The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "A1Z7L8-1" ], "evidence": [ { "id": "R-DME-1181149", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1181149" } ] }, { "id": "R-DME-1181153", "name": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "A1Z7L8-1" ], "evidence": [ { "id": "R-DME-1181153", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1181153" } ] }, { "id": "R-DME-1549526", "name": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-DME-3006353" ], "output_participant_list": [ "R-DME-3009186" ], "enzyme_list": [ "A0A0B4KG59-1", "A1Z7L8-1" ], "evidence": [ { "id": "R-DME-1549526", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1549526" } ] }, { "id": "R-DME-170835", "name": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytoplasmic side of plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "A1Z7L8-1" ], "evidence": [ { "id": "R-DME-170835", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-170835" } ] }, { "id": "R-DME-170843", "name": "TGFBR2 phosphorylates TGFBR1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "A1Z7L8-1" ], "evidence": [ { "id": "R-DME-170843", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-170843" } ] }, { "id": "R-DME-170846", "name": "TGFBR2 recruits TGFBR1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "A1Z7L8-1", "P48375-1" ], "evidence": [ { "id": "R-DME-170846", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-170846" } ] }, { "id": "R-DME-170850", "name": "Phosphorylated SMAD2/3 dissociates from TGFBR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "early endosome", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "A1Z7L8-1" ], "evidence": [ { "id": "R-DME-170850", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-170850" } ] }, { "id": "R-DME-170861", "name": "Dimeric TGF-beta-1 binds to the receptor", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1" ], "evidence": [ { "id": "R-DME-170861", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-170861" } ] }, { "id": "R-DME-170868", "name": "Activated type I receptor phosphorylates SMAD2/3 directly", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "early endosome membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "A1Z7L8-1" ], "evidence": [ { "id": "R-DME-170868", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-170868" } ] }, { "id": "R-DME-173512", "name": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytoplasmic side of plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "A1Z7L8-1" ], "evidence": [ { "id": "R-DME-173512", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-173512" } ] }, { "id": "R-DME-201443", "name": "Type II receptor phosphorylates type I receptor", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "M9PE88-1", "Q9VMT1-1" ], "evidence": [ { "id": "R-DME-201443", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-201443" } ] }, { "id": "R-DME-201453", "name": "Phospho-R-Smad1/5/8 dissociates from the receptor complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "early endosome", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "M9PE88-1", "Q9VMT1-1" ], "evidence": [ { "id": "R-DME-201453", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-201453" } ] }, { "id": "R-DME-201457", "name": "BMP2 binds to the receptor complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "M9PE88-1", "Q9VMT1-1" ], "evidence": [ { "id": "R-DME-201457", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-201457" } ] }, { "id": "R-DME-201475", "name": "I-Smad competes with R-Smad1/5/8 for type I receptor", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "M9PE88-1", "Q9VMT1-1" ], "evidence": [ { "id": "R-DME-201475", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-201475" } ] }, { "id": "R-DME-201476", "name": "Activated type I receptor phosphorylates R-Smad1/5/8 directly", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "M9PE88-1", "Q9VMT1-1" ], "evidence": [ { "id": "R-DME-201476", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-201476" } ] }, { "id": "R-DME-201648", "name": "An anchoring protein, Endofin, recruits R-Smad1/5/8", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, early endosome membrane, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "M9PE88-1", "Q9VMT1-1" ], "evidence": [ { "id": "R-DME-201648", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-201648" } ] }, { "id": "R-DME-201821", "name": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytoplasmic side of plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9V853-1", "A0A0B4KG59-1", "M9PE88-1", "Q9VMT1-1" ], "evidence": [ { "id": "R-DME-201821", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-201821" } ] }, { "id": "R-DME-202604", "name": "Formation of a heteromeric BMP receptor complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "M9PE88-1", "Q9VMT1-1" ], "evidence": [ { "id": "R-DME-202604", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-202604" } ] }, { "id": "R-DME-2128994", "name": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "A1Z7L8-1" ], "evidence": [ { "id": "R-DME-2128994", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2128994" } ] }, { "id": "R-DME-2160931", "name": "Disassembly of tight junctions", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cell junction", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1Z9X0-1", "Q9V853-1", "A0A0B4KG59-1", "A1Z7L8-1" ], "evidence": [ { "id": "R-DME-2160931", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2160931" } ] }, { "id": "R-DME-2160932", "name": "SMURF1 binds phosphorylated PARD6A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cell junction, cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1Z9X0-1", "Q9V853-1", "A0A0B4KG59-1", "A1Z7L8-1" ], "evidence": [ { "id": "R-DME-2160932", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2160932" } ] }, { "id": "R-DME-2160935", "name": "SMURF1 ubiquitinates RHOA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cell junction, cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1Z9X0-1", "Q9V853-1", "A0A0B4KG59-1", "A1Z7L8-1" ], "evidence": [ { "id": "R-DME-2160935", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2160935" } ] }, { "id": "R-DME-2169046", "name": "Degradation of TGF-beta receptor complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "A1Z7L8-1" ], "evidence": [ { "id": "R-DME-2169046", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2169046" } ] }, { "id": "R-DME-4332235", "name": "CBL binds TGFBR2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KG59-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-4332235", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-4332235" } ] }, { "id": "R-DME-4332236", "name": "CBL neddylates TGFBR2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VSF3-1", "A0A0B4KG59-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-4332236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-4332236" } ] } ], "reaction_participants": [ { "participant_id": "R-DME-3006353", "participant_name": "Smox [cytosol]", "crossref": [ { "id": "O96660", "database": "UniProt", "url": "" }, { "id": "NP_001285006.1", "database": "RefSeq", "url": "" }, { "id": "FBgn0025800", "database": "Flybase", "url": "" }, { "id": "NP_511079.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-DME-3009186", "participant_name": "phospho-Smox [cytosol]", "crossref": [ { "id": "NP_001285006.1", "database": "RefSeq", "url": "" }, { "id": "NP_511079.1", "database": "RefSeq", "url": "" }, { "id": "O96660", "database": "UniProt", "url": "" }, { "id": "FBgn0025800", "database": "Flybase", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0B4KG59", "gene_name": "put", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "A0A0B4KG59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KG59" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "A0A0B4KG59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KG59" } ] } ] }, { "uniprot_ac": "A0A8I5ZJI2", "gene_name": "Bmpr1b", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "A0A8I5ZJI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZJI2" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "A0A8I5ZJI2", "database": "UniProtKB", 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