{
    "uniprot_canonical_ac": "A0A0B4K7J2-1",
    "uniprot_ac": "A0A0B4K7J2",
    "uniprot_id": "RBP2_DROME",
    "mass": {
        "chemical_mass": 298931.0,
        "monoisotopic_mass": 298931.0
    },
    "refseq": {
        "ac": "NP_001247302",
        "name": "nucleoporin 358kD, isoform B",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247302"
    },
    "gene_names": [
        {
            "name": "Nup358",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2",
            "id": "A0A0B4K7J2"
        },
        {
            "name": "CG11856; Dmel\\CG11856; dmRanBP; nup358; NUP358; Q9VBU7_DROME; ranbp2; RanBP2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247302",
            "id": "NP_001247302"
        },
        {
            "name": "CG11856",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2",
            "id": "A0A0B4K7J2"
        },
        {
            "name": "Nup358",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247302",
            "id": "NP_001247302"
        },
        {
            "name": "RanBP2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2",
            "id": "A0A0B4K7J2"
        }
    ],
    "protein_names": [
        {
            "name": "E3 SUMO-protein ligase RanBP2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A0A0B4K7J2"
        },
        {
            "name": "2.3.2.-",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A0B4K7J2"
        },
        {
            "name": "358 kDa nucleoporin",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A0B4K7J2"
        },
        {
            "name": "CG11856-PB; Nup358-PB; nucleoporin 358",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247302",
            "id": "NP_001247302"
        },
        {
            "name": "Nuclear pore complex protein Nup358",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A0B4K7J2"
        },
        {
            "name": "nucleoporin 358kD, isoform B",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247302",
            "id": "NP_001247302"
        }
    ],
    "function": [
        {
            "annotation": "E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope (PubMed:17682050). Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway (PubMed:27979731, PubMed:17682050, PubMed:17682050). Plays a role in nuclear mRNA export by recruiting the mRNA transport complex composed of Nxt1 and sbr/Nxf1 to the NPC (PubMed:14729961). Essential during germline development for transposon silencing and piRNA biogenesis probably by regulating piwi localization to the nucleus (PubMed:29735528). During oogenesis, required to form granules that modulate the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0B4K7J2",
                    "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2#function"
                },
                {
                    "database": "PubMed",
                    "id": "29735528",
                    "url": "https://glygen.org/publication/PubMed/29735528"
                },
                {
                    "database": "UniProtKB",
                    "id": "P49792",
                    "url": "https://www.uniprot.org/uniprot/P49792#function"
                },
                {
                    "database": "PubMed",
                    "id": "27979731",
                    "url": "https://glygen.org/publication/PubMed/27979731"
                },
                {
                    "database": "PubMed",
                    "id": "14729961",
                    "url": "https://glygen.org/publication/PubMed/14729961"
                },
                {
                    "database": "PubMed",
                    "id": "17682050",
                    "url": "https://glygen.org/publication/PubMed/17682050"
                },
                {
                    "database": "PubMed",
                    "id": "20547758",
                    "url": "https://glygen.org/publication/PubMed/20547758"
                },
                {
                    "database": "PubMed",
                    "id": "31626769",
                    "url": "https://glygen.org/publication/PubMed/31626769"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0050905",
            "recommended_name": {
                "id": "DOID:0050905",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050905",
                "name": "inflammatory myofibroblastic tumor",
                "description": "A mesenchymal cell neoplasm that has_material_basis_in myofibroblastic cells admixed with inflammatory cells."
            },
            "synonyms": [],
            "evidence": [
                {
                    "id": "0050905",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050905"
                }
            ]
        },
        {
            "disease_id": "DOID:936",
            "recommended_name": {
                "id": "DOID:936",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:936",
                "name": "brain disease",
                "description": "A central nervous system disease that is located_in the brain."
            },
            "synonyms": [
                {
                    "id": "DOID:936",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:936",
                    "name": "encephalopathy",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "936",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:936"
                }
            ]
        },
        {
            "disease_id": "DOID:9538",
            "recommended_name": {
                "id": "DOID:9538",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:9538",
                "name": "multiple myeloma",
                "description": "A myeloid neoplasm that is located_in the plasma cells in bone marrow."
            },
            "synonyms": [
                {
                    "id": "DOID:9538",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9538",
                    "name": "myeloma",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "plasma cell myeloma",
                    "description": "A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)"
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "Kahler disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "Kahler's disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "medullary plasmacytoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "multiple myeloma",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "multiple myeloma, resistance to, Somatic mutation",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "multiple myeloma, susceptibility to, Somatic mutation",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "multiple myeloma/plasma cell myeloma",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "myeloid neoplasm of plasma cell",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "myeloma",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "myeloma, multiple",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "myeloma, plasma cell, malignant",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "myelomatosis",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "plasma cell myeloid neoplasm",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "plasma cell myeloma",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "Al amyloidosis",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "amyloidosis, systemic",
                    "description": ""
                },
                {
                    "id": "MONDO:0009693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009693",
                    "name": "myeloma - multiple",
                    "description": ""
                },
                {
                    "id": "MIM:254500",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/254500",
                    "name": "Multiple myeloma",
                    "description": "Multiple myeloma"
                }
            ],
            "evidence": [
                {
                    "id": "9538",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:9538"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0B4K7J2",
                    "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "gene": [
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            "name": "Nup358",
            "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2",
            "locus": {
                "chromosome": "3R",
                "start_pos": 25258672,
                "end_pos": 25249348,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "FBgn0039302",
                        "url": "https://www.ensembl.org/id/FBgn0039302"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "FBgn0039302",
            "url": "https://bgee.org/?page=gene&gene_id=FBgn0039302",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd13171",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13171",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd13172",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13172",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd13173",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13173",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd13174",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13174",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "FBgn0039302",
            "url": "https://flybase.org/reports/FBgn0039302",
            "database": "FlyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "43041",
            "url": "https://www.ncbi.nlm.nih.gov/gene/43041",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "A0A0B4K7J2",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A0A0B4K7J2*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000156",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000156",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001876",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001876",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011990",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011993",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036443",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036443",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR045255",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR045255",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "dme:Dmel_CG11856",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG11856",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "FRFVDKE",
            "url": "https://omabrowser.org/oma/group/FRFVDKE/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "158765at2759",
            "url": "http://www.orthodb.org/?query=158765at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23138",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23138",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23138:SF169",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23138:SF169",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00638",
            "url": "http://pfam.xfam.org/family/PF00638",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00641",
            "url": "http://pfam.xfam.org/family/PF00641",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_A0A0B4K7J2",
            "url": "http://purl.obolibrary.org/obo/PR_A0A0B4K7J2",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-DME-159227",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-159227",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-159230",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-159230",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-159231",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-159231",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-159236",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-159236",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-3301854",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-3301854",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-3371453",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-3371453",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-4085377",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-4085377",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-4551638",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-4551638",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-4615885",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-4615885",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-5578749",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5578749",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001247302",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247302",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0B4K7J2",
            "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0B4K7J2-1",
            "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0B4K7J2-2",
            "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MFTTRKEVDAHVHKMLGKLQPGRERDIKGLAVARLYMKVQEYPKAIEYLNGYLRVRDDAVGHNMIATCYSRLNPPDVTEALQHYQRSIQIDPRQSEVVIDACELLVKENNASITECARYWLDQANSLDLSGNKQVFNLRMRVNLADSNGERDDTSGGDGEQNTLEILMYKELQARPQDVNIRIQLLRSYVEKMKIDQAFNYALKTELESKNCTSQSNEWYEQIWMVLFKIEMAKDVKKNWRFWHFALHTLDRLVQLSLEGSGLADSSKQLFRLDQYLFKFSTSIERSGDAPQRDLHQACIDHFTGQLLLHAVTLIFKREVLANKNKWMSTLRSALPLLLLGYQVRPIDDSSTNQWIKHCDAEQKQLIQMWRPQGAFRCAQLGRTLLGCLDRSQMEIKNDRENAEFDENKNSGNSMPGLFADSEELLASAHQQCLDKSWRSQIYQQLFTHAEHKLKDTSSHLVRNLRLQLPLFEWPNLAHIENYELQALVLPPHSLAQHVYLALGTDPNKLGDAPRVVFYEGFQRDVKQNLNYCGQDSISQVDVDLYLYATTIQTRRKLQIQREVYDSSNLGNRNAAARPHMMPFANLVGQLGAPEQSNWWDLVVRLNSNQLITEGNRAEQRAQLQHGLEAVRGVNGPKADAIIIFQLGKILNSRSDRSSLEARIDTLYRQGFSILRHQHNQQMESYVRVFKYGSAGSTAAWQDLQSLAEEAVTYFSEKMFRIGQYEQFLDEVRGLHLPMAYFLQSEACHHLEESSKLPRTSRDRYSERRRECLQKTQKLIKNDDKHPLIAAMHRHQQDRNSRGIDNSFGSPDVHNNSSAYEDAEDDFYSHAAFSANRSRRQLEVTPVTPIVMAQPSQEMEQAVKQISKSLCVLKDDVSVGMEAMRQDIKVLTEKFTGLEDLLKKIKISSRDTPTRDVDPAAALGLDDLFIIEDALAEHQQQQQHQQQQSHNQGAIHPVVPNPYTSGFYNGMPNTPSAQERFLQGPYGSPMFNQNQMYNYYAAQAQAQAQAQFLRTPPAPGSIPPPNMFGPRNPNFGLPSMFPPPTVPSVAPYIDAMGNFTQPPPSLIPPPAQPAAPPAPLNILESKPVVALPTPGFFNTTTPVFGASPIQVPQSKPLTVPTVPIPSTAPAPPIAGTVNPPATTAVPPPVHIPQVAPSVPAQPPAPAPVSVPSMFNRALNNQPVEKEPPANVVITSSDPLPKPTTASVQPTLSVTIPAQHIKPSLVQAPEQPAQSAQPAQPSVSGVGSLSFNFGSKSSESPFSFKTQVAKAAAEKQKEQEEAEQNQSGATDPNKTLPQDTSADDYDPRPDFKPIIPLPDEVEVRTGEEGEDIKFTSRAKLFRYVDKEWKERGTGVIKILCDKATGVSRVLMRRDQTHKVCANHTITADITINVANQDKDKKSLLWAANDFADEQVTLERFLVRFKTGELAEEFRVAFTKASEAAKSKETVKPTVNTAEKGSTATAPAAFKSFVTSTPAANSLINKPQEQTKTQPNPDPPATAAKSLFGTLSVSAAPATSAPASATPFASFSFTPNGSSGFGTSTASPFGNLSFGTASAVGSGNNTTLFTTALIKDNTVQGKTLQQESQLNKSNSSDAEEEYVPTAQFVPVIALPDIVEVVTGEENEDVLFEHRAKLLRWDKEANEWKERGLGNMKLLRDRTDPNKVRLLMRREQVHKLCCNQRLLPETKFTYATNCKAAVTWGAQDYSDEELTTALLAVRFKSQDICQQFLEAVQKAQQSIGNEPKKEEVPSAAGEKEKPIKGFGDAFKPKAGSWNCQACYTNNGQDQLYCLACQEPKDATVPPKQSGLDQGNALNLTTSSSNKFSFGFASSATLPATGGFSFGGATQPKEKPAVAVVTASASAPTSVQTAALGFGKSSMTSGFGDAFKPAVGSWSCSACYVNNPGESLYCSACDAPKNDTVPQKEKSLGSGLNLPPTSKFSFGFGAAAAGDKDQAGDGATFNFAAMPAAVAPTTSIGSSSFTFSMTKPKPDQQQPNSTAAKEDEDNDSQEVEEEENNTYFSPVIPLPDKIDVKTGEEDEELLYVHKAKLYRLNESDWKERGLGDVKILRHRQTKKLRVVMRREQVFKICLNHVLNENVVYREKTETSWMFAVHDFSEGESVLERFTLRFKNKEVAQGFMEAIKNALNETAKPIEDSPVVGSVSQSTEANKPSQKNDGAAKSRGGESEVLDVGKTSSVRPTTHEVIPPLPMTLPLLTLPQPLAKPNDYQTPATILFKGSSLSRNNSSASEASKTPSSAFIFGSTDKSEPGKDAGPLANLQKLASGEGQGNVLGSIFRSGSSNENSSDGSVKFFFGGGNKAAEQQKKDSSESVFGGNKADSQSPATQEAPKLAFGGIAAPVFGDANPFGGHKVNLQKSDGKEEPKSIIGGTPLLFGGSNAFGIPKIETQSPAKDFVFGSAPAFGQMATFSFTAAKNEKEKDITSNNTTDLKAEGKEKKELVPETTSTFADLAKTGSTFADLASNPGGTFADLANKTGNDFANLSANSQGTTVGFNKSAGGGFYNLTHQNAFKNFESPQATEECDDDGDATTDDNYDPHYDAIVELPDEIVVTTGEENETKLFGERAKLYRYDAESKQWKERGVGEIKVLEHPELQTFRLIMRQEQIHKLVLNMNISASLQMDYMNAQMKSFLWAGYNYAVDAEGKVDTEGVLERLACRFAKEEIASEFLNTVNSCIKRAKALQGDEENKNDDAPEEQASS",
        "length": 2718,
        "header": "sp|A0A0B4K7J2-1|RBP2_DROME Isoform 1 of E3 SUMO-protein ligase RanBP2  OS=Drosophila melanogaster OX=7227 GN=Nup358 PE=1 SV=1 CANONICAL=A0A0B4K7J2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0B4K7J2-1",
            "url": "",
            "sequence": {
                "sequence": "MFTTRKEVDAHVHKMLGKLQPGRERDIKGLAVARLYMKVQEYPKAIEYLNGYLRVRDDAVGHNMIATCYSRLNPPDVTEALQHYQRSIQIDPRQSEVVIDACELLVKENNASITECARYWLDQANSLDLSGNKQVFNLRMRVNLADSNGERDDTSGGDGEQNTLEILMYKELQARPQDVNIRIQLLRSYVEKMKIDQAFNYALKTELESKNCTSQSNEWYEQIWMVLFKIEMAKDVKKNWRFWHFALHTLDRLVQLSLEGSGLADSSKQLFRLDQYLFKFSTSIERSGDAPQRDLHQACIDHFTGQLLLHAVTLIFKREVLANKNKWMSTLRSALPLLLLGYQVRPIDDSSTNQWIKHCDAEQKQLIQMWRPQGAFRCAQLGRTLLGCLDRSQMEIKNDRENAEFDENKNSGNSMPGLFADSEELLASAHQQCLDKSWRSQIYQQLFTHAEHKLKDTSSHLVRNLRLQLPLFEWPNLAHIENYELQALVLPPHSLAQHVYLALGTDPNKLGDAPRVVFYEGFQRDVKQNLNYCGQDSISQVDVDLYLYATTIQTRRKLQIQREVYDSSNLGNRNAAARPHMMPFANLVGQLGAPEQSNWWDLVVRLNSNQLITEGNRAEQRAQLQHGLEAVRGVNGPKADAIIIFQLGKILNSRSDRSSLEARIDTLYRQGFSILRHQHNQQMESYVRVFKYGSAGSTAAWQDLQSLAEEAVTYFSEKMFRIGQYEQFLDEVRGLHLPMAYFLQSEACHHLEESSKLPRTSRDRYSERRRECLQKTQKLIKNDDKHPLIAAMHRHQQDRNSRGIDNSFGSPDVHNNSSAYEDAEDDFYSHAAFSANRSRRQLEVTPVTPIVMAQPSQEMEQAVKQISKSLCVLKDDVSVGMEAMRQDIKVLTEKFTGLEDLLKKIKISSRDTPTRDVDPAAALGLDDLFIIEDALAEHQQQQQHQQQQSHNQGAIHPVVPNPYTSGFYNGMPNTPSAQERFLQGPYGSPMFNQNQMYNYYAAQAQAQAQAQFLRTPPAPGSIPPPNMFGPRNPNFGLPSMFPPPTVPSVAPYIDAMGNFTQPPPSLIPPPAQPAAPPAPLNILESKPVVALPTPGFFNTTTPVFGASPIQVPQSKPLTVPTVPIPSTAPAPPIAGTVNPPATTAVPPPVHIPQVAPSVPAQPPAPAPVSVPSMFNRALNNQPVEKEPPANVVITSSDPLPKPTTASVQPTLSVTIPAQHIKPSLVQAPEQPAQSAQPAQPSVSGVGSLSFNFGSKSSESPFSFKTQVAKAAAEKQKEQEEAEQNQSGATDPNKTLPQDTSADDYDPRPDFKPIIPLPDEVEVRTGEEGEDIKFTSRAKLFRYVDKEWKERGTGVIKILCDKATGVSRVLMRRDQTHKVCANHTITADITINVANQDKDKKSLLWAANDFADEQVTLERFLVRFKTGELAEEFRVAFTKASEAAKSKETVKPTVNTAEKGSTATAPAAFKSFVTSTPAANSLINKPQEQTKTQPNPDPPATAAKSLFGTLSVSAAPATSAPASATPFASFSFTPNGSSGFGTSTASPFGNLSFGTASAVGSGNNTTLFTTALIKDNTVQGKTLQQESQLNKSNSSDAEEEYVPTAQFVPVIALPDIVEVVTGEENEDVLFEHRAKLLRWDKEANEWKERGLGNMKLLRDRTDPNKVRLLMRREQVHKLCCNQRLLPETKFTYATNCKAAVTWGAQDYSDEELTTALLAVRFKSQDICQQFLEAVQKAQQSIGNEPKKEEVPSAAGEKEKPIKGFGDAFKPKAGSWNCQACYTNNGQDQLYCLACQEPKDATVPPKQSGLDQGNALNLTTSSSNKFSFGFASSATLPATGGFSFGGATQPKEKPAVAVVTASASAPTSVQTAALGFGKSSMTSGFGDAFKPAVGSWSCSACYVNNPGESLYCSACDAPKNDTVPQKEKSLGSGLNLPPTSKFSFGFGAAAAGDKDQAGDGATFNFAAMPAAVAPTTSIGSSSFTFSMTKPKPDQQQPNSTAAKEDEDNDSQEVEEEENNTYFSPVIPLPDKIDVKTGEEDEELLYVHKAKLYRLNESDWKERGLGDVKILRHRQTKKLRVVMRREQVFKICLNHVLNENVVYREKTETSWMFAVHDFSEGESVLERFTLRFKNKEVAQGFMEAIKNALNETAKPIEDSPVVGSVSQSTEANKPSQKNDGAAKSRGGESEVLDVGKTSSVRPTTHEVIPPLPMTLPLLTLPQPLAKPNDYQTPATILFKGSSLSRNNSSASEASKTPSSAFIFGSTDKSEPGKDAGPLANLQKLASGEGQGNVLGSIFRSGSSNENSSDGSVKFFFGGGNKAAEQQKKDSSESVFGGNKADSQSPATQEAPKLAFGGIAAPVFGDANPFGGHKVNLQKSDGKEEPKSIIGGTPLLFGGSNAFGIPKIETQSPAKDFVFGSAPAFGQMATFSFTAAKNEKEKDITSNNTTDLKAEGKEKKELVPETTSTFADLAKTGSTFADLASNPGGTFADLANKTGNDFANLSANSQGTTVGFNKSAGGGFYNLTHQNAFKNFESPQATEECDDDGDATTDDNYDPHYDAIVELPDEIVVTTGEENETKLFGERAKLYRYDAESKQWKERGVGEIKVLEHPELQTFRLIMRQEQIHKLVLNMNISASLQMDYMNAQMKSFLWAGYNYAVDAEGKVDTEGVLERLACRFAKEEIASEFLNTVNSCIKRAKALQGDEENKNDDAPEEQASS",
                "length": 2718,
                "header": "sp|A0A0B4K7J2-1|RBP2_DROME Isoform 1 of E3 SUMO-protein ligase RanBP2  OS=Drosophila melanogaster OX=7227 GN=Nup358 PE=1 SV=1 CANONICAL=A0A0B4K7J2-1"
            },
            "locus": {
                "chromosome": "3R",
                "start_pos": 25258556,
                "end_pos": 25249631,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0304692",
                        "url": "https://www.ensembl.org/id/FBtr0304692"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0293235",
                        "url": "https://www.ensembl.org/id/FBpp0293235"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A0B4K7J2-2",
            "url": "",
            "sequence": {
                "sequence": "MFTTRKEVDAHVHKMLGKLQPGRERDIKGLAVARLYMKVQEYPKAIEYLNGYLRVRDDAVGHNMIATCYSRLNPPDVTEALQHYQRSIQIDPRQSEVVIDACELLVKENNASITECARYWLDQANSLDLSGNKQVFNLRMRVNLADSNGERDDTSGGDGEQNTLEILMYKELQARPQDVNIRIQLLRSYVEKMKIDQAFNYALKTELESKNCTSQSNEWYEQIWMVLFKIEMAKDVKKNWRFWHFALHTLDRLVQLSLEGSGLADSSKQLFRLDQYLFKFSTSIERSGDAPQRDLHQACIDHFTGQLLLHAVTLIFKREVLANKNKWMSTLRSALPLLLLGYQVRPIDDSSTNQWIKHCDAEQKQLIQMWRPQGAFRCAQLGRTLLGCLDRSQMEIKNDRENAEFDENKNSGNSMPGLFADSEELLASAHQQCLDKSWRSQIYQQLFTHAEHKLKDTSSHLVRNLRLQLPLFEWPNLAHIENYELQALVLPPHSLAQHVYLALGTDPNKLGDAPRVVFYEGFQRDVKQNLNYCGQDSISQVDVDLYLYATTIQTRRKLQIQREVYDSSNLGNRNAAARPHMMPFANLVGQLGAPEQSNWWDLVVRLNSNQLITEGNRAEQRAQLQHGLEAVRGVNGPKADAIIIFQLGKILNSRSDRSSLEARIDTLYRQGFSILRHQHNQQMESYVRVFKYGSAGSTAAWQDLQSLAEEAVTYFSEKMFRIGQYEQFLDEVRGLHLPMAYFLQSEACHHLEESSKLPRTSRDRYSERRRECLQKTQKLIKNDDKHPLIAAMHRHQQDRNSRGIDNSFGSPDVHNNSSAYEDAEDDFYSHAAFSANRSRRQLEVTPVTPIVMAQPSQEMEQAVKQISKSLCVLKDDVSVGMEAMRQDIKVLTEKFTGLEDLLKKIKISSRDTPTRDVDPAAALGLDDLFIIEDALAEHQQQQQHQQQQSHNQGAIHPVVPNPYTSGFYNGMPNTPSAQERFLQGPYGSPMFNQNQMYNYYAAQAQAQAQAQFLRTPPAPGSIPPPNMFGPRNPNFGLPSMFPPPTVPSVAPYIDAMGNFTQPPPSLIPPPAQPAAPPAPLNILESKPVVALPTPGFFNTTTPVFGASPIQVPQSKPLTVPTVPIPSTAPAPPIAGTVNPPATTAVPPPVHIPQVAPSVPAQPPAPAPVSVPSMFNRALNNQPVEKEPPANVVITSSDPLPKPTTASVQPTLSVTIPAQHIKPSLVQAPEQPAQSAQPAQPSVSGVGSLSFNFGSKSSESPFSFKTQVAKAAAEKQKEQEEAEQNQSGATDPNKTLPQDTSADDYDPRPDFKPIIPLPDEVEVRTGEEGEDIKFTSRAKLFRYVDKEWKERGTGVIKILCDKATGVSRVLMRRDQTHKVCANHTITADITINVANQDKDKKSLLWAANDFADEQVTLERFLVRFKTGELAEEFRVAFTKASEAAKSKETVKPTVNTAEKGSTATAPAAFKSFVTSTPAANSLINKPQEQTKTQPNPDPPATAAKSLFGTLSVSAAPATSAPASATPFASFSFTPNGSSGFGTSTASPFGNLSFGTASAVGSGNNTTLFTTALIKDNTVQGKTLQQESQLNKSNSSDAEEEYVPTAQFVPVIALPDIVEVVTGEENEDVLFEHRAKLLRWDKEANEWKERGLGNMKLLRDRTDPNKVRLLMRREQVHKLCCNQRLLPETKFTYATNCKAAVTWGAQDYSDEELTTALLAVRFKSQDICQQFLEAVQKAQQSIGNEPKKEEVPSAAGEKEKPIKGFGDAFKPKAGSWNCQACYTNNGQDQLYCLACQEPKDATVPPKQSGLDQGNALNLTTSSSNKFSFGFASSATLPATGGFSFGGATQPKEKPAVAVVTASASAPTSVQTAALGFGKSSMTSGFGDAFKPAVGSWSCSACYVNNPGESLYCSACDAPKNDTVPQKEKSLGSGLNLPPTSKFSFGFGAAAAGDKDQAGDGATFNFAAMPAAVAPTTSIGSSSFTFSMTKPKPDQQQPNSTAAKEDEDNDSQEVEEEENNTYFSPVIPLPDKIDVKTGEEDEELLYVHKAKLYRLNESDWKERGLGDVKILRHRQTKKLRVVMRREQVFKICLNHVLNENVVYREKTETSWMFAVHDFSEGESVLERFTLRFKNKEVAQGFMEAIKNALNETAKPIEDSPVVGSVSQSTEANKPSQKNDGAAKSRGGESEVLDVGKTSSPLAKPNDYQTPATILFKGSSLSRNNSSASEASKTPSSAFIFGSTDKSEPGKDAGPLANLQKLASGEGQGNVLGSIFRSGSSNENSSDGSVKFFFGGGNKAAEQQKKDSSESVFGGNKADSQSPATQEAPKLAFGGIAAPVFGDANPFGGHKVNLQKSDGKEEPKSIIGGTPLLFGGSNAFGIPKIETQSPAKDFVFGSAPAFGQMATFSFTAAKNEKEKDITSNNTTDLKAEGKEKKELVPETTSTFADLAKTGSTFADLASNPGGTFADLANKTGNDFANLSANSQGTTVGFNKSAGGGFYNLTHQNAFKNFESPQATEECDDDGDATTDDNYDPHYDAIVELPDEIVVTTGEENETKLFGERAKLYRYDAESKQWKERGVGEIKVLEHPELQTFRLIMRQEQIHKLVLNMNISASLQMDYMNAQMKSFLWAGYNYAVDAEGKVDTEGVLERLACRFAKEEIASEFLNTVNSCIKRAKALQGDEENKNDDAPEEQASS",
                "length": 2695,
                "header": "sp|A0A0B4K7J2-2|RBP2_DROME Isoform 2 of E3 SUMO-protein ligase RanBP2  OS=Drosophila melanogaster OX=7227 GN=Nup358 PE=1 SV=1 CANONICAL=A0A0B4K7J2-1"
            },
            "locus": {
                "chromosome": "3R",
                "start_pos": 25258556,
                "end_pos": 25249631,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0084813",
                        "url": "https://www.ensembl.org/id/FBtr0084813"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0084188",
                        "url": "https://www.ensembl.org/id/FBpp0084188"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Nucleoporin Nup358 facilitates nuclear import of Methoprene-tolerant (Met) in an importin \u03b2- and Hsp83-dependent manner.",
            "journal": "Insect biochemistry and molecular biology",
            "date": "2017-02",
            "authors": "He Qianyu, Zhang Yuanxi, Zhang Xu, Xu DanDan, Dong Wentao, Li Sheng, Wu Rui",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0B4K7J2",
                    "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27979731",
                    "url": "https://glygen.org/publication/PubMed/27979731"
                }
            ]
        },
        {
            "title": "A critical role for nucleoporin 358 (Nup358) in transposon silencing and piRNA biogenesis in Drosophila.",
            "journal": "The Journal of biological chemistry",
            "date": "2018-06-15",
            "authors": "Parikh Rasesh Y, Lin Haifan, Gangaraju Vamsi K",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0B4K7J2",
                    "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29735528",
                    "url": "https://glygen.org/publication/PubMed/29735528"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "dme:Dmel_CG11856",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG11856",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-DME-159227",
            "name": "Transport of the SLBP independent Mature mRNA",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-159227",
            "resource": "Reactome",
            "description": "Transport of the SLBP independent Mature mRNA"
        },
        {
            "id": "R-DME-159230",
            "name": "Transport of the SLBP Dependant Mature mRNA",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-159230",
            "resource": "Reactome",
            "description": "Transport of the SLBP Dependant Mature mRNA"
        },
        {
            "id": "R-DME-159231",
            "name": "Transport of Mature mRNA Derived from an Intronless Transcript",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-159231",
            "resource": "Reactome",
            "description": "Transport of Mature mRNA Derived from an Intronless Transcript"
        },
        {
            "id": "R-DME-159236",
            "name": "Transport of Mature mRNA derived from an Intron-Containing Transcript",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-159236",
            "resource": "Reactome",
            "description": "Transport of Mature mRNA derived from an Intron-Containing Transcript"
        },
        {
            "id": "R-DME-3301854",
            "name": "Nuclear Pore Complex (NPC) Disassembly",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-3301854",
            "resource": "Reactome",
            "description": "Nuclear Pore Complex (NPC) Disassembly"
        },
        {
            "id": "R-DME-3371453",
            "name": "Regulation of HSF1-mediated heat shock response",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-3371453",
            "resource": "Reactome",
            "description": "Regulation of HSF1-mediated heat shock response"
        },
        {
            "id": "R-DME-4085377",
            "name": "SUMOylation of SUMOylation proteins",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-4085377",
            "resource": "Reactome",
            "description": "SUMOylation of SUMOylation proteins"
        },
        {
            "id": "R-DME-4551638",
            "name": "SUMOylation of chromatin organization proteins",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-4551638",
            "resource": "Reactome",
            "description": "SUMOylation of chromatin organization proteins"
        },
        {
            "id": "R-DME-4615885",
            "name": "SUMOylation of DNA replication proteins",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-4615885",
            "resource": "Reactome",
            "description": "SUMOylation of DNA replication proteins"
        },
        {
            "id": "R-DME-5578749",
            "name": "Transcriptional regulation by small RNAs",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5578749",
            "resource": "Reactome",
            "description": "Transcriptional regulation by small RNAs"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P49792-1",
            "protein_name": "E3 SUMO-protein ligase RanBP2",
            "gene_name": "RANBP2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDPKAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLERAAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKRLKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYANLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKMGQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLNLSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLTRYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIHRKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIGRSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAVNGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIKIIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHRWPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGPVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDDYFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLPTQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDGYSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKSVFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAKLFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGSDRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAVRIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNPSNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQNTKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCAACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANATRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEASATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLKCVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFKFGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGTGFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFSSQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRVKLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGPTLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKSPAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTERVWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSESVKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKAKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDDEDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELQKVQEAQKSQTEEITSTTDSVYTGGTEVMVPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSSTGLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVHNEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMKNYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKTKEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFSNIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDENFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFGSPKGSVCRRITITECGQI",
                "length": 3224
            },
            "evidence": [
                {
                    "id": "A0A0B4K7J2",
                    "url": "https://omabrowser.org/oma/group/A0A0B4K7J2/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 12,
                "go_terms": [
                    {
                        "name": "positive regulation of RNA export from nucleus",
                        "id": "GO:0046833",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046833",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of cell population proliferation",
                        "id": "GO:0008284",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of gene expression",
                        "id": "GO:0010628",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of protein localization",
                        "id": "GO:0032880",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032880",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "germ cell development",
                        "id": "GO:0007281",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007281",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of protein localization to nucleus",
                        "id": "GO:1900182",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900182",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear pore complex assembly",
                        "id": "GO:0051292",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051292",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mRNA transport",
                        "id": "GO:0051028",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051028",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "NLS-bearing protein import into nucleus",
                        "id": "GO:0006607",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006607",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein import into nucleus",
                        "id": "GO:0006606",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ventral cord development",
                        "id": "GO:0007419",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007419",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "juvenile hormone mediated signaling pathway",
                        "id": "GO:0035626",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035626",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "nuclear pore",
                        "id": "GO:0005643",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005643",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "annulate lamellae",
                        "id": "GO:0005642",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005642",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "SUMO transferase activity",
                        "id": "GO:0019789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0B4K7J2",
                                "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 1058,
            "end_pos": 1060,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1098,
            "end_pos": 1100,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 110,
            "end_pos": 112,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1284,
            "end_pos": 1286,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1292,
            "end_pos": 1294,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1381,
            "end_pos": 1383,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1534,
            "end_pos": 1536,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1549,
            "end_pos": 1551,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1562,
            "end_pos": 1564,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1563,
            "end_pos": 1565,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1589,
            "end_pos": 1591,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1592,
            "end_pos": 1594,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1815,
            "end_pos": 1817,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1918,
            "end_pos": 1920,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1996,
            "end_pos": 1998,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2006,
            "end_pos": 2008,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2016,
            "end_pos": 2018,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2053,
            "end_pos": 2055,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 211,
            "end_pos": 213,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2147,
            "end_pos": 2149,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2243,
            "end_pos": 2245,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2244,
            "end_pos": 2246,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2303,
            "end_pos": 2305,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2443,
            "end_pos": 2445,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2444,
            "end_pos": 2446,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2492,
            "end_pos": 2494,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2500,
            "end_pos": 2502,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2513,
            "end_pos": 2515,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2522,
            "end_pos": 2524,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2575,
            "end_pos": 2577,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2632,
            "end_pos": 2634,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 815,
            "end_pos": 817,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 816,
            "end_pos": 818,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 836,
            "end_pos": 838,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "R-DME-111439",
            "name": "Docking of Mature Histone mRNA complex:TAP at the NPC",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nuclear envelope, nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0B4K7J2-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-111439",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-111439"
                }
            ]
        },
        {
            "id": "R-DME-158441",
            "name": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, nuclear envelope, nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0B4K7J2-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-158441",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-158441"
                }
            ]
        },
        {
            "id": "R-DME-158447",
            "name": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, nuclear envelope",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0B4K7J2-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-158447",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-158447"
                }
            ]
        },
        {
            "id": "R-DME-158481",
            "name": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, nuclear envelope, nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0B4K7J2-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-158481",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-158481"
                }
            ]
        },
        {
            "id": "R-DME-158484",
            "name": "Release of the SLBP independent Histone mRNA from the NPC",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, nuclear envelope",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0B4K7J2-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-158484",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-158484"
                }
            ]
        },
        {
            "id": "R-DME-159046",
            "name": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, nuclear envelope, nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0B4K7J2-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-159046",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-159046"
                }
            ]
        },
        {
            "id": "R-DME-159050",
            "name": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, nuclear envelope",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0B4K7J2-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-159050",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-159050"
                }
            ]
        },
        {
            "id": "R-DME-2990882",
            "name": "CDK1 phosphorylates NUP98",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, nuclear envelope",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0B4K7J2-1",
                "P23572-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-2990882",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2990882"
                }
            ]
        },
        {
            "id": "R-DME-4551679",
            "name": "RANBP2 SUMOylates RANBP2 with SUMO2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nuclear envelope, nucleoplasm",
            "input_participant_list": [
                "R-DME-2993756"
            ],
            "output_participant_list": [
                "R-DME-4551720"
            ],
            "enzyme_list": [
                "A0A0B4K7J2-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-4551679",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-4551679"
                }
            ]
        },
        {
            "id": "R-DME-4615987",
            "name": "RANBP2 SUMOylates HDAC4 with SUMO2,3",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nuclear envelope, nucleoplasm",
            "input_participant_list": [
                "R-DME-351581"
            ],
            "output_participant_list": [
                "R-DME-4616029"
            ],
            "enzyme_list": [
                "A0A0B4K7J2-1",
                "M9PHQ2-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-4615987",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-4615987"
                }
            ]
        },
        {
            "id": "R-DME-4655355",
            "name": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q9VKN7-1",
                "A0A0B4K7J2-1",
                "Q9VGF9-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-4655355",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-4655355"
                }
            ]
        },
        {
            "id": "R-DME-5252041",
            "name": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, nuclear envelope, nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0B4K7J2-1",
                "P29844-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-5252041",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5252041"
                }
            ]
        },
        {
            "id": "R-DME-5578744",
            "name": "Importin-8 imports AGO2:miRNA into the nucleus",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, nuclear envelope, nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0B4K7J2-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-5578744",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5578744"
                }
            ]
        },
        {
            "id": "R-DME-75097",
            "name": "Transport of the export-competent mRNP complex through the NPC",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, nuclear envelope, nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q9VHS8-1",
                "A0A0B4K7J2-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-75097",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-75097"
                }
            ]
        },
        {
            "id": "R-DME-75098",
            "name": "mRNP complex dissociates from cytosolic face of NPC",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, nuclear envelope",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q9VHS8-1",
                "A0A0B4K7J2-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-75098",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-75098"
                }
            ]
        },
        {
            "id": "R-DME-77587",
            "name": "Docking of Mature Replication Dependent Histone mRNA with the NPC",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nuclear envelope, nucleoplasm",
            "input_participant_list": [
                "R-DME-111690",
                "R-DME-156649"
            ],
            "output_participant_list": [
                "R-DME-51463",
                "R-DME-51469"
            ],
            "enzyme_list": [
                "A0A0B4K7J2-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-77587",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-77587"
                }
            ]
        },
        {
            "id": "R-DME-77594",
            "name": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nuclear envelope, nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0B4K7J2-1",
                "Q9VE51-1",
                "Q9VPT8-1",
                "Q9VCH5-1"
            ],
            "evidence": [
                {
                    "id": "R-DME-77594",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-DME-77594"
                }
            ]
        }
    ],
    "reaction_participants": [
        {
            "participant_id": "R-DME-111690",
            "participant_name": "sbr [nucleoplasm]",
            "crossref": [
                {
                    "id": "Q9U1H9",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "6IHJ",
                    "database": "PDB",
                    "url": ""
                },
                {
                    "id": "FBgn0003321",
                    "database": "Flybase",
                    "url": ""
                },
                {
                    "id": "Q9U1H9",
                    "database": "PRO",
                    "url": ""
                },
                {
                    "id": "NP_524660.1",
                    "database": "RefSeq",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-DME-156649",
            "participant_name": "Ref1 [nucleoplasm]",
            "crossref": [
                {
                    "id": "Q9V3E7",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "NP_651968.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "Q9V3E7",
                    "database": "PRO",
                    "url": ""
                },
                {
                    "id": "FBgn0010774",
                    "database": "Flybase",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-DME-2993756",
            "participant_name": "Nup358 [nuclear envelope]",
            "crossref": [
                {
                    "id": "A0A0B4K7J2",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "FBgn0039302",
                    "database": "Flybase",
                    "url": ""
                },
                {
                    "id": "NP_001247302.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "NP_651361.2",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "A0A0B4K7J2",
                    "database": "PRO",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-DME-351581",
            "participant_name": "HDAC4 [nucleoplasm]",
            "crossref": [
                {
                    "id": "M9PHQ2",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "NP_001259507.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "FBgn0041210",
                    "database": "Flybase",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-DME-4551720",
            "participant_name": "Nup358 [nuclear envelope]",
            "crossref": [
                {
                    "id": "NP_001247302.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "A0A0B4K7J2",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "A0A0B4K7J2",
                    "database": "PRO",
                    "url": ""
                },
                {
                    "id": "NP_651361.2",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "FBgn0039302",
                    "database": "Flybase",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-DME-4616029",
            "participant_name": "polySUMO2,3-K559-HDAC4 [nucleoplasm]",
            "crossref": [
                {
                    "id": "M9PHQ2",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "FBgn0041210",
                    "database": "Flybase",
                    "url": ""
                },
                {
                    "id": "NP_001259507.1",
                    "database": "RefSeq",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-DME-51463",
            "participant_name": "NCBP2 [nucleoplasm]",
            "crossref": [
                {
                    "id": "Q9V3L6",
                    "database": "PRO",
                    "url": ""
                },
                {
                    "id": "Q9V3L6",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "FBgn0022943",
                    "database": "Flybase",
                    "url": ""
                },
                {
                    "id": "NP_524396.1",
                    "database": "RefSeq",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-DME-51469",
            "participant_name": "Cbp80 [nucleoplasm]",
            "crossref": [
                {
                    "id": "FBgn0022942",
                    "database": "Flybase",
                    "url": ""
                },
                {
                    "id": "NP_726938.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "Q7K4N3",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "NP_524750.2",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "Q7K4N3",
                    "database": "PRO",
                    "url": ""
                }
            ]
        }
    ],
    "reaction_enzymes": [
        {
            "uniprot_ac": "A0A0B4K7J2",
            "gene_name": "Nup358",
            "activity": [
                {
                    "ec_number": "2.3.2.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A0A0B4K7J2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A0B4K7J2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "M9PHQ2",
            "gene_name": "HDAC4",
            "activity": [
                {
                    "ec_number": "3.5.1.98",
                    "activity": "H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone].",
                    "evidence": [
                        {
                            "id": "M9PHQ2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/M9PHQ2"
                        }
                    ]
                },
                {
                    "ec_number": "3.5.1.98",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "M9PHQ2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/M9PHQ2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P23572",
            "gene_name": "Cdk1",
            "activity": [
                {
                    "ec_number": "2.7.11.22",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
                    "evidence": [
                        {
                            "id": "P23572",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P23572"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.23",
                    "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
                    "evidence": [
                        {
                            "id": "P23572",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P23572"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.22",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P23572",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P23572"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P23572",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P23572"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P29844",
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