{ "uniprot_canonical_ac": "A0A087WRT4-1", "uniprot_ac": "A0A087WRT4", "uniprot_id": "A0A087WRT4_MOUSE", "mass": { "chemical_mass": 507531.0, "monoisotopic_mass": 507531.0 }, "refseq": { "ac": "XP_006509330", "name": "protocadherin Fat 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006509330" }, "gene_names": [ { "name": "Fat1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A087WRT4", "id": "A0A087WRT4" }, { "name": "2310038E12Rik; Fath; mFat1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074755", "id": "NP_001074755" }, { "name": "Fat1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074755", "id": "NP_001074755" } ], "protein_names": [ { "name": "FAT atypical cadherin 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A087WRT4" }, { "name": "fat 1 cadherin; FAT tumor suppressor homolog 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074755", "id": "NP_001074755" }, { "name": "protocadherin Fat 1 isoform X10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006509340", "id": "XP_006509340" }, { "name": "protocadherin Fat 1 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006509330", "id": "XP_006509330" }, { "name": "protocadherin Fat 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074755", "id": "NP_001074755" } ], "function": [ { "annotation": "Astrocyte-intrinsic and -extrinsic Fat1 activities regulate astrocyte development and angiogenesis in the retina.", "evidence": [ { "database": "RefSeq", "id": "NP_001074755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074755" }, { "database": "PubMed", "id": "35050341", "url": "https://glygen.org/publication/PubMed/35050341" } ] }, { "annotation": "Effects of cyclic tensile strain and microgravity on the distribution of actin fiber and Fat1 cadherin in murine articular chondrocytes.", "evidence": [ { "database": "RefSeq", "id": "NP_001074755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074755" }, { "database": "PubMed", "id": "34627073", "url": "https://glygen.org/publication/PubMed/34627073" } ] }, { "annotation": "N-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001074755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074755" }, { "database": "PubMed", "id": "37686333", "url": "https://glygen.org/publication/PubMed/37686333" } ] } ], "disease": [ { "disease_id": "DOID:0050866", "recommended_name": { "id": "DOID:0050866", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050866", "name": "oral squamous cell carcinoma", "description": "An oral cavity cancer that has_material_basis_in squamous cells." }, "synonyms": [ { "id": "DOID:0050866", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050866", "name": "mouth squamous cell carcinoma", "description": "" } ], "evidence": [ { "id": "0050866", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050866" } ] }, { "disease_id": "DOID:11727", "recommended_name": { "id": "DOID:11727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11727", "name": "facioscapulohumeral muscular dystrophy", "description": "" }, "synonyms": [ { "id": "DOID:11727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11727", "name": "Landouzy Dejerine muscular dystrophy", "description": "" }, { "id": "DOID:11727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11727", "name": "Landouzy-Dejerine muscular dystrophy", "description": "" }, { "id": "DOID:11727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11727", "name": "Muscular dystrophy, Landouzy-Dejerine", "description": "" } ], "evidence": [ { "id": "11727", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11727" } ] }, { "disease_id": "DOID:1184", "recommended_name": { "id": "DOID:1184", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1184", "name": "nephrotic syndrome", "description": "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability." }, "synonyms": [], "evidence": [ { "id": "1184", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1184" } ] }, { "disease_id": "DOID:3748", "recommended_name": { "id": "DOID:3748", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3748", "name": "esophagus squamous cell carcinoma", "description": "An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus." }, "synonyms": [ { "id": "DOID:3748", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3748", "name": "SCC of esophagus", "description": "" }, { "id": "DOID:3748", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3748", "name": "SCC of oesophagus", "description": "" }, { "id": "DOID:3748", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3748", "name": "oesophagus squamous cell carcinoma", "description": "" } ], "evidence": [ { "id": "3748", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3748" } ] }, { "disease_id": "DOID:3908", "recommended_name": { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma." }, "synonyms": [ { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "NSCLC", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "Non-small cell lung cancer", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "non-small cell lung carcinoma", "description": "" } ], "evidence": [ { "id": "3908", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ] }, { "disease_id": "DOID:5409", "recommended_name": { "id": "DOID:5409", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5409", "name": "lung small cell carcinoma", "description": "A lung carcinoma that has_material_basis_in primitive-appearing cells that are smaller than normal cells and is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008433", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008433", "name": "small cell lung carcinoma", "description": "Small cell lung cancer (SCLC) is a highly aggressive malignant neoplasm, accounting for 10-15% of lung cancer cases, characterized byrapid growth, and early metastasis. 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"o-glyco-site-loss" ], "start_pos": 3831, "end_pos": 3831, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SSS->NSS).", "chr_id": "8", "chr_pos": "45492840", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S3831", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3398573814", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3398573814" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 4041, "end_pos": 4041, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KCS->NCS).", "chr_id": "8", "chr_pos": "45494930", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K4041", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs221543291", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs221543291" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 999, "end_pos": 999, "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->DLT).", "chr_id": "8", "chr_pos": "45406245", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N999", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A087WRT4", "url": "https://www.uniprot.org/uniprot/A0A087WRT4" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Fat1", "url": "https://www.uniprot.org/uniprot/A0A087WRT4", "locus": { "chromosome": "8", "start_pos": 45505294, "end_pos": 45388484, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000070047", "url": "https://www.ensembl.org/id/ENSMUSG00000070047" } ] } } ], "crossref": [ { "id": "ENSMUSG00000070047", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000070047", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00110", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00110", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "14107", "url": "https://www.ncbi.nlm.nih.gov/gene/14107", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "2653", "url": "https://glyconnect.expasy.org/browser/proteins/2653", "database": "GlyConnect", "categories": [ "Glycan", "Glycoproteomics" ] }, { "id": "GPDB0001156", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0001156", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0002655", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0002655", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:14107", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14107", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "109168", "url": "http://www.informatics.jax.org/marker/MGI:109168", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "YSSLYYE", "url": "https://omabrowser.org/oma/group/YSSLYYE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2961370at2759", "url": "http://www.orthodb.org/?query=2961370at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24026", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24026", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24026:SF125", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24026:SF125", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "http://pfam.xfam.org/family/PF00008", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "http://pfam.xfam.org/family/PF00028", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02210", "url": "http://pfam.xfam.org/family/PF02210", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07645", "url": "http://pfam.xfam.org/family/PF07645", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_006509340", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006509340", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A087WPU4", "url": "https://www.uniprot.org/uniprot/A0A087WPU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087WPU4-1", "url": "https://www.uniprot.org/uniprot/A0A087WPU4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087WRT4", "url": "https://www.uniprot.org/uniprot/A0A087WRT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087WRT4-1", "url": "https://www.uniprot.org/uniprot/A0A087WRT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1L1SQU7", "url": "https://www.uniprot.org/uniprot/A0A1L1SQU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1L1SQU7-1", "url": "https://www.uniprot.org/uniprot/A0A1L1SQU7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4A3", "url": "https://www.uniprot.org/uniprot/F2Z4A3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4A3-1", "url": "https://www.uniprot.org/uniprot/F2Z4A3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRHLTLLLLLLLFLQQFGDSDGSQRLEPTPPIQFTHFQYNVTVHENSAAKTYVGHPRKMGIYILDPSWEIRYKIVSGDSENLFKAEEYVLGDFCFLRIRTKGGNTAILNREVRDHYTLIVKAVEKATDAEARAKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDVFAIHPTSGVVVLTGRLDFLETQLYELEILAADRGMKLYGSSGVSSLAKLTVHVEQANECAPIITAVTLSPSELDKDPTYAIITVEDCDQGANGEIASLSIVAGDLLQQFKTVRSFPGSKAFKVKAVGAVDWDSHPYGYNLTLQAKDKGTPPQFSPVKVVHIISPQFRAGPVKFEMDVYRAEISEFAPPHTPVVLVKAIPSYSHLRYVFKSAPGKPKFGLNHNTGLISILEPIRRQHTSHFELEVTTSDKRASARVVVKVLGTNSNPPEFTQTSYKASIDENAPIGAAVTRVSAMDPDEGENGYVTYSIANLNHVPFVIDHFTGTVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFERINCEGTIPRDLGVGEQITTVSAIDADELQLVRYQIEAGNELDLFGLNPSSGVLSLKHSLTDGLGAKVSFHSLRITATDGENFATPLYINLTVAASRKPVNLQCEETGVAKMLAEKLLQANKLHSQGDVEDIFFDSYSVNTHTPQFGVTLPTGIEVKENLPVGANILFMNATDLDSGFNGKLVYAISGGNDDSCFTIDMETGVLKVLSPLDREVMDKYTLNITVYDLGIPQRAAWRLLDVTVLDANDNAPEFLQESYFVEVSEDKEVNSEIIQVEATDKDLGPSGHVTYAILTDTEKFSIDSMTGVVKIIQPLDREVQPVHYLKIEARDQATEEPRLFSTVLLKVSLDDVNDNPPRFIPPNYSVKVREDLPEGTIIMWLEAYDPDVGQSSQVRYSLLDHGEGHFDVDKLSGAVRIVQQLDFEKKQLYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHTPVFSSFVEKGVVKEDVPTGSSVMTVSAHDEDTGRDGEIRYSIRDGSGIGVFRIDEETGVIETSDRLDRESTSHYWLTVYATDQGVVPLSSFIEVYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLTYRITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGVPPRSTIARVIVKILDENDNRPQFLQKFYKIRLPEREKADGDRSASKREPLYRVIAADKDEGPNAELSYSIEEGNEHGRFSIEPKTGVVSSKKFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSSEPISFEESVFSFTVMESDPVAHMIGVISVEPPGMPLWFDIIGGNYDSHFDVDKGTGTIIVAKPLDAEQKSSYNLTVEATDGTTTILTQVLIKVIDTNDHRPQFSTSKYEVAVPEDTEPEVEILQISAVDRDEKNKLIYTLQSSIDPASLKKFRLDPATGALYTAEKLDHEAIHQHVLTVMVRDQDVPVKRNFARIVVNVSDKNDHAPWFTSPSYDGRVYESAAVGSVVLQVTALDKDKGRNAEVLYSIESGNIGNSFTIDPILGSIKTARELDRSHQVDYDLMVKATDKGDPPMSEMTSVRIAVTVADNASPKFTSKEYSAEISEAIRIGSFVGMVSAHSQSSVMYEIRDGNMGDAFNINPHSGSIITQRALDFETLPMYSLTVQGTNMAGLSTNTTVVVHVRDENDNPPVFTQAEYSGFISESASVNSVVLTDRNVPLVIRATDADRESNALLVYQIVEPSVHNYFAIDPTTGAIRTVLSLDYEETHAFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFSKSLYEVSLLLPTYRGVNVITVNATDADSKAFSQVMYSITEGNIGEKFSMDHKTGTIAIQNTTQLRSRYELTVRASDGRFTSMASVKINVKESRESPLKFTQDAYSAVVKENSTEARTLAVITAIGNPLNEPLFYRILNPDRRFKISHTSGVLSTTGIPFDREQQETFDVVVEVTKEHEPSAVAHVVVKVTVEDQNDNAPVFVNLPYYAVVKVDAEVGHVIRYVTAIDRDSGRNGDIHYYLKEHHDHFQIGPSGDISLKKQFEHDTLNKEYLVTVVAKDGGSPAFSAEVLVPITVMNKAMPVFEKAFYSAEIPENIQMHSPVVHIQANSPEGLKVFYSITDGDPFSQFTINFNTGVVNVIAPLDFESHPAYKLSVRATDSLTGAHAEVFVDIIVEDINDNPPVFVQPSYSTTLSEASVIGTPVLQVRATDSDSEPNRGISYQLIGNHSKSHDHFHIDSNTGLISLVRALDYEQSQQHRIFVRAVDGGMPALSSDVVVTVAVTDLNDNPPLFEQQVYEARISEHAAHGHFVMCVRACDADSSDLDKLEYSILSGNDHKSFIIDRETGIITLSNLRRHTLKPFYSLNVSVSDGVFRSSARVNVTVMGGNLHSPVFHQNEYEVELAENAPLHTLVVQVKASDRDSGIYSHVTYHIVNDFAKDRFYVNDRGQIFTLEKLDRETPAEKVISIRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRSTKYEVNIGSSAAKGTSVVKVFASDADEGSNADVTYAIEADSESVKENLEINKLTGLITTKESLIGLENEFFTFFVRAVDSGSPPRESVVPVYIKILPPEVQLPRFSEPFYTYTISEDTPIGTEIDLIRVEHGGAVLYILVKGNTPESNRDEFFVIDRQNGRLKLEKSLDHETTKWYQFSILARCTLDDYEVVASIDVSIQVKDANDNSPVLESSPYEAFIVENLPGGSRVIQIRASDLDSGANGQVMYSLDQSQDADIIESFAINMETGWITTLKELDHEERASYQIKVVASDHGEKVQLSSTAIVGVTVTDVNDSPPRFTAEIYKGTVSEDDPPGGVIAILSTTDADTEEINRQVSYFITGGDALGQFAVENVQSDWRVYVKKPLDREQKDSYLLTVTATDGTFSSKARVEVKVLDANDNSPVCEKTSYSDTIPEDALPGKLVMQVSATDADIRSNAEITYTLFGSGAEKFKLNPDTGELRTLALLDREEQAVYNLLVKATDGGGRSCQAAIVLTLEDVNDNAPEFTAEPYTITVFENTEPGTPLTRVQATDADTGLNRKISYSLVESADGQFSINERSGIIQLEKHLDRELQAVYTLTLKAVDQGLPRRLTATGTVVVSVLDINDNPPVFEYREYGASVSEDIVIGTEVLQVYAASRDIEANAEITYAIISGNEHGKFSIDSKTGAIFIIESLDYESSHEYYLTVEATDGGTPSLSDVATVNINVTDINDNSPVFSQDTYTTVVSEDAALEQPVITIMADDADGPSNSHIHYSIIEGNQGSPFTIDPVRGEVKVTKPLDRETISGYTLTVQAADNGNPPRVNTTTVNIDVSDVNDNAPLFSRDNYSVIIQENKPVGFSVLKLVVTDKDSSHNGPPFFFTIVSGNDENAFEVNQHGVLLTAATIKRKVKDHYLLHVKVADSGKPQLSSMTHIDIRVIEESIHPPAILPLEIFITAFGEEYSGGVIGKIHATDQDVYDTLMYSLDPHMDGLFSVSSTGGKLIAHRKLDIGQYLLNVSVTDGKFTTVADITVHIQQVTQEMLNHTVAIRFANLTPEEFVGDYWRNFQRALRNILGVRKNDIQIVSLQPSEPHSHLDVLLFVERSGGTHVSTKQLLHKINSSVTDVEEIIGVRILEVFQKLCAGLDCPWKFCDEKVSVDENVMSTHSTARLSFVTPRHHRTAVCLCKDGTCPPVHHGCEDNPCPAGSECVADPREEKYSCVCPGGGFGKCPGSSSITFTGNSFVKYRLLENENRLEMKLSMRLRTYSSHAVVMYARGTDYSILEIHTGRLQYKFDCGSGPGIVSVQSIQVNDGQWHAVSLEVEGNYAKLVLDEVHTASGTAPGALKTLNLDNYVFFGGHLRQQGTKHGRGAQVASGFRGCMDSIYLNGQELPLNNKPRAYAHIEEWVDLSHGCLLTATEDCSSSPCQNGGVCNPSPTGGYYCKCSALYVGTFCEVSVNPCSSNPCLYGGTCMVDNGGFVCQCRGLYTGQRCQLSPYCKDDPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECAGNPCRNGALCENTHGSYHCNCSQEYRGKHCEDASPNHYVSTPWNIGLAEGIGIIVFIAGIVLLVMVFVLCRKMISRKKKRQAEPEDKRLGPTTAFLQRPYFDSKLNKNIYSDIPPQVPVRPISYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTFNPESMHGHRKAVAVCSVAPNLPPPPPSNSPSDSDSIQKPSWDFDYDAKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESCDDNESLAAPDLSKPRGYHWDTSDWMPSVPLPDIQEFPNYEAIDEHTPLYSADPNAIDTDYYPGGYDIESDFPPPPEDFPAPDELPPLPPEFSDQFESIHPPRDMPAAGSLGSSSRSRQRFNLNQYLPNFYPADMSEPQKQGAGENSPCREPYTPYPPGYQRNFEAPTIENMPMSVYASTASCSDVSACCEVESEVMMSDYESGDDGHFEEVTIPPLDSQQHTEV", "length": 4602, "header": "tr|A0A087WRT4-1|A0A087WRT4_MOUSE Isoform 1 of FAT atypical cadherin 1 OS=Mus musculus OX=10090 GN=Fat1 PE=1 SV=2 CANONICAL=A0A087WRT4-1" }, "isoforms": [ { "isoform_ac": "A0A087WPU4-1", "url": "", "sequence": { "sequence": "XRPYFDSKLNKNIYSDIPPQVPVRPISYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTFNPESMHGHRKAVAVCSVAPNLPPPPPSNSPSDSDSIQKPSWDFDYDAKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESCDDNAPIWIRAF", "length": 159, "header": "tr|A0A087WPU4-1|A0A087WRT4_MOUSE Computationally mapped isoform of FAT atypical cadherin 1 OS=Mus musculus OX=10090 GN=Fat1 PE=1 SV=1 CANONICAL=A0A087WRT4-1" }, "locus": { "chromosome": "8", "start_pos": 45498794, "end_pos": 45497278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000186342.3", "url": "https://www.ensembl.org/id/ENSMUST00000186342.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000139921.3", "url": "https://www.ensembl.org/id/ENSMUSP00000139921.3" } ] } }, { "isoform_ac": "A0A087WRT4-1", "url": "", "sequence": { "sequence": "MGRHLTLLLLLLLFLQQFGDSDGSQRLEPTPPIQFTHFQYNVTVHENSAAKTYVGHPRKMGIYILDPSWEIRYKIVSGDSENLFKAEEYVLGDFCFLRIRTKGGNTAILNREVRDHYTLIVKAVEKATDAEARAKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDVFAIHPTSGVVVLTGRLDFLETQLYELEILAADRGMKLYGSSGVSSLAKLTVHVEQANECAPIITAVTLSPSELDKDPTYAIITVEDCDQGANGEIASLSIVAGDLLQQFKTVRSFPGSKAFKVKAVGAVDWDSHPYGYNLTLQAKDKGTPPQFSPVKVVHIISPQFRAGPVKFEMDVYRAEISEFAPPHTPVVLVKAIPSYSHLRYVFKSAPGKPKFGLNHNTGLISILEPIRRQHTSHFELEVTTSDKRASARVVVKVLGTNSNPPEFTQTSYKASIDENAPIGAAVTRVSAMDPDEGENGYVTYSIANLNHVPFVIDHFTGTVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFERINCEGTIPRDLGVGEQITTVSAIDADELQLVRYQIEAGNELDLFGLNPSSGVLSLKHSLTDGLGAKVSFHSLRITATDGENFATPLYINLTVAASRKPVNLQCEETGVAKMLAEKLLQANKLHSQGDVEDIFFDSYSVNTHTPQFGVTLPTGIEVKENLPVGANILFMNATDLDSGFNGKLVYAISGGNDDSCFTIDMETGVLKVLSPLDREVMDKYTLNITVYDLGIPQRAAWRLLDVTVLDANDNAPEFLQESYFVEVSEDKEVNSEIIQVEATDKDLGPSGHVTYAILTDTEKFSIDSMTGVVKIIQPLDREVQPVHYLKIEARDQATEEPRLFSTVLLKVSLDDVNDNPPRFIPPNYSVKVREDLPEGTIIMWLEAYDPDVGQSSQVRYSLLDHGEGHFDVDKLSGAVRIVQQLDFEKKQLYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHTPVFSSFVEKGVVKEDVPTGSSVMTVSAHDEDTGRDGEIRYSIRDGSGIGVFRIDEETGVIETSDRLDRESTSHYWLTVYATDQGVVPLSSFIEVYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLTYRITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGVPPRSTIARVIVKILDENDNRPQFLQKFYKIRLPEREKADGDRSASKREPLYRVIAADKDEGPNAELSYSIEEGNEHGRFSIEPKTGVVSSKKFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSSEPISFEESVFSFTVMESDPVAHMIGVISVEPPGMPLWFDIIGGNYDSHFDVDKGTGTIIVAKPLDAEQKSSYNLTVEATDGTTTILTQVLIKVIDTNDHRPQFSTSKYEVAVPEDTEPEVEILQISAVDRDEKNKLIYTLQSSIDPASLKKFRLDPATGALYTAEKLDHEAIHQHVLTVMVRDQDVPVKRNFARIVVNVSDKNDHAPWFTSPSYDGRVYESAAVGSVVLQVTALDKDKGRNAEVLYSIESGNIGNSFTIDPILGSIKTARELDRSHQVDYDLMVKATDKGDPPMSEMTSVRIAVTVADNASPKFTSKEYSAEISEAIRIGSFVGMVSAHSQSSVMYEIRDGNMGDAFNINPHSGSIITQRALDFETLPMYSLTVQGTNMAGLSTNTTVVVHVRDENDNPPVFTQAEYSGFISESASVNSVVLTDRNVPLVIRATDADRESNALLVYQIVEPSVHNYFAIDPTTGAIRTVLSLDYEETHAFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFSKSLYEVSLLLPTYRGVNVITVNATDADSKAFSQVMYSITEGNIGEKFSMDHKTGTIAIQNTTQLRSRYELTVRASDGRFTSMASVKINVKESRESPLKFTQDAYSAVVKENSTEARTLAVITAIGNPLNEPLFYRILNPDRRFKISHTSGVLSTTGIPFDREQQETFDVVVEVTKEHEPSAVAHVVVKVTVEDQNDNAPVFVNLPYYAVVKVDAEVGHVIRYVTAIDRDSGRNGDIHYYLKEHHDHFQIGPSGDISLKKQFEHDTLNKEYLVTVVAKDGGSPAFSAEVLVPITVMNKAMPVFEKAFYSAEIPENIQMHSPVVHIQANSPEGLKVFYSITDGDPFSQFTINFNTGVVNVIAPLDFESHPAYKLSVRATDSLTGAHAEVFVDIIVEDINDNPPVFVQPSYSTTLSEASVIGTPVLQVRATDSDSEPNRGISYQLIGNHSKSHDHFHIDSNTGLISLVRALDYEQSQQHRIFVRAVDGGMPALSSDVVVTVAVTDLNDNPPLFEQQVYEARISEHAAHGHFVMCVRACDADSSDLDKLEYSILSGNDHKSFIIDRETGIITLSNLRRHTLKPFYSLNVSVSDGVFRSSARVNVTVMGGNLHSPVFHQNEYEVELAENAPLHTLVVQVKASDRDSGIYSHVTYHIVNDFAKDRFYVNDRGQIFTLEKLDRETPAEKVISIRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRSTKYEVNIGSSAAKGTSVVKVFASDADEGSNADVTYAIEADSESVKENLEINKLTGLITTKESLIGLENEFFTFFVRAVDSGSPPRESVVPVYIKILPPEVQLPRFSEPFYTYTISEDTPIGTEIDLIRVEHGGAVLYILVKGNTPESNRDEFFVIDRQNGRLKLEKSLDHETTKWYQFSILARCTLDDYEVVASIDVSIQVKDANDNSPVLESSPYEAFIVENLPGGSRVIQIRASDLDSGANGQVMYSLDQSQDADIIESFAINMETGWITTLKELDHEERASYQIKVVASDHGEKVQLSSTAIVGVTVTDVNDSPPRFTAEIYKGTVSEDDPPGGVIAILSTTDADTEEINRQVSYFITGGDALGQFAVENVQSDWRVYVKKPLDREQKDSYLLTVTATDGTFSSKARVEVKVLDANDNSPVCEKTSYSDTIPEDALPGKLVMQVSATDADIRSNAEITYTLFGSGAEKFKLNPDTGELRTLALLDREEQAVYNLLVKATDGGGRSCQAAIVLTLEDVNDNAPEFTAEPYTITVFENTEPGTPLTRVQATDADTGLNRKISYSLVESADGQFSINERSGIIQLEKHLDRELQAVYTLTLKAVDQGLPRRLTATGTVVVSVLDINDNPPVFEYREYGASVSEDIVIGTEVLQVYAASRDIEANAEITYAIISGNEHGKFSIDSKTGAIFIIESLDYESSHEYYLTVEATDGGTPSLSDVATVNINVTDINDNSPVFSQDTYTTVVSEDAALEQPVITIMADDADGPSNSHIHYSIIEGNQGSPFTIDPVRGEVKVTKPLDRETISGYTLTVQAADNGNPPRVNTTTVNIDVSDVNDNAPLFSRDNYSVIIQENKPVGFSVLKLVVTDKDSSHNGPPFFFTIVSGNDENAFEVNQHGVLLTAATIKRKVKDHYLLHVKVADSGKPQLSSMTHIDIRVIEESIHPPAILPLEIFITAFGEEYSGGVIGKIHATDQDVYDTLMYSLDPHMDGLFSVSSTGGKLIAHRKLDIGQYLLNVSVTDGKFTTVADITVHIQQVTQEMLNHTVAIRFANLTPEEFVGDYWRNFQRALRNILGVRKNDIQIVSLQPSEPHSHLDVLLFVERSGGTHVSTKQLLHKINSSVTDVEEIIGVRILEVFQKLCAGLDCPWKFCDEKVSVDENVMSTHSTARLSFVTPRHHRTAVCLCKDGTCPPVHHGCEDNPCPAGSECVADPREEKYSCVCPGGGFGKCPGSSSITFTGNSFVKYRLLENENRLEMKLSMRLRTYSSHAVVMYARGTDYSILEIHTGRLQYKFDCGSGPGIVSVQSIQVNDGQWHAVSLEVEGNYAKLVLDEVHTASGTAPGALKTLNLDNYVFFGGHLRQQGTKHGRGAQVASGFRGCMDSIYLNGQELPLNNKPRAYAHIEEWVDLSHGCLLTATEDCSSSPCQNGGVCNPSPTGGYYCKCSALYVGTFCEVSVNPCSSNPCLYGGTCMVDNGGFVCQCRGLYTGQRCQLSPYCKDDPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECAGNPCRNGALCENTHGSYHCNCSQEYRGKHCEDASPNHYVSTPWNIGLAEGIGIIVFIAGIVLLVMVFVLCRKMISRKKKRQAEPEDKRLGPTTAFLQRPYFDSKLNKNIYSDIPPQVPVRPISYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTFNPESMHGHRKAVAVCSVAPNLPPPPPSNSPSDSDSIQKPSWDFDYDAKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESCDDNESLAAPDLSKPRGYHWDTSDWMPSVPLPDIQEFPNYEAIDEHTPLYSADPNAIDTDYYPGGYDIESDFPPPPEDFPAPDELPPLPPEFSDQFESIHPPRDMPAAGSLGSSSRSRQRFNLNQYLPNFYPADMSEPQKQGAGENSPCREPYTPYPPGYQRNFEAPTIENMPMSVYASTASCSDVSACCEVESEVMMSDYESGDDGHFEEVTIPPLDSQQHTEV", "length": 4602, "header": "tr|A0A087WRT4-1|A0A087WRT4_MOUSE Isoform 1 of FAT atypical cadherin 1 OS=Mus musculus OX=10090 GN=Fat1 PE=1 SV=2 CANONICAL=A0A087WRT4-1" }, "locus": { "chromosome": "8", "start_pos": 45504443, "end_pos": 45403251, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000189017.8", "url": "https://www.ensembl.org/id/ENSMUST00000189017.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000140765.3", "url": "https://www.ensembl.org/id/ENSMUSP00000140765.3" } ] } }, { "isoform_ac": "A0A1L1SQU7-1", "url": "", "sequence": { "sequence": "MGRHLTLLLLLLLFLQQFGDSDGSQRLEPTPPIQFTHFQYNVTVHENSAAKTYVGHPRKMGIYILDPSWEIRYKIVSGDSENLFKAEEYVLGDFCFLRIRTKGGNTAILNREVRDHYTLIVKAVEKATDAEARAKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDVFAIHPTSGVVVLTGRLDFLETQLYELEILAADRGMKLYGSSGVSSLAKLTVHVEQANECAPIITAVTLSPSELDKDPTYAIITVEDCDQGANGEIASLSIVAGDLLQQFKTVRSFPGSKAFKVKAVGAVDWDSHPYGYNLTLQAKDKGTPPQFSPVKVVHIISPQFRAGPVKFEMDVYRAEISEFAPPHTPVVLVKAIPSYSHLRYVFKSAPGKPKFGLNHNTGLISILEPIRRQHTSHFELEVTTSDKRASARVVVKVLGTNSNPPEFTQTSYKASIDENAPIGAAVTRVSAMDPDEGENGYVTYSIANLNHVPFVIDHFTGTVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFERINCEGTIPRDLGVGEQITTVSAIDADELQLVRYQIEAGNELDLFGLNPSSGVLSLKHSLTDGLGAKVSFHSLRITATDGENFATPLYINLTVAASRKPVNLQCEETGVAKMLAEKLLQANKLHSQGDVEDIFFDSYSVNTHTPQFGVTLPTGIEVKENLPVGANILFMNATDLDSGFNGKLVYAISGGNDDSCFTIDMETGVLKVLSPLDREVMDKYTLNITVYDLGIPQRAAWRLLDVTVLDANDNAPEFLQESYFVEVSEDKEVNSEIIQVEATDKDLGPSGHVTYAILTDTEKFSIDSMTGVVKIIQPLDREVQPVHYLKIEARDQATEEPRLFSTVLLKVSLDDVNDNPPRFIPPNYSVKVREDLPEGTIIMWLEAYDPDVGQSSQVRYSLLDHGEGHFDVDKLSGAVRIVQQLDFEKKQLYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHTPVFSSFVEKGVVKEDVPTGSSVMTVSAHDEDTGRDGEIRYSIRDGSGIGVFRIDEETGVIETSDRLDRESTSHYWLTVYATDQGVVPLSSFIEVYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLTYRITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGVPPRSTIARVIVKILDENDNRPQFLQKFYKIRLPEREKADGDRSASKREPLYRVIAADKDEGPNAELSYSIEEGNEHGRFSIEPKTGVVSSKKFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSSEPISFEESVFSFTVMESDPVAHMIGVISVEPPGMPLWFDIIGDALAREVFYIFQLTCDPNCTAEGGNYDSHFDVDKGTGTIIVAKPLDAEQKSSYNLTVEATDGTTTILTQVLIKVIDTNDHRPQFSTSKYEVAVPEDTEPEVEILQISAVDRDEKNKLIYTLQSSIDPASLKKFRLDPATGALYTAEKLDHEAIHQHVLTVMVRDQDVPVKRNFARIVVNVSDKNDHAPWFTSPSYDGRVYESAAVGSVVLQVTALDKDKGRNAEVLYSIESGNIGNSFTIDPILGSIKTARELDRSHQVDYDLMVKATDKGDPPMSEMTSVRIAVTVADNASPKFTSKEYSAEISEAIRIGSFVGMVSAHSQSSVMYEIRDGNMGDAFNINPHSGSIITQRALDFETLPMYSLTVQGTNMAGLSTNTTVVVHVRDENDNPPVFTQAEYSGFISESASVNSVVLTDRNVPLVIRATDADRESNALLVYQIVEPSVHNYFAIDPTTGAIRTVLSLDYEETHAFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFSKSLYEVSLLLPTYRGVNVITVNATDADSKAFSQVMYSITEGNIGEKFSMDHKTGTIAIQNTTQLRSRYELTVRASDGRFTSMASVKINVKESRESPLKFTQDAYSAVVKENSTEARTLAVITAIGNPLNEPLFYRILNPDRRFKISHTSGVLSTTGIPFDREQQETFDVVVEVTKEHEPSAVAHVVVKVTVEDQNDNAPVFVNLPYYAVVKVDAEVGHVIRYVTAIDRDSGRNGDIHYYLKEHHDHFQIGPSGDISLKKQFEHDTLNKEYLVTVVAKDGGSPAFSAEVLVPITVMNKAMPVFEKAFYSAEIPENIQMHSPVVHIQANSPEGLKVFYSITDGDPFSQFTINFNTGVVNVIAPLDFESHPAYKLSVRATDSLTGAHAEVFVDIIVEDINDNPPVFVQPSYSTTLSEASVIGTPVLQVRATDSDSEPNRGISYQLIGNHSKSHDHFHIDSNTGLISLVRALDYEQSQQHRIFVRAVDGGMPALSSDVVVTVAVTDLNDNPPLFEQQVYEARISEHAAHGHFVMCVRACDADSSDLDKLEYSILSGNDHKSFIIDRETGIITLSNLRRHTLKPFYSLNVSVSDGVFRSSARVNVTVMGGNLHSPVFHQNEYEVELAENAPLHTLVVQVKASDRDSGIYSHVTYHIVNDFAKDRFYVNDRGQIFTLEKLDRETPAEKVISIRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRSTKYEVNIGSSAAKGTSVVKVFASDADEGSNADVTYAIEADSESVKENLEINKLTGLITTKESLIGLENEFFTFFVRAVDSGSPPRESVVPVYIKILPPEVQLPRFSEPFYTYTISEDTPIGTEIDLIRVEHGGAVLYILVKGNTPESNRDEFFVIDRQNGRLKLEKSLDHETTKWYQFSILARCTLDDYEVVASIDVSIQVKDANDNSPVLESSPYEAFIVENLPGGSRVIQIRASDLDSGANGQVMYSLDQSQDADIIESFAINMETGWITTLKELDHEERASYQIKVVASDHGEKVQLSSTAIVGVTVTDVNDSPPRFTAEIYKGTVSEDDPPGGVIAILSTTDADTEEINRQVSYFITGGDALGQFAVENVQSDWRVYVKKPLDREQKDSYLLTVTATDGTFSSKARVEVKVLDANDNSPVCEKTSYSDTIPEDALPGKLVMQVSATDADIRSNAEITYTLFGSGAEKFKLNPDTGELRTLALLDREEQAVYNLLVKATDGGGRSCQAAIVLTLEDVNDNAPEFTAEPYTITVFENTEPGTPLTRVQATDADTGLNRKISYSLVESADGQFSINERSGIIQLEKHLDRELQAVYTLTLKAVDQGLPRRLTATGTVVVSVLDINDNPPVFEYREYGASVSEDIVIGTEVLQVYAASRDIEANAEITYAIISGNEHGKFSIDSKTGAIFIIESLDYESSHEYYLTVEATDGGTPSLSDVATVNINVTDINDNSPVFSQDTYTTVVSEDAALEQPVITIMADDADGPSNSHIHYSIIEGNQGSPFTIDPVRGEVKVTKPLDRETISGYTLTVQAADNGNPPRVNTTTVNIDVSDVNDNAPLFSRDNYSVIIQENKPVGFSVLKLVVTDKDSSHNGPPFFFTIVSGNDENAFEVNQHGVLLTAATIKRKVKDHYLLHVKVADSGKPQLSSMTHIDIRVIEESIHPPAILPLEIFITAFGEEYSGGVIGKIHATDQDVYDTLMYSLDPHMDGLFSVSSTGGKLIAHRKLDIGQYLLNVSVTDGKFTTVADITVHIQQVTQEMLNHTVAIRFANLTPEEFVGDYWRNFQRALRNILGVRKNDIQIVSLQPSEPHSHLDVLLFVERSGGTHVSTKQLLHKINSSVTDVEEIIGVRILEVFQKLCAGLDCPWKFCDEKVSVDENVMSTHSTARLSFVTPRHHRTAVCLCKDGTCPPVHHGCEDNPCPAGSECVADPREEKYSCVCPGGGFGKCPGSSSITFTGNSFVKYRLLENENRLEMKLSMRLRTYSSHAVVMYARGTDYSILEIHTGRLQYKFDCGSGPGIVSVQSIQVNDGQWHAVSLEVEGNYAKLVLDEVHTASGTAPGALKTLNLDNYVFFGGHLRQQGTKHGRGAQVASGFRGCMDSIYLNGQELPLNNKPRAYAHIEEWVDLSHGCLLTATEDCSSSPCQNGGVCNPSPTGGYYCKCSALYVGTFCEVSVNPCSSNPCLYGGTCMVDNGGFVCQCRGLYTGQRCQLSPYCKDDPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECAGNPCRNGALCENTHGSYHCNCSQEYRGKHCEDASPNHYVSTPWNIGLAEGIGIIVFIAGIVLLVMVFVLCRKMISRKKKRQAEPEDKRLGPTTAFLQRPYFDSKLNKNIYSDIPPQVPVRPISYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTFNPESMHGHRKAVAVCSVAPNLPPPPPSNSPSDSDSIQKPSWDFDYDAKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESCDDNASIVTVIHLVNAVVDTVNKEESLAAPDLSKPRGYHWDTSDWMPSVPLPDIQEFPNYEAIDEHTPLYSADPNAIDTDYYPGGYDIESDFPPPPEDFPAPDELPPLPPEFSDQFESIHPPRDMPAAGSLGSSSRSRQRFNLNQYLPNFYPADMSEPQKQGAGENSPCREPYTPYPPGYQRNFEAPTIENMPMSVYASTASCSDVSACCEVESEVMMSDYESGDDGHFEEVTIPPLDSQQHTEV", "length": 4645, "header": "tr|A0A1L1SQU7-1|A0A087WRT4_MOUSE Computationally mapped isoform of FAT atypical cadherin 1 OS=Mus musculus OX=10090 GN=Fat1 PE=1 SV=1 CANONICAL=A0A087WRT4-1" }, "locus": { "chromosome": "8", "start_pos": 45504443, "end_pos": 45403251, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000215588.2", "url": "https://www.ensembl.org/id/ENSMUST00000215588.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000149194.2", "url": "https://www.ensembl.org/id/ENSMUSP00000149194.2" } ] } }, { "isoform_ac": "F2Z4A3-1", "url": "", "sequence": { "sequence": "MGRHLTLLLLLLLFLQQFGDSDGSQRLEPTPPIQFTHFQYNVTVHENSAAKTYVGHPRKMGIYILDPSWEIRYKIVSGDSENLFKAEEYVLGDFCFLRIRTKGGNTAILNREVRDHYTLIVKAVEKATDAEARAKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDVFAIHPTSGVVVLTGRLDFLETQLYELEILAADRGMKLYGSSGVSSLAKLTVHVEQANECAPIITAVTLSPSELDKDPTYAIITVEDCDQGANGEIASLSIVAGDLLQQFKTVRSFPGSKAFKVKAVGAVDWDSHPYGYNLTLQAKDKGTPPQFSPVKVVHIISPQFRAGPVKFEMDVYRAEISEFAPPHTPVVLVKAIPSYSHLRYVFKSAPGKPKFGLNHNTGLISILEPIRRQHTSHFELEVTTSDKRASARVVVKVLGTNSNPPEFTQTSYKASIDENAPIGAAVTRVSAMDPDEGENGYVTYSIANLNHVPFVIDHFTGTVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFERINCEGTIPRDLGVGEQITTVSAIDADELQLVRYQIEAGNELDLFGLNPSSGVLSLKHSLTDGLGAKVSFHSLRITATDGENFATPLYINLTVAASRKPVNLQCEETGVAKMLAEKLLQANKLHSQGDVEDIFFDSYSVNTHTPQFGVTLPTGIEVKENLPVGANILFMNATDLDSGFNGKLVYAISGGNDDSCFTIDMETGVLKVLSPLDREVMDKYTLNITVYDLGIPQRAAWRLLDVTVLDANDNAPEFLQESYFVEVSEDKEVNSEIIQVEATDKDLGPSGHVTYAILTDTEKFSIDSMTGVVKIIQPLDREVQPVHYLKIEARDQATEEPRLFSTVLLKVSLDDVNDNPPRFIPPNYSVKVREDLPEGTIIMWLEAYDPDVGQSSQVRYSLLDHGEGHFDVDKLSGAVRIVQQLDFEKKQLYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHTPVFSSFVEKGVVKEDVPTGSSVMTVSAHDEDTGRDGEIRYSIRDGSGIGVFRIDEETGVIETSDRLDRESTSHYWLTVYATDQGVVPLSSFIEVYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLTYRITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGVPPRSTIARVIVKILDENDNRPQFLQKFYKIRLPEREKADGDRSASKREPLYRVIAADKDEGPNAELSYSIEEGNEHGRFSIEPKTGVVSSKKFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSSEPISFEESVFSFTVMESDPVAHMIGVISVEPPGMPLWFDIIGGNYDSHFDVDKGTGTIIVAKPLDAEQKSSYNLTVEATDGTTTILTQVLIKVIDTNDHRPQFSTSKYEVAVPEDTEPEVEILQISAVDRDEKNKLIYTLQSSIDPASLKKFRLDPATGALYTAEKLDHEAIHQHVLTVMVRDQDVPVKRNFARIVVNVSDKNDHAPWFTSPSYDGRVYESAAVGSVVLQVTALDKDKGRNAEVLYSIESGNIGNSFTIDPILGSIKTARELDRSHQVDYDLMVKATDKGDPPMSEMTSVRIAVTVADNASPKFTSKEYSAEISEAIRIGSFVGMVSAHSQSSVMYEIRDGNMGDAFNINPHSGSIITQRALDFETLPMYSLTVQGTNMAGLSTNTTVVVHVRDENDNPPVFTQAEYSGFISESASVNSVVLTDRNVPLVIRATDADRESNALLVYQIVEPSVHNYFAIDPTTGAIRTVLSLDYEETHAFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFSKSLYEVSLLLPTYRGVNVITVNATDADSKAFSQVMYSITEGNIGEKFSMDHKTGTIAIQNTTQLRSRYELTVRASDGRFTSMASVKINVKESRESPLKFTQDAYSAVVKENSTEARTLAVITAIGNPLNEPLFYRILNPDRRFKISHTSGVLSTTGIPFDREQQETFDVVVEVTKEHEPSAVAHVVVKVTVEDQNDNAPVFVNLPYYAVVKVDAEVGHVIRYVTAIDRDSGRNGDIHYYLKEHHDHFQIGPSGDISLKKQFEHDTLNKEYLVTVVAKDGGSPAFSAEVLVPITVMNKAMPVFEKAFYSAEIPENIQMHSPVVHIQANSPEGLKVFYSITDGDPFSQFTINFNTGVVNVIAPLDFESHPAYKLSVRATDSLTGAHAEVFVDIIVEDINDNPPVFVQPSYSTTLSEASVIGTPVLQVRATDSDSEPNRGISYQLIGNHSKSHDHFHIDSNTGLISLVRALDYEQSQQHRIFVRAVDGGMPALSSDVVVTVAVTDLNDNPPLFEQQVYEARISEHAAHGHFVMCVRACDADSSDLDKLEYSILSGNDHKSFIIDRETGIITLSNLRRHTLKPFYSLNVSVSDGVFRSSARVNVTVMGGNLHSPVFHQNEYEVELAENAPLHTLVVQVKASDRDSGIYSHVTYHIVNDFAKDRFYVNDRGQIFTLEKLDRETPAEKVISIRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRSTKYEVNIGSSAAKGTSVVKVFASDADEGSNADVTYAIEADSESVKENLEINKLTGLITTKESLIGLENEFFTFFVRAVDSGSPPRESVVPVYIKILPPEVQLPRFSEPFYTYTISEDTPIGTEIDLIRVEHGGAVLYILVKGNTPESNRDEFFVIDRQNGRLKLEKSLDHETTKWYQFSILARCTLDDYEVVASIDVSIQVKDANDNSPVLESSPYEAFIVENLPGGSRVIQIRASDLDSGANGQVMYSLDQSQDADIIESFAINMETGWITTLKELDHEERASYQIKVVASDHGEKVQLSSTAIVGVTVTDVNDSPPRFTAEIYKGTVSEDDPPGGVIAILSTTDADTEEINRQVSYFITGGDALGQFAVENVQSDWRVYVKKPLDREQKDSYLLTVTATDGTFSSKARVEVKVLDANDNSPVCEKTSYSDTIPEDALPGKLVMQVSATDADIRSNAEITYTLFGSGAEKFKLNPDTGELRTLALLDREEQAVYNLLVKATDGGGRSCQAAIVLTLEDVNDNAPEFTAEPYTITVFENTEPGTPLTRVQATDADTGLNRKISYSLVESADGQFSINERSGIIQLEKHLDRELQAVYTLTLKAVDQGLPRRLTATGTVVVSVLDINDNPPVFEYREYGASVSEDIVIGTEVLQVYAASRDIEANAEITYAIISGNEHGKFSIDSKTGAIFIIESLDYESSHEYYLTVEATDGGTPSLSDVATVNINVTDINDNSPVFSQDTYTTVVSEDAALEQPVITIMADDADGPSNSHIHYSIIEGNQGSPFTIDPVRGEVKVTKPLDRETISGYTLTVQAADNGNPPRVNTTTVNIDVSDVNDNAPLFSRDNYSVIIQENKPVGFSVLKLVVTDKDSSHNGPPFFFTIVSGNDENAFEVNQHGVLLTAATIKRKVKDHYLLHVKVADSGKPQLSSMTHIDIRVIEESIHPPAILPLEIFITAFGEEYSGGVIGKIHATDQDVYDTLMYSLDPHMDGLFSVSSTGGKLIAHRKLDIGQYLLNVSVTDGKFTTVADITVHIQQVTQEMLNHTVAIRFANLTPEEFVGDYWRNFQRALRNILGVRKNDIQIVSLQPSEPHSHLDVLLFVERSGGTHVSTKQLLHKINSSVTDVEEIIGVRILEVFQKLCAGLDCPWKFCDEKVSVDENVMSTHSTARLSFVTPRHHRTAVCLCKDGTCPPVHHGCEDNPCPAGSECVADPREEKYSCVCPGGGFGKCPGSSSITFTGNSFVKYRLLENENRLEMKLSMRLRTYSSHAVVMYARGTDYSILEIHTGRLQYKFDCGSGPGIVSVQSIQVNDGQWHAVSLEVEGNYAKLVLDEVHTASGTAPGALKTLNLDNYVFFGGHLRQQGTKHGRGAQVASGFRGCMDSIYLNGQELPLNNKPRAYAHIEEWVDLSHGCLLTATEDCSSSPCQNGGVCNPSPTGGYYCKCSALYVGTFCEVSVNPCSSNPCLYGGTCMVDNGGFVCQCRGLYTGQRCQLSPYCKDDPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECAGNPCRNGALCENTHGSYHCNCSQEYRGKHCEDASPNHYVSTPWNIGLAEGIGIIVFIAGIVLLVMVFVLCRKMISRKKKRQAEPEDKRLGPTTAFLQRPYFDSKLNKNIYSDIPPQVPVRPISYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTFNPESMHGHRKAVAVCSVAPNLPPPPPSNSPSDSDSIQKPSWDFDYDAKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESCDDNGYHWDTSDWMPSVPLPDIQEFPNYEAIDEHTPLYSADPNAIDTDYYPGGYDIESDFPPPPEDFPAPDELPPLPPEFSDQFESIHPPRDMPAAGSLGSSSRSRQRFNLNQYLPNFYPADMSEPQKQGAGENSPCREPYTPYPPGYQRNFEAPTIENMPMSVYASTASCSDVSACCEVESEVMMSDYESGDDGHFEEVTIPPLDSQQHTEV", "length": 4590, "header": "tr|F2Z4A3-1|A0A087WRT4_MOUSE Computationally mapped isoform of FAT atypical cadherin 1 OS=Mus musculus OX=10090 GN=Fat1 PE=1 SV=1 CANONICAL=A0A087WRT4-1" }, "locus": { "chromosome": "8", "start_pos": 45504443, "end_pos": 45403251, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000191428.7", "url": "https://www.ensembl.org/id/ENSMUST00000191428.7" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000140596.2", "url": "https://www.ensembl.org/id/ENSMUSP00000140596.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G06110VR", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 1553, "start_aa": "Asn", "end_pos": 1553, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1553", "evidence": [ { "id": "2653", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2653" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G06110VR", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 1904, "start_aa": "Asn", "end_pos": 1904, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1904", "evidence": [ { "id": "2653", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2653" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G70101JE", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 1904, "start_aa": "Asn", "end_pos": 1904, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1904", "evidence": [ { "id": "2653", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2653" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G06110VR", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 1942, "start_aa": "Asn", "end_pos": 1942, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1942", "evidence": [ { "id": "2653", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2653" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G39188ZX", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 1993, "start_aa": "Asn", "end_pos": 1993, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1993", "evidence": [ { "id": "2653", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2653" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G05724UK", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 2327, "start_aa": "Asn", "end_pos": 2327, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2327", "evidence": [ { "id": "2653", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2653" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G06110VR", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 2327, "start_aa": "Asn", "end_pos": 2327, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2327", "evidence": [ { "id": "2653", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2653" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G39188ZX", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 2327, "start_aa": "Asn", "end_pos": 2327, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2327", "evidence": [ { "id": "2653", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2653" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G70101JE", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 2327, "start_aa": "Asn", "end_pos": 2327, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2327", "evidence": [ { "id": "2653", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2653" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G05724UK", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 41, "start_aa": "Asn", "end_pos": 41, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn41", "evidence": [ { "id": "2653", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2653" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G14260UH", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 41, "start_aa": "Asn", "end_pos": 41, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn41", "evidence": [ { "id": "2653", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2653" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G64527OM", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 41, "start_aa": "Asn", "end_pos": 41, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn41", "evidence": [ { "id": "2653", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2653" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G06110VR", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 999, "start_aa": "Asn", "end_pos": 999, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn999", "evidence": [ { "id": "2653", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2653" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.", "journal": "Nature communications", "date": "2019", "authors": "Riley NM, Hebert AS, Westphall MS, Coon JJ", "evidence": [ { "database": "GlyConnect", "id": "2653", "url": "https://glyconnect.expasy.org/browser/proteins/2653" } ], "reference": [ { "type": "PubMed", "id": "30899004", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "title": "Effects of cyclic tensile strain and microgravity on the distribution of actin fiber and Fat1 cadherin in murine articular chondrocytes.", "journal": "Journal of biomechanics", "date": "2021", "authors": "Hatakeyama J, Nomura M, Wakimoto Y, Inoue S, Li C, Takamura D, Akisue T, Moriyama H", "evidence": [ { "database": "RefSeq", "id": "NP_001074755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074755" } ], "reference": [ { "type": "PubMed", "id": "34627073", "url": "https://glygen.org/publication/PubMed/34627073" } ] }, { "title": "Astrocyte-intrinsic and -extrinsic Fat1 activities regulate astrocyte development and angiogenesis in the retina.", "journal": "Development (Cambridge, England)", "date": "2022", "authors": "Helmbacher F", "evidence": [ { "database": "RefSeq", "id": "NP_001074755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074755" } ], "reference": [ { "type": "PubMed", "id": "35050341", "url": "https://glygen.org/publication/PubMed/35050341" } ] }, { "title": "n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.", "journal": "International journal of molecular sciences", "date": "2023-08-31", "authors": "Hernandez Jessica, Sch\u00e4ffer Julia, Herden Christiane, Pflieger Fabian Johannes, Reiche Sylvia, K\u00f6rber Svenja, Kitagawa Hiromu, Welter Joelle, Michels Susanne, Culmsee Carsten, Bier Jens, Sommer Natascha, Kang Jing X, Mayer Konstantin, Hecker Matthias, Rummel Christoph", "evidence": [ { "database": "RefSeq", "id": "NP_001074755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074755" } ], "reference": [ { "type": "PubMed", "id": "37686333", "url": "https://glygen.org/publication/PubMed/37686333" } ] } ], "pathway": [ { "id": "mmu:14107", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14107", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K5L1-1", "protein_name": "FAT atypical cadherin 1", "gene_name": "Fat1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRHLALLLLLLLFLQHFGDGDGSQRLEPTPSLQFTHVQYNVTVHENSAAKTYVGHPRKMGIYILDPSWEIRYKIISGDNENLFKAEEYVLGDFCFLRIRTKGGNTAILNREVRDHYTLVIKAVEKVTDAEARAKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVVVLTGRLDVLETQRYELEILAVDRGMKLYGSSGVSSLAKLTVHVEQANECAPEITAVTLSPSELDKDPTYAIITVEDCDQGANGEIASLSIVAGDLLQQFKTVRSFPGSKAFKVKAVGGVDWDSHPYGYNLTVQAKDKGTPPQFSPVKVIHVISPQFRAGPVKFEMDVYRAEISEFAPPHTPVVLVKAIPSYSHLRYVFKSTPGKPKFGLNHNTGLISILEPIKRQHTTHFELEVTTSDRRASTKVVVKVVGTNSNPPEFTQTSYKASFDENAPVGTPVMRVSAVDPDEGENGYVTYSIANLNHVPFVIDHFTGAVSTSENLDYELMPRVYMLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKTNCEGTIPRDLGVGEQITTVSAIDADELQLVRYQIEAGNELDLFGLNPSSGVLSLKHSLMDGLGAKVSFHSLRITATDGENFATPLYINLTVAASRKPVNLRCEETGVAKMLAEKLLQANKLHHQGDAEDIFFDSHSVNAHAPQFRGSLPTGIEVKEDLPVGASILFMNATDLDSGFNGKLVYAISGGNDDSCFTVDMETGMLKVLSPLDREVTDKYTLNITVYDLGIPQRAAWRLLDVTVLDANDNAPEFLQESYFVEVSEDKEINSEIIQVEATDKDLGPSGHVTYAILTDTEKFAIDRVTGVVKIIQPLDREVQRVHYLKIEARDQATEEPWLSSTVLLKVSLDDVNDNPPRFIPPSYSVKVREDLPEGTIIMWLEAHDPDVGQSSQVRYSLLDHGEGHFDVDKLSGAVRIVQQLDFEKKQLYNLTVRAKDKGKPASLSSTGYVEVEVVDVNENLHAPVFSSFVEKGTVKEDVPMGSSVMTVSAHDEDTGRDGEIRYSIRDGSGVGVFRIDEETGVIETSDRLDRESTSHYWLTVYATDQGVVPLSSFIEVYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSSDKLTYRITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGVPPRSTIARVIVKILDENDNRPQFLQKFYKIRLPEREKADGDRSAKREPLYRVIAADKDEGPNAELSYSIEEGNEHGRFSIEPKTGVVSSKKFSAAGEYDILSIKAIDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESVFSFTVMESDPVAHMIGVISVEPPGMPLWFDIIGGNYDSHFDVDKGTGTIIVAKPLDAEQKSSYNLTVEATDGTSTILTQVLIKVIDTNDHRPQFSTSKYEVSVPEDTEPETEILQISAVDRDEKNKLIYTLQSSIDPASLKKFRLDPATGALYTSEKLDHEAIHQHVLTVMVRDQDVPVKRNFARIIVNVSDMNDHSPWFTSSSYEGRVYESAAVGSVVLQVTALDRDKGRNAEVLYSIESGNIGNSFTIDPILGSIKTARELDRSHQVDYDLMVKATDKGEPPMSEMTSVRISVTVADNASPKFTSKEYSAEISEAIRIGSFVGMVSAHSQSSVMYEVKDGNIGDAFNINPHSGSIVTQRALDFETLPIYTLTVQGTNMAGLSTNTTVVVHIQDENDNPPAFTRAEYSGFISESASVNSVVLTDKNVPLVIRATDADRESNALLVYQIVEPSVHNYFAIDPTTGAIHTVLSLDYEETRVFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFSKSLYEASLLLPTYKGVNVITVNATDADSRAFSQLIYSITKGNIGEKFSMDHKTGTIAIQNTTQLRSRYELTVRASDGRFTSVASVRINVKESRESPLKFTQDAYSAVVKENSTEAKTLAVITAIGNPINEPLFYRILNPDRRFKISHTSGVLSTTGIPFDREQQETFVVVVEVTKEREPSAVAHVVVKVTVEDQNDNAPVFVNLPYYAVVKVDAEVGHVIRHVTAIDRDSGRNGDVHYYLKEHHDHFEIGPSGDISLKKQFEHDTLNKEYLVTVVAKDGGNPAFSAEVLVPITVMNKAMPVFEKAFYSAEIPENVQTHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFESHPAYKLSIRATDSLTGAHAEVFVDIVVEDINDNPPVFVQQSYSTTLSEASVIGAPILQVRATDSDSEPNRGISYQLIGNHSKSHDHFHIDSHTGLISLVRALDYEQFQQHKLLVRAVDGGMPPLSSDVVVTVDVTDLNDNPPLFEQQVYEARISEHAAHGHFVMCVKACDADRSDLDRLEYSILSGNDHKSFVIDGETGIITLSNPRRHTLKPFYSLNVSVSDGVFRSSARVNVTVMGGNLHSPVFHQNEYEVELAENAPLHTLVVQVKATDRDSGIYGHLTYHLVNDFAKDRFYVNDGGQVFTLERLDREAPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRSTKYEVNVGSSAAKGTSVVKVFASDADEGSNADVTYAIEADSESVEENLEINQLTGLITTKESLIGLENEFFTFFVRAVDNGSPPKESVVPVYVKILPPEVQLPRFSEPFYTYSISEDMPIGTEIDLIRVEHSGTVLYTLVKGNTPESNRDEFFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTLDDYEVVASIDVSIQVKDANDNSPVLESNPYEAFIVENLPAGSRVIQVRASDLDSGVNGQVMYSLDQSQDADIIESFAINMETGWITTLKELDHEERASYQIKVVASDHGEKVQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPPGGVIAILSTTDADSEEINRQVSYFITGGDALGQFAVENMQNDWRVYVKKPLDREQKDSYLLTVTATDGTFSSKARVEVKVLDANDNSPVCERTAYSDAIPEDALPGKLVMQVSATDADIRSNAEITYTLFGSGAEKFKLNPDTGELRTLALLDREEQAVYHLLVKATDGGGRSCQATIVLTLEDVNDNTPEFTADPYAITVFENTEPGTPLTRVQATDADAGLNRKISYSLLDSADGQFSINEQSGILQLEKHLDRELQAVYTLTLKAADQGLPRKLTATGTVVVSVLDINDNPPVFEYREYGATVSEDIVIGTEVLQVYAASRDIEANAEITYAIISGNEHGKFSIDSKTGAIFIIENLDYESSHGYYLTVEATDGGTPSLSDVATVNINITDINDNSPVFSQDSYTTVVSEDAALEQPVITIMADDADGPSNSHILYSIIEGNQGSPFTIDPVRGEIKVTKPLDRETISGYTLTVQAADNGNPPRVNTTTVNIDVSDVNDNAPLFSRDNYSVIIQENKPVGFSVLKLVVTDKDSSHNGPPFSFAIVSGNDDNMFEVNQHGVLLTAATVKRKVKDHYLLHVKVADNGKPQLSSLTHIDIRVIEESIHPPAILPLEIFITASGEEYSGGVIGKIHATDQDVYDTLTYSLDPHMDGLFSVSSTGGKLIAHRKLDIGQYLLNVSVTDGKFTTVADITVHIQQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQRALRNILGIRKNDIQIVSLQPSEPHSHLDVLLFVEKSGGTQISTKQLLHKINSSVTDIEEIIGVRILDVFQKLCAGLDCPWKFCDEKVSVDENIMSTHSTARLSFVTPRHHRTAVCLCKDGTCPPVHQGCEDNPCPAGSECVADPREEKYSCVCPGGGFAKCPGSSSITFTGSSFVKYRLMENENRLEMKLTMRLRTYSSHAVVMYARGTDYSILEIHTGRLQYKFDCGSGPGIVSVQSIQVNDGQWHAVSLEVEGNYAKLVLDEVHTASGTAPGALKTLNLDNYVIFGGHLRQQGTKHGRNTQVANGFRGCMDSIYLNGQELPLNNKPRAYAHIEEWVDLAHGCLLTATEDCSSNPCQNGGVCNPSPTGGYYCKCSALHAGTYCEVSVNPCSSNPCLYGGTCMVDNGGFVCQCRGLYTGQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECAGNPCRNGALCENTHGSYHCNCSQEYRGKHCEDATPNHYVSTPWNIGLAEGIGIIVFIAGIFLLVVVFVLCRKMISRKKKHQAEPEDKRLGPTTAFLQRPYFDSKPSKNIYSDIPPQVPVRPISYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTFNPESMHGHRKAVAVCSVAPNLPPPPPSNSPSDSDSIQKPSWDFDYDAKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESCDDNESLAAPDLSKPRGYHWDTSDWMPSVPLPDIQEFPNYEVIDEHTPLYSADPNAIDTDYYPGGYDIESDFPPPPEDFPAPDELPPLPPEFSDQFESIHPPRDMPAAGSLGSSSRNRQRFNLNQYLPNFYPVDMSEPQKQGAGENSTCREPYTPYPPGYQRNFEAPTIENMPMSVYTSTASCSDVSACCEVESEVMMSDYESGDDGHFEEVTIPPLDSQQHTEV", "length": 4601 }, "evidence": [ { "id": "45226963", "url": "http://www.informatics.jax.org/homology/45226963", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14517-1", "protein_name": "Protocadherin Fat 1", "gene_name": "FAT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKIHATDQDVYDTLTYSLDPQMDNLFSVSSTGGKLIAHKKLDIGQYLLNVSVTDGKFTTVADITVHIRQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQRALRNILGVRRNDIQIVSLQSSEPHPHLDVLLFVEKPGSAQISTKQLLHKINSSVTDIEEIIGVRILNVFQKLCAGLDCPWKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVCLCKEGRCPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQCPGSSSMTLTGNSYVKYRLTENENKLEMKLTMRLRTYSTHAVVMYARGTDYSILEIHHGRLQYKFDCGSGPGIVSVQSIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGHIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRGLYTGQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCEDAAPNQYVSTPWNIGLAEGIGIVVFVAGIFLLVVVFVLCRKMISRKKKHQAEPKDKHLGPATAFLQRPYFDSKLNKNIYSDIPPQVPVRPISYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTFNPESVHGHRKAVAVCSVAPNLPPPPPSNSPSDSDSIQKPSWDFDYDTKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESCDDNGYHWDTSDWMPSVPLPDIQEFPNYEVIDEQTPLYSADPNAIDTDYYPGGYDIESDFPPPPEDFPAADELPPLPPEFSNQFESIHPPRDMPAAGSLGSSSRNRQRFNLNQYLPNFYPLDMSEPQTKGTGENSTCREPHAPYPPGYQRHFEAPAVESMPMSVYASTASCSDVSACCEVESEVMMSDYESGDDGHFEEVTIPPLDSQQHTEV", "length": 4588 }, "evidence": [ { "id": "45226963", "url": "http://www.informatics.jax.org/homology/45226963", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A087WRT4", "url": "https://www.uniprot.org/uniprot/A0A087WRT4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A087WRT4", "url": "https://www.uniprot.org/uniprot/A0A087WRT4" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "A0A087WRT4", "url": "https://www.uniprot.org/uniprot/A0A087WRT4" } ], "pmid": "" }, { "name": "lamellipodium", "id": 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