{
    "uniprot_canonical_ac": "A0A0G2JVP1-1",
    "uniprot_ac": "A0A0G2JVP1",
    "uniprot_id": "A0A0G2JVP1_RAT",
    "mass": {
        "chemical_mass": 57753.0,
        "monoisotopic_mass": 57753.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Vrk2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1",
            "id": "A0A0G2JVP1"
        }
    ],
    "protein_names": [
        {
            "name": "VRK serine/threonine kinase 2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A0G2JVP1"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JVP1",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Vrk2",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1",
            "locus": {
                "chromosome": "14",
                "start_pos": 100313601,
                "end_pos": 100434527,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000007864",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000007864"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000007864",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000007864",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "360991",
            "url": "https://www.ncbi.nlm.nih.gov/gene/360991",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000719",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR008271",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011009",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:360991",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:360991",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "HEYKNTK",
            "url": "https://omabrowser.org/oma/group/HEYKNTK/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "4064676at2759",
            "url": "http://www.orthodb.org/?query=4064676at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11909",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11909",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11909:SF100",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11909:SF100",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00069",
            "url": "http://pfam.xfam.org/family/PF00069",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-2980766",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2980766",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-2995383",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2995383",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9013149",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013149",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9013404",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013404",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9013405",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013405",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9013408",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013408",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9013423",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013423",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "XP_008768654",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008768654",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1311585",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311585",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2JVP1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2JVP1-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3ZUF8",
            "url": "https://www.uniprot.org/uniprot/D3ZUF8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3ZUF8-1",
            "url": "https://www.uniprot.org/uniprot/D3ZUF8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAPRRKEKYKLPVPLPEGKILDDMEGNQWALGKMIGSGGFGLIYLAFPTNKPEKDARHVIKVEYQENGPLFSELKFYQRAAKRECIQKWVKQRKLDYLGVPVFYGFGLTDFKGRSYRFMVMERLGIDLQKLLNQNGAFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYANPDRVYLADYGLSYRYCPNGNHKQYHEDPRKGHNGTLEFTSLDAHKGVAPSRRSDVEILGYCMLRWLCGKLPWETNLENPVAVQTAKTKLLDELPESVLKWTTSGSSCRELAEFFMYVHNLAYDAKPDYQKLKKILNPDGVPLGPLDFSTKAQGVNMQTPIHRKVDSPKAIKKPANEFPTKYTRKVCGETRATWREEQEERRPAVLLSDLATPENSRTRKVREYSDTFSEMLSFRQTQSYPRFQGSHCKPYLDCTRRDPIRKPRPLPQYGSKPTGNLGVTDLESSPRFWPAVLQLTLSEEAKADVYYYGLTIFCLLTLVCLALCFL",
        "length": 503,
        "header": "tr|A0A0G2JVP1-1|A0A0G2JVP1_RAT Isoform 1 of VRK serine/threonine kinase 2  OS=Rattus norvegicus OX=10116 GN=Vrk2 PE=4 SV=1 CANONICAL=A0A0G2JVP1-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2JVP1-1",
            "url": "",
            "sequence": {
                "sequence": "MAPRRKEKYKLPVPLPEGKILDDMEGNQWALGKMIGSGGFGLIYLAFPTNKPEKDARHVIKVEYQENGPLFSELKFYQRAAKRECIQKWVKQRKLDYLGVPVFYGFGLTDFKGRSYRFMVMERLGIDLQKLLNQNGAFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYANPDRVYLADYGLSYRYCPNGNHKQYHEDPRKGHNGTLEFTSLDAHKGVAPSRRSDVEILGYCMLRWLCGKLPWETNLENPVAVQTAKTKLLDELPESVLKWTTSGSSCRELAEFFMYVHNLAYDAKPDYQKLKKILNPDGVPLGPLDFSTKAQGVNMQTPIHRKVDSPKAIKKPANEFPTKYTRKVCGETRATWREEQEERRPAVLLSDLATPENSRTRKVREYSDTFSEMLSFRQTQSYPRFQGSHCKPYLDCTRRDPIRKPRPLPQYGSKPTGNLGVTDLESSPRFWPAVLQLTLSEEAKADVYYYGLTIFCLLTLVCLALCFL",
                "length": 503,
                "header": "tr|A0A0G2JVP1-1|A0A0G2JVP1_RAT Isoform 1 of VRK serine/threonine kinase 2  OS=Rattus norvegicus OX=10116 GN=Vrk2 PE=4 SV=1 CANONICAL=A0A0G2JVP1-1"
            },
            "locus": {
                "chromosome": "14",
                "start_pos": 100431107,
                "end_pos": 100313821,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000086299.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000086299.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000069563.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000069563.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D3ZUF8-1",
            "url": "",
            "sequence": {
                "sequence": "MAPRRKEKYKLPVPLPEGKILDDMEGNQWALGKMIGSGGFGLIYLAFPTNKPEKDARHVIKVEYQENGPLFSELKFYQRAAKRECIQKWVKQRKLDYLGVPVFYGFGLTDFKGRSYRFMVMERLGIDLQKLLNQNGAFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYANPDRLSYPPLSAAPSRRSDVEILGYCMLRWLCGKLPWETNLENPVAVQTTAG",
                "length": 229,
                "header": "tr|D3ZUF8-1|A0A0G2JVP1_RAT Computationally mapped isoform of VRK serine/threonine kinase 2  OS=Rattus norvegicus OX=10116 GN=Vrk2 PE=4 SV=1 CANONICAL=A0A0G2JVP1-1"
            },
            "locus": {
                "chromosome": "14",
                "start_pos": 100431107,
                "end_pos": 100329043,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000068190.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000068190.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000063285.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000063285.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:360991",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:360991",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-2980766",
            "name": "Nuclear Envelope Breakdown",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2980766",
            "resource": "Reactome",
            "description": "Nuclear Envelope Breakdown"
        },
        {
            "id": "R-RNO-2995383",
            "name": "Initiation of Nuclear Envelope (NE) Reformation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2995383",
            "resource": "Reactome",
            "description": "Initiation of Nuclear Envelope (NE) Reformation"
        },
        {
            "id": "R-RNO-9013149",
            "name": "RAC1 GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013149",
            "resource": "Reactome",
            "description": "RAC1 GTPase cycle"
        },
        {
            "id": "R-RNO-9013404",
            "name": "RAC2 GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013404",
            "resource": "Reactome",
            "description": "RAC2 GTPase cycle"
        },
        {
            "id": "R-RNO-9013405",
            "name": "RHOD GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013405",
            "resource": "Reactome",
            "description": "RHOD GTPase cycle"
        },
        {
            "id": "R-RNO-9013408",
            "name": "RHOG GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013408",
            "resource": "Reactome",
            "description": "RHOG GTPase cycle"
        },
        {
            "id": "R-RNO-9013423",
            "name": "RAC3 GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013423",
            "resource": "Reactome",
            "description": "RAC3 GTPase cycle"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q86Y07-1",
            "protein_name": "Serine/threonine-protein kinase VRK2",
            "gene_name": "VRK2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLSEETNADVYYYRIIIPVLLMLVFLALFFL",
                "length": 508
            },
            "evidence": [
                {
                    "id": "45232041",
                    "url": "http://www.informatics.jax.org/homology/45232041",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8BN21-1",
            "protein_name": "Serine/threonine-protein kinase VRK2",
            "gene_name": "Vrk2",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MAPRRKEKYKLPVPLPEGKILDDMEGNRWALGKMIGSGGFGLIYLAFPTNKPNKDARHVIKLEYQENGPLFSELKFYQRAAKRECIQKWIQQRKLDYLGIPVFYGFGLTDFKGRSYRFMVMERLGIDLQKLLDQNGGFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLDFTNPDRVYLADYGLSYRYCPNGNHKQYQEDPRKGHNGTIEFTSLDAHKGVAPSRRSDVEILGYCMLHWLFGKLPWEAKLDDPVAVQTAKTNLLDELPESVLKWAPSGSSCSELVKYLMYVHNLAYDDKPDYQKLKKILNPDGVPLGPLEFSTKVQSVHVRTPAQQKVDSPKATRKPANEFPAKFPKKVHRETRARQREEQEDSQPTMLQSRPAAPENSRTRKIHEYSDIFSEMQSLQQTPSYMSFQGSYCKPYLDCTRRDPIRKPRSLPRYRHTPTGNLGVTDLESSPRFWPAIFQLTLSEETKADVYYYGITIFCLLIFVFLALYFL",
                "length": 503
            },
            "evidence": [
                {
                    "id": "45232041",
                    "url": "http://www.informatics.jax.org/homology/45232041",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 7,
                "go_terms": [
                    {
                        "name": "regulation of interleukin-1-mediated signaling pathway",
                        "id": "GO:2000659",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000659",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVP1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein phosphorylation",
                        "id": "GO:0006468",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVP1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "signal transduction",
                        "id": "GO:0007165",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVP1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein autophosphorylation",
                        "id": "GO:0046777",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046777",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVP1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to oxidative stress",
                        "id": "GO:0034599",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034599",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVP1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "peptidyl-serine phosphorylation",
                        "id": "GO:0018105",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018105",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVP1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of MAPK cascade",
                        "id": "GO:0043408",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043408",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVP1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 4,
                "go_terms": [
                    {
                        "name": "protein serine/threonine kinase activity",
                        "id": "GO:0004674",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVP1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ATP binding",
                        "id": "GO:0005524",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVP1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein kinase binding",
                        "id": "GO:0019901",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVP1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein domain specific binding",
                        "id": "GO:0019904",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVP1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 8,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVP1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear envelope",
                        "id": "GO:0005635",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVP1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVP1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVP1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
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