{
    "uniprot_canonical_ac": "A0A0B4KG38-1",
    "uniprot_ac": "A0A0B4KG38",
    "uniprot_id": "A0A0B4KG38_DROME",
    "mass": {
        "chemical_mass": 93619.0,
        "monoisotopic_mass": 93619.0
    },
    "refseq": {
        "ac": "NP_001137680",
        "name": "semaphorin 2b, isoform B",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137680"
    },
    "gene_names": [
        {
            "name": "Sema2b",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KG38",
            "id": "A0A0B4KG38"
        },
        {
            "name": "CG30322; CG33960; CG4383; Dmel\\CG33960; sema-2b; Sema-2b; sema2b; SemaIIB",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137680",
            "id": "NP_001137680"
        },
        {
            "name": "CG30322",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KG38",
            "id": "A0A0B4KG38"
        },
        {
            "name": "CG33960-RA",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KG38",
            "id": "A0A0B4KG38"
        },
        {
            "name": "CG33960",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KG38",
            "id": "A0A0B4KG38"
        },
        {
            "name": "CG4383",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KG38",
            "id": "A0A0B4KG38"
        },
        {
            "name": "Dmel\\CG33960",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KG38",
            "id": "A0A0B4KG38"
        },
        {
            "name": "Dmel_CG33960",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KG38",
            "id": "A0A0B4KG38"
        },
        {
            "name": "Sema-2b",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KG38",
            "id": "A0A0B4KG38"
        },
        {
            "name": "Sema2b",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137680",
            "id": "NP_001137680"
        },
        {
            "name": "SemaIIB",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KG38",
            "id": "A0A0B4KG38"
        },
        {
            "name": "sema-2b",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KG38",
            "id": "A0A0B4KG38"
        },
        {
            "name": "sema2b",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KG38",
            "id": "A0A0B4KG38"
        }
    ],
    "protein_names": [
        {
            "name": "CG33960-PA; Sema2b-PA; semaphorin; semiphorin; Semaphorin-2b; semaphorin2b; Sema-2b",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033952",
            "id": "NP_001033952"
        },
        {
            "name": "CG33960-PB; Sema2b-PB; semaphorin; semiphorin; Semaphorin-2b; semaphorin2b; Sema-2b",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137680",
            "id": "NP_001137680"
        },
        {
            "name": "CG33960-PD; Sema2b-PD; semaphorin; semiphorin; Semaphorin-2b; semaphorin2b; Sema-2b",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261024",
            "id": "NP_001261024"
        },
        {
            "name": "Semaphorin 2b, isoform D",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A0B4KG38"
        },
        {
            "name": "semaphorin 2b, isoform A",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033952",
            "id": "NP_001033952"
        },
        {
            "name": "semaphorin 2b, isoform B",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137680",
            "id": "NP_001137680"
        },
        {
            "name": "semaphorin 2b, isoform D",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261024",
            "id": "NP_001261024"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0050834",
            "recommended_name": {
                "id": "DOID:0050834",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050834",
                "name": "CHARGE syndrome",
                "description": "A syndrome that is characterized by a pattern of congenital anomalies including choanal atresia and malformations of the heart, inner ear, and retina."
            },
            "synonyms": [
                {
                    "id": "DOID:0050834",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050834",
                    "name": "CHARGE association",
                    "description": ""
                },
                {
                    "id": "MONDO:0008965",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008965",
                    "name": "CHARGE syndrome",
                    "description": "CHARGE syndrome is a multiple congenital anomaly syndrome characterized by the variable combination of multiple anomalies, mainly Coloboma; Choanal atresia/stenosis; Cranial nerve dysfunction; Characteristic ear anomalies (known as the major 4 C's)."
                },
                {
                    "id": "MONDO:0008965",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008965",
                    "name": "CHARGE association",
                    "description": ""
                },
                {
                    "id": "MONDO:0008965",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008965",
                    "name": "CHARGE syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008965",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008965",
                    "name": "Hall-Hittner syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008965",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008965",
                    "name": "coloboma, heart defects, choanal atresia, retardation of Growth and development, genital abnormalities, and Ear anomalies association",
                    "description": ""
                },
                {
                    "id": "MONDO:0008965",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008965",
                    "name": "coloboma, heart malformation, choanal atresia, retardation of Growth and development, genital abnormalities, and Ear malformations (CHARGE) association",
                    "description": ""
                },
                {
                    "id": "MONDO:0008965",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008965",
                    "name": "coloboma-heart defects-atresia choanae-retardation of growth and development-genitourinary problems-ear abnormalities syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008965",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008965",
                    "name": "Charge association--coloboma, heart anomaly, choanal atresia, retardation, genital and Ear anomalies",
                    "description": ""
                },
                {
                    "id": "MONDO:0008965",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008965",
                    "name": "coloboma, heart anomaly, choanal atresia, retardation, genital and ear anomalies",
                    "description": ""
                },
                {
                    "id": "MIM:214800",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/214800",
                    "name": "CHARGE syndrome",
                    "description": "CHARGE syndrome"
                }
            ],
            "evidence": [
                {
                    "id": "0050834",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050834"
                }
            ]
        },
        {
            "disease_id": "DOID:0090080",
            "recommended_name": {
                "id": "DOID:0090080",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0090080",
                "name": "hypogonadotropic hypogonadism 16 with or without anosmia",
                "description": "A hypogonadotropic hypogonadism that has_material_basis_in mutation in the SEMA3A gene on chromosome 7, sometimes in association with mutations in other genes."
            },
            "synonyms": [
                {
                    "id": "MONDO:0013961",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013961",
                    "name": "hypogonadotropic hypogonadism 16 with or without anosmia",
                    "description": "Any hypogonadotropic hypogonadism in which the cause of the disease is a mutation in the SEMA3A gene."
                },
                {
                    "id": "MONDO:0013961",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013961",
                    "name": "SEMA3A hypogonadotropic hypogonadism",
                    "description": ""
                },
                {
                    "id": "MONDO:0013961",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013961",
                    "name": "hypogonadotropic hypogonadism 16 with or without anosmia",
                    "description": ""
                },
                {
                    "id": "MONDO:0013961",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013961",
                    "name": "hypogonadotropic hypogonadism caused by mutation in SEMA3A",
                    "description": ""
                },
                {
                    "id": "MONDO:0013961",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013961",
                    "name": "HH16",
                    "description": ""
                },
                {
                    "id": "MIM:614897",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/614897",
                    "name": "Hypogonadotropic hypogonadism 16 with or without anosmia",
                    "description": "Hypogonadotropic hypogonadism 16 with or without anosmia"
                }
            ],
            "evidence": [
                {
                    "id": "0090080",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090080"
                }
            ]
        },
        {
            "disease_id": "DOID:224",
            "recommended_name": {
                "id": "DOID:224",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:224",
                "name": "transient cerebral ischemia",
                "description": "A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death."
            },
            "synonyms": [
                {
                    "id": "DOID:224",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:224",
                    "name": "TIA",
                    "description": ""
                },
                {
                    "id": "DOID:224",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:224",
                    "name": "TIA - Transient ischaemic attack",
                    "description": ""
                },
                {
                    "id": "DOID:224",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:224",
                    "name": "Transient cerebral ischaemia",
                    "description": ""
                },
                {
                    "id": "DOID:224",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:224",
                    "name": "Transient ischemic attacks",
                    "description": ""
                },
                {
                    "id": "DOID:224",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:224",
                    "name": "transient ischemic attack",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "224",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:224"
                }
            ]
        },
        {
            "disease_id": "DOID:7148",
            "recommended_name": {
                "id": "DOID:7148",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:7148",
                "name": "rheumatoid arthritis",
                "description": "An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint."
            },
            "synonyms": [
                {
                    "id": "DOID:7148",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:7148",
                    "name": "Arthritis or polyarthritis, rheumatic",
                    "description": ""
                },
                {
                    "id": "DOID:7148",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:7148",
                    "name": "atrophic Arthritis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008383",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008383",
                    "name": "rheumatoid arthritis",
                    "description": "A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor."
                },
                {
                    "id": "MONDO:0008383",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008383",
                    "name": "atrophic arthritis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008383",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008383",
                    "name": "RA",
                    "description": ""
                },
                {
                    "id": "MONDO:0008383",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008383",
                    "name": "arthritis or polyarthritis, rheumatic",
                    "description": ""
                },
                {
                    "id": "MONDO:0008383",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008383",
                    "name": "arthritis, rheumatoid",
                    "description": ""
                },
                {
                    "id": "MONDO:0008383",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008383",
                    "name": "autoimmune arthritis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008383",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008383",
                    "name": "rheumatoid arthritis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008383",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008383",
                    "name": "rheumatoid arthritis, progression of",
                    "description": ""
                },
                {
                    "id": "MONDO:0008383",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008383",
                    "name": "rheumatoid arthritis, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MIM:180300",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/180300",
                    "name": "Rheumatoid arthritis",
                    "description": "Rheumatoid arthritis"
                }
            ],
            "evidence": [
                {
                    "id": "7148",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:7148"
                }
            ]
        },
        {
            "disease_id": "DOID:891",
            "recommended_name": {
                "id": "DOID:891",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:891",
                "name": "progressive myoclonus epilepsy",
                "description": "A variable age at onset electroclinical syndrome characterised by a relentlessly progressive disease course until death."
            },
            "synonyms": [
                {
                    "id": "DOID:891",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:891",
                    "name": "PME",
                    "description": ""
                },
                {
                    "id": "DOID:891",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:891",
                    "name": "progressive myoclonic epilepsy",
                    "description": ""
                },
                {
                    "id": "MONDO:0010682",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010682",
                    "name": "obsolete myoclonic epilepsy, progressive, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010682",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010682",
                    "name": "myoclonic epilepsy, progressive",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "Unverricht-Lundborg syndrome",
                    "description": "Unverricht-Lundborg disease (ULD) is a rare progressive myoclonic epilepsy disorder characterized by action- and stimulus-sensitive myoclonus, and tonic-clonic seizures with ataxia, but with only a mild cognitive decline over time."
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "PME type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "ULD",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "Unverricht - Lundborg disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "Unverricht's disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "Unverricht-Lundborg disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "Unverricht-Lundborg syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "epilepsy, progressive myoclonic 1A (Unverricht and Lundborg)",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "progressive myoclonic epilepsy type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "progressive myoclonus epilepsy type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "Baltic myoclonic epilepsy",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "EPM1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "Uld",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "epilepsy, progressive myoclonic type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "epilepsy, progressive myoclonic, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "epilepsy, progressive myoclonic, 1A",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "epilepsy, progressive myoclonus 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "myoclonic epilepsy of Unverricht and Lundborg",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "myoclonus progressive epilepsy of Unverricht and Lundborg",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "progressive myoclonic epilepsy",
                    "description": ""
                },
                {
                    "id": "MONDO:0009698",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009698",
                    "name": "progressive myoclonus epilepsy Baltic myoclonic epilepsy",
                    "description": ""
                },
                {
                    "id": "MIM:254800",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/254800",
                    "name": "Epilepsy, progressive myoclonic 1",
                    "description": "Epilepsy, progressive myoclonic 1"
                }
            ],
            "evidence": [
                {
                    "id": "891",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:891"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0B4KG38",
                    "url": "https://www.uniprot.org/uniprot/A0A0B4KG38"
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            ],
            "common_name": "Fruit fly"
        }
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            "name": "Sema2b",
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                "start_pos": 16431758,
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                "evidence": [
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                        "id": "FBgn0264273",
                        "url": "https://www.ensembl.org/id/FBgn0264273"
                    }
                ]
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        }
    ],
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        {
            "id": "FBgn0264273",
            "url": "https://bgee.org/?page=gene&gene_id=FBgn0264273",
            "database": "Bgee",
            "categories": [
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            ]
        },
        {
            "id": "cd11238",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11238",
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            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "FBgn0264273",
            "url": "https://flybase.org/reports/FBgn0264273",
            "database": "FlyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "246538",
            "url": "https://www.ncbi.nlm.nih.gov/gene/246538",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001627",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001627",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015943",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027231",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027231",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036352",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036352",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "dme:Dmel_CG33960",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG33960",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "ESRQMQC",
            "url": "https://omabrowser.org/oma/group/ESRQMQC/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5399685at2759",
            "url": "http://www.orthodb.org/?query=5399685at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11036",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11036:SF90",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036:SF90",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "6QP8",
            "url": "https://www.rcsb.org/structure/6QP8",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "PF01403",
            "url": "http://pfam.xfam.org/family/PF01403",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-399954",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-399954",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-399955",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-399955",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-399956",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-399956",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-416572",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-416572",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-416700",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-416700",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001261024",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261024",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0B4KG38",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KG38",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0B4KG38-1",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KG38-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A1ZAF5",
            "url": "https://www.uniprot.org/uniprot/A1ZAF5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A1ZAF5-1",
            "url": "https://www.uniprot.org/uniprot/A1ZAF5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q29QV5",
            "url": "https://www.uniprot.org/uniprot/Q29QV5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q29QV5-1",
            "url": "https://www.uniprot.org/uniprot/Q29QV5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
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        "sequence": "MPLNAQLKIAQSVNKVTYAKVSDSNCCAKKQQKYSIADFSQAKRQAGSMCATGKGKHRLCSLSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTGSSAAHHLRHHKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYKMPTDDTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTCHNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRCVSDPYCGWDKDVNACRPYQLGLLQDVANETSGICDTSVLRKKVTSSYGQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRYDSYLDGTLLCSYGVTVDAHRCSPPSQKQDYQKIYSHWCNEFEKYKSAMKQWQAKQEQCGLKDKTGPISSNGKHVNDVFSNDALVXPRKYLYSFEFLSSATEGVASAHRKLYIFVFVLTIFARF",
        "length": 824,
        "header": "tr|A0A0B4KG38-1|A0A0B4KG38_DROME Isoform 1 of Semaphorin 2b, isoform D  OS=Drosophila melanogaster OX=7227 GN=Sema2b PE=1 SV=1 CANONICAL=A0A0B4KG38-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0B4KG38-1",
            "url": "",
            "sequence": {
                "sequence": "MPLNAQLKIAQSVNKVTYAKVSDSNCCAKKQQKYSIADFSQAKRQAGSMCATGKGKHRLCSLSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTGSSAAHHLRHHKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYKMPTDDTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTCHNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRCVSDPYCGWDKDVNACRPYQLGLLQDVANETSGICDTSVLRKKVTSSYGQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRYDSYLDGTLLCSYGVTVDAHRCSPPSQKQDYQKIYSHWCNEFEKYKSAMKQWQAKQEQCGLKDKTGPISSNGKHVNDVFSNDALVXPRKYLYSFEFLSSATEGVASAHRKLYIFVFVLTIFARF",
                "length": 824,
                "header": "tr|A0A0B4KG38-1|A0A0B4KG38_DROME Isoform 1 of Semaphorin 2b, isoform D  OS=Drosophila melanogaster OX=7227 GN=Sema2b PE=1 SV=1 CANONICAL=A0A0B4KG38-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 16429437,
                "end_pos": 16399094,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0329992",
                        "url": "https://www.ensembl.org/id/FBtr0329992"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0303027",
                        "url": "https://www.ensembl.org/id/FBpp0303027"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A1ZAF5-1",
            "url": "",
            "sequence": {
                "sequence": "MPLNAQLKIAQSVNKVTYAKVSDSNCCAKKQQKYSIADFSQAKRQAGSMCATGKGKHRLCSLSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTGSSAAHHLRHHKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDILNCVSKGKREVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYKMPTDDTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTCHNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRCVSDPYCGWDKDVNACRPYQLGLLQDVANETSGICDTSVLRKKVTSSYGQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRYDSYLDGTLLCSYGVTVDAHRCSPPSQKQDYQKIYSHWCNEFEKYKSAMKQWQAKQEQCGLKDKTGPISSNGKHVNDVFSNDALV",
                "length": 784,
                "header": "tr|A1ZAF5-1|A1ZAF5_DROME Computationally mapped isoform of Semaphorin 2b, isoform C  OS=Drosophila melanogaster OX=7227 GN=Sema2b PE=2 SV=1 CANONICAL=A0A0B4KG38-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 16428812,
                "end_pos": 16399094,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0329991",
                        "url": "https://www.ensembl.org/id/FBtr0329991"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0303026",
                        "url": "https://www.ensembl.org/id/FBpp0303026"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q29QV5-1",
            "url": "",
            "sequence": {
                "sequence": "MPLNAQLKIAQSVNKVTYAKVSDSNCCAKKQQKYSIADFSQAKRQAGSMCATGKGKHRLCSLSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTGSSAAHHLRHHKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYKMPTDDTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTCHNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRCVSDPYCGWDKDVNACRPYQLGLLQDVANETSGICDTSVLRKKVTSSYGQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRYDSYLDGTLLCSYGVTVDAHRCSPPSQKQDYQKIYSHWCNEFEKYKSAMKQWQAKQEQCGLKDKTGPISSNGKHVNDVFSNDALV",
                "length": 785,
                "header": "tr|Q29QV5-1|A0A0B4KG38_DROME Computationally mapped isoform of Semaphorin 2b, isoform D  OS=Drosophila melanogaster OX=7227 GN=Sema2b PE=1 SV=1 CANONICAL=A0A0B4KG38-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 16428812,
                "end_pos": 16399094,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0290009",
                        "url": "https://www.ensembl.org/id/FBtr0290009"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0288448",
                        "url": "https://www.ensembl.org/id/FBpp0288448"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.",
            "journal": "Nat. Commun.",
            "date": "2019",
            "authors": "Rozbesky Daniel, Robinson Ross A, Jain Vitul, Renner Max, Malinauskas Tomas, Harlos Karl, Siebold Christian, Jones E Yvonne",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0B4KG38",
                    "url": "https://www.uniprot.org/uniprot/A0A0B4KG38"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31417095",
                    "url": "https://glygen.org/publication/PubMed/31417095"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "dme:Dmel_CG33960",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG33960",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-DME-399954",
            "name": "Sema3A PAK dependent Axon repulsion",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-399954",
            "resource": "Reactome",
            "description": "Sema3A PAK dependent Axon repulsion"
        },
        {
            "id": "R-DME-399955",
            "name": "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-399955",
            "resource": "Reactome",
            "description": "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"
        },
        {
            "id": "R-DME-399956",
            "name": "CRMPs in Sema3A signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-399956",
            "resource": "Reactome",
            "description": "CRMPs in Sema3A signaling"
        },
        {
            "id": "R-DME-416572",
            "name": "Sema4D induced cell migration and growth-cone collapse",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-416572",
            "resource": "Reactome",
            "description": "Sema4D induced cell migration and growth-cone collapse"
        },
        {
            "id": "R-DME-416700",
            "name": "Other semaphorin interactions",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-416700",
            "resource": "Reactome",
            "description": "Other semaphorin interactions"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "semaphorin receptor binding",
                        "id": "GO:0030215",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030215",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KG38",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KG38"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chemorepellent activity",
                        "id": "GO:0045499",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045499",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KG38",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KG38"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 10,
                "go_terms": [
                    {
                        "name": "positive regulation of cell migration",
                        "id": "GO:0030335",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KG38",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KG38"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "semaphorin-plexin signaling pathway",
                        "id": "GO:0071526",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071526",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KG38",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KG38"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative chemotaxis",
                        "id": "GO:0050919",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050919",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KG38",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KG38"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "axon guidance",
                        "id": "GO:0007411",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KG38",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KG38"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dendrite self-avoidance",
                        "id": "GO:0070593",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070593",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KG38",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KG38"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of cell-matrix adhesion",
                        "id": "GO:0001952",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001952",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KG38",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KG38"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "olfactory bulb axon guidance",
                        "id": "GO:0071678",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071678",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KG38",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KG38"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of axon extension involved in axon guidance",
                        "id": "GO:0048843",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048843",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KG38",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KG38"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synaptic target attraction",
                        "id": "GO:0016200",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016200",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KG38",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KG38"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dendrite guidance",
                        "id": "GO:0070983",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070983",
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