{ "uniprot_canonical_ac": "A0A096MJY4-1", "uniprot_ac": "A0A096MJY4", "uniprot_id": "MEF2C_RAT", "mass": { "chemical_mass": 51217.0, "monoisotopic_mass": 51217.0 }, "refseq": {}, "gene_names": [ { "name": "Mef2c", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4" } ], "protein_names": [ { "name": "Myocyte-specific enhancer factor 2C", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A096MJY4" }, { "name": "Myocyte enhancer factor 2C", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A096MJY4" } ], "function": [ { "annotation": "Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes (PubMed:15862299). Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4#function" }, { "database": "UniProtKB", "id": "Q8CFN5", "url": "https://www.uniprot.org/uniprot/Q8CFN5#function" }, { "database": "PubMed", "id": "15862299", "url": "https://glygen.org/publication/PubMed/15862299" } ] } ], "disease": [ { "disease_id": "DOID:0060041", "recommended_name": { "id": "DOID:0060041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060041", "name": "autism spectrum disorder", "description": "A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior." }, "synonyms": [], "evidence": [ { "id": "0060041", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060041" } ] }, { "disease_id": "DOID:0070050", "recommended_name": { "id": "DOID:0070050", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070050", "name": "neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language", "description": "An autosomal dominant intellectual developmental disorder that is characterized by global developmental delay with hypotonia, poor motor development with limited walking, impaired intellectual development with poor or absent speech, and behavioral abnormalities and that has_material_basis_in an autosomal dominant mutation of the MEF2C gene on chromosome 5q14.3." }, "synonyms": [ { "id": "DOID:0070050", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070050", "name": "autosomal dominant mental retardation 20", "description": "" }, { "id": "DOID:0070050", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070050", "name": "MRD20", "description": "" }, { "id": "DOID:0070050", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070050", "name": "mental retardation, autosomal dominant 20", "description": "" }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "intellectual disability, autosomal dominant 20", "description": "Any autosomal dominant non-syndromic intellectual disability in which the cause of the disease is a mutation in the MEF2C gene." }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "MEF2C autosomal dominant non-syndromic intellectual disability", "description": "" }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "MRD20", "description": "" }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "autosomal dominant non-syndromic intellectual disability caused by mutation in MEF2C", "description": "" }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "chromosome 5q14.3 deletion syndrome", "description": "" }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "intellectual disability, autosomal dominant 20", "description": "" }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "intellectual disability, autosomal dominant type 20", "description": "" }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "mental retardation, autosomal dominant 20", "description": "" }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "mental retardation, autosomal dominant type 20", "description": "" }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language", "description": "" }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "autosomal dominant intellectual disability 20", "description": "" }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "autosomal dominant mental retardation 20", "description": "" }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "chromosome 5Q14.3 deletion syndrome, proximal", "description": "" }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "intellectual disability, stereotypic movements, epilepsy, and/or cerebral malformations", "description": "" }, { "id": "MONDO:0013266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013266", "name": "mental retardation, stereotypic movements, epilepsy, and/or cerebral malformations", "description": "" }, { "id": "MIM:613443", "resource": "MIM", "url": "https://www.omim.org/entry/613443", "name": "Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language", "description": "Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language" } ], "evidence": [ { "id": "0070050", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070050" } ] }, { "disease_id": "DOID:1059", "recommended_name": { "id": "DOID:1059", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1059", "name": "intellectual disability", "description": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills." }, "synonyms": [], "evidence": [ { "id": "1059", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1059" } ] }, { "disease_id": "DOID:1094", "recommended_name": { "id": "DOID:1094", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1094", "name": "attention deficit hyperactivity disorder", "description": "A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone and symptoms starting before seven years of age." }, "synonyms": [ { "id": "DOID:1094", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1094", "name": "ADHD", "description": "" }, { "id": "DOID:1094", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1094", "name": "attention deficit disorder", "description": "" }, { "id": "DOID:1094", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1094", "name": "hyperkinetic disorder", "description": "" }, { "id": "MONDO:0012151", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012151", "name": "attention deficit-hyperactivity disorder, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012151", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012151", "name": "ADHD3", "description": "" }, { "id": "MONDO:0012151", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012151", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 3", "description": "" }, { "id": "MONDO:0012151", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012151", "name": "attention deficit-hyperactivity disorder, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "attention deficit-hyperactivity disorder, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "ADHD2", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 2", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "attention deficit-hyperactivity disorder, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012149", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012149", "name": "attention deficit-hyperactivity disorder, susceptibility to, 1", "description": "" }, { "id": "MONDO:0012149", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012149", "name": "ADHD1", "description": "" }, { "id": "MONDO:0012149", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012149", "name": "attention deficit-hyperactivity disorder, susceptibility to, 1", "description": "" }, { "id": "MONDO:0012149", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012149", "name": "attention deficit-hyperactivity disorder, susceptibility to, type 1", "description": "" }, { "id": "MONDO:0012152", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "attention deficit-hyperactivity disorder, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012152", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "ADHD4", "description": "" }, { "id": "MONDO:0012152", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 4", "description": "" }, { "id": "MONDO:0012152", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "attention deficit-hyperactivity disorder, susceptibility to, 4", "description": "" }, { "id": "MONDO:0100518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100518", "name": "hereditary attention deficit-hyperactivity disorder", "description": "An instance of attention deficit-hyperactivity disorder that is caused by an inherited genomic modification in an individual." }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "attention deficit-hyperactivity disorder, susceptibility to, 6", "description": "" }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "ADHD6", "description": "" }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 6", "description": "" }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "attention deficit-hyperactivity disorder, susceptibility to, 6", "description": "" }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "digit span quantitative trait locus", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "attention deficit-hyperactivity disorder, susceptibility to, 5", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "ADHD5", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 5", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "attention deficit-hyperactivity disorder, susceptibility to, 5", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "motor timing quantitative trait locus", "description": "" } ], "evidence": [ { "id": "1094", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1094" } ] }, { "disease_id": "DOID:1824", "recommended_name": { "id": "DOID:1824", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1824", "name": "status epilepticus", "description": "" }, "synonyms": [ { "id": "DOID:1824", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1824", "name": "Grand mal status", "description": "" } ], "evidence": [ { "id": "1824", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1824" } ] }, { "disease_id": "DOID:5844", "recommended_name": { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia." }, "synonyms": [ { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "Myocardial infarct", "description": "" }, { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "heart attack", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, type 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "Mci2", "description": "" } ], "evidence": [ { "id": "5844", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "common_name": "Rat" } ], "gene": [ { "name": "Mef2c", "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "locus": { "chromosome": "2", "start_pos": 14132880, "end_pos": 13993438, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000033134", "url": "https://www.ensembl.org/id/ENSRNOG00000033134" } ] } } ], "crossref": [ { "id": "ENSRNOG00000033134", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000033134", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00265", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00265", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "499497", "url": "https://www.ncbi.nlm.nih.gov/gene/499497", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022102", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022102", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:499497", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:499497", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MATNSYS", "url": "https://omabrowser.org/oma/group/MATNSYS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "448298at2759", "url": "http://www.orthodb.org/?query=448298at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11945", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11945", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11945:SF534", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11945:SF534", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48019", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48019", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48019:SF90", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48019:SF90", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48019:SF93", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48019:SF93", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00319", "url": "http://pfam.xfam.org/family/PF00319", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12347", "url": "http://pfam.xfam.org/family/PF12347", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A096MJY4", "url": "http://purl.obolibrary.org/obo/PR_A0A096MJY4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-525793", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-525793", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_006224017", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006224017", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1563119", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1563119", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A096MJ09", "url": "https://www.uniprot.org/uniprot/A0A096MJ09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJ09-1", "url": "https://www.uniprot.org/uniprot/A0A096MJ09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJ23", "url": "https://www.uniprot.org/uniprot/A0A096MJ23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJ23-1", "url": "https://www.uniprot.org/uniprot/A0A096MJ23-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJ29", "url": "https://www.uniprot.org/uniprot/A0A096MJ29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJ29-1", "url": "https://www.uniprot.org/uniprot/A0A096MJ29-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJD9", "url": "https://www.uniprot.org/uniprot/A0A096MJD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJD9-1", "url": "https://www.uniprot.org/uniprot/A0A096MJD9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJY4-1", "url": "https://www.uniprot.org/uniprot/A0A096MJY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MKI4", "url": "https://www.uniprot.org/uniprot/A0A096MKI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MKI4-1", "url": "https://www.uniprot.org/uniprot/A0A096MKI4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT", "length": 473, "header": "sp|A0A096MJY4-1|MEF2C_RAT Isoform 1 of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1" }, "isoforms": [ { "isoform_ac": "A0A096MJ09-1", "url": "", "sequence": { "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSALNKKENKGSESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT", "length": 483, "header": "tr|A0A096MJ09-1|A0A096MJ09_RAT Computationally mapped isoform of Myocyte enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=2 CANONICAL=A0A096MJY4-1" }, "locus": { "chromosome": "2", "start_pos": 14131581, "end_pos": 14044331, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000076992.3", "url": "https://www.ensembl.org/id/ENSRNOT00000076992.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000067948.2", "url": "https://www.ensembl.org/id/ENSRNOP00000067948.2" } ] } }, { "isoform_ac": "A0A096MJ23-1", "url": "", "sequence": { "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT", "length": 441, "header": "tr|A0A096MJ23-1|A0A096MJ23_RAT Computationally mapped isoform of Myocyte enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1" }, "locus": { "chromosome": "2", "start_pos": 14131581, "end_pos": 14044331, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000076481.3", "url": "https://www.ensembl.org/id/ENSRNOT00000076481.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000067963.1", "url": "https://www.ensembl.org/id/ENSRNOP00000067963.1" } ] } }, { "isoform_ac": "A0A096MJ29-1", "url": "", "sequence": { "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKENKGSESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT", "length": 431, "header": "tr|A0A096MJ29-1|A0A096MJ29_RAT Computationally mapped isoform of Myocyte enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1" }, "locus": { "chromosome": "2", "start_pos": 14131581, "end_pos": 14044331, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000075931.3", "url": "https://www.ensembl.org/id/ENSRNOT00000075931.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000067970.2", "url": "https://www.ensembl.org/id/ENSRNOP00000067970.2" } ] } }, { "isoform_ac": "A0A096MJD9-1", "url": "", "sequence": { "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT", "length": 393, "header": "tr|A0A096MJD9-1|A0A096MJD9_RAT Computationally mapped isoform of Myocyte enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=2 CANONICAL=A0A096MJY4-1" }, "locus": { "chromosome": "2", "start_pos": 14131581, "end_pos": 14044331, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000076136.3", "url": "https://www.ensembl.org/id/ENSRNOT00000076136.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068094.2", "url": "https://www.ensembl.org/id/ENSRNOP00000068094.2" } ] } }, { "isoform_ac": "A0A096MJY4-1", "url": "", "sequence": { "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT", "length": 473, "header": "sp|A0A096MJY4-1|MEF2C_RAT Isoform 1 of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1" }, "locus": {} }, { "isoform_ac": "A0A096MKI4-1", "url": "", "sequence": { "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT", "length": 422, "header": "tr|A0A096MKI4-1|A0A096MKI4_RAT Computationally mapped isoform of Myocyte enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=2 CANONICAL=A0A096MJY4-1" }, "locus": { "chromosome": "2", "start_pos": 14131581, "end_pos": 14044331, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000076230.3", "url": "https://www.ensembl.org/id/ENSRNOT00000076230.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068527.2", "url": "https://www.ensembl.org/id/ENSRNOP00000068527.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 106, "end_pos": 106, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "site_lbl": "Ser106" }, { "start_pos": 110, "end_pos": 110, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "A0A096MJY4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A096MJY4" } ], "site_lbl": "Ser110" }, { "start_pos": 222, "end_pos": 222, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "A0A096MJY4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A096MJY4" } ], "site_lbl": "Ser222" }, { "start_pos": 228, "end_pos": 228, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "site_lbl": "Ser228" }, { "start_pos": 240, "end_pos": 240, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "A0A096MJY4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A096MJY4" } ], "site_lbl": "Ser240" }, { "start_pos": 293, "end_pos": 293, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by MAPK14", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "site_lbl": "Thr293" }, { "start_pos": 300, "end_pos": 300, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by MAPK14", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "site_lbl": "Thr300" }, { "start_pos": 396, "end_pos": 396, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CDK5", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "site_lbl": "Ser396" }, { "start_pos": 419, "end_pos": 419, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by MAPK7", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "site_lbl": "Ser419" }, { "start_pos": 445, "end_pos": 445, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "site_lbl": "Ser445" }, { "start_pos": 59, "end_pos": 59, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CK2", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "site_lbl": "Ser59" }, { "start_pos": 98, "end_pos": 98, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "A0A096MJY4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A096MJY4" } ], "site_lbl": "Ser98" } ], "glycation": [], "keywords": [], "publication": [ { "title": "MEF2C DNA-binding activity is inhibited through its interaction with the regulatory protein Ki-1/57.", "journal": "FEBS letters", "date": "2005", "authors": "Kobarg CB, Kobarg J, Crosara-Alberto DP, Theizen TH, Franchini KG", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "reference": [ { "type": "PubMed", "id": "15862299", "url": "https://glygen.org/publication/PubMed/15862299" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" }, { "database": "iPTMnet", "id": "A0A096MJY4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A096MJY4" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "rno:499497", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:499497", "resource": "KEGG Pathway" }, { "id": "R-RNO-525793", "name": "Myogenesis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-525793", "resource": "Reactome", "description": "Myogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "Q06413-1", "protein_name": "Myocyte-specific enhancer factor 2C", "gene_name": "MEF2C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT", "length": 473 }, "evidence": [ { "id": "45224071", "url": "http://www.informatics.jax.org/homology/45224071", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CFN5-1", "protein_name": "Myocyte-specific enhancer factor 2C", "gene_name": "Mef2c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPSFEMPVTIPVSSHNSLVYSNPVSTLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLSIKSEPVSPPRDRTTTPSRYPQHTTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT", "length": 474 }, "evidence": [ { "id": "45224071", "url": "http://www.informatics.jax.org/homology/45224071", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 18, "go_terms": [ { "name": "minor groove of adenine-thymine-rich DNA binding", "id": "GO:0003680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003680", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": 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"" }, { "name": "blood vessel development", "id": "GO:0001568", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001568", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": "neural crest cell differentiation", "id": "GO:0014033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014033", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": "B cell receptor signaling pathway", "id": "GO:0050853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050853", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": "https://www.uniprot.org/uniprot/A0A096MJY4" } ], "pmid": "" }, { "name": "positive regulation of bone mineralization", "id": "GO:0030501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030501", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJY4", "url": 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