{ "uniprot_canonical_ac": "A0A0B4K692-1", "uniprot_ac": "A0A0B4K692", "uniprot_id": "NEP2_DROME", "mass": { "chemical_mass": 88125.0, "monoisotopic_mass": 88125.0 }, "refseq": { "ac": "NP_001246914", "name": "neprilysin 2, isoform B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246914" }, "gene_names": [ { "name": "Nep2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0B4K692", "id": "A0A0B4K692" }, { "name": "BcDNA:GH07643; CG9761; Dmel\\CG9761; DmNEP2; dNEP2; nep2; NEP2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246914", "id": "NP_001246914" }, { "name": "CG9761", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4K692", "id": "A0A0B4K692" }, { "name": "Nep2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246914", "id": "NP_001246914" } ], "protein_names": [ { "name": "Neprilysin-2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A0B4K692" }, { "name": "3.4.24.11", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0B4K692" }, { "name": "CG9761-PB; Nep2-PB; neprilysin-2; neprilysin 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246914", "id": "NP_001246914" }, { "name": "neprilysin 2, isoform B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246914", "id": "NP_001246914" } ], "function": [ { "annotation": "Metalloendoprotease which cleaves peptides such as tachykinin peptide TK-2 at the amino side of hydrophobic residues (PubMed:15554877, PubMed:17157960). Functions in female fertility, embryogenesis and memory formation (PubMed:24395329, PubMed:27629706). Required in females for normal patterns of egg laying, probably due to its function in sperm retention and preventing sperm displacement by rival ejaculates (PubMed:24395329). Also required for normal patterns of hatching due to its important role in early embryonic development (PubMed:24395329). Required in the dorsal paired medial neurons for the proper formation of middle-term memory (PubMed:27629706). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep3 and Nep4 in normal long-term memory formation (PubMed:27629706).", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4K692", "url": "https://www.uniprot.org/uniprot/A0A0B4K692#function" }, { "database": "PubMed", "id": "17157960", "url": "https://glygen.org/publication/PubMed/17157960" }, { "database": "PubMed", "id": "24395329", "url": "https://glygen.org/publication/PubMed/24395329" }, { "database": "PubMed", "id": "27629706", "url": "https://glygen.org/publication/PubMed/27629706" }, { "database": "PubMed", "id": "15554877", "url": "https://glygen.org/publication/PubMed/15554877" } ] } ], "disease": [ { "disease_id": "DOID:0050646", "recommended_name": { "id": "DOID:0050646", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050646", "name": "distal arthrogryposis", "description": "A muscle tissue disease characterized by congenital joint contractures of hand and feet." }, "synonyms": [ { "id": "DOID:0050646", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050646", "name": "Arthrogryposis Multiplex Congenita", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis, distal, type 1A", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis multiplex congenita", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "AMC", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "DA1A", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis, distal, type 1A", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis multiplex congenita, distal, type 1", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis, distal, type 1", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis, distal, type 2B4", "description": "" }, { "id": "MIM:108120", "resource": "MIM", "url": "https://www.omim.org/entry/108120", "name": "Arthrogryposis, distal, 1A", "description": "Arthrogryposis, distal, 1A" } ], "evidence": [ { "id": "0050646", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050646" } ] }, { "disease_id": "DOID:0111594", "recommended_name": { "id": "DOID:0111594", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111594", "name": "distal arthrogryposis type 5D", "description": "A distal arthrogryposis characterized by severe camptodactyly of the hands, mild camptodactyly of the toes, extension contractures of the knee, and distinctive facial features that has_material_basis_in homozygous or compound heterozygous mutation in the ECEL1 gene on chromosome 2q37.1." }, "synonyms": [ { "id": "DOID:0111594", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111594", "name": "distal arthrogryposis type 5 without ophthalmoparesis", "description": "" }, { "id": "DOID:0111594", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111594", "name": "DA5D", "description": "" }, { "id": "DOID:0111594", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111594", "name": "distal arthrogryposis type 5 without ophthalmoplegia", "description": "" }, { "id": "MONDO:0014028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014028", "name": "distal arthrogryposis type 5D", "description": "Distal arthrogryposis type 5D is a rare subtype of distal arthrogryposis syndrome characterized by arthrogryposis multiplex congenita affecting the hands, feet, ankle, shoulders and/or neck, with camptodactyly of the fingers and limited knee and hip extension, associated with asymmetric ptosis and, less frequently, other ocular manifestations (e.g. ophthalmoplegia, strabismus). Affected individuals frequently have a bulbous nose, furrowed tongue, micro/retrognathia, a short neck, congenital hip dislocation, club feet, scoliosis and short stature." }, { "id": "MONDO:0014028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014028", "name": "DA5D", "description": "" }, { "id": "MONDO:0014028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014028", "name": "ECEL1 distal arthrogryposis", "description": "" }, { "id": "MONDO:0014028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014028", "name": "distal arthrogryposis caused by mutation in ECEL1", "description": "" }, { "id": "MONDO:0014028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014028", "name": "distal arthrogryposis type 5 without ophthalmoparesis", "description": "" }, { "id": "MONDO:0014028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014028", "name": "distal arthrogryposis type 5 without ophthalmoplegia", "description": "" }, { "id": "MONDO:0014028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014028", "name": "arthrogryposis, distal, type 5D", "description": "" }, { "id": "MIM:615065", "resource": "MIM", "url": "https://www.omim.org/entry/615065", "name": "Arthrogryposis, distal, 5D", "description": "Arthrogryposis, distal, 5D" } ], "evidence": [ { "id": "0111594", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111594" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A0A0B4K692", "url": "https://www.uniprot.org/uniprot/A0A0B4K692" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Nep2", "url": "https://www.uniprot.org/uniprot/A0A0B4K692", "locus": { "chromosome": "3R", "start_pos": 4719458, "end_pos": 4731878, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0027570", "url": "https://www.ensembl.org/id/FBgn0027570" } ] } } ], "crossref": [ { "id": "FBgn0027570", "url": "https://bgee.org/?page=gene&gene_id=FBgn0027570", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.4.24.B14", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.24.B14&UniProtAcc=A0A0B4K692", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd08662", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08662", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "FBgn0027570", "url": "https://flybase.org/reports/FBgn0027570", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "40588", "url": "https://www.ncbi.nlm.nih.gov/gene/40588", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000718", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000718", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018497", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018497", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042089", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042089", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG9761", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG9761", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TMKMRIT", "url": "https://omabrowser.org/oma/group/TMKMRIT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "202716at2759", "url": "http://www.orthodb.org/?query=202716at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11733", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11733", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11733:SF224", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11733:SF224", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01431", "url": "http://pfam.xfam.org/family/PF01431", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05649", "url": "http://pfam.xfam.org/family/PF05649", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A0B4K692", "url": "http://purl.obolibrary.org/obo/PR_A0A0B4K692", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DME-5578768", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5578768", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001246914", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246914", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0B4K692", "url": "https://www.uniprot.org/uniprot/A0A0B4K692", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K692-1", "url": "https://www.uniprot.org/uniprot/A0A0B4K692-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4K692-2", "url": "https://www.uniprot.org/uniprot/A0A0B4K692-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQTVIQNPNWWRRRNKLEKSLLVSLGIMFVVLATGFGLWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTASKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKDIITAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLALSREYLVKGFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW", "length": 774, "header": "sp|A0A0B4K692-1|NEP2_DROME Isoform 1 of Neprilysin-2 OS=Drosophila melanogaster OX=7227 GN=Nep2 PE=1 SV=1 CANONICAL=A0A0B4K692-1" }, "isoforms": [ { "isoform_ac": "A0A0B4K692-1", "url": "", "sequence": { "sequence": "MQTVIQNPNWWRRRNKLEKSLLVSLGIMFVVLATGFGLWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTASKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKDIITAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLALSREYLVKGFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW", "length": 774, "header": "sp|A0A0B4K692-1|NEP2_DROME Isoform 1 of Neprilysin-2 OS=Drosophila melanogaster OX=7227 GN=Nep2 PE=1 SV=1 CANONICAL=A0A0B4K692-1" }, "locus": { "chromosome": "3R", "start_pos": 4731562, "end_pos": 4719956, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0305133", "url": "https://www.ensembl.org/id/FBtr0305133" }, { "database": "Ensembl Peptide", "id": "FBpp0293663", "url": "https://www.ensembl.org/id/FBpp0293663" } ] } }, { "isoform_ac": "A0A0B4K692-2", "url": "", "sequence": { "sequence": "MQTVIQNPNWWRRRNKLEKSLLVSLGIMFVVLATGFGLWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTASKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKDIITAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLALSREYLVKGFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW", "length": 763, "header": "sp|A0A0B4K692-2|NEP2_DROME Isoform 2 of Neprilysin-2 OS=Drosophila melanogaster OX=7227 GN=Nep2 PE=1 SV=1 CANONICAL=A0A0B4K692-1" }, "locus": { "chromosome": "3R", "start_pos": 4731562, "end_pos": 4719956, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0078891", "url": "https://www.ensembl.org/id/FBtr0078891" }, { "database": "Ensembl Peptide", "id": "FBpp0078531", "url": "https://www.ensembl.org/id/FBpp0078531" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 173, "start_aa": "Asn", "end_pos": 173, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn173", "evidence": [ { "id": "A0A0B4K692", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4K692#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 239, "start_aa": "Asn", "end_pos": 239, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn239", "evidence": [ { "id": "A0A0B4K692", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4K692#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 264, "start_aa": "Asn", "end_pos": 264, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn264", "evidence": [ { "id": "A0A0B4K692", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4K692#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 305, "start_aa": "Asn", "end_pos": 305, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn305", "evidence": [ { "id": "A0A0B4K692", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4K692#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 315, "start_aa": "Asn", "end_pos": 315, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn315", "evidence": [ { "id": "A0A0B4K692", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4K692#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 358, "start_aa": "Asn", "end_pos": 358, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn358", "evidence": [ { "id": "A0A0B4K692", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4K692#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 554, "start_aa": "Asn", "end_pos": 554, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn554", "evidence": [ { "id": "A0A0B4K692", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4K692#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", 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The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane, secretory granule membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VN01-1", "Q9VYJ1-1", "A0A0B4KH77-1", "Q9VAM2-1", "Q9W2S7-1", "X2JG15-1", "A1ZAB3-1", "Q8T062-1", "Q9W436-1", "Q8IMQ2-1", "Q9VAS0-1", "Q9VAS1-1", "Q9VCU3-1", "Q9VFW9-1", "Q9W2S8-1", "Q7KN92-1", "Q7KY04-1", "Q9Y136-1", "A1Z910-1", "Q8IN25-1", "Q8MRN5-1", "Q9VAS2-1", "Q9VAY0-1", "Q9VD87-1", "Q0KI00-1", "Q95SR0-1", "Q9VAS4-1", "Q9VCU1-1", "Q9VFX0-1", "Q9W4B8-1", "Q8SWX4-1", "Q9VD85-1", "Q9VH96-1", "Q9W1S1-1", "A0A0B4K692-1", "Q9VAQ8-1", "Q9VCU2-1" ], "evidence": [ { "id": "R-DME-6798743", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6798743" } ] }, { "id": "R-DME-9727607", "name": "MME:Zn2+ binds sacubitrilat", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. 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