{
    "uniprot_canonical_ac": "A0A0B4KEE7-1",
    "uniprot_ac": "A0A0B4KEE7",
    "uniprot_id": "A0A0B4KEE7_DROME",
    "mass": {
        "chemical_mass": 161601.0,
        "monoisotopic_mass": 161601.0
    },
    "refseq": {
        "ac": "NP_610316",
        "name": "Leucine-rich repeat, isoform B",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610316"
    },
    "gene_names": [
        {
            "name": "LRR",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7",
            "id": "A0A0B4KEE7"
        },
        {
            "name": "CG1399",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7",
            "id": "A0A0B4KEE7"
        },
        {
            "name": "CG1576",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7",
            "id": "A0A0B4KEE7"
        },
        {
            "name": "Carmil; CG1399; CG1576; Dmel\\CG1399; Dmel\\LRR",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724593",
            "id": "NP_724593"
        },
        {
            "name": "Dmel\\CG1399",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7",
            "id": "A0A0B4KEE7"
        },
        {
            "name": "Dmel\\LRR",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7",
            "id": "A0A0B4KEE7"
        },
        {
            "name": "Dmel_CG1399",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7",
            "id": "A0A0B4KEE7"
        },
        {
            "name": "LRR",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724593",
            "id": "NP_724593"
        }
    ],
    "protein_names": [
        {
            "name": "CG1399-PA; LRR-PA; dcarmil; leucine-rich repeat",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724593",
            "id": "NP_724593"
        },
        {
            "name": "CG1399-PB; LRR-PB; dcarmil; leucine-rich repeat",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610316",
            "id": "NP_610316"
        },
        {
            "name": "CG1399-PC; LRR-PC; dcarmil; leucine-rich repeat",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163075",
            "id": "NP_001163075"
        },
        {
            "name": "CG1399-PD; LRR-PD; dcarmil; leucine-rich repeat",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163076",
            "id": "NP_001163076"
        },
        {
            "name": "CG1399-PF; LRR-PF; dcarmil; leucine-rich repeat",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260788",
            "id": "NP_001260788"
        },
        {
            "name": "CG1399-PG; LRR-PG; dcarmil; leucine-rich repeat",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163077",
            "id": "NP_001163077"
        },
        {
            "name": "Leucine-rich repeat, isoform A",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724593",
            "id": "NP_724593"
        },
        {
            "name": "Leucine-rich repeat, isoform B",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610316",
            "id": "NP_610316"
        },
        {
            "name": "Leucine-rich repeat, isoform C",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163075",
            "id": "NP_001163075"
        },
        {
            "name": "Leucine-rich repeat, isoform D",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163076",
            "id": "NP_001163076"
        },
        {
            "name": "Leucine-rich repeat, isoform F",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260788",
            "id": "NP_001260788"
        },
        {
            "name": "Leucine-rich repeat, isoform F",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A0B4KEE7"
        },
        {
            "name": "Leucine-rich repeat, isoform G",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163077",
            "id": "NP_001163077"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0111984",
            "recommended_name": {
                "id": "DOID:0111984",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111984",
                "name": "immunodeficiency 58",
                "description": "A combined T cell and B cell immunodeficiency characterized by defective T-cell function with decreased Treg cells and deficient CD3/CD28 costimulation responses in both CD4+ and CD8+ T cells, variable impairment in B-cell function, early-onset skin lesions, recurrent respiratory infections or allergies, and chronic persistent infections that has_material_basis_in homozygous or compound heterozygous mutation in the CARMIL2 gene on chromosome 16q22.1."
            },
            "synonyms": [
                {
                    "id": "DOID:0111984",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111984",
                    "name": "IMD58",
                    "description": ""
                },
                {
                    "id": "DOID:0111984",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111984",
                    "name": "severe combined immunodeficiency due to CARMIL2 deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0029134",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0029134",
                    "name": "severe combined immunodeficiency due to CARMIL2 deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0029134",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0029134",
                    "name": "immunodeficiency 58",
                    "description": ""
                },
                {
                    "id": "MONDO:0029134",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0029134",
                    "name": "IMD58",
                    "description": ""
                },
                {
                    "id": "MIM:618131",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/618131",
                    "name": "Immunodeficiency 58",
                    "description": "Immunodeficiency 58"
                }
            ],
            "evidence": [
                {
                    "id": "0111984",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111984"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0B4KEE7",
                    "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "gene": [
        {
            "name": "LRR",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7",
            "locus": {
                "chromosome": "2R",
                "start_pos": 7676540,
                "end_pos": 7698902,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "FBgn0033212",
                        "url": "https://www.ensembl.org/id/FBgn0033212"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "FBgn0033212",
            "url": "https://bgee.org/?page=gene&gene_id=FBgn0033212",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "FBgn0033212",
            "url": "https://flybase.org/reports/FBgn0033212",
            "database": "FlyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "35715",
            "url": "https://www.ncbi.nlm.nih.gov/gene/35715",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "A1Z734",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A1Z734*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001611",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011993",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR031943",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR031943",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR032675",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR041245",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041245",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "dme:Dmel_CG1399",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG1399",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "DKQENRV",
            "url": "https://omabrowser.org/oma/group/DKQENRV/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5476233at2759",
            "url": "http://www.orthodb.org/?query=5476233at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24112",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24112",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24112:SF66",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24112:SF66",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13516",
            "url": "http://pfam.xfam.org/family/PF13516",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF16000",
            "url": "http://pfam.xfam.org/family/PF16000",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF17888",
            "url": "http://pfam.xfam.org/family/PF17888",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-983231",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-983231",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001260788",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260788",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0B4KEE7",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0B4KEE7-1",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A1Z734",
            "url": "https://www.uniprot.org/uniprot/A1Z734",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A1Z734-1",
            "url": "https://www.uniprot.org/uniprot/A1Z734-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "E1JGZ7",
            "url": "https://www.uniprot.org/uniprot/E1JGZ7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "E1JGZ7-1",
            "url": "https://www.uniprot.org/uniprot/E1JGZ7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "E1JGZ8",
            "url": "https://www.uniprot.org/uniprot/E1JGZ8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "E1JGZ8-1",
            "url": "https://www.uniprot.org/uniprot/E1JGZ8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6NND6",
            "url": "https://www.uniprot.org/uniprot/Q6NND6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6NND6-1",
            "url": "https://www.uniprot.org/uniprot/Q6NND6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8IGL5",
            "url": "https://www.uniprot.org/uniprot/Q8IGL5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8IGL5-1",
            "url": "https://www.uniprot.org/uniprot/Q8IGL5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSTRSQLTKDLNESVKSILGRHTKILVKYMVKLETKGDKTENRVLVFTPVRVYLLSAKVPTKIECHFHYLDIVGVESKKSTHFSIVTNDRPYSFVTTGDAGNFSSVRHNHLLNADVILTDLASAIKQIFPTVPLKYIIRKIDIQPPERETIFSEEFRPSDPRNVGPCGGFSAQYACMCDFHGVPYREEVAWDVDTIYLSHDTRVLNLRDFDHLEPKDLMAIVSALEYNTFFRGLKAAHMRLSHETLERILHVLKRSMWLEELHLEALGLRWDFLNKLSISVITNSNPAIRTIDLSHNIIEDKGASSLCALFGKIVQGAIHLAGPIAKVSKGLCKLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGNSLKDDITNLHNFLAQPNVLEHLDLASTDITLENLFGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFSLKHLNIAGCKLPMEALKNLLLGLACNESTAGLYLDLSSNTLGAQGAHVLESCIHGVRVLQSLDISDNNLDAELAPVLTAISKNPSIRTLHLTRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELVLSENKLKHDLHDFINALGSNQSLQKLDISGNFMGDVGARLLAKALQINNRLRTIYMDKNGVTLQGYADIVYALEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNCNGLKRATGQGFRLQHGFMLSSTHQLVDKLVAETQDTISLAKGGSESASAVQRLITDAENCKQLMPKLQEAVRNESHPIEMKMTRVASELSYTIKSYLEETMETMMRTGIEQCPKTLGNQIVVQDLRKALAERLVVPEEFLQICLLNNAGSEIMNKVGEIEQSLAAAISDRATDEVLEALTRYRRGMGIAESPSVLLDEPQTPDIVRSRSSHDADGLIIRPGGRGSILPKLGLESPTKLEYLNLATPHLPTKRRSLAKKVRPQSVVENLSLGHFPDLLESPSSHRSNSQLSARAAAGAAALVGAANMTDSIAVDDGGVDECCDSITELPSASFQLQHLVKGRPKRAKTRAPTRPLVTTECAGGSREIGEGLEHFFRPGSVTPTTLTPLVSPTSEECSSLSFVDSPTMSRDGNGHMTSEETTPILEERRPIKLERQSPLLKSASWATRSRSTDNLEKYSPLVGRKSPLVKMRTEGGPGSGSATGAEETSMPSSNLLKATAREDKTRSPSSDSIKSHAAGEGSVIVKTGNGILRTPIVLQKPRPWSVVGSEPKAGGDLITGNGNADSSKTTPDKLEEDDVEIVTFGNTCSGSIVGITPGIALSTSGGGSIVGITPGGALEKKSVRELAAGLNRMELPLKPPVMPRTLLNATSVRTSTSSTGSTSNSVSVSSSTNANTSMTVLNQSQTRSRIVSSTSSTDSTETITERSTTSTSSSSSSSYEKQHAKACANLISNEILSMRNGQLGAKSGSCAESGGVKRIAGKEISTLFEETLVEELQQSMATRRGFRDSTYTKEDVVDL",
        "length": 1486,
        "header": "tr|A0A0B4KEE7-1|A0A0B4KEE7_DROME Isoform 1 of Leucine-rich repeat, isoform F  OS=Drosophila melanogaster OX=7227 GN=LRR PE=1 SV=1 CANONICAL=A0A0B4KEE7-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0B4KEE7-1",
            "url": "",
            "sequence": {
                "sequence": "MSTRSQLTKDLNESVKSILGRHTKILVKYMVKLETKGDKTENRVLVFTPVRVYLLSAKVPTKIECHFHYLDIVGVESKKSTHFSIVTNDRPYSFVTTGDAGNFSSVRHNHLLNADVILTDLASAIKQIFPTVPLKYIIRKIDIQPPERETIFSEEFRPSDPRNVGPCGGFSAQYACMCDFHGVPYREEVAWDVDTIYLSHDTRVLNLRDFDHLEPKDLMAIVSALEYNTFFRGLKAAHMRLSHETLERILHVLKRSMWLEELHLEALGLRWDFLNKLSISVITNSNPAIRTIDLSHNIIEDKGASSLCALFGKIVQGAIHLAGPIAKVSKGLCKLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGNSLKDDITNLHNFLAQPNVLEHLDLASTDITLENLFGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFSLKHLNIAGCKLPMEALKNLLLGLACNESTAGLYLDLSSNTLGAQGAHVLESCIHGVRVLQSLDISDNNLDAELAPVLTAISKNPSIRTLHLTRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELVLSENKLKHDLHDFINALGSNQSLQKLDISGNFMGDVGARLLAKALQINNRLRTIYMDKNGVTLQGYADIVYALEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNCNGLKRATGQGFRLQHGFMLSSTHQLVDKLVAETQDTISLAKGGSESASAVQRLITDAENCKQLMPKLQEAVRNESHPIEMKMTRVASELSYTIKSYLEETMETMMRTGIEQCPKTLGNQIVVQDLRKALAERLVVPEEFLQICLLNNAGSEIMNKVGEIEQSLAAAISDRATDEVLEALTRYRRGMGIAESPSVLLDEPQTPDIVRSRSSHDADGLIIRPGGRGSILPKLGLESPTKLEYLNLATPHLPTKRRSLAKKVRPQSVVENLSLGHFPDLLESPSSHRSNSQLSARAAAGAAALVGAANMTDSIAVDDGGVDECCDSITELPSASFQLQHLVKGRPKRAKTRAPTRPLVTTECAGGSREIGEGLEHFFRPGSVTPTTLTPLVSPTSEECSSLSFVDSPTMSRDGNGHMTSEETTPILEERRPIKLERQSPLLKSASWATRSRSTDNLEKYSPLVGRKSPLVKMRTEGGPGSGSATGAEETSMPSSNLLKATAREDKTRSPSSDSIKSHAAGEGSVIVKTGNGILRTPIVLQKPRPWSVVGSEPKAGGDLITGNGNADSSKTTPDKLEEDDVEIVTFGNTCSGSIVGITPGIALSTSGGGSIVGITPGGALEKKSVRELAAGLNRMELPLKPPVMPRTLLNATSVRTSTSSTGSTSNSVSVSSSTNANTSMTVLNQSQTRSRIVSSTSSTDSTETITERSTTSTSSSSSSSYEKQHAKACANLISNEILSMRNGQLGAKSGSCAESGGVKRIAGKEISTLFEETLVEELQQSMATRRGFRDSTYTKEDVVDL",
                "length": 1486,
                "header": "tr|A0A0B4KEE7-1|A0A0B4KEE7_DROME Isoform 1 of Leucine-rich repeat, isoform F  OS=Drosophila melanogaster OX=7227 GN=LRR PE=1 SV=1 CANONICAL=A0A0B4KEE7-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 7698146,
                "end_pos": 7677645,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0332911",
                        "url": "https://www.ensembl.org/id/FBtr0332911"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0305131",
                        "url": "https://www.ensembl.org/id/FBpp0305131"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A1Z734-1",
            "url": "",
            "sequence": {
                "sequence": "MGEMRTMEMMTHIDQYLRRIIELQIRDVVKQNRDKESVKSILGRHTKILVKYMVKLETKGDKTENRVLVFTPVRVYLLSAKVPTKIECHFHYLDIVGVESKKSTHFSIVTNDRPYSFVTTGDAGNFSSNADVILTDLASAIKQIFPTVPLKYIIRKIDIQPPERETIFSEEFRPSDPRNVGPCGGFSAQYACMCDFHGVPYREEVAWDVDTIYLSHDTRVLNLRDFDHLEPKDLMAIVSALEYNTFFRGLKAAHMRLSHETLERILHVLKRSMWLEELHLEALGLRWDFLNKLSISVITNSNPAIRTIDLSHNIIEDKGAIHLAGPIAKVSKGLCKLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGNSLKDDITNLHNFLAQPNVLEHLDLASTDITLENLFGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFSLKHLNIAGCKLPMEALKNLLLGLACNESTAGLYLDLSSNTLGAQGAHVLESCIHGVRVLQSLDISDNNLDAELAPVLTAISKNPSIRTLHLTRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELVLSENKLKHDLHDFINALGSNQSLQKLDISGNFMGDVGARLLAKALQINNRLRTIYMDKNGVTLQGYADIVYALEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNCNGLKRATGQGFRLQHGFMLSSTHQLVDKLVAETQDTISLAKGGSESASAVQRLITDAENCKQLMPKLQEAVRNESHPIEMKMTRVASELSYTIKSYLEETMETMMRTGIEQCPKTLGNQIVVQDLRKALAERLVVPEEFLQICLLNNAGSEIMNKVGEIEQSLAAAISDRATDEVLEALTRYRRGMGIAESPSVLLDEPQTPDIVRSRSSHDADGLIIRPGGRGSILPKLGLESPTATPHLPTKRRSLAKKVRPQSVVENLSLGHFPDLLESPSSHRSNSQLSARAAAGAAALVGAANMTDSIAVDDGGVDECCDSITELPSASFQLQHLVKGRPKRAKTRAPTRPLVTTECAGGSREIGEGLEHFFRPGSVTPTTLTPLVSPTSEECSSLSFVDSPTMSRDGNGHMTSEETTPILEERRPIKLERQSPLLKSASWATRSRSTDNLEKYSPLVGRKSPLVKMRTEGGPGSGSATGAEETSMPSSNLLKATAREDKTRSPSSDSIKSHAAGEGSVIVKTGNGILRTPIVLQKPRPWSVVGSEPKAGGDLITGNGNADSSKTTPDKLEEDDVEIVTFGNTCSGSIVGITPGIALSTSGGGSIVGITPGGALEKKSVRELAAGLNRMELPLKPPVMPRTLLNATSVRTSTSSTGSTSNSVSVSSSTNANTSMTVLNQSQTRSRIVSSTSSTDSTETITERSTTSTSSSSSSSYEKQHAKACANLISNEILSMRNGQLGAKSGSCAESGGVKRIAGKEISTLFEV",
                "length": 1452,
                "header": "tr|A1Z734-1|A1Z734_DROME Computationally mapped isoform of Leucine-rich repeat, isoform B  OS=Drosophila melanogaster OX=7227 GN=LRR PE=1 SV=2 CANONICAL=A0A0B4KEE7-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 7695194,
                "end_pos": 7677995,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0088939",
                        "url": "https://www.ensembl.org/id/FBtr0088939"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0088013",
                        "url": "https://www.ensembl.org/id/FBpp0088013"
                    }
                ]
            }
        },
        {
            "isoform_ac": "E1JGZ7-1",
            "url": "",
            "sequence": {
                "sequence": "MSTRSQLTKDLNESVKSILGRHTKILVKYMVKLETKGDKTENRVLVFTPVRVYLLSAKVPTKIECHFHYLDIVGVESKKSTHFSIVTNDRPYSFVTTGDAGNFSSNADVILTDLASAIKQIFPTVPLKYIIRKIDIQPPERETIFSEEFRPSDPRNVGPCGGFSAQYACMCDFHGVPYREEVAWDVDTIYLSHDTRVLNLRDFDHLEPKDLMAIVSALEYNTFFRGLKAAHMRLSHETLERILHVLKRSMWLEELHLEALGLRWDFLNKLSISVITNSNPAIRTIDLSHNIIEDKGAIHLAGPIAKVSKGLCKLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGNSLKDDITNLHNFLAQPNVLEHLDLASTDITLENLFGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFSLKHLNIAGCKLPMEALKNLLLGLACNESTAGLYLDLSSNTLGAQGAHVLESCIHGVRVLQSLDISDNNLDAELAPVLTAISKNPSIRTLHLTRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELVLSENKLKHDLHDFINALGSNQSLQKLDISGNFMGDVGARLLAKALQINNRLRTIYMDKNGVTLQGYADIVYALEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNCNGLKRATGQGFRLQHGFMLSSTHQLVDKLVAETQDTISLAKGGSESASAVQRLITDAENCKQLMPKLQEAVRNESHPIEMKMTRVASELSYTIKSYLEETMETMMRTGIEQCPKTLGNQIVVQDLRKALAERLVVPEEFLQICLLNNAGSEIMNKVGEIEQSLAAAISDRATDEVLEALTRYRRGMGIAESPSVLLDEPQTPDIVRSRSSHDADGLIIRPGGRGSILPKLGLESPTATPHLPTKRRSLAKKVRPQSVVENLSLGHFPDLLESPSSHRSNSQLSARAAAGAAALVGAANMTDSIAVDDGGVDECCDSITELPSASFQLQHLVKGRPKRAKTRAPTRPLVTTECAGGSREIGEGLEHFFRPGSVTPTTLTPLVSPTSEECSSLSFVDSPTMSRDGNGHMTSEETTPILEERRPIKLERQSPLLKSASWATRSRSTDNLEKYSPLVGRKSPLVKMRTEGGPGSGSATGAEETSMPSSNLLKATAREDKTRSPSSDSIKSHAAGEGSVIVKTGNGILRTPIVLQKPRPWSVVGSEPKAGGDLITGNGNADSSKTTPDKLEEDDVEIVTFGNTCSGSIVGITPGIALSTSGGGSIVGITPGGALEKKSVRELAAGLNRMGDIS",
                "length": 1296,
                "header": "tr|E1JGZ7-1|A0A0B4KEE7_DROME Computationally mapped isoform of Leucine-rich repeat, isoform F  OS=Drosophila melanogaster OX=7227 GN=LRR PE=1 SV=2 CANONICAL=A0A0B4KEE7-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 7698146,
                "end_pos": 7677724,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0332912",
                        "url": "https://www.ensembl.org/id/FBtr0332912"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0305132",
                        "url": "https://www.ensembl.org/id/FBpp0305132"
                    }
                ]
            }
        },
        {
            "isoform_ac": "E1JGZ8-1",
            "url": "",
            "sequence": {
                "sequence": "MSTRSQLTKDLNESVKSILGRHTKILVKYMVKLETKGDKTENRVLVFTPVRVYLLSAKVPTKIECHFHYLDIVGVESKKSTHFSIVTNDRPYSFVTTGDAGNFSSNADVILTDLASAIKQIFPTVPLKYIIRKIDIQPPERETIFSEEFRPSDPRNVGPCGGFSAQYACMCDFHGVPYREEVAWDVDTIYLSHDTRVLNLRDFDHLEPKDLMAIVSALEYNTFFRGLKAAHMRLSHETLERILHVLKRSMWLEELHLEALGLRWDFLNKLSISVITNSNPAIRTIDLSHNIIEDKGAIHLAGPIAKVSKGLCKLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGNSLKDDITNLHNFLAQPNVLEHLDLASTDITLENLFGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFSLKHLNIAGCKLPMEALKNLLLGLACNESTAGLYLDLSSNTLGAQGAHVLESCIHGVRVLQSLDISDNNLDAELAPVLTAISKNPSIRTLHLTRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELVLSENKLKHDLHDFINALGSNQSLQKLDISGNFMGDVGARLLAKALQINNRLRTIYMDKNGVTLQGYADIVYALEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNCNGLKRATGQGFRLQHGFMLSSTHQLVDKLVAETQDTISLAKGGSESASAVQRLITDAENCKQLMPKLQEAVRNESHPIEMKMTRVASELSYTIKSYLEETMETMMRTGIEQCPKTLGNQIVVQDLRKALAERLVVPEEFLQICLLNNAGSEIMNKVGEIEQSLAAAISDRATDEVLEALTRYRRGMGIAESPSVLLDEPQTPDIVRSRSSHDADGLIIRPGGRGSILPKLGLESPTATPHLPTKRRSLAKKVRPQSVVENLSLGHFPDLLESPSSHRSNSQLSARAAAGAAALVGAANMTDSIAVDDGGVDECCDSITELPSASFQLQHLVKGRPKRAKTRAPTRPLVTTECAGGSREIGEGLEHFFRPGSVTPTTLTPLVSPTSEECSSLSFVDSPTMSRDGNGHMTSEETTPILEERRPIKLERQSPLLKSASWATRSRSTDNLEKYSPLVGRKSPLVKMRTEGGPGSGSATGAEETSMPSSNLLKATAREDKTRSPSSDSIKSHAAGEGSVIVKTGNGILRTPIVLQKPRPWSVVGSEPKAGGDLITGNGNADSSKTTPDKLEEDDVEIVTFGNTCSGSIVGITPGIALSTSGGGSIVGITPGGALEKKSVRELAAGLNRMELPLKPPVMPRTLLNATSVRTSTSSTGSTSNSVSVSSSTNANTSMTVLNQSQTRSRIVSSTSSTDSTETITERSTTSTSSSSSSSYEKQHAKACANLISNEILSMRNGQLGAKSGSCAESGGVKRIAGKEISTLFEV",
                "length": 1429,
                "header": "tr|E1JGZ8-1|A0A0B4KEE7_DROME Computationally mapped isoform of Leucine-rich repeat, isoform F  OS=Drosophila melanogaster OX=7227 GN=LRR PE=1 SV=1 CANONICAL=A0A0B4KEE7-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 7698146,
                "end_pos": 7677995,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0300779",
                        "url": "https://www.ensembl.org/id/FBtr0300779"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0290003",
                        "url": "https://www.ensembl.org/id/FBpp0290003"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q6NND6-1",
            "url": "",
            "sequence": {
                "sequence": "MTDSIAVDDGGVDECCDSITELPSASFQLQHLVKGRPKRAKTRAPTRPLVTTECAGGSREIGEGLEHFFRPGSVTPTTLTPLVSPTSEECSSLSFVDSPTMSRDGNGHMTSEETTPILEERRPIKLERQSPLLKSASWATRSRSTDNLEKYSPLVGRKSPLVKMRTEGGPGSGSATGAEETSMPSSNLLKATAREDKTRSPSSDSIKSHAAGEGSVIVKTGNGILRTPIVLQKPRPWSVVGSEPKAGGDLITGNGNADSSKTTPDKLEEDDVEIVTFGNTCSGSIVGITPGIALSTSGGGSIVGITPGGALEKKSVRELAAGLNRMELPLKPPVMPRTLLNATSVRTSTSSTGSTSNSVSVSSSTNANTSMTVLNQSQTRSRIVSSTSSTDSTETITERSTTSTSSSSSSSYEKQHAKACANLISNEILSMRNGQLGAKSGSCAESGGVKRIAGKEISTLFEETLVEELQQSMATRRGFRDSTYTKEDVVDL",
                "length": 492,
                "header": "tr|Q6NND6-1|A0A0B4KEE7_DROME Computationally mapped isoform of Leucine-rich repeat, isoform F  OS=Drosophila melanogaster OX=7227 GN=LRR PE=1 SV=1 CANONICAL=A0A0B4KEE7-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 7679744,
                "end_pos": 7677645,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0300780",
                        "url": "https://www.ensembl.org/id/FBtr0300780"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0290004",
                        "url": "https://www.ensembl.org/id/FBpp0290004"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8IGL5-1",
            "url": "",
            "sequence": {
                "sequence": "MGLMRTLCCCFGAGQSNQSSGASPAYKACPDEEPLEELVTDPERADQSPKNEIEQSLAAAISDRATDEVLEALTRYRRGMGIAESPSVLLDEPQTPDIVRSRSSHDADGLIIRPGGRGSILPKLGLESPTATPHLPTKRRSLAKKVRPQSVVENLSLGHFPDLLESPSSHRSNSQLSARAAAGAAALVGAANMTDSIAVDDGGVDECCDSITELPSASFQLQHLVKGRPKRAKTRAPTRPLVTTECAGGSREIGEGLEHFFRPGSVTPTTLTPLVSPTSEECSSLSFVDSPTMSRDGNGHMTSEETTPILEERRPIKLERQSPLLKSASWATRSRSTDNLEKYSPLVGRKSPLVKMRTEGGPGSGSATGAEETSMPSSNLLKATAREDKTRSPSSDSIKSHAAGEGSVIVKTGNGILRTPIVLQKPRPWSVVGSEPKAGGDLITGNGNADSSKTTPDKLEEDDVEIVTFGNTCSGSIVGITPGIALSTSGGGSIVGITPGGALEKKSVRELAAGLNRMELPLKPPVMPRTLLNATSVRTSTSSTGSTSNSVSVSSSTNANTSMTVLNQSQTRSRIVSSTSSTDSTETITERSTTSTSSSSSSSYEKQHAKACANLISNEILSMRNGQLGAKSGSCAESGGVKRIAGKEISTLFEV",
                "length": 655,
                "header": "tr|Q8IGL5-1|A0A0B4KEE7_DROME Computationally mapped isoform of Leucine-rich repeat, isoform F  OS=Drosophila melanogaster OX=7227 GN=LRR PE=1 SV=1 CANONICAL=A0A0B4KEE7-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 7681692,
                "end_pos": 7677995,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0088940",
                        "url": "https://www.ensembl.org/id/FBtr0088940"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0088014",
                        "url": "https://www.ensembl.org/id/FBpp0088014"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "dme:Dmel_CG1399",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG1399",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-DME-983231",
            "name": "Factors involved in megakaryocyte development and platelet production",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-983231",
            "resource": "Reactome",
            "description": "Factors involved in megakaryocyte development and platelet production"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KEE7",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "lamellipodium",
                        "id": "GO:0030027",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KEE7",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "muscle tendon junction",
                        "id": "GO:0005927",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005927",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KEE7",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KEE7",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 7,
                "go_terms": [
                    {
                        "name": "immune response",
                        "id": "GO:0006955",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KEE7",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell migration",
                        "id": "GO:0016477",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KEE7",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cilium assembly",
                        "id": "GO:0060271",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KEE7",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of non-canonical NF-kappaB signal transduction",
                        "id": "GO:1901223",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901223",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KEE7",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of Arp2/3 complex-mediated actin nucleation",
                        "id": "GO:0034315",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034315",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KEE7",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of immune response",
                        "id": "GO:0050777",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050777",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KEE7",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "response to insecticide",
                        "id": "GO:0017085",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017085",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4KEE7",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4KEE7"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 102,
            "end_pos": 104,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 12,
            "end_pos": 14,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1335,
            "end_pos": 1337,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1362,
            "end_pos": 1364,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1369,
            "end_pos": 1371,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 357,
            "end_pos": 359,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 422,
            "end_pos": 424,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 475,
            "end_pos": 477,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 594,
            "end_pos": 596,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 650,
            "end_pos": 652,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 762,
            "end_pos": 764,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 956,
            "end_pos": 958,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 994,
            "end_pos": 996,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
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