The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06766-1", "A0A0G2JV76-1" ], "evidence": [ { "id": "R-RNO-110376", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-110376" } ] }, { "id": "R-RNO-5649705", "name": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06766-1", "A0A0G2JV76-1" ], "evidence": [ { "id": "R-RNO-5649705", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5649705" } ] }, { "id": "R-RNO-5649723", "name": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06766-1", "A0A0G2JV76-1" ], "evidence": [ { "id": "R-RNO-5649723", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5649723" } ] }, { "id": "R-RNO-5649726", "name": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06766-1", "A0A0G2JV76-1" ], "evidence": [ { "id": "R-RNO-5649726", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5649726" } ] }, { "id": "R-RNO-5649734", "name": "LIG3 ligates NEIL1,NEIL2-generated single strand break", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06766-1", "A0A0G2JV76-1" ], "evidence": [ { "id": "R-RNO-5649734", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5649734" } ] }, { "id": "R-RNO-5687673", "name": "MRN recruits LIG3:XRCC1 to MMEJ sites", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9JIM0-1", "Q9JIL8-1", "B1WC58-1", "A0A0G2JV76-1" ], "evidence": [ { "id": "R-RNO-5687673", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5687673" } ] }, { "id": "R-RNO-5687675", "name": "LIG3 ligates remaining SSBs in MMEJ", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9JIM0-1", "Q9JIL8-1", "B1WC58-1", "A0A0G2JV76-1" ], "evidence": [ { "id": "R-RNO-5687675", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5687675" } ] }, { "id": "R-RNO-6782227", "name": "Ligation of newly synthesized repair patch to incised DNA in TC-NER", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9JMJ4-1", "Q4G005-1", "D3ZEG9-1", "G3V8Y5-1", "Q4VSI4-1", "D4A5A6-1", "P51952-1", "D3Z8X4-1", "O54747-1", "A0A0G2JV76-1" ], "evidence": [ { "id": "R-RNO-6782227", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6782227" } ] }, { "id": "R-RNO-73931", "name": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06766-1", "A0A0G2JV76-1" ], "evidence": [ { "id": "R-RNO-73931", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73931" } ] }, { "id": "R-RNO-73932", "name": "Resynthesis of excised residue by POLB", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06766-1", "A0A0G2JV76-1" ], "evidence": [ { "id": "R-RNO-73932", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73932" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JV76", "gene_name": "Lig3", "activity": [ { "ec_number": "6.5.1.1", "activity": "ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.", "evidence": [ { "id": "A0A0G2JV76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JV76" } ] }, { "ec_number": "6.5.1.1", "activity": "", "evidence": [ { "id": "A0A0G2JV76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JV76" } ] } ] }, { "uniprot_ac": "B1WC58", "gene_name": "Rbbp8", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "B1WC58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WC58" } ] } ] }, { "uniprot_ac": "D3Z8X4", "gene_name": "Pole", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "D3Z8X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8X4" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "D3Z8X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8X4" } ] } ] }, { "uniprot_ac": "D3ZEG9", "gene_name": "Ercc2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEG9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEG9" } ] } ] }, { "uniprot_ac": "D4A5A6", "gene_name": "Polr2a", "activity": [ { "ec_number": "2.7.7.6", "activity": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1).", "evidence": [ { "id": "D4A5A6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A5A6" } ] }, { "ec_number": "2.7.7.6", "activity": "", "evidence": [ { "id": "D4A5A6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A5A6" } ] } ] }, { "uniprot_ac": "G3V8Y5", "gene_name": "Polr2b", "activity": [ { "ec_number": "2.7.7.6", "activity": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1).", "evidence": [ { "id": "G3V8Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V8Y5" } ] }, { "ec_number": "2.7.7.6", "activity": "", "evidence": [ { "id": "G3V8Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V8Y5" } ] } ] }, { "uniprot_ac": "O54747", "gene_name": "Pold1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O54747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54747" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "O54747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54747" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "O54747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54747" } ] } ] }, { "uniprot_ac": "P06766", "gene_name": "Polb", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] }, { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] }, { "ec_number": "4.2.99.-", "activity": "", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] } ] }, { "uniprot_ac": "P51952", "gene_name": "Cdk7", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P51952", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51952" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P51952", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51952" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P51952", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51952" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P51952", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51952" } ] } ] }, { "uniprot_ac": "Q4G005", "gene_name": "Ercc3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q4G005", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4G005" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q4G005", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4G005" } ] } ] }, { "uniprot_ac": "Q4VSI4", "gene_name": "Usp7", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "Q4VSI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4VSI4" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "Q4VSI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4VSI4" } ] } ] }, { "uniprot_ac": "Q9JIL8", "gene_name": "Rad50", "activity": [ { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q9JIL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIL8" } ] } ] }, { "uniprot_ac": "Q9JIM0", "gene_name": "Mre11", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q9JIM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIM0" } ] } ] }, { "uniprot_ac": "Q9JMJ4", "gene_name": "Prpf19", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9JMJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMJ4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9JMJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMJ4" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }