{ "uniprot_canonical_ac": "A0A0B4LET0-1", "uniprot_ac": "A0A0B4LET0", "uniprot_id": "A0A0B4LET0_DROME", "mass": { "chemical_mass": 61945.0, "monoisotopic_mass": 61945.0 }, "refseq": { "ac": "NP_610641", "name": "uncharacterized protein, isoform A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610641" }, "gene_names": [ { "name": "Dmel\\CG7737", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0B4LET0", "id": "A0A0B4LET0" }, { "name": "CG7737", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610641", "id": "NP_610641" }, { "name": "CG7737", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4LET0", "id": "A0A0B4LET0" }, { "name": "Dmel\\CG7737", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610641", "id": "NP_610641" }, { "name": "Dmel_CG7737", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4LET0", "id": "A0A0B4LET0" } ], "protein_names": [ { "name": "1.-.-.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0B4LET0" }, { "name": "CG7737-PA; spermine oxidase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610641", "id": "NP_610641" }, { "name": "CG7737-PB; spermine oxidase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286308", "id": "NP_001286308" }, { "name": "Uncharacterized protein, isoform B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0B4LET0" }, { "name": "uncharacterized protein, isoform A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610641", "id": "NP_610641" }, { "name": "uncharacterized protein, isoform B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286308", "id": "NP_001286308" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A0A0B4LET0", "url": "https://www.uniprot.org/uniprot/A0A0B4LET0" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Dmel\\CG7737", "url": "https://www.uniprot.org/uniprot/A0A0B4LET0", "locus": { "chromosome": "2R", "start_pos": 11226746, "end_pos": 11222871, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0033584", "url": "https://www.ensembl.org/id/FBgn0033584" } ] } } ], "crossref": [ { "id": "FBgn0033584", "url": "https://bgee.org/?page=gene&gene_id=FBgn0033584", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0033584", "url": "https://flybase.org/reports/FBgn0033584", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "36174", "url": "https://www.ncbi.nlm.nih.gov/gene/36174", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "A0A0B4LET0", "url": "https://www.ebi.ac.uk/intact/interactors/id:A0A0B4LET0*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "Q7K4C2", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q7K4C2*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG7737", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG7737", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EFFDNYQ", "url": "https://omabrowser.org/oma/group/EFFDNYQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2642916at2759", "url": "http://www.orthodb.org/?query=2642916at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10742", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10742", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10742:SF398", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10742:SF398", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01593", "url": "http://pfam.xfam.org/family/PF01593", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-DME-141334", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-141334", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-351200", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-351200", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001286308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286308", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0B4LET0", "url": "https://www.uniprot.org/uniprot/A0A0B4LET0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4LET0-1", "url": "https://www.uniprot.org/uniprot/A0A0B4LET0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7K4C2", "url": "https://www.uniprot.org/uniprot/Q7K4C2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7K4C2-1", "url": "https://www.uniprot.org/uniprot/Q7K4C2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLYGKWTVIKLKCLELQCTIAISKFPMHNIQLPGMSGAQRNQDRKIVVIGAGASGVACATKLLELGFQNVLVVEAEDRLGGRIHTIPFADNVIDLGAQWCHGERDNIVYELTRKQDEELLESTGPVYENYECVRSNGDVVPEEVSSRLKAIVGDSLVTRQLELRHCSGSLGSYLTNKFYDTLRRPENSDIDAEVASEFFVNYQKFENSVEASDTLEQVSGRGYLDYWECEGDILLNWKDKGYVELLRLLMRSRELNVEHGVLEQRLLLGTRVVKINWNRNDGRVELQMSNGETCIADHVVVTVSLGVLKDQHLRLFEPQLPVEKQRAIDGLAFGTVNKIFVEFPEAFWPEDWTGFTMLWRDEDLDDIRGTSRAWLEDVFGFYRVSYQPRILAGWITNESGRHMETLPVDEVQAGVMYLFRRFLRWKIPDPANFRTSAWYTNDNFRGSYSYRSMDTEQLGTGARELSHPLTVVATTPEKDKDSEDEAWQQSRCDRPIVQFAGEASSEHYYSTVHGAVEAGWREARRLAQFYGISVSRSGTKSQL", "length": 543, "header": "tr|A0A0B4LET0-1|A0A0B4LET0_DROME Isoform 1 of Uncharacterized protein, isoform B OS=Drosophila melanogaster OX=7227 GN=Dmel\\CG7737 PE=1 SV=1 CANONICAL=A0A0B4LET0-1" }, "isoforms": [ { "isoform_ac": "A0A0B4LET0-1", "url": "", "sequence": { "sequence": "MLYGKWTVIKLKCLELQCTIAISKFPMHNIQLPGMSGAQRNQDRKIVVIGAGASGVACATKLLELGFQNVLVVEAEDRLGGRIHTIPFADNVIDLGAQWCHGERDNIVYELTRKQDEELLESTGPVYENYECVRSNGDVVPEEVSSRLKAIVGDSLVTRQLELRHCSGSLGSYLTNKFYDTLRRPENSDIDAEVASEFFVNYQKFENSVEASDTLEQVSGRGYLDYWECEGDILLNWKDKGYVELLRLLMRSRELNVEHGVLEQRLLLGTRVVKINWNRNDGRVELQMSNGETCIADHVVVTVSLGVLKDQHLRLFEPQLPVEKQRAIDGLAFGTVNKIFVEFPEAFWPEDWTGFTMLWRDEDLDDIRGTSRAWLEDVFGFYRVSYQPRILAGWITNESGRHMETLPVDEVQAGVMYLFRRFLRWKIPDPANFRTSAWYTNDNFRGSYSYRSMDTEQLGTGARELSHPLTVVATTPEKDKDSEDEAWQQSRCDRPIVQFAGEASSEHYYSTVHGAVEAGWREARRLAQFYGISVSRSGTKSQL", "length": 543, "header": "tr|A0A0B4LET0-1|A0A0B4LET0_DROME Isoform 1 of Uncharacterized protein, isoform B OS=Drosophila melanogaster OX=7227 GN=Dmel\\CG7737 PE=1 SV=1 CANONICAL=A0A0B4LET0-1" }, "locus": { "chromosome": "2R", "start_pos": 11226113, "end_pos": 11223599, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0339479", "url": "https://www.ensembl.org/id/FBtr0339479" }, { "database": "Ensembl Peptide", "id": "FBpp0308562", "url": "https://www.ensembl.org/id/FBpp0308562" } ] } }, { "isoform_ac": "Q7K4C2-1", "url": "", "sequence": { "sequence": "MSGAQRNQDRKIVVIGAGASGVACATKLLELGFQNVLVVEAEDRLGGRIHTIPFADNVIDLGAQWCHGERDNIVYELTRKQDEELLESTGPVYENYECVRSNGDVVPEEVSSRLKAIVGDSLVTRQLELRHCSGSLGSYLTNKFYDTLRRPENSDIDAEVASEFFVNYQKFENSVEASDTLEQVSGRGYLDYWECEGDILLNWKDKGYVELLRLLMRSRELNVEHGVLEQRLLLGTRVVKINWNRNDGRVELQMSNGETCIADHVVVTVSLGVLKDQHLRLFEPQLPVEKQRAIDGLAFGTVNKIFVEFPEAFWPEDWTGFTMLWRDEDLDDIRGTSRAWLEDVFGFYRVSYQPRILAGWITNESGRHMETLPVDEVQAGVMYLFRRFLRWKIPDPANFRTSAWYTNDNFRGSYSYRSMDTEQLGTGARELSHPLTVVATTPEKDKDSEDEAWQQSRCDRPIVQFAGEASSEHYYSTVHGAVEAGWREARRLAQFYGISVSRSGTKSQL", "length": 509, "header": "tr|Q7K4C2-1|A0A0B4LET0_DROME Computationally mapped isoform of Uncharacterized protein, isoform B OS=Drosophila melanogaster OX=7227 GN=Dmel\\CG7737 PE=1 SV=1 CANONICAL=A0A0B4LET0-1" }, "locus": { "chromosome": "2R", "start_pos": 11226113, "end_pos": 11224587, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0088105", "url": "https://www.ensembl.org/id/FBtr0088105" }, { "database": "Ensembl Peptide", "id": "FBpp0087206", "url": "https://www.ensembl.org/id/FBpp0087206" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "dme:Dmel_CG7737", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG7737", "resource": "KEGG Pathway" }, { "id": "R-DME-141334", "name": "PAOs oxidise polyamines to amines", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-141334", "resource": "Reactome", "description": "PAOs oxidise polyamines to amines" }, { "id": "R-DME-351200", "name": "Interconversion of polyamines", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-351200", "resource": "Reactome", "description": "Interconversion of polyamines" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "polyamine oxidase activity", "id": "GO:0046592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046592", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4LET0", "url": "https://www.uniprot.org/uniprot/A0A0B4LET0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-DME-141341", "name": "SMOX-3 oxidises SPN to SPM", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, peroxisomal matrix", "input_participant_list": [ "R-ALL-141342" ], "output_participant_list": [ "R-ALL-141324", "R-ALL-141328" ], "enzyme_list": [ "Q9VVK1-1", "A0A0B4LET0-1" ], "evidence": [ { "id": "R-DME-141341", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-141341" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-141324", "participant_name": "SPM [peroxisomal matrix]", "crossref": [ { "id": "C00315", "database": "COMPOUND", "url": "" }, { "id": "57834", "database": "ChEBI", "url": "" }, { "id": "000001532612", "database": "ZINC", "url": "" }, { "id": "C00315", "database": "COMPOUND", "url": "" }, { "id": "57834", "database": "ChEBI", "url": "" }, { "id": "000001532612", "database": "ZINC", "url": "" }, { "id": "000001532612", "database": "ZINC", "url": "" }, { "id": "C00315", "database": "COMPOUND", "url": "" }, { "id": "57834", "database": "ChEBI", "url": "" }, { "id": "C00315", "database": "COMPOUND", "url": "" }, { "id": "57834", "database": "ChEBI", "url": "" }, { "id": "000001532612", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-141328", "participant_name": "3APAL [peroxisomal matrix]", "crossref": [ { "id": "C02229", "database": "COMPOUND", "url": "" }, { "id": "18090", "database": "ChEBI", "url": "" }, { "id": "8143896", "database": "PubChem Substance", "url": "" }, { "id": "000001529387", "database": "ZINC", "url": "" }, { "id": "HMDB0001106", "database": "HMDB Metabolite", "url": "" }, { "id": "C02229", "database": "COMPOUND", "url": "" }, { "id": "8143896", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0001106", "database": "HMDB Metabolite", "url": "" }, { "id": "000001529387", "database": "ZINC", "url": "" }, { "id": "18090", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-141342", "participant_name": "SPN [peroxisomal matrix]", "crossref": [ { "id": "45725", "database": "ChEBI", "url": "" }, { "id": "C00750", "database": "COMPOUND", "url": "" }, { "id": "000001532734", "database": "ZINC", "url": "" }, { "id": "C00750", "database": "COMPOUND", "url": "" }, { "id": "45725", "database": "ChEBI", "url": "" }, { "id": "000001532734", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0B4LET0", "gene_name": "Dmel\\CG7737", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "A0A0B4LET0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4LET0" } ] } ] }, { "uniprot_ac": "Q9VVK1", "gene_name": "Dmel\\CG7460", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "Q9VVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VVK1" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }