{
    "uniprot_canonical_ac": "A0A0G2JWT6-1",
    "uniprot_ac": "A0A0G2JWT6",
    "uniprot_id": "A0A0G2JWT6_RAT",
    "mass": {
        "chemical_mass": 38601.0,
        "monoisotopic_mass": 38601.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Pex16",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWT6",
            "id": "A0A0G2JWT6"
        }
    ],
    "protein_names": [
        {
            "name": "Peroxisomal membrane protein PEX16",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A0A0G2JWT6"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0080377",
            "recommended_name": {
                "id": "DOID:0080377",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080377",
                "name": "peroxisomal biogenesis disorder",
                "description": "A peroxisomal biogenesis disorder that has_material_basis_in defects in PEX genes."
            },
            "synonyms": [
                {
                    "id": "MONDO:0008953",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008953",
                    "name": "peroxisome biogenesis disorder 1A (Zellweger)",
                    "description": ""
                },
                {
                    "id": "MONDO:0008953",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008953",
                    "name": "peroxisome biogenesis disorder 1A (Zellweger)",
                    "description": ""
                },
                {
                    "id": "MONDO:0008953",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008953",
                    "name": "Cerebrohepatorenal syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008953",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008953",
                    "name": "PBD1A",
                    "description": ""
                },
                {
                    "id": "MONDO:0008953",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008953",
                    "name": "Zs",
                    "description": ""
                },
                {
                    "id": "MONDO:0008953",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008953",
                    "name": "peroxisome biogenesis disorder, complementation group 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008953",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008953",
                    "name": "peroxisome biogenesis disorder, complementation group E",
                    "description": ""
                },
                {
                    "id": "MIM:214100",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/214100",
                    "name": "Peroxisome biogenesis disorder 1A",
                    "description": "Peroxisome biogenesis disorder 1A"
                }
            ],
            "evidence": [
                {
                    "id": "0080377",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080377"
                }
            ]
        },
        {
            "disease_id": "DOID:0080483",
            "recommended_name": {
                "id": "DOID:0080483",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080483",
                "name": "peroxisome biogenesis disorder 8A",
                "description": "A peroxisomal biogenesis disorder that has_material_basis_in homozygous mutation in the PEX16 gene on chromosome 11p11."
            },
            "synonyms": [
                {
                    "id": "DOID:0080483",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080483",
                    "name": "peroxisome biogenesis disorder 8A (Zellweger)",
                    "description": ""
                },
                {
                    "id": "MONDO:0013942",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013942",
                    "name": "peroxisome biogenesis disorder 8A (Zellweger)",
                    "description": ""
                },
                {
                    "id": "MONDO:0013942",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013942",
                    "name": "peroxisome biogenesis disorder 8A (Zellweger)",
                    "description": ""
                },
                {
                    "id": "MONDO:0013942",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013942",
                    "name": "PBD8A",
                    "description": ""
                },
                {
                    "id": "MONDO:0013942",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013942",
                    "name": "peroxisome biogenesis disorder, complementation group 9",
                    "description": ""
                },
                {
                    "id": "MONDO:0013942",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013942",
                    "name": "peroxisome biogenesis disorder, complementation group D",
                    "description": ""
                },
                {
                    "id": "MIM:614876",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/614876",
                    "name": "Peroxisome biogenesis disorder 8A",
                    "description": "Peroxisome biogenesis disorder 8A"
                }
            ],
            "evidence": [
                {
                    "id": "0080483",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080483"
                }
            ]
        },
        {
            "disease_id": "DOID:905",
            "recommended_name": {
                "id": "DOID:905",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:905",
                "name": "Zellweger syndrome",
                "description": "A peroxisomal biogenesis disorder that is characterized by the reduction or absence of functional peroxisomes in the cells of an individual that has_material_basis_in autosomal recessive inheritance of a mutation in the peroxisome biogenesis factor (PEX) genes."
            },
            "synonyms": [
                {
                    "id": "DOID:905",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:905",
                    "name": "cerebrohepatorenal syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:905",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:905",
                    "name": "congenital iron overload",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "905",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:905"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JWT6",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JWT6"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Pex16",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWT6",
            "locus": {
                "chromosome": "3",
                "start_pos": 78353207,
                "end_pos": 78343164,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000006539",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000006539"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000006539",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000006539",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "IPR013919",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013919",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "RDLMSKQ",
            "url": "https://omabrowser.org/oma/group/RDLMSKQ/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5317016at2759",
            "url": "http://www.orthodb.org/?query=5317016at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13299",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13299",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13299:SF0",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13299:SF0",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF08610",
            "url": "http://pfam.xfam.org/family/PF08610",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9603798",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9603798",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "XP_006234629",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006234629",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1311372",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311372",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2JV14",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JV14",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2JV14-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JV14-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2JWT6",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWT6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2JWT6-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWT6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6A5Q8",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A5Q8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6A5Q8-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A5Q8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3ZGV2",
            "url": "https://www.uniprot.org/uniprot/D3ZGV2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3ZGV2-1",
            "url": "https://www.uniprot.org/uniprot/D3ZGV2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MEKLRLLGLRYQEYVTRHPAATAQLETAVRGLSYLLAGRFSDSHELSELVYSASNLLVLLNDGILRKELRKKLPVSLSQQKLLTWLSVLECVEVFMEMGAAKVWGEVGRWLVIALIQLAKAVLRMFLLIWFKTGIQTSPPIVPLDRETQAQPLDGDHNLGSPEPSYVGKRSNRVVRTLQNSPSLHSRHWGAPQQREIRQKQQQEELSTPPTPLGLQETIAESLYIARPLLHLLSLGLWGQRSWAPWLLSGVVDMTSLSLLSDRKNLTRRERLELRRRTILLLYYLLRSPFYDRFSEAKILFLLQLLADHIPGIGLVARPLMDYLPSWQKIYFYSWG",
        "length": 336,
        "header": "tr|A0A0G2JWT6-1|A0A0G2JWT6_RAT Isoform 1 of Peroxisomal membrane protein PEX16  OS=Rattus norvegicus OX=10116 GN=Pex16 PE=3 SV=1 CANONICAL=A0A0G2JWT6-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2JV14-1",
            "url": "",
            "sequence": {
                "sequence": "MEKLRLLGLRYQEYVTRHPAATAQLETAVRGLSYLLAGRFSDSHELSELVYSASNLLVLLNDGILRKELRKKLPVSLSQQKLLTWLSVLECVEVFMEMGAAKVWGEVGRWLVIALIQLAKAVLRMFLLIWFKTGIQTSPPIVPLDRETQAQPLDGDHNLGSPEPSYVGKRSNRVVRTLQNSPSLHSRHWGAPQQREIRQKQQQEELSTPPTPLGLQETIAESLYIARPLLHLLSLGLWGQRSWAPWLLSGVVDMTSLSLLSDRKNLTRRERLELRRRTILLLYYLLRSPFYDRFSEAKILFLLQLLADHIPGIGLVAS",
                "length": 318,
                "header": "tr|A0A0G2JV14-1|A0A0G2JWT6_RAT Computationally mapped isoform of Peroxisomal membrane protein PEX16  OS=Rattus norvegicus OX=10116 GN=Pex16 PE=3 SV=2 CANONICAL=A0A0G2JWT6-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 78353050,
                "end_pos": 78347352,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000086217.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000086217.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000069312.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000069312.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A0G2JWT6-1",
            "url": "",
            "sequence": {
                "sequence": "MEKLRLLGLRYQEYVTRHPAATAQLETAVRGLSYLLAGRFSDSHELSELVYSASNLLVLLNDGILRKELRKKLPVSLSQQKLLTWLSVLECVEVFMEMGAAKVWGEVGRWLVIALIQLAKAVLRMFLLIWFKTGIQTSPPIVPLDRETQAQPLDGDHNLGSPEPSYVGKRSNRVVRTLQNSPSLHSRHWGAPQQREIRQKQQQEELSTPPTPLGLQETIAESLYIARPLLHLLSLGLWGQRSWAPWLLSGVVDMTSLSLLSDRKNLTRRERLELRRRTILLLYYLLRSPFYDRFSEAKILFLLQLLADHIPGIGLVARPLMDYLPSWQKIYFYSWG",
                "length": 336,
                "header": "tr|A0A0G2JWT6-1|A0A0G2JWT6_RAT Isoform 1 of Peroxisomal membrane protein PEX16  OS=Rattus norvegicus OX=10116 GN=Pex16 PE=3 SV=1 CANONICAL=A0A0G2JWT6-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 78352470,
                "end_pos": 78347352,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000086530.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000086530.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000070009.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000070009.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6A5Q8-1",
            "url": "",
            "sequence": {
                "sequence": "MEKLRLLGLRYQEYVTRHPAATAQLETAVRGLSYLLAGRFSDSHELSELVYSASNLLVLLNDGILRKELRKKLPVSLSQQKLLTWLSVLECVEVFMEMGAAKVWGEVGRWLVIALIQLAKAVLRMFLLIWFKTGIQTSPPIVPLDRETQAQPLDGDHNLGSPEPSYVGKRSNRVVRTLQNSPSLHSRHWGAPQQREIRQKQQQEELSTPPTPLGLQETIAESLYIARPLLHLLSLGLWGQRSWAPWLLSGVVDMTSLSLLSDRKNLTRRERLELRRRTILLLYYLLRSPFYDRFSEAKILFLLQLLADHIPGIGLVASKCG",
                "length": 321,
                "header": "tr|A0A8I6A5Q8-1|A0A0G2JWT6_RAT Computationally mapped isoform of Peroxisomal membrane protein PEX16  OS=Rattus norvegicus OX=10116 GN=Pex16 PE=3 SV=1 CANONICAL=A0A0G2JWT6-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 78351926,
                "end_pos": 78347352,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000103955.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000103955.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000086386.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000086386.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D3ZGV2-1",
            "url": "",
            "sequence": {
                "sequence": "MRKLGGNLDLPFKVASPIPTSCLSWCTLPLTCLCCSMTGSFGRSFEKLPVSLSQQKLLTWLSVLECVEVFMEMGAAKVWGEVGRWLVIALIQLAKAVLRMFLLIWFKTGIQTSPPIVPLDRETQAQPLDGDHNLGSPEPSYVGKRSNRVVRTLQNSPSLHSRHWGAPQQREIRQKQQQEELSTPPTPLGLQETIAESLYIARPLLHLLSLGLWGQRSWAPWLLSGVVDMTSLSLLSDRKNLTRRERLELRRRTILLLYYLLRSPFYDRFSEAKILFLLQLLADHIPGIGLVARPLMDYLPSWQKIYFYSWG",
                "length": 311,
                "header": "tr|D3ZGV2-1|D3ZGV2_RAT Computationally mapped isoform of Peroxisomal membrane protein PEX16  OS=Rattus norvegicus OX=10116 GN=Pex16 PE=1 SV=4 CANONICAL=A0A0G2JWT6-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 78352470,
                "end_pos": 78343308,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000008986.8",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000008986.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000008986.7",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000008986.7"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "R-RNO-9603798",
            "name": "Class I peroxisomal membrane protein import",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9603798",
            "resource": "Reactome",
            "description": "Class I peroxisomal membrane protein import"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "peroxisome",
                        "id": "GO:0005777",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWT6",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWT6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "peroxisomal membrane",
                        "id": "GO:0005778",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWT6",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWT6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum",
                        "id": "GO:0005783",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWT6",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWT6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum membrane",
                        "id": "GO:0005789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWT6",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWT6"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 8,
                "go_terms": [
                    {
                        "name": "peroxisome organization",
                        "id": "GO:0007031",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007031",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWT6",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWT6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein targeting to peroxisome",
                        "id": "GO:0006625",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006625",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWT6",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWT6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein import into peroxisome matrix",
                        "id": "GO:0016558",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016558",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWT6",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWT6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "peroxisome membrane biogenesis",
                        "id": "GO:0016557",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016557",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWT6",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWT6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
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