The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [ "R-ALL-1454930" ], "output_participant_list": [ "R-ALL-1454919" ], "enzyme_list": [ "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1" ], "evidence": [ { "id": "R-DME-1454916", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1454916" } ] }, { "id": "R-DME-383190", "name": "HCO3- transport through ion channel", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1" ], "evidence": [ { "id": "R-DME-383190", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-383190" } ] }, { "id": "R-DME-429157", "name": "ABCC4 accumulation of dense granule contents", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, platelet dense granule membrane, platelet dense granule lumen", "input_participant_list": [], "output_participant_list": [ "R-ALL-114565" ], "enzyme_list": [ "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1" ], "evidence": [ { "id": "R-DME-429157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-429157" } ] }, { "id": "R-DME-5678863", "name": "CFTR transports Cl- from cytosol to extracellular region", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [ "R-ALL-352022" ], "output_participant_list": [], "enzyme_list": [ "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1" ], "evidence": [ { "id": "R-DME-5678863", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5678863" } ] }, { "id": "R-DME-8866277", "name": "AP-2 directly binds some endocytic cargo", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1" ], "evidence": [ { "id": "R-DME-8866277", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8866277" } ] }, { "id": "R-DME-8866546", "name": "RNF5 and RNF185 ubiquitinate misfolded CFTR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q7KN62-1", "Q9VAN4-1", "Q9W2I5-1", "Q8IR26-1", "Q9VC63-1", "Q9VFY3-1", "A0A0B4KGI0-1", "A0A1Z1CK50-1", "Q8IQM1-1", "Q9VGM1-1", "Q961D3-1", "Q9VXP1-1" ], "evidence": [ { "id": "R-DME-8866546", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8866546" } ] }, { "id": "R-DME-8866553", "name": "misfolded CFTR is degraded by the 26S proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q7KMQ0-1", "Q8T915-1", "Q9V3V6-1", "Q9V3H2-1", "Q9VAN4-1", "Q9W2I5-1", "Q9W414-1", "Q9V405-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1" ], "evidence": [ { "id": "R-DME-8866553", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8866553" } ] }, { "id": "R-DME-8866851", "name": "CFTR transits to the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1" ], "evidence": [ { "id": "R-DME-8866851", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8866851" } ] }, { "id": "R-DME-8867754", "name": "F- and N- BAR domain proteins bind the clathrin-coated pit", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [ "R-DME-8867737" ], "output_participant_list": [ "R-DME-1604624" ], "enzyme_list": [ "P04412-1", "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q7K3H0-1", "Q961D3-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8867754", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8867754" } ] }, { "id": "R-DME-8867756", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8867756", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8867756" } ] }, { "id": "R-DME-8868071", "name": "Clathrin recruits PIK3C2A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q7K3H0-1", "Q961D3-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8868071", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868071" } ] }, { "id": "R-DME-8868072", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [ "R-ALL-392417" ], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q7K3H0-1", "Q961D3-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8868072", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868072" } ] }, { "id": "R-DME-8868230", "name": "SNX9 recruits components of the actin polymerizing machinery", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P02572-1", "P04412-1", "P10987-1", "P83967-1", "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "P02574-1", "P10981-1", "P53501-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8868230", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868230" } ] }, { "id": "R-DME-8868236", "name": "BAR domain proteins recruit dynamin", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P02572-1", "P04412-1", "P10987-1", "P83967-1", "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "P02574-1", "P10981-1", "P27619-1", "P53501-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8868236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868236" } ] }, { "id": "R-DME-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O46094-1", "P02572-1", "P04412-1", "P10987-1", "P83967-1", "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "P02574-1", "P10981-1", "P27619-1", "P53501-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1", "Q9VSK2-1", "Q5U0V7-1" ], "evidence": [ { "id": "R-DME-8868648", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868648" } ] }, { "id": "R-DME-8868651", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O46094-1", "P02572-1", "P04412-1", "P10987-1", "P83967-1", "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "P02574-1", "P10981-1", "P27619-1", "P53501-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1", "Q9VSK2-1", "Q5U0V7-1" ], "evidence": [ { "id": "R-DME-8868651", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868651" } ] }, { "id": "R-DME-8868658", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "clathrin-coated endocytic vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O46094-1", "P02572-1", "P04412-1", "P10987-1", "P83967-1", "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "P02574-1", "P10981-1", "P27619-1", "P53501-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1", "Q9VSK2-1", "Q5U0V7-1" ], "evidence": [ { "id": "R-DME-8868658", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868658" } ] }, { "id": "R-DME-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "clathrin-coated endocytic vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O46094-1", "P02572-1", "P04412-1", "P10987-1", "P83967-1", "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "P02574-1", "P10981-1", "P27619-1", "P53501-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1", "Q9VSK2-1", "Q5U0V7-1" ], "evidence": [ { "id": "R-DME-8868660", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868660" } ] }, { "id": "R-DME-8868661", "name": "Dynamin-mediated GTP hydrolysis promotes vesicle scission", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane, clathrin-coated endocytic vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O46094-1", "P02572-1", "P04412-1", "P10987-1", "P83967-1", "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "P02574-1", "P10981-1", "P27619-1", "P53501-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1", "Q9VSK2-1", "Q5U0V7-1" ], "evidence": [ { "id": "R-DME-8868661", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868661" } ] }, { "id": "R-DME-9641109", "name": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35128-1", "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1", "Q7KTX7-1" ], "evidence": [ { "id": "R-DME-9641109", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9641109" } ] }, { "id": "R-DME-9641111", "name": "Parkin transfers Ub to misfolded proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35128-1", "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1", "Q7KTX7-1" ], "evidence": [ { "id": "R-DME-9641111", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9641111" } ] }, { "id": "R-DME-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35128-1", "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1", "Q7KTX7-1" ], "evidence": [ { "id": "R-DME-9641127", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9641127" } ] }, { "id": "R-DME-9646348", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "M9PJN5-1", "Q9VGM1-1", "Q961D3-1" ], "evidence": [ { "id": "R-DME-9646348", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9646348" } ] }, { "id": "R-DME-9750546", "name": "ABCC4 transports TPMP substrates from cytosol to extracellular region", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1" ], "evidence": [ { "id": "R-DME-9750546", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9750546" } ] }, { "id": "R-DME-9753283", "name": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1" ], "evidence": [ { "id": "R-DME-9753283", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9753283" } ] }, { "id": "R-DME-9753284", "name": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VAN4-1", "Q9W2I5-1", "Q9VC63-1", "A0A0B4KGI0-1", "Q9VGM1-1", "Q961D3-1" ], "evidence": [ { "id": "R-DME-9753284", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9753284" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-114565", "participant_name": "ADP [platelet dense granule lumen]", "crossref": [ { "id": "C00008", "database": "COMPOUND", "url": "" }, { "id": "456216", "database": "ChEBI", "url": "" }, { "id": "000012360703", "database": "ZINC", "url": "" }, { "id": "C00008", "database": "COMPOUND", "url": "" }, { "id": "456216", "database": "ChEBI", "url": "" }, { "id": "000012360703", "database": "ZINC", "url": "" }, { "id": "C00008", "database": "COMPOUND", "url": "" }, { "id": "456216", "database": "ChEBI", "url": "" }, { "id": "000012360703", "database": "ZINC", "url": "" }, { "id": "C00008", "database": "COMPOUND", "url": "" }, { "id": "456216", "database": "ChEBI", "url": "" }, { "id": "000012360703", "database": "ZINC", "url": "" }, { "id": "C00008", "database": "COMPOUND", "url": "" }, { "id": "456216", "database": "ChEBI", "url": "" }, { "id": "000012360703", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-1454919", "participant_name": "organic anion [extracellular region]", "crossref": [ { "id": "25696", "database": "ChEBI", "url": "" }, { "id": "25696", "database": "ChEBI", "url": "" }, { "id": "25696", "database": "ChEBI", "url": "" }, { "id": "25696", "database": "ChEBI", "url": "" }, { "id": "25696", "database": "ChEBI", "url": "" }, { "id": "25696", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1454930", "participant_name": "organic anion [cytosol]", "crossref": [ { "id": "25696", "database": "ChEBI", "url": "" }, { "id": "25696", "database": "ChEBI", "url": "" }, { "id": "25696", "database": "ChEBI", "url": "" }, { "id": "25696", "database": "ChEBI", "url": "" }, { "id": "25696", "database": "ChEBI", "url": "" }, { "id": "25696", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-352022", "participant_name": "Cl- [cytosol]", "crossref": [ { "id": "C00115", "database": "COMPOUND", "url": "" }, { "id": "17996", "database": "ChEBI", "url": "" }, { "id": "8145194", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000492", "database": "HMDB Metabolite", "url": "" }, { "id": "C00115", "database": "COMPOUND", "url": "" }, { "id": "17996", "database": "ChEBI", "url": "" }, { "id": "8145194", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000492", "database": "HMDB Metabolite", "url": "" }, { "id": "C00115", "database": "COMPOUND", "url": "" }, { "id": "17996", "database": "ChEBI", "url": "" }, { "id": "8145194", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000492", "database": "HMDB Metabolite", "url": "" }, { "id": "C00115", "database": "COMPOUND", "url": "" }, { "id": "17996", "database": "ChEBI", "url": "" }, { "id": "8145194", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000492", "database": "HMDB Metabolite", "url": "" }, { "id": "C00115", "database": "COMPOUND", "url": "" }, { "id": "17996", "database": "ChEBI", "url": "" }, { "id": "8145194", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000492", "database": "HMDB Metabolite", "url": "" }, { "id": "C00115", "database": "COMPOUND", "url": "" }, { "id": "17996", "database": "ChEBI", "url": "" }, { "id": "8145194", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000492", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-392417", "participant_name": "PI4P [plasma membrane]", "crossref": [ { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-DME-1604624", "participant_name": "Pi3K68D [cytosol]", "crossref": [ { "id": "NP_524028.2", "database": "RefSeq", "url": "" }, { "id": "Q7K3H0", "database": "UniProt", "url": "" }, { "id": "NP_729743.1", "database": "RefSeq", "url": "" }, { "id": "FBgn0015278", "database": "Flybase", "url": "" }, { "id": "NP_001163420.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-DME-8867737", "participant_name": "SH3PX1 [cytosol]", "crossref": [ { "id": "Q9NCC3", "database": "UniProt", "url": "" }, { "id": "FBgn0040475", "database": "Flybase", "url": "" }, { "id": "NP_648348.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0B4KGI0", "gene_name": "Mrp5", "activity": [ { "ec_number": "3.6.1.3", "activity": "", "evidence": [ { "id": "A0A0B4KGI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KGI0" } ] } ] }, { "uniprot_ac": "A0A1Z1CK50", "gene_name": "Dmel\\CG34308", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A1Z1CK50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1Z1CK50" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A1Z1CK50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1Z1CK50" } ] } ] }, { "uniprot_ac": "M9PJN5", "gene_name": "HDAC6", "activity": [ { "ec_number": "3.5.1.98", "activity": "H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone].", "evidence": [ { "id": "M9PJN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M9PJN5" } ] } ] }, { "uniprot_ac": "O46094", "gene_name": "Ocrl", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "O46094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O46094" } ] } ] }, { "uniprot_ac": "P02572", "gene_name": "Act42A", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P02572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P02572" } ] } ] }, { "uniprot_ac": "P02574", "gene_name": "Act79B", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P02574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P02574" } ] } ] }, { "uniprot_ac": "P04412", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04412" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04412" } ] } ] }, { "uniprot_ac": "P10981", "gene_name": "Act87E", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P10981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10981" } ] } ] }, { "uniprot_ac": "P10987", "gene_name": "Act5C", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P10987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10987" } ] } ] }, { "uniprot_ac": "P27619", "gene_name": "shi", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P27619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27619" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "P27619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27619" } ] } ] }, { "uniprot_ac": "P35128", "gene_name": "ben", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 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[E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IR26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IR26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8IR26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IR26" } ] } ] }, { "uniprot_ac": "Q8T915", "gene_name": "Prosbeta2R2", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "Q8T915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T915" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "Q8T915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T915" } ] } ] }, { "uniprot_ac": "Q961D3", "gene_name": "rdog", "activity": [ { "ec_number": "3.6.1.3", "activity": "", "evidence": [ { "id": "Q961D3", "database": "UniProtKB", "url": 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