{
    "uniprot_canonical_ac": "A0A096MJY1-1",
    "uniprot_ac": "A0A096MJY1",
    "uniprot_id": "A0A096MJY1_RAT",
    "mass": {
        "chemical_mass": 62958.0,
        "monoisotopic_mass": 62958.0
    },
    "refseq": {
        "ac": "XP_001077762",
        "name": "glypican-6 isoform X2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001077762"
    },
    "gene_names": [
        {
            "name": "Gpc6",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A096MJY1",
            "id": "A0A096MJY1"
        },
        {
            "name": "Gpc6",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001077762",
            "id": "XP_001077762"
        }
    ],
    "protein_names": [
        {
            "name": "Glypican 6",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A096MJY1"
        },
        {
            "name": "glypican-6 isoform X2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001077762",
            "id": "XP_001077762"
        }
    ],
    "function": [
        {
            "annotation": "Cell surface proteoglycan.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A096MJY1",
                    "url": "https://www.uniprot.org/uniprot/A0A096MJY1#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "RU003519",
                    "url": "https://www.uniprot.org/uniprot/RU003519#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A8I6A609",
                    "url": "https://www.uniprot.org/uniprot/A0A8I6A609#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0080844",
            "recommended_name": {
                "id": "DOID:0080844",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080844",
                "name": "omodysplasia 1",
                "description": "An omodysplasia that is characterized by severe congenital micromelia with shortening and distal tapering of the humeri and femora to give a club-like appearance and that has_material_basis_in homozygous or compound heterozygous mutation in the GPC6 gene on chromosome 13q32."
            },
            "synonyms": [
                {
                    "id": "MONDO:0009779",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009779",
                    "name": "autosomal recessive omodysplasia",
                    "description": "Autosomal recessive form of omodysplasia."
                },
                {
                    "id": "MONDO:0009779",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009779",
                    "name": "autosomal recessive omodysplasia",
                    "description": ""
                },
                {
                    "id": "MONDO:0009779",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009779",
                    "name": "micromelic dysplasia-dislocation of radius syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0009779",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009779",
                    "name": "omodysplasia type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009779",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009779",
                    "name": "omodysplasia, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0009779",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009779",
                    "name": "OMOD1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009779",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009779",
                    "name": "micromelic dysplasia congenita with dislocation of radius",
                    "description": ""
                },
                {
                    "id": "MONDO:0009779",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009779",
                    "name": "micromelic dysplasia, congenital, with dislocation of radius",
                    "description": ""
                },
                {
                    "id": "MONDO:0009779",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009779",
                    "name": "omodysplasia 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009779",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009779",
                    "name": "omodysplasia autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0009779",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009779",
                    "name": "omodysplasia generalised form",
                    "description": ""
                },
                {
                    "id": "MONDO:0009779",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009779",
                    "name": "omodysplasia generalized form",
                    "description": ""
                },
                {
                    "id": "MONDO:0009779",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009779",
                    "name": "omodysplasia, generalised form",
                    "description": ""
                },
                {
                    "id": "MONDO:0009779",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009779",
                    "name": "omodysplasia, generalized form",
                    "description": ""
                },
                {
                    "id": "MIM:258315",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/258315",
                    "name": "Omodysplasia 1",
                    "description": "Omodysplasia 1"
                }
            ],
            "evidence": [
                {
                    "id": "0080844",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080844"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A096MJY1",
                    "url": "https://www.uniprot.org/uniprot/A0A096MJY1"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Gpc6",
            "url": "https://www.uniprot.org/uniprot/A0A096MJY1",
            "locus": {
                "chromosome": "15",
                "start_pos": 95024006,
                "end_pos": 94029884,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000046660",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000046660"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000046660",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000046660",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "691984",
            "url": "https://www.ncbi.nlm.nih.gov/gene/691984",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001863",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001863",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019803",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019803",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:691984",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:691984",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "XDESSGS",
            "url": "https://omabrowser.org/oma/group/XDESSGS/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2939408at2759",
            "url": "http://www.orthodb.org/?query=2939408at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10822",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10822",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10822:SF31",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10822:SF31",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01153",
            "url": "http://pfam.xfam.org/family/PF01153",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-1971475",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1971475",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-2022928",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2022928",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-2024096",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2024096",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-975634",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975634",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "XP_001077762",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001077762",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1593308",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1593308",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A096MJY1",
            "url": "https://www.uniprot.org/uniprot/A0A096MJY1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A096MJY1-1",
            "url": "https://www.uniprot.org/uniprot/A0A096MJY1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6A609",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A609",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6A609-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A609-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MPSWIRAVILPLSGLLLTLPAAADVKARSCSEVRQAYGAKGFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSTLPYTICKDERVTAGTSNDEECWNGHSKARYLPEIMNDGLTNQINNPEVEVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREEESSASKLSSSLISWSLVCVVLALQRLNR",
        "length": 555,
        "header": "tr|A0A096MJY1-1|A0A096MJY1_RAT Isoform 1 of Glypican 6  OS=Rattus norvegicus OX=10116 GN=Gpc6 PE=3 SV=1 CANONICAL=A0A096MJY1-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A096MJY1-1",
            "url": "",
            "sequence": {
                "sequence": "MPSWIRAVILPLSGLLLTLPAAADVKARSCSEVRQAYGAKGFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSTLPYTICKDERVTAGTSNDEECWNGHSKARYLPEIMNDGLTNQINNPEVEVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREEESSASKLSSSLISWSLVCVVLALQRLNR",
                "length": 555,
                "header": "tr|A0A096MJY1-1|A0A096MJY1_RAT Isoform 1 of Glypican 6  OS=Rattus norvegicus OX=10116 GN=Gpc6 PE=3 SV=1 CANONICAL=A0A096MJY1-1"
            },
            "locus": {
                "chromosome": "15",
                "start_pos": 95023690,
                "end_pos": 94030931,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000076400.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000076400.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000068304.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000068304.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6A609-1",
            "url": "",
            "sequence": {
                "sequence": "MPSWIRAVILPLSGLLLTLPAAADVKARSCSEVRQAYGAKGFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLRTVWRTMQHSVTDIKEKLKLSKKVWSTLPYTICKDERVTAGTSNDEECWNGHSKARYLPEIMNDGLTNQINNPEVEVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREEESSASKLSSSLISWSLVCVVLALQRLNR",
                "length": 565,
                "header": "tr|A0A8I6A609-1|A0A8I6A609_RAT Computationally mapped isoform of Glypican 6  OS=Rattus norvegicus OX=10116 GN=Gpc6 PE=1 SV=1 CANONICAL=A0A096MJY1-1"
            },
            "locus": {
                "chromosome": "15",
                "start_pos": 95023690,
                "end_pos": 94030931,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000119031.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000119031.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000086451.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000086451.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:691984",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:691984",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-1971475",
            "name": "A tetrasaccharide linker sequence is required for GAG synthesis",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1971475",
            "resource": "Reactome",
            "description": "A tetrasaccharide linker sequence is required for GAG synthesis"
        },
        {
            "id": "R-RNO-2022928",
            "name": "HS-GAG biosynthesis",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2022928",
            "resource": "Reactome",
            "description": "HS-GAG biosynthesis"
        },
        {
            "id": "R-RNO-2024096",
            "name": "HS-GAG degradation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2024096",
            "resource": "Reactome",
            "description": "HS-GAG degradation"
        },
        {
            "id": "R-RNO-975634",
            "name": "Retinoid metabolism and transport",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975634",
            "resource": "Reactome",
            "description": "Retinoid metabolism and transport"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9R087-1",
            "protein_name": "Glypican-6",
            "gene_name": "Gpc6",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MPSWIRAVILPLSGLLLTLPAAADVKARSCSEVRQAYGAKGFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDERVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVEVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREEESSASKFSSSLISWSLVCMVLALQRLYR",
                "length": 555
            },
            "evidence": [
                {
                    "id": "45236204",
                    "url": "http://www.informatics.jax.org/homology/45236204",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9Y625-1",
            "protein_name": "Glypican-6",
            "gene_name": "GPC6",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MPSWIGAVILPLLGLLLSLPAGADVKARSCGEVRQAYGAKGFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR",
                "length": 555
            },
            "evidence": [
                {
                    "id": "45236204",
                    "url": "http://www.informatics.jax.org/homology/45236204",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 6,
                "go_terms": [
                    {
                        "name": "glutamatergic synapse",
                        "id": "GO:0098978",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJY1",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJY1",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell surface",
                        "id": "GO:0009986",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJY1",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synapse",
                        "id": "GO:0045202",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJY1",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "collagen-containing extracellular matrix",
                        "id": "GO:0062023",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023",
                        "evidence": [
                            {
                                "database": "UniProtKB",
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