{ "uniprot_canonical_ac": "A0A0G2JVY2-1", "uniprot_ac": "A0A0G2JVY2", "uniprot_id": "A0A0G2JVY2_RAT", "mass": { "chemical_mass": 124109.0, "monoisotopic_mass": 124109.0 }, "refseq": { "ac": "XP_006237414", "name": "scavenger receptor cysteine-rich type 1 protein M130 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006237414" }, "gene_names": [ { "name": "Cd163", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JVY2", "id": "A0A0G2JVY2" }, { "name": "Cd163", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006237414", "id": "XP_006237414" }, { "name": "ED2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006237414", "id": "XP_006237414" } ], "protein_names": [ { "name": "CD163 molecule", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2JVY2" }, { "name": "scavenger receptor cysteine-rich type 1 protein M130 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006237414", "id": "XP_006237414" } ], "function": [], "disease": [ { "disease_id": "DOID:0050120", "recommended_name": { "id": "DOID:0050120", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050120", "name": "hemophagocytic lymphohistiocytosis", "description": "A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages." }, "synonyms": [ { "id": "DOID:0050120", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050120", "name": "haemophagocytic syndrome", "description": "" }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "familial hemophagocytic lymphohistiocytosis type 1", "description": "Familial Hemophagocytic lymphohistiocytosis (FHL) is a rare primary immunodeficiency characterized by a macrophage activation syndrome with an onset usually occurring within a few months or less common several years after birth." }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "familial hemophagocytic lymphohistiocytosis", "description": "" }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "FHL1", "description": "" }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "HLH1", "description": "" }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "HPLH1", "description": "" }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "familial HLH", "description": "" }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "familial hemophagocytic lymphohistiocytosis type 1", "description": "" }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "Erythrophagocytic lymphohistiocytosis, familial", "description": "" }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "Hlh1", "description": "" }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "Hplh1", "description": "" }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "familial hemophagocytic lymphohistiocytosis 1", "description": "" }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "hemophagocytic lymphohistiocytosis, familial", "description": "" }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "hemophagocytic lymphohistiocytosis, familial, 1", "description": "" }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "hemophagocytic reticulosis, familial", "description": "" }, { "id": "MONDO:0009974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009974", "name": "reticulosis, familial histiocytic", "description": "" } ], "evidence": [ { "id": "0050120", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050120" } ] }, { "disease_id": "DOID:0050523", "recommended_name": { "id": "DOID:0050523", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050523", "name": "adult T-cell leukemia/lymphoma", "description": "A T-cell acute leukemia that results_in abnormal increase of lymphocytes, derives_from T-cells, has_material_basis_in Human T-lymphotropic virus 1 (HTLV-1), which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The infection results_in_formation_of skin lesions." }, "synonyms": [ { "id": "DOID:0050523", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050523", "name": "adult T-cell leukemia", "description": "" }, { "id": "DOID:0050523", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050523", "name": "Adult T-cell leukemia/lymphoma (HTLV-1 positive)", "description": "" } ], "evidence": [ { "id": "0050523", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050523" } ] }, { "disease_id": "DOID:0080208", "recommended_name": { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "metabolic dysfunction-associated steatotic liver disease", "description": "A steatotic liver disease characterized by at least one of five cardiometabolic risk factors (adjusted for age, sex and ethnicity), alcohol consumption below 140g/week (female) or 210g/week (male), and no other discernible cause. The five cardiometabolic risk factors are:(1) Body mass index 25 kg/m2 (adult), 23 kg/m2 (adult Asian), or 85th percentile (pediatric); waist circumference > 94 cm (adult male), 80 cm (adult female), or 95th percentile (pediatric); or ethnicity adjusted equivalents.(2) Fasting serum glucose 5.6 mmol/L, 2-hr post-load glucose levels 7.8 mmol/L, glycated hemoglobin (HbA1c) 5.7% (39 mmol/L), type 2 diabetes, treatment for type 2 diabetes, previously diagnosed or treated type 2 diabetes (pediatric only), or serum glucose 11.1 mmol/L (pediatric only).(3) Blood pressure lower of 130/85 mmHg or 95th percentile (age < 13 years), or 130/85 mmHg (age 13 years); or specific hypertensive drug treatment.(4) Plasma triglycerides 1.15 mmol/L (age < 10 years) or 1.70 mmol/L (age 10 years); or lipid lowering treatment.(5) Plasma high-density lipoprotein cholesterol 1.0 mmol/L (adult male, pediatric) or 1.3 mmol/L (adult female); or lipid lowering treatment." }, "synonyms": [ { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "non-alcoholic fatty liver disease", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "NAFLD", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "metabolic dysfunction-associated fatty liver disease", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "metabolic dysfunction-related steatotic liver disease", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "MAFLD", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "MASLD", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "metabolic-associated fatty liver disease", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "nonalcoholic fatty liver disease", "description": "" }, { "id": "MONDO:0013246", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013246", "name": "fatty liver disease, nonalcoholic, susceptibility to, 2", "description": "" }, { "id": "MONDO:0013246", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013246", "name": "NAFLD2", "description": "" }, { "id": "MONDO:0013246", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013246", "name": "fatty liver disease, nonalcoholic, susceptibility to, 2", "description": "" }, { "id": "MONDO:0021105", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021105", "name": "NAFLD1", "description": "" }, { "id": "MONDO:0021105", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021105", "name": "NAFLD1", "description": "" }, { "id": "MONDO:0021105", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021105", "name": "fatty liver disease, nonalcoholic, susceptibility to, 1", "description": "" }, { "id": "MONDO:0021105", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021105", "name": "liver disease, alcoholic, susceptibility to, 1", "description": "" }, { "id": "MIM:613282", "resource": "MIM", "url": "https://www.omim.org/entry/613282", "name": "Non-alcoholic fatty liver disease 1", "description": "Non-alcoholic fatty liver disease 1" } ], "evidence": [ { "id": "0080208", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080208" } ] }, { "disease_id": "DOID:0081292", "recommended_name": { "id": "DOID:0081292", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0081292", "name": "traumatic brain injury", "description": "A brain disease that is characterized by brain dysfunction caused by an outside force, usually a violent blow to the head." }, "synonyms": [], "evidence": [ { "id": "0081292", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0081292" } ] }, { "disease_id": "DOID:10887", "recommended_name": { "id": "DOID:10887", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10887", "name": "lepromatous leprosy", "description": "A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas." }, "synonyms": [ { "id": "DOID:10887", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10887", "name": "type L leprosy", "description": "" } ], "evidence": [ { "id": "10887", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10887" } ] }, { "disease_id": "DOID:11077", "recommended_name": { "id": "DOID:11077", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11077", "name": "brucellosis", "description": "A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue." }, "synonyms": [ { "id": "DOID:11077", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11077", "name": "Maltese fever", "description": "" }, { "id": "DOID:11077", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11077", "name": "undulant fever", "description": "" } ], "evidence": [ { "id": "11077", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11077" } ] }, { "disease_id": "DOID:11266", "recommended_name": { "id": "DOID:11266", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11266", "name": "Hantavirus hemorrhagic fever with renal syndrome", "description": "A viral infectious disease that is a hemorrhagic fever, located in kidney, has_material_basis_in Orthohantavirus dobravaense, has_material_basis_in Orthohantavirus hantanense, has_material_basis_in Orthohantavirus puumalaense, has_material_basis_in Orthohantavirus seoulense, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom proteinuria, and has symptom renal failure." }, "synonyms": [ { "id": "DOID:11266", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11266", "name": "HFRS", "description": "" }, { "id": "DOID:11266", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11266", "name": "Hemorrhagic fever, Russian", "description": "" }, { "id": "DOID:11266", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11266", "name": "Hemorrhagic nephrosonephritis", "description": "" }, { "id": "DOID:11266", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11266", "name": "Puumala virus nephropathy", "description": "" } ], "evidence": [ { "id": "11266", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11266" } ] }, { "disease_id": "DOID:12365", "recommended_name": { "id": "DOID:12365", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12365", "name": "malaria", "description": "A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle." }, "synonyms": [ { "id": "DOID:12365", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12365", "name": "induced malaria", "description": "" } ], "evidence": [ { "id": "12365", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:12365" } ] }, { "disease_id": "DOID:13141", "recommended_name": { "id": "DOID:13141", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13141", "name": "uveitis", "description": "An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid." }, "synonyms": [], "evidence": [ { "id": "13141", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13141" } ] }, { "disease_id": "DOID:13254", "recommended_name": { "id": "DOID:13254", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13254", "name": "diverticulitis of colon", "description": "A colonic disease characterized by the formation and inflammation of diverticula within the colon wall." }, "synonyms": [ { "id": "DOID:13254", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13254", "name": "colonic diverticular disease", "description": "" } ], "evidence": [ { "id": "13254", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13254" } ] }, { "disease_id": "DOID:2280", "recommended_name": { "id": "DOID:2280", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2280", "name": "hidradenitis suppurativa", "description": "A hidradenitis that is characterized by chronic inflammation of the apocrine sweat glands, has_symptom painful nodules, abscesses, sinus tract formation, scarring, erythema, pruritis, and pain, and has_material_basis_in chronic inflammation of the apocrine sweat glands leading to recurrent folliculitis and an accompanying immune response that worsens inflammation." }, "synonyms": [ { "id": "DOID:2280", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2280", "name": "Acne inversa, familial", "description": "" }, { "id": "MONDO:0007728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007728", "name": "acne inversa, familial, 1", "description": "Any familial acne inversa in which the cause of the disease is a mutation in the NCSTN gene." }, { "id": "MONDO:0007728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007728", "name": "NCSTN familial acne inversa", "description": "" }, { "id": "MONDO:0007728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007728", "name": "acne inversa, familial, 1", "description": "" }, { "id": "MONDO:0007728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007728", "name": "acne inversa, familial, type 1", "description": "" }, { "id": "MONDO:0007728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007728", "name": "familial acne inversa caused by mutation in NCSTN", "description": "" }, { "id": "MONDO:0007728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007728", "name": "ACNINV1", "description": "" }, { "id": "MONDO:0007728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007728", "name": "acne inversa, familial", "description": "" }, { "id": "MONDO:0007728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007728", "name": "hidradenitis suppurativa, familial", "description": "" }, { "id": "MONDO:0013397", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013397", "name": "acne inversa, familial, 2", "description": "Any familial acne inversa in which the cause of the disease is a mutation in the PSENEN gene." }, { "id": "MONDO:0013397", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013397", "name": "PSENEN familial acne inversa", "description": "" }, { "id": "MONDO:0013397", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013397", "name": "acne inversa, familial, 2", "description": "" }, { "id": "MONDO:0013397", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013397", "name": "acne inversa, familial, type 2", "description": "" }, { "id": "MONDO:0013397", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013397", "name": "familial acne inversa caused by mutation in PSENEN", "description": "" }, { "id": "MONDO:0013397", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013397", "name": "ACNINV2", "description": "" }, { "id": "MONDO:0013397", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013397", "name": "acne inversa, familial, 2, with or without Dowling-Degos disease", "description": "" }, { "id": "MONDO:0013398", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013398", "name": "acne inversa, familial, 3", "description": "Any familial acne inversa in which the cause of the disease is a mutation in the PSEN1 gene." }, { "id": "MONDO:0013398", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013398", "name": "PSEN1 familial acne inversa", "description": "" }, { "id": "MONDO:0013398", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013398", "name": "acne inversa, familial, 3", "description": "" }, { "id": "MONDO:0013398", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013398", "name": "acne inversa, familial, type 3", "description": "" }, { "id": "MONDO:0013398", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013398", "name": "familial acne inversa caused by mutation in PSEN1", "description": "" }, { "id": "MONDO:0013398", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013398", "name": "ACNINV3", "description": "" }, { "id": "MIM:142690", "resource": "MIM", "url": "https://www.omim.org/entry/142690", "name": "Acne inversa, familial, 1", "description": "Acne inversa, familial, 1" }, { "id": "MIM:613736", "resource": "MIM", "url": "https://www.omim.org/entry/613736", "name": "Acne inversa, familial, 2, with or without Dowling-Degos disease", "description": "Acne inversa, familial, 2, with or without Dowling-Degos disease" }, { "id": "MIM:613737", "resource": "MIM", "url": "https://www.omim.org/entry/613737", "name": "Acne inversa, familial, 3", "description": "Acne inversa, familial, 3" } ], "evidence": [ { "id": "2280", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2280" } ] }, { "disease_id": "DOID:2913", "recommended_name": { "id": "DOID:2913", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2913", "name": "acute pancreatitis", "description": "A pancreatitis that is characterized by inflammation of the pancreas over a short period of time and has symptoms of severe abdominal pain, nausea, vomiting, diarrhea, fever, and shock." }, "synonyms": [], "evidence": [ { "id": "2913", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2913" } ] }, { "disease_id": "DOID:2921", "recommended_name": { "id": "DOID:2921", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2921", "name": "glomerulonephritis", "description": "A nephritis that causes inflammation of the glomeruli located_in kidney." }, "synonyms": [], "evidence": [ { "id": "2921", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2921" } ] }, { "disease_id": "DOID:2957", "recommended_name": { "id": "DOID:2957", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2957", "name": "pulmonary tuberculosis", "description": "A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis." }, "synonyms": [], "evidence": [ { "id": "2957", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2957" } ] }, { "disease_id": "DOID:4325", "recommended_name": { "id": "DOID:4325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4325", "name": "Ebola hemorrhagic fever", "description": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted by contaminated fomites, or transmitted by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding." }, "synonyms": [ { "id": "DOID:4325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4325", "name": "Ebola virus disease", "description": "" } ], "evidence": [ { "id": "4325", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4325" } ] }, { "disease_id": "DOID:5082", "recommended_name": { "id": "DOID:5082", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5082", "name": "liver cirrhosis", "description": "" }, "synonyms": [ { "id": "DOID:5082", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5082", "name": "Cirrhosis", "description": "" }, { "id": "DOID:5082", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5082", "name": "cirrhosis of liver", "description": "" }, { "id": "MONDO:0005155", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005155", "name": "cirrhosis of liver", "description": "A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy." }, { "id": "MONDO:0005155", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005155", "name": "cirrhosis", "description": "" }, { "id": "MONDO:0005155", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005155", "name": "cirrhosis of liver", "description": "" }, { "id": "MONDO:0005155", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005155", "name": "liver cirrhosis", "description": "" } ], "evidence": [ { "id": "5082", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5082" } ] }, { "disease_id": "DOID:526", "recommended_name": { "id": "DOID:526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:526", "name": "human immunodeficiency virus infectious disease", "description": "A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands." }, "synonyms": [ { "id": "DOID:526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:526", "name": "HIV infection", "description": "" } ], "evidence": [ { "id": "526", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:526" } ] }, { "disease_id": "DOID:552", "recommended_name": { "id": "DOID:552", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:552", "name": "pneumonia", "description": "A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing." }, "synonyms": [ { "id": "DOID:552", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:552", "name": "acute pneumonia", "description": "" } ], "evidence": [ { "id": "552", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:552" } ] }, { "disease_id": "DOID:8476", "recommended_name": { "id": "DOID:8476", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8476", "name": "Whipple disease", "description": "" }, "synonyms": [ { "id": "DOID:8476", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8476", "name": "Whipple's disease", "description": "" }, { "id": "DOID:8476", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8476", "name": "intestinal lipodystrophy", "description": "" } ], "evidence": [ { "id": "8476", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:8476" } ] }, { "disease_id": "DOID:9111", "recommended_name": { "id": "DOID:9111", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9111", "name": "cutaneous leishmaniasis", "description": "A leishmaniasis that involves skin infection caused by Leishmania species, resulting in one or more cutaneous lesions." }, "synonyms": [ { "id": "DOID:9111", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9111", "name": "Asian Desert Cutaneous Leishmaniasis", "description": "" }, { "id": "DOID:9111", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9111", "name": "Leproid leishmaniasis", "description": "" }, { "id": "DOID:9111", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9111", "name": "diffuse cutaneous leishmaniasis", "description": "" } ], "evidence": [ { "id": "9111", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9111" } ] }, { "disease_id": "DOID:9146", "recommended_name": { "id": "DOID:9146", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9146", "name": "visceral leishmaniasis", "description": "A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver." }, "synonyms": [ { "id": "DOID:9146", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9146", "name": "Infection by visceral leishmaniasis", "description": "" }, { "id": "DOID:9146", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9146", "name": "Kala-Azar", "description": "" }, { "id": "MONDO:0021012", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021012", "name": "susceptibility to visceral leishmaniasis, 1", "description": "" }, { "id": "MONDO:0021012", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021012", "name": "KAZA1", "description": "" }, { "id": "MONDO:0021012", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021012", "name": "kala-Azar, susceptibility to, 1", "description": "" }, { "id": "MONDO:0021012", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021012", "name": "leishmaniasis, visceral, susceptibility to, 1", "description": "" }, { "id": "MONDO:0012660", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012660", "name": "susceptibility to visceral leishmaniasis, 2", "description": "" }, { "id": "MONDO:0012660", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012660", "name": "KAZA2", "description": "" }, { "id": "MONDO:0012660", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012660", "name": "kala-AZAR, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012660", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012660", "name": "leishmaniasis, visceral, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012661", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012661", "name": "susceptibility to visceral leishmaniasis, 3", "description": "" }, { "id": "MONDO:0012661", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012661", "name": "KAZA3", "description": "" }, { "id": "MONDO:0012661", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012661", "name": "kala-AZAR, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012661", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012661", "name": "leishmaniasis, visceral, susceptibility to, 3", "description": "" } ], "evidence": [ { "id": "9146", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9146" } ] }, { "disease_id": "DOID:9261", "recommended_name": { "id": "DOID:9261", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9261", "name": "nasopharynx carcinoma", "description": "A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract." }, "synonyms": [ { "id": "DOID:9261", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9261", "name": "Nasopharyngeal carcinoma", "description": "" }, { "id": "DOID:9261", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9261", "name": "malignant Nasopharyngeal tumor", "description": "" }, { "id": "DOID:9261", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9261", "name": "malignant neoplasm of nasopharynx", "description": "" }, { "id": "DOID:9261", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9261", "name": "nasopharynx cancer", "description": "" }, { "id": "MONDO:0008067", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008067", "name": "nasopharyngeal carcinoma, susceptibility to, 2", "description": "" }, { "id": "MONDO:0008067", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008067", "name": "nasopharyngeal carcinoma, susceptibility to, 2", "description": "" }, { "id": "MONDO:0008067", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008067", "name": "nasopharyngeal carcinoma, susceptibility to, type 2", "description": "" }, { "id": "MONDO:0008067", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008067", "name": "NPCA2", "description": "" }, { "id": "MONDO:0008067", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008067", "name": "Npca2", "description": "" }, { "id": "MONDO:0011775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011775", "name": "nasopharyngeal carcinoma, susceptibility to, 1", "description": "Any nasopharyngeal carcinoma in which the cause of the disease is a mutation in the TP53 gene." }, { "id": "MONDO:0011775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011775", "name": "TP53 nasopharyngeal carcinoma", "description": "" }, { "id": "MONDO:0011775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011775", "name": "nasopharyngeal carcinoma 1", "description": "" }, { "id": "MONDO:0011775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011775", "name": "nasopharyngeal carcinoma caused by mutation in TP53", "description": "" }, { "id": "MONDO:0011775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011775", "name": "nasopharyngeal carcinoma, somatic", "description": "" }, { "id": "MONDO:0011775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011775", "name": "nasopharyngeal carcinoma, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011775", "name": "NPC", "description": "" }, { "id": "MONDO:0011775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011775", "name": "Npca", "description": "" }, { "id": "MONDO:0011775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011775", "name": "nasopharyngeal cancer", "description": "" }, { "id": "MONDO:0011775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011775", "name": "nasopharyngeal carcinoma", "description": "" } ], "evidence": [ { "id": "9261", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9261" } ] }, { "disease_id": "DOID:936", "recommended_name": { "id": "DOID:936", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:936", "name": "brain disease", "description": "A central nervous system disease that is located_in the brain." }, "synonyms": [ { "id": "DOID:936", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:936", "name": "encephalopathy", "description": "" } ], "evidence": [ { "id": "936", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:936" } ] }, { "disease_id": "DOID:9452", "recommended_name": { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "steatotic liver disease", "description": "A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in at least 5% of hepatocytes." }, "synonyms": [ { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "SLD", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "fatty liver disease", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "Fatty change of liver", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "Steatosis of liver", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "alcoholic fatty liver", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "hepatic lipidosis", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "hepatic steatosis", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "visceral steatosis, congenital", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "visceral steatosis, congenital", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "White liver disease", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "fatal neonatal hepatic steatosis", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "fatty liver disease, congenital", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "fatty metamorphosis of viscera", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "steatosis of liver", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "visceral steatosis", "description": "" } ], "evidence": [ { "id": "9452", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9452" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JVY2", "url": "https://www.uniprot.org/uniprot/A0A0G2JVY2" } ], "common_name": "Rat" } ], "gene": [ { "name": "Cd163", "url": "https://www.uniprot.org/uniprot/A0A0G2JVY2", "locus": { "chromosome": "4", "start_pos": 157117878, "end_pos": 157085093, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000010253", "url": "https://www.ensembl.org/id/ENSRNOG00000010253" } ] } } ], "crossref": [ { "id": "ENSRNOG00000010253", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000010253", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "312701", "url": "https://www.ncbi.nlm.nih.gov/gene/312701", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:312701", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:312701", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AGENKCS", "url": "https://omabrowser.org/oma/group/AGENKCS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5403281at2759", "url": "http://www.orthodb.org/?query=5403281at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19331", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19331", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19331:SF441", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19331:SF441", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48071", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48071", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48071:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48071:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00530", "url": "http://pfam.xfam.org/family/PF00530", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2168880", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_006237414", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006237414", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1310382", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310382", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2JVY2", "url": "https://www.uniprot.org/uniprot/A0A0G2JVY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JVY2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JVY2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZQF0", "url": "https://www.uniprot.org/uniprot/A0A8I5ZQF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZQF0-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZQF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z9U2", "url": "https://www.uniprot.org/uniprot/D3Z9U2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z9U2-1", "url": "https://www.uniprot.org/uniprot/D3Z9U2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKNRMVLLGGAGSPGYKGFVHLGFFVVAVSSLLSVSAVTQAPEGRKKELRLAGGENNCSGRVELKIHEKWGTVCGNGWSMNEVSVVCQQLGCPTLIKAPGWANASAGSGDIWMDKVSCTGNESALWDCKHEGWGKHNCTHEQDAGVTCADGSNLEMRLVNSGDNRCSGRVEIKFQGKWGTVCDDNFSKDHASVICKQLGCGSAISFSGSAKLGAGSGQIWLDDLACNGNESAIWDCKHRGWGRHNCDHAEDVGVICLDGADLSLRLVDGVSKCSGRLEVRFQGEWGTVCDDSWDRRDASVVCKQLGCPTAITAIGRVNASEGSGPIWLDSISCEGHEPALWECKHQEWGKHYCNHKEDAGVTCSDGADLELRLVGGGSRCAGMVEVEIQKLTGKVCSRGWTLTDADVVCRQLGCGSALQTQSKIYSKTKTEATNTWLFPGSCSGNETSLWQCKNWQWGGLSCDHFEEAQVTCSGHRKPRLVGGEIPCSGRVEVKHGDTWGSVCDFDLSLEAAGVVCRELQCGTVVSILGGAHFGEGSGQIWGEEFQCSGDESHLSLCSVAPPLDRTCSHSRDVSIVCSRYIDIRLADGKSSCEGRVELKTLGAWGPLCSSHWDIEDAHVLCQQLKCGVALSTPGGAHFGKGAGQVWRHKFHCTGTEEHIGDCPMTALGTPMCSDGQVASVICSGNQSHTLLPCSSSSSVQTTSSTIAKDSDVPCIASGQLRLVGGGGRCAGRVEVYHEGSWGTICDDSWDLTDANVVCKQLDCGVAINATGSAYFGEGTGDIWLDEIDCSGKESHIWQCHSHGWGRHNCRHKEDAGVVCSEFMSLRLTNEAHRVNCTGRLEVFYNGTWGSIGSSNMSPTTVGVVCRQLGCADNGTVKPTSSDKTPTRPMWTDSVQCPKGVDTLWQCPSSPWKQRQASPSQESWIVCDDKIRLQEGHTDCSGRVEIWHRGSWGTVCDDSWDLNDAEVACKQLGCGQAVEALKEAAFGPGTGPIWLNEMKCRGNESSLWDCPARPWSHSDCGHKEDASVKCLPRMTLESQHGTGHSTLTALLVCGAILLVLLIAFLLWTLKRRQTQRLTVSSRGEVLIHQVQYQEMDSKTDDLDLLKSSENSNDSYDFNADGLTSLSKYLPISGIKRGPIIHNPLRLAFKKP", "length": 1151, "header": "tr|A0A0G2JVY2-1|A0A0G2JVY2_RAT Isoform 1 of CD163 molecule OS=Rattus norvegicus OX=10116 GN=Cd163 PE=1 SV=2 CANONICAL=A0A0G2JVY2-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JVY2-1", "url": "", "sequence": { "sequence": "MGKNRMVLLGGAGSPGYKGFVHLGFFVVAVSSLLSVSAVTQAPEGRKKELRLAGGENNCSGRVELKIHEKWGTVCGNGWSMNEVSVVCQQLGCPTLIKAPGWANASAGSGDIWMDKVSCTGNESALWDCKHEGWGKHNCTHEQDAGVTCADGSNLEMRLVNSGDNRCSGRVEIKFQGKWGTVCDDNFSKDHASVICKQLGCGSAISFSGSAKLGAGSGQIWLDDLACNGNESAIWDCKHRGWGRHNCDHAEDVGVICLDGADLSLRLVDGVSKCSGRLEVRFQGEWGTVCDDSWDRRDASVVCKQLGCPTAITAIGRVNASEGSGPIWLDSISCEGHEPALWECKHQEWGKHYCNHKEDAGVTCSDGADLELRLVGGGSRCAGMVEVEIQKLTGKVCSRGWTLTDADVVCRQLGCGSALQTQSKIYSKTKTEATNTWLFPGSCSGNETSLWQCKNWQWGGLSCDHFEEAQVTCSGHRKPRLVGGEIPCSGRVEVKHGDTWGSVCDFDLSLEAAGVVCRELQCGTVVSILGGAHFGEGSGQIWGEEFQCSGDESHLSLCSVAPPLDRTCSHSRDVSIVCSRYIDIRLADGKSSCEGRVELKTLGAWGPLCSSHWDIEDAHVLCQQLKCGVALSTPGGAHFGKGAGQVWRHKFHCTGTEEHIGDCPMTALGTPMCSDGQVASVICSGNQSHTLLPCSSSSSVQTTSSTIAKDSDVPCIASGQLRLVGGGGRCAGRVEVYHEGSWGTICDDSWDLTDANVVCKQLDCGVAINATGSAYFGEGTGDIWLDEIDCSGKESHIWQCHSHGWGRHNCRHKEDAGVVCSEFMSLRLTNEAHRVNCTGRLEVFYNGTWGSIGSSNMSPTTVGVVCRQLGCADNGTVKPTSSDKTPTRPMWTDSVQCPKGVDTLWQCPSSPWKQRQASPSQESWIVCDDKIRLQEGHTDCSGRVEIWHRGSWGTVCDDSWDLNDAEVACKQLGCGQAVEALKEAAFGPGTGPIWLNEMKCRGNESSLWDCPARPWSHSDCGHKEDASVKCLPRMTLESQHGTGHSTLTALLVCGAILLVLLIAFLLWTLKRRQTQRLTVSSRGEVLIHQVQYQEMDSKTDDLDLLKSSENSNDSYDFNADGLTSLSKYLPISGIKRGPIIHNPLRLAFKKP", "length": 1151, "header": "tr|A0A0G2JVY2-1|A0A0G2JVY2_RAT Isoform 1 of CD163 molecule OS=Rattus norvegicus OX=10116 GN=Cd163 PE=1 SV=2 CANONICAL=A0A0G2JVY2-1" }, "locus": { "chromosome": "4", "start_pos": 157117688, "end_pos": 157085190, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000084588.2", "url": "https://www.ensembl.org/id/ENSRNOT00000084588.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000069665.2", "url": "https://www.ensembl.org/id/ENSRNOP00000069665.2" } ] } }, { "isoform_ac": "A0A8I5ZQF0-1", "url": "", "sequence": { "sequence": "MGMDRLEIILQFHMSYKGFVHLGFFVVAVSSLLSVSAVTQAPEGRKKELRLAGGENNCSGRVELKIHEKWGTVCGNGWSMNEVSVVCQQLGCPTLIKAPGWANASAGSGDIWMDKVSCTGNESALWDCKHEGWGKHNCTHEQDAGVTCADGSNLEMRLVNSGDNRCSGRVEIKFQGKWGTVCDDNFSKDHASVICKQLGCGSAISFSGSAKLGAGSGQIWLDDLACNGNESAIWDCKHRGWGRHNCDHAEDVGVICLDGADLSLRLVDGVSKCSGRLEVRFQGEWGTVCDDSWDRRDASVVCKQLGCPTAITAIGRVNASEGSGPIWLDSISCEGHEPALWECKHQEWGKHYCNHKEDAGVTCSDGADLELRLVGGGSRCAGMVEVEIQKLTGKVCSRGWTLTDADVVCRQLGCGSALQTQSKIYSKTKTEATNTWLFPGSCSGNETSLWQCKNWQWGGLSCDHFEEAQVTCSGHRKPRLVGGEIPCSGRVEVKHGDTWGSVCDFDLSLEAAGVVCRELQCGTVVSILGGAHFGEGSGQIWGEEFQCSGDESHLSLCSVAPPLDRTCSHSRDVSIVCSRYIDIRLADGKSSCEGRVELKTLGAWGPLCSSHWDIEDAHVLCQQLKCGVALSTPGGAHFGKGAGQVWRHKFHCTGTEEHIGDCPMTALGTPMCSDGQVASVICSGNQSHTLLPCSSSSSVQTTSSTIAKDSDVPCIASGQLRLVGGGGRCAGRVEVYHEGSWGTICDDSWDLTDANVVCKQLDCGVAINATGSAYFGEGTGDIWLDEIDCSGKESHIWQCHSHGWGRHNCRHKEDAGVVCSEFMSLRLTNEAHRVNCTGRLEVFYNGTWGSIGSSNMSPTTVGVVCRQLGCADNGTVKPTSSDKTPTRPMWTDSVQCPKGVDTLWQCPSSPWKQRQASPSQESWIVCDDKIRLQEGHTDCSGRVEIWHRGSWGTVCDDSWDLNDAEVACKQLGCGQAVEALKEAAFGPGTGPIWLNEMKCRGNESSLWDCPARPWSHSDCGHKEDASVKCLPRMTLESQHGTGHSTLTALLVCGAILLVLLIAFLLWTLKRRQTQRLTVSSRGEVLIHQVQYQEMDSKTDDLDLLKSSGQ", "length": 1109, "header": "tr|A0A8I5ZQF0-1|A0A8I5ZQF0_RAT Computationally mapped isoform of CD163 molecule OS=Rattus norvegicus OX=10116 GN=Cd163 PE=1 SV=1 CANONICAL=A0A0G2JVY2-1" }, "locus": { "chromosome": "4", "start_pos": 157114032, "end_pos": 157085590, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000096376.1", "url": "https://www.ensembl.org/id/ENSRNOT00000096376.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000080333.1", "url": "https://www.ensembl.org/id/ENSRNOP00000080333.1" } ] } }, { "isoform_ac": "D3Z9U2-1", "url": "", "sequence": { "sequence": "MGKNRMVLLGGAGSPGYKGFVHLGFFVVAVSSLLSVSAVTQAPEGRKKELRLAGGENNCSGRVELKIHEKWGTVCGNGWSMNEVSVVCQQLGCPTLIKAPGWANASAGSGDIWMDKVSCTGNESALWDCKHEGWGKHNCTHEQDAGVTCADGSNLEMRLVNSGDNRCSGRVEIKFQGKWGTVCDDNFSKDHASVICKQLGCGSAISFSGSAKLGAGSGQIWLDDLACNGNESAIWDCKHRGWGRHNCDHAEDVGVICLDGADLSLRLVDGVSKCSGRLEVRFQGEWGTVCDDSWDRRDASVVCKQLGCPTAITAIGRVNASEGSGPIWLDSISCEGHEPALWECKHQEWGKHYCNHKEDAGVTCSDGADLELRLVGGGSRCAGMVEVEIQKLTGKVCSRGWTLTDADVVCRQLGCGSALQTQSKIYSKTKTEATNTWLFPGSCSGNETSLWQCKNWQWGGLSCDHFEEAQVTCSGHRKPRLVGGEIPCSGRVEVKHGDTWGSVCDFDLSLEAAGVVCRELQCGTVVSILGGAHFGEGSGQIWGEEFQCSGDESHLSLCSVAPPLDRTCSHSRDVSIVCSRYIDIRLADGKSSCEGRVELKTLGAWGPLCSSHWDIEDAHVLCQQLKCGVALSTPGGAHFGKGAGQVWRHKFHCTGTEEHIGDCPMTALGTPMCSDGQVASVICSGNQSHTLLPCSSSSSVQTTSSTIAKDSDVPCIASGQLRLVGGGGRCAGRVEVYHEGSWGTICDDSWDLTDANVVCKQLDCGVAINATGSAYFGEGTGDIWLDEIDCSGKESHIWQCHSHGWGRHNCRHKEDAGVVCSEFMSLRLTNEAHRVNCTGRLEVFYNGTWGSIGSSNMSPTTVGVVCRQLGCADNGTVKPTSSDKTPTRPMWTDSVQCPKGVDTLWQCPSSPWKQRQASPSQESWIVCDDKIRLQEGHTDCSGRVEIWHRGSWGTVCDDSWDLNDAEVACKQLGCGQAVEALKEAAFGPGTGPIWLNEMKCRGNESSLWDCPARPWSHSDCGHKEDASVKCLPRMTLESQHGTGHSTLTALLVCGAILLVLLIAFLLWTLKRRQTQRLTVSSRGEVLIHQVQYQEMDSKTDDLDLLKSSGQ", "length": 1110, "header": "tr|D3Z9U2-1|D3Z9U2_RAT Computationally mapped isoform of CD163 molecule OS=Rattus norvegicus OX=10116 GN=Cd163 PE=4 SV=2 CANONICAL=A0A0G2JVY2-1" }, "locus": { "chromosome": "4", "start_pos": 157114032, "end_pos": 157085190, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000068407.2", "url": "https://www.ensembl.org/id/ENSRNOT00000068407.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000058828.2", "url": "https://www.ensembl.org/id/ENSRNOP00000058828.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:312701", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:312701", "resource": "KEGG Pathway" }, { "id": "R-RNO-2168880", "name": "Scavenging of heme from plasma", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2168880", "resource": "Reactome", "description": "Scavenging of heme from plasma" } ], "orthologs": [ { "uniprot_canonical_ac": "Q2VLH6-1", "protein_name": "Scavenger receptor cysteine-rich type 1 protein M130", "gene_name": "Cd163", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGGHRMVLLGGAGSPGCKRFVHLGFFVVAVSSLLSASAVTNAPGEMKKELRLAGGENNCSGRVELKIHDKWGTVCSNGWSMNEVSVVCQQLGCPTSIKALGWANSSAGSGYIWMDKVSCTGNESALWDCKHDGWGKHNCTHEKDAGVTCSDGSNLEMRLVNSAGHRCLGRVEIKFQGKWGTVCDDNFSKDHASVICKQLGCGSAISFSGSAKLGAGSGPIWLDDLACNGNESALWDCKHRGWGKHNCDHAEDVGVICLEGADLSLRLVDGVSRCSGRLEVRFQGEWGTVCDDNWDLRDASVVCKQLGCPTAISAIGRVNASEGSGQIWLDNISCEGHEATLWECKHQEWGKHYCHHREDAGVTCSDGADLELRLVGGGSRCAGIVEVEIQKLTGKMCSRGWTLADADVVCRQLGCGSALQTQAKIYSKTGATNTWLFPGSCNGNETTFWQCKNWQWGGLSCDNFEEAKVTCSGHREPRLVGGEIPCSGRVEVKHGDVWGSVCDFDLSLEAASVVCRELQCGTVVSILGGAHFGEGSGQIWGEEFQCSGDESHLSLCSVAPPLDRTCTHSRDVSVVCSRYIDIRLAGGESSCEGRVELKTLGAWGPLCSSHWDMEDAHVLCQQLKCGVAQSIPEGAHFGKGAGQVWSHMFHCTGTEEHIGDCLMTALGAPTCSEGQVASVICSGNQSQTLLPCSSLSPVQTTSSTIPKESEVPCIASGQLRLVGGGGRCAGRVEVYHEGSWGTVCDDNWDMTDANVVCKQLDCGVAINATGSAYFGEGAGAIWLDEVICTGKESHIWQCHSHGWGRHNCRHKEDAGVICSEFMSLRLTNEAHKENCTGRLEVFYNGTWGSIGSSNMSPTTVGVVCRQLGCADNGTVKPIPSDKTPSRPMWVDRVQCPKGVDTLWQCPSSPWKQRQASPSSQESWIICDNKIRLQEGHTDCSGRVEIWHKGSWGTVCDDSWDLNDAKVVCKQLGCGQAVKALKEAAFGPGTGPIWLNEIKCRGNESSLWDCPAKPWSHSDCGHKEDASIQCLPKMTSESHHGTGHPTLTALLVCGAILLVLLIVFLLWTLKRRQIQRLTVSSRGEVLIHQVQYQEMDSKADDLDLLKSSGVIQRHTEKENDNL", "length": 1121 }, "evidence": [ { "id": "45237826", "url": "http://www.informatics.jax.org/homology/45237826", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86VB7-1", "protein_name": "Scavenger receptor cysteine-rich type 1 protein M130", "gene_name": "CD163", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSKLRMVLLEDSGSADFRRHFVNLSPFTITVVLLLSACFVTSSLGGTDKELRLVDGENKCSGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMDHVSCRGNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTRGGNMCSGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCKHQGWGKHNCDHAEDAGVICSKGADLSLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRVNASKGFGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNEDAGVTCSDGSDLELRLRGGGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKIQATNTWLFLSSCNGNETSLWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEFQCEGHESHLSLCPVAPRPEGTCSHSRDVGVVCSRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDCPVTALGASLCPSEQVASVICSGNQSQTLSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGRCAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQCHSHGWGQQNCRHKEDAGVICSEFMSLRLTSEASREACAGRLEVFYNGAWGTVGKSSMSETTVGVVCRQLGCADKGKINPASLDKAMSIPMWVDNVQCPKGPDTLWQCPSSPWEKRLASPSEETWITCDNKIRLQEGPTSCSGRVEIWHGGSWGTVCDDSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDCPARRWGHSECGHKEDAAVNCTDISVQKTPQKATTGRSSRQSSFIAVGILGVVLLAIFVALFFLTKKRRQRQRLAVSSRGENLVHQIQYREMNSCLNADDLDLMNSSENSHESADFSAAELISVSKFLPISGMEKEAILSHTEKENGNL", "length": 1156 }, "evidence": [ { "id": "45237826", "url": "http://www.informatics.jax.org/homology/45237826", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "scavenger receptor activity", "id": "GO:0005044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005044", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JVY2", "url": "https://www.uniprot.org/uniprot/A0A0G2JVY2" } ], "pmid": "" }, { "name": "scaffold protein binding", "id": "GO:0097110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097110", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JVY2", "url": "https://www.uniprot.org/uniprot/A0A0G2JVY2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JVY2", "url": "https://www.uniprot.org/uniprot/A0A0G2JVY2" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JVY2", "url": "https://www.uniprot.org/uniprot/A0A0G2JVY2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1003, "end_pos": 1005, "annotation": "n_glycosylation_sequon" }, { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1112, "end_pos": 1114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 230, "end_pos": 232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 446, "end_pos": 448, "annotation": "n_glycosylation_sequon" }, { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" }, { "start_pos": 686, "end_pos": 688, "annotation": "n_glycosylation_sequon" }, { "start_pos": 769, "end_pos": 771, "annotation": "n_glycosylation_sequon" }, { "start_pos": 836, "end_pos": 838, "annotation": "n_glycosylation_sequon" }, { "start_pos": 846, "end_pos": 848, "annotation": "n_glycosylation_sequon" }, { "start_pos": 856, "end_pos": 858, "annotation": "n_glycosylation_sequon" }, { "start_pos": 874, "end_pos": 876, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }