1 CANONICAL=A0A0G2JXG7-1" }, "locus": { "chromosome": "17", "start_pos": 41078466, "end_pos": 40808575, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000117749.1", "url": "https://www.ensembl.org/id/ENSRNOT00000117749.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000081294.1", "url": "https://www.ensembl.org/id/ENSRNOP00000081294.1" } ] } }, { "isoform_ac": "F1M0N7-1", "url": "", "sequence": { "sequence": "MICFKALIKGLCFPSPSLQLELTFSYLEIHGVICHKPTQMVVETEKCNVSMKMASLEDASDVLAHIGTCLRRIFPGLSPLRIMKKVSMEPSERLASLQALWDSQTLAEPGPCGGFSQMYACVCDWLGFSYREEVQWDVDTIYLTQDTRELNLQDFSHLEHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNLLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNVLRGDDLSHMYNFLAQPNTIVHLDLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQINLSGTKLSPEPLKALLLGLACNHSLKGVSLDLSNCESLHCMTSLVTCVLTPCVLVFPGLESDLSTLIVWLSRNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEDSPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNSMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTSPEKTEEALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRACGGDAIQEDLKAAERLMRDAKNSKTLLPNLYHVGGASWAGASGLSSSPIQEILESMAGEVTRVVDEQLKGLLESMVDAAENLCPNVMRKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDSLSNSHRKLANHFSRLSKSLPQREDLEVELVEEKPVKRAILTVEDLTEVEKLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPSVRQEKRSSGLISELPSEEGRRLEHFTKLRPKRNKKQQPTQAAVCSINIIPHDGEQNGLMGRVDEGVDEFFTKKVTKMDCKRSSTRCSDTHDLVEGDEKKKRDSRRSGFLNLIKSRSRSERPPTVLMTEELSSPKGAVRSPPVDTARKEIKAAEHNGAPERTEEMRTPEPLEEGLAEEAGRAERSDSRGSPQGGRRYVQVMGSGLLAEMKAKQERRAACAQKKLGNDVISQDPSSPVMSNTERLDGGATVPKLQPGLPEARFGLGTPEKNAKAEPRVDGGCRSRNSSSMPTSPKPLLQSPKPSPAARPSIPQKPRTASKPEDTPDSPSGPSSPKVALLPPILKKVSLDKERDDQSSSQSSPRTFSQEVSRRSWGPAQEYQEQKQRNLGKDGHQGSKSSDSGEEAEKEFIFV", "length": 1320, "header": "tr|F1M0N7-1|F1M0N7_RAT Computationally mapped isoform of Capping protein regulator and myosin 1 linker 1 OS=Rattus norvegicus OX=10116 GN=Carmil1 PE=1 SV=3 CANONICAL=A0A0G2JXG7-1" }, "locus": { "chromosome": "17", "start_pos": 41087441, "end_pos": 40925607, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000059510.4", "url": "https://www.ensembl.org/id/ENSRNOT00000059510.4" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000056268.4", "url": "https://www.ensembl.org/id/ENSRNOP00000056268.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:306941", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:306941", "resource": "KEGG Pathway" }, { "id": "R-RNO-983231", "name": "Factors involved in megakaryocyte development and platelet production", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983231", "resource": "Reactome", "description": "Factors involved in megakaryocyte development and platelet production" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5VZK9-1", "protein_name": "F-actin-uncapping protein LRRC16A", "gene_name": "CARMIL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTEESSDVPRELIESIKDVIGRKIKISVKKKVKLEVKGDKVENKVLVLTSCRAFLVTARIPTKLELTFSYLEIHGVVCSKSAQMIVETEKCSISMKMASPEDVSEVLAHIGTCLRKIFPGLSPVRIMKKVSMEPSERLASLQALWDSQTVAEQGPCGGFSQMYACVCDWLGFSYREEVQWDVDTIYLTQDTRELNLQDFSHLDHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTNPEKTEDALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRNCGGDAIQEDLKSAERLMRDAKNSKTLLPNLYHVGGASWAGASGLLSSPIQETLESMAGEVTRVVDEQLKALLESMVDAAENLCPNVMKKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDALSHCHHKLADHFSRRGKTLPQQESLEIELAEEKPVKRSIITVEELTEIERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPSLRQEKRSSGFISELPSEEGKKLEHFTKLRPKRNKKQQPTQAAVCAANIVSQDGEQNGLMGRVDEGVDEFFTKKVTKMDSKKWSTRGSESHELNEGGDEKKKRDSRKSSGFLNLIKSRSKSERPPTILMTEEPSSPKGAVRSPPVDCPRKDTKAAEHNGNSERIEEIKTPDSFEESQGEEIGKVERSDSKSSPQAGRRYGVQVMGSGLLAEMKAKQEKRAACAQKKLGNDAVSQDSSSPALSGVERSDGGGAVPKLHPGLPENRFGLGTPEKNTKAEPKAEAGSRSRSSSSTPTSPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKVPSDKERDGQSSPQPSPRTFSQEVSRRSWGQQAQEYQEQKQRSSSKDGHQGSKSNDSGEEAEKEFIFV", "length": 1371 }, "evidence": [ { "id": "45237825", "url": "http://www.informatics.jax.org/homology/45237825", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q6EDY6-1", "protein_name": "F-actin-uncapping protein LRRC16A", "gene_name": "Carmil1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTDESSDVPRELMESIKDVIGRKIKISVKKKVKLEVKGDRVENKVLVLTSCRAFLLSARIPSKLELTFSYLEIHGVICHKPAQMVVETEKCNMSMKMVSPEDVSEVLAHIGTCLRRIFPGLSPLRIMKKVSMEPSERLASLQALWDSQTLAEPGPCGGFSQMYACVCDWLGFSYKEEVQWDVDTIYLTQDTRELNLQDFSHLEHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRIDFAQKLAGALAHNPNSGLHTINLAGNSLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNALRGDDLSHMYNFLAQPNTIVHLDLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQINLSGTKLSPEPLKALLLGLACNHSLKGVSLDLSNCELGHCLRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEDSPLQSLSLADSKLKAEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDAAQALKTNPEKTEEALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRACGGDAIQEDLKAAERLMRDAKNSKTLLPNLYHVGGASWAGASGLSSSPIQETLESMAGEVTRVVDEQLKDLLESMVDAAETLCPNVMRKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDSLSSSHRKLANHFSRLNKSLPQREDLEVELVEEKPVKRAILTVEDLTEVERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPSVRQEKRSSGLISELPSEEGRRLEHFTKLRPKRNKKQQPTQAAVCTISILPQDGEQNGLMGRVDEGVDEFFTKKVTKMDCKRSSSRSSDAHELGEGDEKKKRDSRRSGFLNLIKSRSRSERPPTVLMTEELSSPKGAMRSPPVDTTRKEIKAAEHNGAPDRTEEIKTPEPLEEGPAEEAGRAERSDSRGSPQGGRRYVQVMGSGLLAEMKAKQERRAACAQKKLGNDVISQDPSSPVSCNTERLEGGATVPKLQPGLPEARFGSGTPEKNAKAEPRVDGGCRSRSSSSMPTSPKPLLQSPKPSPSARPSIPQKPRTASRPEDTPDSPSGPSSPKVALLPPILKKVSSDKERDGQNSSQSSPRSFSQEASRRSWGPAQEYQEQKQRSSGKDGHQGSKCSDSGEEAEKEFIFV", "length": 1374 }, "evidence": [ { "id": "45237825", "url": "http://www.informatics.jax.org/homology/45237825", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "cell leading edge", "id": "GO:0031252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031252", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "macropinosome", "id": "GO:0044354", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044354", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "filamentous actin", "id": "GO:0031941", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031941", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "urate metabolic process", "id": "GO:0046415", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046415", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "positive regulation of stress fiber assembly", "id": "GO:0051496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051496", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "lamellipodium assembly", "id": "GO:0030032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030032", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "positive regulation of substrate adhesion-dependent cell spreading", "id": "GO:1900026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900026", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "ruffle organization", "id": "GO:0031529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031529", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "regulation of Arp2/3 complex-mediated actin nucleation", "id": "GO:0034315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034315", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "actin filament network formation", "id": "GO:0051639", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051639", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "positive regulation of actin filament polymerization", "id": "GO:0030838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030838", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "macropinocytosis", "id": "GO:0044351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044351", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "barbed-end actin filament uncapping", "id": "GO:0051638", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051638", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "positive regulation of lamellipodium organization", "id": "GO:1902745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902745", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" }, { "name": "negative regulation of barbed-end actin filament capping", "id": "GO:2000813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000813", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXG7", "url": "https://www.uniprot.org/uniprot/A0A0G2JXG7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], 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