{ "uniprot_canonical_ac": "A0A0B4K7I2-1", "uniprot_ac": "A0A0B4K7I2", "uniprot_id": "A0A0B4K7I2_DROME", "mass": { "chemical_mass": 60967.0, "monoisotopic_mass": 60967.0 }, "refseq": { "ac": "NP_725914", "name": "smooth, isoform B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725914" }, "gene_names": [ { "name": "sm", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2", "id": "A0A0B4K7I2" }, { "name": "BcDNA:GH10856; CG9218; Dmel\\CG9218; l(2)05338; Sm; smo", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261094", "id": "NP_001261094" }, { "name": "BcDNA:GH10856", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2", "id": "A0A0B4K7I2" }, { "name": "CG9218", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2", "id": "A0A0B4K7I2" }, { "name": "Dmel\\CG9218", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2", "id": "A0A0B4K7I2" }, { "name": "Dmel_CG9218", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2", "id": "A0A0B4K7I2" }, { "name": "Sm", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2", "id": "A0A0B4K7I2" }, { "name": "l(2)05338", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2", "id": "A0A0B4K7I2" }, { "name": "sm-RB", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2", "id": "A0A0B4K7I2" }, { "name": "smooth", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2", "id": "A0A0B4K7I2" }, { "name": "smo", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2", "id": "A0A0B4K7I2" }, { "name": "sm", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261094", "id": "NP_001261094" } ], "protein_names": [ { "name": "CG9218-PAA; sm-PAA; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246434", "id": "NP_001246434" }, { "name": "CG9218-PAB; sm-PAB; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261093", "id": "NP_001261093" }, { "name": "CG9218-PAC; sm-PAC; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261094", "id": "NP_001261094" }, { "name": "CG9218-PB; sm-PB; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725914", "id": "NP_725914" }, { "name": "CG9218-PE; sm-PE; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027440", "id": "NP_001027440" }, { "name": "CG9218-PG; sm-PG; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036561", "id": "NP_001036561" }, { "name": "CG9218-PH; sm-PH; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027439", "id": "NP_001027439" }, { "name": "CG9218-PI; sm-PI; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725915", "id": "NP_725915" }, { "name": "CG9218-PJ; sm-PJ; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246424", "id": "NP_001246424" }, { "name": "CG9218-PK; sm-PK; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246423", "id": "NP_001246423" }, { "name": "CG9218-PL; sm-PL; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246425", "id": "NP_001246425" }, { "name": "CG9218-PM; sm-PM; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246426", "id": "NP_001246426" }, { "name": "CG9218-PO; sm-PO; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246427", "id": "NP_001246427" }, { "name": "CG9218-PP; sm-PP; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725913", "id": "NP_725913" }, { "name": "CG9218-PT; sm-PT; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246428", "id": "NP_001246428" }, { "name": "CG9218-PU; sm-PU; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246429", "id": "NP_001246429" }, { "name": "CG9218-PV; sm-PV; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246430", "id": "NP_001246430" }, { "name": "CG9218-PZ; sm-PZ; smooth", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246433", "id": "NP_001246433" }, { "name": "Smooth, isoform T", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0B4K7I2" }, { "name": "smooth, isoform AA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246434", "id": "NP_001246434" }, { "name": "smooth, isoform AB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261093", "id": "NP_001261093" }, { "name": "smooth, isoform AC", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261094", "id": "NP_001261094" }, { "name": "smooth, isoform B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725914", "id": "NP_725914" }, { "name": "smooth, isoform E", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027440", "id": "NP_001027440" }, { "name": "smooth, isoform G", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036561", "id": "NP_001036561" }, { "name": "smooth, isoform H", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027439", "id": "NP_001027439" }, { "name": "smooth, isoform I", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725915", "id": "NP_725915" }, { "name": "smooth, isoform J", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246424", "id": "NP_001246424" }, { "name": "smooth, isoform K", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246423", "id": "NP_001246423" }, { "name": "smooth, isoform L", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246425", "id": "NP_001246425" }, { "name": "smooth, isoform M", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246426", "id": "NP_001246426" }, { "name": "smooth, isoform O", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246427", "id": "NP_001246427" }, { "name": "smooth, isoform P", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725913", "id": "NP_725913" }, { "name": "smooth, isoform T", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246428", "id": "NP_001246428" }, { "name": "smooth, isoform U", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246429", "id": "NP_001246429" }, { "name": "smooth, isoform V", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246430", "id": "NP_001246430" }, { "name": "smooth, isoform Z", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246433", "id": "NP_001246433" } ], "function": [], "disease": [ { "disease_id": "DOID:0050457", "recommended_name": { "id": "DOID:0050457", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050457", "name": "Sertoli cell-only syndrome", "description": "A male infertility disease characterized by male sterility, has_material_basis_in azospermia without abnormal sexual development." }, "synonyms": [ { "id": "DOID:0050457", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050457", "name": "DEL CASTILLO SYNDROME", "description": "" }, { "id": "DOID:0050457", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050457", "name": "Germinal Cell Aplasia", "description": "" } ], "evidence": [ { "id": "0050457", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050457" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ], "evidence": [ { "id": "1319", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1319" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "evidence": [ { "id": "1324", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:418", "recommended_name": { "id": "DOID:418", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:418", "name": "systemic scleroderma", "description": "A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies." }, "synonyms": [ { "id": "DOID:418", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:418", "name": "Scleroderma", "description": "" }, { "id": "DOID:418", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:418", "name": "Scleroderma syndrome", "description": "" }, { "id": "DOID:418", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:418", "name": "progressive systemic sclerosis", "description": "" }, { "id": "DOID:418", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:418", "name": "systemic sclerosis", "description": "" }, { "id": "MONDO:0008418", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008418", "name": "scleroderma, familial progressive", "description": "" }, { "id": "MONDO:0008418", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008418", "name": "scleroderma, familial progressive", "description": "" }, { "id": "MONDO:0008418", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008418", "name": "Crest syndrome", "description": "" }, { "id": "MONDO:0008418", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008418", "name": "systemic sclerosis, susceptibility to", "description": "" } ], "evidence": [ { "id": "418", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:418" } ] }, { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MIM:114550", "resource": "MIM", "url": "https://www.omim.org/entry/114550", "name": "Hepatocellular carcinoma", "description": "Hepatocellular carcinoma" } ], "evidence": [ { "id": "684", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:684" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A0A0B4K7I2", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "sm", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2", "locus": { "chromosome": "2R", "start_pos": 19517864, "end_pos": 19631508, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0003435", "url": "https://www.ensembl.org/id/FBgn0003435" } ] } } ], "crossref": [ { "id": "FBgn0003435", "url": "https://bgee.org/?page=gene&gene_id=FBgn0003435", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12424", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12424", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12427", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12427", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12694", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12694", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "FBgn0003435", "url": "https://flybase.org/reports/FBgn0003435", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "37254", "url": "https://www.ncbi.nlm.nih.gov/gene/37254", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "A1ZBN3", "url": "https://www.ebi.ac.uk/intact/interactors/id:A1ZBN3*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "D5AEJ9", "url": "https://www.ebi.ac.uk/intact/interactors/id:D5AEJ9*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "Q6NND8", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q6NND8*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "Q7JMZ7", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q7JMZ7*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "Q8IHH3", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8IHH3*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG9218", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG9218", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DQHINVC", "url": "https://omabrowser.org/oma/group/DQHINVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4825346at2759", "url": "http://www.orthodb.org/?query=4825346at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15592", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15592", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15592:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15592:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11835", "url": "http://pfam.xfam.org/family/PF11835", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13893", "url": "http://pfam.xfam.org/family/PF13893", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-DME-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-72163", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-72203", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-72203", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001246428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246428", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0B4K7B0", "url": "https://www.uniprot.org/uniprot/A0A0B4K7B0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K7B0-1", "url": "https://www.uniprot.org/uniprot/A0A0B4K7B0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K7H8", "url": "https://www.uniprot.org/uniprot/A0A0B4K7H8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K7H8-1", "url": "https://www.uniprot.org/uniprot/A0A0B4K7H8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K7I2", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K7I2-1", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K7I6", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K7I6-1", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K7W3", "url": "https://www.uniprot.org/uniprot/A0A0B4K7W3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K7W3-1", "url": "https://www.uniprot.org/uniprot/A0A0B4K7W3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K7W7", "url": "https://www.uniprot.org/uniprot/A0A0B4K7W7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K7W7-1", "url": "https://www.uniprot.org/uniprot/A0A0B4K7W7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K852", "url": "https://www.uniprot.org/uniprot/A0A0B4K852", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K852-1", "url": "https://www.uniprot.org/uniprot/A0A0B4K852-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K8A1", "url": "https://www.uniprot.org/uniprot/A0A0B4K8A1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K8A1-1", "url": "https://www.uniprot.org/uniprot/A0A0B4K8A1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K8A2", "url": "https://www.uniprot.org/uniprot/A0A0B4K8A2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K8A2-1", "url": "https://www.uniprot.org/uniprot/A0A0B4K8A2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4KEV0", "url": "https://www.uniprot.org/uniprot/A0A0B4KEV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4KEV0-1", "url": "https://www.uniprot.org/uniprot/A0A0B4KEV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4KF04", "url": "https://www.uniprot.org/uniprot/A0A0B4KF04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4KF04-1", "url": "https://www.uniprot.org/uniprot/A0A0B4KF04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0C4DHD5", "url": "https://www.uniprot.org/uniprot/A0A0C4DHD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0C4DHD5-1", "url": "https://www.uniprot.org/uniprot/A0A0C4DHD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1ZBN3", "url": "https://www.uniprot.org/uniprot/A1ZBN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1ZBN3-1", "url": "https://www.uniprot.org/uniprot/A1ZBN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D5AEJ9", "url": "https://www.uniprot.org/uniprot/D5AEJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D5AEJ9-1", "url": "https://www.uniprot.org/uniprot/D5AEJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0E914", "url": "https://www.uniprot.org/uniprot/Q0E914", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q0E914-1", "url": "https://www.uniprot.org/uniprot/Q0E914-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6NND8", "url": "https://www.uniprot.org/uniprot/Q6NND8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6NND8-1", "url": "https://www.uniprot.org/uniprot/Q6NND8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7JMZ7", "url": "https://www.uniprot.org/uniprot/Q7JMZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7JMZ7-1", "url": "https://www.uniprot.org/uniprot/Q7JMZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8IHH3", "url": "https://www.uniprot.org/uniprot/Q8IHH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8IHH3-1", "url": "https://www.uniprot.org/uniprot/Q8IHH3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARSTPQQNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTVKEIGNGRSPLLQEPLYVATLSTPQQHVSHQHHHHLRQQQQQQHQQQAPQQQPHPQHLHHQQQLVAPAQSHNLYQFKEPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 552, "header": "tr|A0A0B4K7I2-1|A0A0B4K7I2_DROME Isoform 1 of Smooth, isoform T OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "isoforms": [ { "isoform_ac": "A0A0B4K7B0-1", "url": "", "sequence": { "sequence": "MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARSTPQQNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTGEILPSKSLFSIPENVVMLESQPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 494, "header": "tr|A0A0B4K7B0-1|A0A0B4K7B0_DROME Computationally mapped isoform of Smooth, isoform O OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19628630, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0308785", "url": "https://www.ensembl.org/id/FBtr0308785" }, { "database": "Ensembl Peptide", "id": "FBpp0300942", "url": "https://www.ensembl.org/id/FBpp0300942" } ] } }, { "isoform_ac": "A0A0B4K7H8-1", "url": "", "sequence": { "sequence": "MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARSTPQQNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTVATLSTPQQHVSHQHHHHLRQQQQQQHQQQAPQQQPHPQHLHHQQQLVAPAQSHNLYQFKEPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 535, "header": "tr|A0A0B4K7H8-1|A0A0B4K7H8_DROME Computationally mapped isoform of Smooth, isoform K OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19628630, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0304654", "url": "https://www.ensembl.org/id/FBtr0304654" }, { "database": "Ensembl Peptide", "id": "FBpp0293196", "url": "https://www.ensembl.org/id/FBpp0293196" } ] } }, { "isoform_ac": "A0A0B4K7I2-1", "url": "", "sequence": { "sequence": "MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARSTPQQNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTVKEIGNGRSPLLQEPLYVATLSTPQQHVSHQHHHHLRQQQQQQHQQQAPQQQPHPQHLHHQQQLVAPAQSHNLYQFKEPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 552, "header": "tr|A0A0B4K7I2-1|A0A0B4K7I2_DROME Isoform 1 of Smooth, isoform T OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19628630, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0308790", "url": "https://www.ensembl.org/id/FBtr0308790" }, { "database": "Ensembl Peptide", "id": "FBpp0300947", "url": "https://www.ensembl.org/id/FBpp0300947" } ] } }, { "isoform_ac": "A0A0B4K7I6-1", "url": "", "sequence": { "sequence": "MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARSTPQQNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTGKSLFSIPENVVMLESQPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 491, "header": "tr|A0A0B4K7I6-1|A0A0B4K7I6_DROME Computationally mapped isoform of Smooth, isoform Z OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19628630, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0308796", "url": "https://www.ensembl.org/id/FBtr0308796" }, { "database": "Ensembl Peptide", "id": "FBpp0300953", "url": "https://www.ensembl.org/id/FBpp0300953" } ] } }, { "isoform_ac": "A0A0B4K7W3-1", "url": "", "sequence": { "sequence": "MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARSTPQQNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTVKEIGNGRSPLLQEPLYEPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 492, "header": "tr|A0A0B4K7W3-1|A0A0B4K7W3_DROME Computationally mapped isoform of Smooth, isoform L OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19628630, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0304655", "url": "https://www.ensembl.org/id/FBtr0304655" }, { "database": "Ensembl Peptide", "id": "FBpp0293197", "url": "https://www.ensembl.org/id/FBpp0293197" } ] } }, { "isoform_ac": "A0A0B4K7W7-1", "url": "", "sequence": { "sequence": "MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARSTPQQNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTGEILPIATLSTPQQHVSHQHHHHLRQQQQQQHQQQAPQQQPHPQHLHHQQQLVAPAQSHNLYQFKEPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 540, "header": "tr|A0A0B4K7W7-1|A0A0B4K7W7_DROME Computationally mapped isoform of Smooth, isoform V OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19628630, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0308792", "url": "https://www.ensembl.org/id/FBtr0308792" }, { "database": "Ensembl Peptide", "id": "FBpp0300949", "url": "https://www.ensembl.org/id/FBpp0300949" } ] } }, { "isoform_ac": "A0A0B4K852-1", "url": "", "sequence": { "sequence": "MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARSTPQQNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTGEILPIKEIGNGRSPLLQEPLYEPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 497, "header": "tr|A0A0B4K852-1|A0A0B4K852_DROME Computationally mapped isoform of Smooth, isoform M OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19628630, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0304656", "url": "https://www.ensembl.org/id/FBtr0304656" }, { "database": "Ensembl Peptide", "id": "FBpp0293198", "url": "https://www.ensembl.org/id/FBpp0293198" } ] } }, { "isoform_ac": "A0A0B4K8A1-1", "url": "", "sequence": { "sequence": "MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTGEILPIKEIGNGRSPLLQEPLYGTRPQPYSKSLFSIPENVVMLESQPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 515, "header": "tr|A0A0B4K8A1-1|A0A0B4K8A1_DROME Computationally mapped isoform of Smooth, isoform U OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19628630, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0308791", "url": "https://www.ensembl.org/id/FBtr0308791" }, { "database": "Ensembl Peptide", "id": "FBpp0300948", "url": "https://www.ensembl.org/id/FBpp0300948" } ] } }, { "isoform_ac": "A0A0B4K8A2-1", "url": "", "sequence": { "sequence": "MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTGEILPIKEIGNGRSPLLQEPLYGKSLFSIPENVVMLESQPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 508, "header": "tr|A0A0B4K8A2-1|A0A0B4K8A2_DROME Computationally mapped isoform of Smooth, isoform AA OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19628630, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0308797", "url": "https://www.ensembl.org/id/FBtr0308797" }, { "database": "Ensembl Peptide", "id": "FBpp0300954", "url": "https://www.ensembl.org/id/FBpp0300954" } ] } }, { "isoform_ac": "A0A0B4KEV0-1", "url": "", "sequence": { "sequence": "MLESQPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 301, "header": "tr|A0A0B4KEV0-1|A0A0B4K7I2_DROME Computationally mapped isoform of Smooth, isoform T OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19546024, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0332857", "url": "https://www.ensembl.org/id/FBtr0332857" }, { "database": "Ensembl Peptide", "id": "FBpp0305079", "url": "https://www.ensembl.org/id/FBpp0305079" } ] } }, { "isoform_ac": "A0A0B4KF04-1", "url": "", "sequence": { "sequence": "MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARSTPQQNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTGEMQSTVVVALDDAAEERAEKWENSTEKRILWMLQPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 509, "header": "tr|A0A0B4KF04-1|A0A0B4KF04_DROME Computationally mapped isoform of Smooth, isoform AB OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19628630, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0310331", "url": "https://www.ensembl.org/id/FBtr0310331" }, { "database": "Ensembl Peptide", "id": "FBpp0302014", "url": "https://www.ensembl.org/id/FBpp0302014" } ] } }, { "isoform_ac": "A0A0C4DHD5-1", "url": "", "sequence": { "sequence": "MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTGEILPKPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 434, "header": "tr|A0A0C4DHD5-1|A0A0C4DHD5_DROME Computationally mapped isoform of Smooth, isoform P OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19628630, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0308786", "url": "https://www.ensembl.org/id/FBtr0308786" }, { "database": "Ensembl Peptide", "id": "FBpp0300943", "url": "https://www.ensembl.org/id/FBpp0300943" } ] } }, { "isoform_ac": "A1ZBN3-1", "url": "", "sequence": { "sequence": "MNNLNANASAFLWQVPPPQQLTPQSVQQQTVQSVQSMQSVQHSQLLQSAVVSQPRKFGGNKSNYNYMQNHAIMGPGGGPMGGIGGNPNIYRKRHSINTYNAGLYQTNEPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 404, "header": "tr|A1ZBN3-1|A1ZBN3_DROME Computationally mapped isoform of FI03683p OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19546770, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0086495", "url": "https://www.ensembl.org/id/FBtr0086495" }, { "database": "Ensembl Peptide", "id": "FBpp0085684", "url": "https://www.ensembl.org/id/FBpp0085684" } ] } }, { "isoform_ac": "D5AEJ9-1", "url": "", "sequence": { "sequence": "MNNLNANASAFLWQVPPPQQLTPQSVQQQTVQSVQSMQSVQHSQLLQSAVVSQPRKFGGNKSNYNYMQNHAIMGPGGGPMGGIGGNPNIYRKRHSINTYNAGLYQTNVATLSTPQQHVSHQHHHHLRQQQQQQHQQQAPQQQPHPQHLHHQQQLVAPAQSHNLYQFKEPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 464, "header": "tr|D5AEJ9-1|D5AEJ9_DROME Computationally mapped isoform of Smooth, isoform J OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19546770, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0304653", "url": "https://www.ensembl.org/id/FBtr0304653" }, { "database": "Ensembl Peptide", "id": "FBpp0293195", "url": "https://www.ensembl.org/id/FBpp0293195" } ] } }, { "isoform_ac": "Q0E914-1", "url": "", "sequence": { "sequence": "MKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 260, "header": "tr|Q0E914-1|Q0E914_DROME Computationally mapped isoform of Smooth, isoform Y OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19538101, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0308793", "url": "https://www.ensembl.org/id/FBtr0308793" }, { "database": "Ensembl Peptide", "id": "FBpp0300950", "url": "https://www.ensembl.org/id/FBpp0300950" } ] } }, { "isoform_ac": "Q6NND8-1", "url": "", "sequence": { "sequence": "MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARSTPQQNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTGEILPKPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 480, "header": "tr|Q6NND8-1|Q6NND8_DROME Computationally mapped isoform of Smooth, isoform H OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19628630, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0301609", "url": "https://www.ensembl.org/id/FBtr0301609" }, { "database": "Ensembl Peptide", "id": "FBpp0290824", "url": "https://www.ensembl.org/id/FBpp0290824" } ] } }, { "isoform_ac": "Q7JMZ7-1", "url": "", "sequence": { "sequence": "MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARSTPQQNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTEPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 475, "header": "tr|Q7JMZ7-1|Q7JMZ7_DROME Computationally mapped isoform of Smooth, isoform E OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19628630, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0100232", "url": "https://www.ensembl.org/id/FBtr0100232" }, { "database": "Ensembl Peptide", "id": "FBpp0099612", "url": "https://www.ensembl.org/id/FBpp0099612" } ] } }, { "isoform_ac": "Q8IHH3-1", "url": "", "sequence": { "sequence": "MNNLNANASAFLWQVPPPQQLTPQSVQQQTVQSVQSMQSVQHSQLLQSAVVSQPRKFGGNKSNYNYMQNHAIMGPGGGPMGGIGGNPNIYRKRHSINTYNAGLYQTNGKSLFSIPENVVMLESQPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN", "length": 420, "header": "tr|Q8IHH3-1|Q8IHH3_DROME Computationally mapped isoform of Smooth, isoform I OS=Drosophila melanogaster OX=7227 GN=sm PE=1 SV=1 CANONICAL=A0A0B4K7I2-1" }, "locus": { "chromosome": "2R", "start_pos": 19546770, "end_pos": 19530567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0301610", "url": "https://www.ensembl.org/id/FBtr0301610" }, { "database": "Ensembl Peptide", "id": "FBpp0290825", "url": "https://www.ensembl.org/id/FBpp0290825" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Genetic and molecular analysis of smooth, a quantitative trait locus affecting bristle number in Drosophila melanogaster.", "journal": "Genetics", "date": "1997", "authors": "zur Lage P, Shrimpton A D, Flavell A J, Mackay T F, Brown A J", "evidence": [ { "database": "UniProtKB", "id": "Q7JMZ7", "url": "https://www.uniprot.org/uniprot/Q7JMZ7" } ], "reference": [ { "type": "PubMed", "id": "9178010", "url": "https://glygen.org/publication/PubMed/9178010" } ] } ], "pathway": [ { "id": "dme:Dmel_CG9218", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG9218", "resource": "KEGG Pathway" }, { "id": "R-DME-72163", "name": "mRNA Splicing - Major Pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" }, { "id": "R-DME-72203", "name": "Processing of Capped Intron-Containing Pre-mRNA", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-72203", "resource": "Reactome", "description": "Processing of Capped Intron-Containing Pre-mRNA" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4K7I2", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4K7I2", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4K7I2", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "adult feeding behavior", "id": "GO:0008343", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008343", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4K7I2", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2" } ], "pmid": "" }, { "name": "regulation of RNA splicing", "id": "GO:0043484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043484", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4K7I2", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4K7I2", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2" } ], "pmid": "" }, { "name": "determination of adult lifespan", "id": "GO:0008340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008340", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4K7I2", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4K7I2", "url": "https://www.uniprot.org/uniprot/A0A0B4K7I2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 488, "end_pos": 490, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }