{
    "uniprot_canonical_ac": "A0A0B4KGD0-1",
    "uniprot_ac": "A0A0B4KGD0",
    "uniprot_id": "A0A0B4KGD0_DROME",
    "mass": {
        "chemical_mass": 56299.0,
        "monoisotopic_mass": 56299.0
    },
    "refseq": {
        "ac": "NP_477179",
        "name": "apontic, isoform B",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477179"
    },
    "gene_names": [
        {
            "name": "apt",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "3041; Apt; APT; CG5393; Dmel\\CG5393; l(2)03041; l(2)06369; l(2)09049; l(2)59Ea; l(2)k11531; tdf; TDF; TDF/APT; Tdp",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477180",
            "id": "NP_477180"
        },
        {
            "name": "3041",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "APT",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "Apt",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "CG5393",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "Dmel\\CG5393",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "Dmel_CG5393",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "TDF",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "Tdp",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "apt-RC",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "apt",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477180",
            "id": "NP_477180"
        },
        {
            "name": "l(2)03041",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "l(2)06369",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "l(2)09049",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "l(2)59Ea",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "l(2)k11531",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "tdf",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "id": "A0A0B4KGD0"
        }
    ],
    "protein_names": [
        {
            "name": "Regulatory protein zeste",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A0A0B4KGD0"
        },
        {
            "name": "CG5393-PA; apt-PA; apontic; trachea defective; tracheal defective; tracheae defective",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477180",
            "id": "NP_477180"
        },
        {
            "name": "CG5393-PB; apt-PB; apontic; trachea defective; tracheal defective; tracheae defective",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477179",
            "id": "NP_477179"
        },
        {
            "name": "CG5393-PE; apt-PE; apontic; trachea defective; tracheal defective; tracheae defective",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_726344",
            "id": "NP_726344"
        },
        {
            "name": "CG5393-PF; apt-PF; apontic; trachea defective; tracheal defective; tracheae defective",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261153",
            "id": "NP_001261153"
        },
        {
            "name": "apontic, isoform A",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477180",
            "id": "NP_477180"
        },
        {
            "name": "apontic, isoform B",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477179",
            "id": "NP_477179"
        },
        {
            "name": "apontic, isoform E",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_726344",
            "id": "NP_726344"
        },
        {
            "name": "apontic, isoform F",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261153",
            "id": "NP_001261153"
        }
    ],
    "function": [
        {
            "annotation": "Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O61602",
                    "url": "https://www.uniprot.org/uniprot/O61602#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "ARBA00025466",
                    "url": "https://www.uniprot.org/uniprot/ARBA00025466#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9W1M6",
                    "url": "https://www.uniprot.org/uniprot/Q9W1M6#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A0B4KGD0",
                    "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q8MLR4",
                    "url": "https://www.uniprot.org/uniprot/Q8MLR4#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0B4KGD0",
                    "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "gene": [
        {
            "name": "apt",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "locus": {
                "chromosome": "2R",
                "start_pos": 23599526,
                "end_pos": 23564891,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "FBgn0015903",
                        "url": "https://www.ensembl.org/id/FBgn0015903"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "FBgn0015903",
            "url": "https://bgee.org/?page=gene&gene_id=FBgn0015903",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "FBgn0015903",
            "url": "https://flybase.org/reports/FBgn0015903",
            "database": "FlyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "37734",
            "url": "https://www.ncbi.nlm.nih.gov/gene/37734",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "A0A0B4KGD0",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A0A0B4KGD0*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "O61602",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:O61602*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "Q9W1M6",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9W1M6*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR028002",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028002",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "dme:Dmel_CG5393",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG5393",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "NETFNNH",
            "url": "https://omabrowser.org/oma/group/NETFNNH/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3338519at2759",
            "url": "http://www.orthodb.org/?query=3338519at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21411",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21411",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21411:SF0",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21411:SF0",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13873",
            "url": "http://pfam.xfam.org/family/PF13873",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001261153",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261153",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0B4KGD0",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0B4KGD0-1",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KGD0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "O61602",
            "url": "https://www.uniprot.org/uniprot/O61602",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "O61602-1",
            "url": "https://www.uniprot.org/uniprot/O61602-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8MLR4",
            "url": "https://www.uniprot.org/uniprot/Q8MLR4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8MLR4-1",
            "url": "https://www.uniprot.org/uniprot/Q8MLR4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9W1M6",
            "url": "https://www.uniprot.org/uniprot/Q9W1M6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9W1M6-1",
            "url": "https://www.uniprot.org/uniprot/Q9W1M6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MLNYWEGQSGASNSTVRVNKQYSATDLEAFMKIAANWQNSNHNLLEGVDIKTEMTQYMNSPSMNMYKKRERTQNWNHQEKKYLLDLCRKDMRIIENKRLDAGLTAVKNKAWKIIHQKFSNQFGTDRTCNRLKEQWRRMKACTRNEILDYNNRLARFGAEVADRKKPSPFTFEVWDFMQEAKKACKSEALDGIDYSKIPLALEEGFEYREDYKFNPEDHDMDDSRTPPQELCDVDIKEEENNETFNETFNHHHLNQSDILGSGERLSVSPNHSISRNGIHEAESPATISTSNVLDSSGAYMAGGGDMSGFQANFNMNNISATLEALNALRSGQFPSAAAAAAAAIHQHQAQAQVAMHHQHNNNNNNNNNNEDDEDSMKPQSKRQRTSSGSMLGSEDQAPVLAPSVPASSDSQALERSGSSNGLTMPGTAVSTNANSSSSNNNNFELRMFMEMQSKEHMMRMKILEVQLQAAKHSRDLVEINKTLALQKLQLELASKRLPS",
        "length": 499,
        "header": "tr|A0A0B4KGD0-1|A0A0B4KGD0_DROME Isoform 1 of Regulatory protein zeste  OS=Drosophila melanogaster OX=7227 GN=apt PE=1 SV=1 CANONICAL=A0A0B4KGD0-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0B4KGD0-1",
            "url": "",
            "sequence": {
                "sequence": "MLNYWEGQSGASNSTVRVNKQYSATDLEAFMKIAANWQNSNHNLLEGVDIKTEMTQYMNSPSMNMYKKRERTQNWNHQEKKYLLDLCRKDMRIIENKRLDAGLTAVKNKAWKIIHQKFSNQFGTDRTCNRLKEQWRRMKACTRNEILDYNNRLARFGAEVADRKKPSPFTFEVWDFMQEAKKACKSEALDGIDYSKIPLALEEGFEYREDYKFNPEDHDMDDSRTPPQELCDVDIKEEENNETFNETFNHHHLNQSDILGSGERLSVSPNHSISRNGIHEAESPATISTSNVLDSSGAYMAGGGDMSGFQANFNMNNISATLEALNALRSGQFPSAAAAAAAAIHQHQAQAQVAMHHQHNNNNNNNNNNEDDEDSMKPQSKRQRTSSGSMLGSEDQAPVLAPSVPASSDSQALERSGSSNGLTMPGTAVSTNANSSSSNNNNFELRMFMEMQSKEHMMRMKILEVQLQAAKHSRDLVEINKTLALQKLQLELASKRLPS",
                "length": 499,
                "header": "tr|A0A0B4KGD0-1|A0A0B4KGD0_DROME Isoform 1 of Regulatory protein zeste  OS=Drosophila melanogaster OX=7227 GN=apt PE=1 SV=1 CANONICAL=A0A0B4KGD0-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 23598524,
                "end_pos": 23596748,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0332926",
                        "url": "https://www.ensembl.org/id/FBtr0332926"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0305146",
                        "url": "https://www.ensembl.org/id/FBpp0305146"
                    }
                ]
            }
        },
        {
            "isoform_ac": "O61602-1",
            "url": "",
            "sequence": {
                "sequence": "MVNKQYSATDLEAFMKIAANWQNSNHNLLEGVDIKTEMTQYMNSPSMNMYKKRERTQNWNHQEKKYLLDLCRKDMRIIENKRLDAGLTAVKNKAWKIIHQKFSNQFGTDRTCNRLKEQWRRMKACTRNEILDYNNRLARFGAEVADRKKPSPFTFEVWDFMQEAKKACKSEALDGIDYSKIPLALEEGFEYREDYKFNPEDHDMDDSRTPPQELCDVDIKEEENNETFNETFNHHHLNQSDILGSGERLSVSPNHSISRNGIHEAESPATISTSNVLDSSGAYMAGGGDMSGFQANFNMNNISATLEALNALRSGQFPSAAAAAAAAIHQHQAQAQVAMHHQHNNNNNNNNNNEDDEDSMKPQSKRQRTSSGSMLGSEDQAPVLAPSVPASSDSQALERSGSSNGLTMPGTAVSTNANSSSSNNNNFELRMFMEMQSKEHMMRMKILEVQLQAAKHSRDLVEINKTLALQKLQLELASKRLPS",
                "length": 483,
                "header": "tr|O61602-1|A0A0B4KGD0_DROME Computationally mapped isoform of Regulatory protein zeste  OS=Drosophila melanogaster OX=7227 GN=apt PE=1 SV=1 CANONICAL=A0A0B4KGD0-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 23598524,
                "end_pos": 23581466,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0072070",
                        "url": "https://www.ensembl.org/id/FBtr0072070"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0071979",
                        "url": "https://www.ensembl.org/id/FBpp0071979"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8MLR4-1",
            "url": "",
            "sequence": {
                "sequence": "MKIAANWQNSNHNLLEGVDIKTEMTQYMNSPSMNMYKKRERTQNWNHQEKKYLLDLCRKDMRIIENKRLDAGLTAVKNKAWKIIHQKFSNQFGTDRTCNRLKEQWRRMKACTRNEILDYNNRLARFGAEVADRKKPSPFTFEVWDFMQEAKKACKSEALDGIDYSKIPLALEEGFEYREDYKFNPEDHDMDDSRTPPQELCDVDIKEEENNETFNETFNHHHLNQSDILGSGERLSVSPNHSISRNGIHEAESPATISTSNVLDSSGAYMAGGGDMSGFQANFNMNNISATLEALNALRSGQFPSAAAAAAAAIHQHQAQAQVAMHHQHNNNNNNNNNNEDDEDSMKPQSKRQRTSSGSMLGSEDQAPVLAPSVPASSDSQALERSGSSNGLTMPGTAVSTNANSSSSNNNNFELRMFMEMQSKEHMMRMKILEVQLQAAKHSRDLVEINKTLALQKLQLELASKRLPS",
                "length": 469,
                "header": "tr|Q8MLR4-1|Q8MLR4_DROME Computationally mapped isoform of Regulatory protein zeste  OS=Drosophila melanogaster OX=7227 GN=apt PE=1 SV=1 CANONICAL=A0A0B4KGD0-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 23598524,
                "end_pos": 23596931,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0072068",
                        "url": "https://www.ensembl.org/id/FBtr0072068"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0071977",
                        "url": "https://www.ensembl.org/id/FBpp0071977"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q9W1M6-1",
            "url": "",
            "sequence": {
                "sequence": "MTMANGAVNKQYSATDLEAFMKIAANWQNSNHNLLEGVDIKTEMTQYMNSPSMNMYKKRERTQNWNHQEKKYLLDLCRKDMRIIENKRLDAGLTAVKNKAWKIIHQKFSNQFGTDRTCNRLKEQWRRMKACTRNEILDYNNRLARFGAEVADRKKPSPFTFEVWDFMQEAKKACKSEALDGIDYSKIPLALEEGFEYREDYKFNPEDHDMDDSRTPPQELCDVDIKEEENNETFNETFNHHHLNQSDILGSGERLSVSPNHSISRNGIHEAESPATISTSNVLDSSGAYMAGGGDMSGFQANFNMNNISATLEALNALRSGQFPSAAAAAAAAIHQHQAQAQVAMHHQHNNNNNNNNNNEDDEDSMKPQSKRQRTSSGSMLGSEDQAPVLAPSVPASSDSQALERSGSSNGLTMPGTAVSTNANSSSSNNNNFELRMFMEMQSKEHMMRMKILEVQLQAAKHSRDLVEINKTLALQKLQLELASKRLPS",
                "length": 489,
                "header": "tr|Q9W1M6-1|A0A0B4KGD0_DROME Computationally mapped isoform of Regulatory protein zeste  OS=Drosophila melanogaster OX=7227 GN=apt PE=1 SV=2 CANONICAL=A0A0B4KGD0-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 23598524,
                "end_pos": 23565030,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0072066",
                        "url": "https://www.ensembl.org/id/FBtr0072066"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0071975",
                        "url": "https://www.ensembl.org/id/FBpp0071975"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "dme:Dmel_CG5393",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG5393",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "DNA-binding transcription factor activity",
                        "id": "GO:0003700",
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                                "id": "A0A0B4KGD0",
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                                "id": "A0A0B4KGD0",
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                                "id": "A0A0B4KGD0",
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                                "id": "A0A0B4KGD0",
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