{ "uniprot_canonical_ac": "A0A0G2JVF0-1", "uniprot_ac": "A0A0G2JVF0", "uniprot_id": "A0A0G2JVF0_RAT", "mass": { "chemical_mass": 107336.0, "monoisotopic_mass": 107336.0 }, "refseq": { "ac": "NP_653341", "name": "rho GTPase-activating protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653341" }, "gene_names": [ { "name": "Arhgap4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JVF0", "id": "A0A0G2JVF0" } ], "protein_names": [ { "name": "Rho GTPase activating protein 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2JVF0" }, { "name": "rho GTPase-activating protein 4 isoform X6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006229608", "id": "XP_006229608" }, { "name": "rho GTPase-activating protein 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653341", "id": "NP_653341" } ], "function": [ { "annotation": "ARHGAP4 occured in the hippocampus, ventral region of the brainstem and striatum, and in cerebellar granule cells. Subcellularly, ARHGAP4 localized to the Golgi complex and could redistribute to the microtubules, for example during mitosis.", "evidence": [ { "database": "RefSeq", "id": "NP_653341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653341" }, { "database": "PubMed", "id": "12414125", "url": "https://glygen.org/publication/PubMed/12414125" } ] }, { "annotation": "These observations suggest that ARHGAP4 can act as a potent inhibitor of cell and axon motility when it is localized to the leading edge of motile cells and axons.", "evidence": [ { "database": "RefSeq", "id": "NP_653341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653341" }, { "database": "PubMed", "id": "17804252", "url": "https://glygen.org/publication/PubMed/17804252" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JVF0", "url": "https://www.uniprot.org/uniprot/A0A0G2JVF0" } ], "common_name": "Rat" } ], "gene": [ { "name": "Arhgap4", "url": "https://www.uniprot.org/uniprot/A0A0G2JVF0", "locus": { "chromosome": "X", "start_pos": 151632454, "end_pos": 151651128, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000058545", "url": "https://www.ensembl.org/id/ENSRNOG00000058545" } ] } } ], "crossref": [ { "id": "ENSRNOG00000058545", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000058545", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07656", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07656", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "246249", "url": "https://www.ncbi.nlm.nih.gov/gene/246249", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:246249", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:246249", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ECAGARG", "url": "https://omabrowser.org/oma/group/ECAGARG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2904755at2759", "url": "http://www.orthodb.org/?query=2904755at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14166", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14166", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14166:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14166:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "http://pfam.xfam.org/family/PF00018", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00611", "url": "http://pfam.xfam.org/family/PF00611", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00620", "url": "http://pfam.xfam.org/family/PF00620", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8980692", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013148", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013149", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_653341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653341", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "628901", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=628901", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2JVF0", "url": "https://www.uniprot.org/uniprot/A0A0G2JVF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JVF0-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JVF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZY52", "url": "https://www.uniprot.org/uniprot/A0A8I5ZY52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZY52-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZY52-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AIK5", "url": "https://www.uniprot.org/uniprot/A0A8I6AIK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AIK5-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AIK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AN89", "url": "https://www.uniprot.org/uniprot/A0A8I6AN89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AN89-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AN89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GIQ7", "url": "https://www.uniprot.org/uniprot/A0A8I6GIQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GIQ7-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GIQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAHGKLRRERGLQPEYEAQVKVMRGQLSEQLHCLELQGELRRDLLLELAEFMRRRAEVELEYSRGLDKLAERFTSRSGRLGGSSREQQSFRKEPTLLSPLHCWAMLLEHTRQQSRESATLSEVLAGPLAQRLSHIAEDVGRIVKKSKDLVQQLQDELLEVVSELQTQGYLAWASLQTKKTYHVYHLESMNAETKLREAERQEEKRSGKSALPTTTAASATTTITIETELHRKGSLKKGGRLVEKRQAKFLEHKLKCTKARNEYLLSLASVNAAVSNYYLHDILDLMDCCDTGFHLALEQALRSYTAAESRTQTSHMQGLGSLEEALEALDPPGDKAKVLEVHAMAFCPPLRFDYQPHEGDEVAEIQVEMELRDEILPRAQNIQSRLDQKTIETEEVNKTLKATLQALLEVVASEDGDILDSLQASPSTESLKSTSSDPGTRQAGRRRNQQQETETFYITKLQEYLSGRSILAKLQAKHEKLQEAIQRGNKEEQETSSWTQCTERKFHKSHHPYPGSQCTQRLFGGDLEKFIQSTGQPVPLVVKSCIRFINLNGLQHEGIFRVSGAQARILEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPLDMFNELLASAELEVVGERVELVSHLLSRLPRPVLVVLRYLFTFLNHLAQYSDENMMDSYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLILQPAWVFPPTAMLPGPIYEKCMAPPSASCLGDGQLESLAGEPELELKTGTKAQEDDSEGVVEAVACFAYTGRTAQELTFQQGDTLRLYARASSDWWRGEHAGVRGLIPHKYITLSEGDEKQMTGSGLQAMGESLSHPESVLTLEFTNRLELGTPPEALGPSGHRRHCLVPTSPEQHVEMDKAVAQNMDSVFKELLGKAAVRQGHGLASTASPSLGTRNLKPLACSSFSKNKVFSRGPGAPVSPSVSHPQGPDSTRKPV", "length": 965, "header": "tr|A0A0G2JVF0-1|A0A0G2JVF0_RAT Isoform 1 of Rho GTPase activating protein 4 OS=Rattus norvegicus OX=10116 GN=Arhgap4 PE=1 SV=2 CANONICAL=A0A0G2JVF0-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JVF0-1", "url": "", "sequence": { "sequence": "MAAHGKLRRERGLQPEYEAQVKVMRGQLSEQLHCLELQGELRRDLLLELAEFMRRRAEVELEYSRGLDKLAERFTSRSGRLGGSSREQQSFRKEPTLLSPLHCWAMLLEHTRQQSRESATLSEVLAGPLAQRLSHIAEDVGRIVKKSKDLVQQLQDELLEVVSELQTQGYLAWASLQTKKTYHVYHLESMNAETKLREAERQEEKRSGKSALPTTTAASATTTITIETELHRKGSLKKGGRLVEKRQAKFLEHKLKCTKARNEYLLSLASVNAAVSNYYLHDILDLMDCCDTGFHLALEQALRSYTAAESRTQTSHMQGLGSLEEALEALDPPGDKAKVLEVHAMAFCPPLRFDYQPHEGDEVAEIQVEMELRDEILPRAQNIQSRLDQKTIETEEVNKTLKATLQALLEVVASEDGDILDSLQASPSTESLKSTSSDPGTRQAGRRRNQQQETETFYITKLQEYLSGRSILAKLQAKHEKLQEAIQRGNKEEQETSSWTQCTERKFHKSHHPYPGSQCTQRLFGGDLEKFIQSTGQPVPLVVKSCIRFINLNGLQHEGIFRVSGAQARILEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPLDMFNELLASAELEVVGERVELVSHLLSRLPRPVLVVLRYLFTFLNHLAQYSDENMMDSYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLILQPAWVFPPTAMLPGPIYEKCMAPPSASCLGDGQLESLAGEPELELKTGTKAQEDDSEGVVEAVACFAYTGRTAQELTFQQGDTLRLYARASSDWWRGEHAGVRGLIPHKYITLSEGDEKQMTGSGLQAMGESLSHPESVLTLEFTNRLELGTPPEALGPSGHRRHCLVPTSPEQHVEMDKAVAQNMDSVFKELLGKAAVRQGHGLASTASPSLGTRNLKPLACSSFSKNKVFSRGPGAPVSPSVSHPQGPDSTRKPV", "length": 965, "header": "tr|A0A0G2JVF0-1|A0A0G2JVF0_RAT Isoform 1 of Rho GTPase activating protein 4 OS=Rattus norvegicus OX=10116 GN=Arhgap4 PE=1 SV=2 CANONICAL=A0A0G2JVF0-1" }, "locus": { "chromosome": "X", "start_pos": 151651018, "end_pos": 151636446, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000085410.2", "url": "https://www.ensembl.org/id/ENSRNOT00000085410.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000069460.2", "url": "https://www.ensembl.org/id/ENSRNOP00000069460.2" } ] } }, { "isoform_ac": "A0A8I5ZY52-1", "url": "", "sequence": { "sequence": "MAAHGKLRRERGLQPEYEAQVKVMRGQLSEQLHCLELQGELRRDLLLELAEFMRRRAEVELEYSRGLDKLAERFTSRSGRLGGSSREQQSFRKEPTLLSPLHCWAMLLEHTRQQSRESATLSEVLAGPLAQRLSHIAEDVGRIVKKSKDLVQQLQDELLEVVSELQTTKKTYHVYHLESMNAETKLREAERQEEKRSGKSALPTTTAASATTTITIETELHRKGSLKKGGRLVEKRQAKFLEHKLKCTKARNEYLLSLASVNAAVSNYYLHDILDLMDCCDTGFHLALEQALRSYTAAESRTQTSHMQGLGSLEEALEALDPPGDKAKVLEVHAMAFCPPLRFDYQPHEGDEVNKTLKATLQALLEVVASEDGDILDSLQASPSTESLKSTSSDPGTRQAGRRRNQQQETETFYITKLQEYLSGRSILAKLQAKHEKLQEAIQRGNKEEQETSSWTQCTERKFHKSHHPYPGSQCTQRLFGGDLEKFIQSTGQPVPLVVKSCIRFINLNGLQHEGIFRVSGAQARILEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPLDMFNELLASAELEVVGERVELVSHLLSRLPRPVLVVLRYLFTFLNHLAQYSDENMMDSYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLILQPAWVFPPTAMLPGPIYEKCMAPPSASCLGDGQLESLAGEPELELKTGTKAQEDDSEGVVEAVACFAYTGRTAQELTFQQGDTLRLYARASSDWWRGEHAGVRGLIPHKYITLSEGDEKQMTGSGLQAMGESLSHPESVLTLEFTNRLELGTPPEALGPSGHRRHCLVPTSPEQHVEMDKAVAQNMDSVFKELLGKAAVRQGHGLASTASPSLGTRNLKPLACSSFSKNKVFSRGPGAPVSPSVSHPQGPDSTRKPV", "length": 921, "header": "tr|A0A8I5ZY52-1|A0A0G2JVF0_RAT Computationally mapped isoform of Rho GTPase activating protein 4 OS=Rattus norvegicus OX=10116 GN=Arhgap4 PE=1 SV=1 CANONICAL=A0A0G2JVF0-1" }, "locus": { "chromosome": "X", "start_pos": 151651018, "end_pos": 151636446, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000109822.1", "url": "https://www.ensembl.org/id/ENSRNOT00000109822.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000083983.1", "url": "https://www.ensembl.org/id/ENSRNOP00000083983.1" } ] } }, { "isoform_ac": "A0A8I6AIK5-1", "url": "", "sequence": { "sequence": "MAAHGKLRRERGLQPEYEAQVKVMRGQLSEQLHCLELQGELRRDLLLELAEFMRRRAEVELEYSRGLDKLAERFTSRSGRLGGSSREQQSFRKEPTLLSPLHCWAMLLEHTRQQSRESATLSEVLAGPLAQRLSHIAEDVGRIVKKTKKTYHVYHLESMNAETKLREAERQEEKRSGKSALPTTTAASATTTITIETELHRKGSLKKGGRLVEKRQAKFLEHKLKCTKARNEYLLSLASVNAAVSNYYLHDILDLMDCCDTGFHLALEQALRSYTAAESRTQTSHMQGLGSLEEALEALDPPGDKAKVLEVHAMAFCPPLRFDYQPHEGDEVAEIQVEMELRDEILPRAQNIQSRLDQKTIETEEVNKTLKATLQALLEVVASEDGDILDSLQASPSTESLKSTSSDPGTRQAGRRRNQQQETETFYITKLQEYLSGRSILAKLQAKHEKLQEAIQRGNKEEQETSSWTQCTERKFHKSHHPYPGSQCTQRLFGGDLEKFIQSTGQPVPLVVKSCIRFINLNGLQHEGIFRVSGAQARILEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPLDMFNELLASAELEVVGERVELVSHLLSRLPRPVLVVLRYLFTFLNHLAQYSDENMMDSYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLILQPAWVFPPTAMLPGPIYEKCMAPPSASCLGDGQLESLAGEPELELKTGTKAQEDDSEGVVEAVACFAYTGRTAQELTFQQGDTLRLYARASSDWWRGEHAGVRGLIPHKYITLSEGDEKQMTGSGLQAMGESLSHPESVLTLEFTNRLELGTPPEALGPSGHRRHCLVPTSPEQHVEMDKAVAQNMDSVFKELLGKAAVRQGHGLASTASPSLGTRNLKPLACSSFSKNKVFSRGPGAPVSPSVSHPQGPDSTRKPV", "length": 934, "header": "tr|A0A8I6AIK5-1|A0A0G2JVF0_RAT Computationally mapped isoform of Rho GTPase activating protein 4 OS=Rattus norvegicus OX=10116 GN=Arhgap4 PE=1 SV=1 CANONICAL=A0A0G2JVF0-1" }, "locus": { "chromosome": "X", "start_pos": 151651018, "end_pos": 151636446, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000109725.1", "url": "https://www.ensembl.org/id/ENSRNOT00000109725.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000094863.1", "url": "https://www.ensembl.org/id/ENSRNOP00000094863.1" } ] } }, { "isoform_ac": "A0A8I6AN89-1", "url": "", "sequence": { "sequence": "MAAHGKLRRERGLQPEYEAQVKVMRGQLSEQLHCLELQGELRRDLLLELAEFMRRRAEVELEYSRGLDKLAERFTSRSGRLGGSSREQQSFRKEPTLLSPLHCWAMLLEHTRQQSRESATLSEVLAGPLAQRLSHIAEDVGRIVKKSKDLVQQLQDELLEVVSELQTTKKTYHVYHLESMNAETKLREAERQEEKRSGKSALPTTTAASATTTITIETELHRKGSLKKGGRLVEKRQAKFLEHKLKCTKARNEYLLSLASVNAAVSNYYLHDILDLMDVAEIQVEMELRDEILPRAQNIQSRLDQKTIETEEVNKTLKATLQALLEVVASEDGDILDSLQASPSTESLKSTSSDPGTRQAGRRRNQQQETETFYITKLQEYLSGRSILAKLQAKHEKLQEAIQRGNKEEQETSSWTQCTERKFHKSHHPYPGSQCTQRLFGGDLEKFIQSTGQPVPLVVKSCIRFINLNGLQHEGIFRVSGAQARILEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPLDMFNELLASAELEVVGERVELVSHLLSRLPRPVLVVLRYLFTFLNHLAQYSDENMMDSYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLILQPAWVFPPTAMLPGPIYEKCMAPPSASCLGDGQLESLAGEPELELKTGTKAQEDDSEGVVEAVACFAYTGRTAQELTFQQGDTLRLYARASSDWWRGEHAGVRGLIPHKYITLSEGDEKQMTGSGLQAMGESLSHPESVLTLEFTNRLELGTPPEALGPSGHRRHCLVPTSPEQHVEMDKAVAQNMDSVFKELLGKAAVRQGHGLASTASPSLGTRNLKPLACSSFSKNKVFSRGPGAPVSPSVSHPQGPDSTRKPV", "length": 881, "header": "tr|A0A8I6AN89-1|A0A8I6AN89_RAT Computationally mapped isoform of Rho GTPase activating protein 4 OS=Rattus norvegicus OX=10116 GN=Arhgap4 PE=4 SV=1 CANONICAL=A0A0G2JVF0-1" }, "locus": { "chromosome": "X", "start_pos": 151651018, "end_pos": 151636446, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000117215.1", "url": "https://www.ensembl.org/id/ENSRNOT00000117215.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000095360.1", "url": "https://www.ensembl.org/id/ENSRNOP00000095360.1" } ] } }, { "isoform_ac": "A0A8I6GIQ7-1", "url": "", "sequence": { "sequence": "MAAHGKLRRERGLQPEYEAQVKVMRGQLSEQLHCLELQGELRRDLLLELAEFMRRRAEVELEYSRGLDKLAERFTSRSGRLGGSSREQQSFRKEPTLLSPLHCWAMLLEHTRQQSRESATLSEVLAGPLAQRLSHIAEDVGRIVKKSKDLVQQLQDELLEVVSELQTVAEIQVEMELRDEILPRAQNIQSRLDQKTIETEEVNKTLKATLQALLEVVASEDGDILDSLQASPSTESLKSTSSDPGTRQAGRRRNQQQETETFYITKLQEYLSGRSILAKLQAKHEKLQEAIQRGNKEEQETSSWTQCTERKFHKSHHPYPGSQCTQRLFGGDLEKFIQSTGQPVPLVVKSCIRFINLNGLQHEGIFRVSGAQARILEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPLDMFNELLASAELEVVGERVELVSHLLSRLPRPVLVVLRYLFTFLNHLAQYSDENMMDSYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLILQPAWVFPPTAMLPGPIYEKCMAPPSASCLGDGQLESLAGEPELELKTGTKAQEDDSEGVVEAVACFAYTGRTAQELTFQQGDTLRLYARASSDWWRGEHAGVRGLIPHKYITLSEGDEKQMTGSGLQAMGESLSHPESVLTLEFTNRLELGTPPEALGPSGHRRHCLVPTSPEQHVEMDKAVAQNMDSVFKELLGKAAVRQGHGLASTASPSLGTRNLKPLACSSFSKNKVFSRGPGAPVSPSVSHPQGPDSTRKPV", "length": 770, "header": "tr|A0A8I6GIQ7-1|A0A8I6GIQ7_RAT Computationally mapped isoform of Rho GTPase activating protein 4 OS=Rattus norvegicus OX=10116 GN=Arhgap4 PE=4 SV=1 CANONICAL=A0A0G2JVF0-1" }, "locus": { "chromosome": "X", "start_pos": 151651018, "end_pos": 151636446, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000104884.1", "url": "https://www.ensembl.org/id/ENSRNOT00000104884.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000091062.1", "url": "https://www.ensembl.org/id/ENSRNOP00000091062.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules.", "journal": "Brain research. Molecular brain research", "date": "2002", "authors": "Foletta VC, Brown FD, Young WS 3rd", "evidence": [ { "database": "RefSeq", "id": "NP_653341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653341" } ], "reference": [ { "type": "PubMed", "id": "12414125", "url": "https://glygen.org/publication/PubMed/12414125" } ] }, { "title": "ARHGAP4 is a novel RhoGAP that mediates inhibition of cell motility and axon outgrowth.", "journal": "Molecular and cellular neurosciences", "date": "2007", "authors": "Vogt DL, Gray CD, Young WS 3rd, Orellana SA, Malouf AT", "evidence": [ { "database": "RefSeq", "id": "NP_653341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653341" } ], "reference": [ { "type": "PubMed", "id": "17804252", "url": "https://glygen.org/publication/PubMed/17804252" } ] } ], "pathway": [ { "id": "rno:246249", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:246249", "resource": "KEGG Pathway" }, { "id": "R-RNO-8980692", "name": "RHOA GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-RNO-9013148", "name": "CDC42 GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-RNO-9013149", "name": "RAC1 GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013149", "resource": "Reactome", "description": "RAC1 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "B1AUY3-1", "protein_name": "Rho GTPase activating protein 4", "gene_name": "Arhgap4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAHGKLRRERGLQPEYDAQVKEMRWQLSEQLHCLELQGELRRDLLQELAEFMRRRAEVELEYSRGLDKLAERFTSRSGRLGGSSQEQQSFRKEPTLLSPLHCWAVLLEHTRQQSRESAALSEVLAGPLAQRLSHISEDVGRIVKKSKDLVQQLQAELLEVVSELQTQGYFAWASLQTKKMYHVYHSESMNAETKLREAERQEEKRSGRSALSTTTTTSATTTTTTTTVETGPHRKSSLKKGGRLVEKRQAKYLEHKLKCTKARNEYLLSLASVNAAISNYYLHDILDLMDCCDTGFHLALEQALRSYTAAESRTQTSQMQGLGSLEEALEALDPPGDKAKVLEVHAMAFCPPLRFEYQPHEDDEVAEVLIEMELWDEILPRAQNIQSRLDQKTIETEEVNKTLKATLKALLEAVASEDGDILDSLQASPSTESLKSTSSDPGTRQTGRRRNQQQETETFYITKLQEYLSGRSILSKLQAKHEKLQEAIQQGNKEKQETSRTQCTERKFHKSHPPHPRFQYNQRLFGGDLEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQARISEIRDAFERGEDPLEKGCTVHDLDSVAGVLKLYFRSLEPPLFPLDMFNELLASAELEVVGERVEPVSHLLFKLPRPVLVVLRYLFTFLNHLAQYSDENMMDSYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLILQPARIFPPPAMLPGPIYEKCMAPPSASCLGDGQLESLIGEPELELKTGTTAQEDDQEGVLEAVACFAYTGRTAQELTFQRGDVLRLYARASSDWWRGEHAGVQGLIPHKYITLCEGDEKQMAGSGLQAMGESVSHPEGFLTLEFANRLELGTPPEALGPSRHRRPCLVPTSPEGHVEMDKAVAQNMNSVFKELLGKTAVRQGHGLASTASPSLGTLTPLACSSISKNKVFSRGPGAPISPSTSHPQGPDSTRKPV", "length": 965 }, "evidence": [ 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