{ "uniprot_canonical_ac": "Q9Z2U4-1", "uniprot_ac": "Q9Z2U4", "uniprot_id": "ELF4_MOUSE", "mass": { "chemical_mass": 70800.0, "monoisotopic_mass": 70800.0 }, "refseq": {}, "gene_names": [ { "name": "Elf4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9Z2U4", "id": "Q9Z2U4" }, { "name": "Mef", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9Z2U4", "id": "Q9Z2U4" } ], "protein_names": [ { "name": "ETS-related transcription factor Elf-4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9Z2U4" }, { "name": "E74-like factor 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z2U4" }, { "name": "Myeloid Elf-1-like factor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z2U4" } ], "function": [ { "annotation": "Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of LYZ. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Transactivates the PRF1 promoter in natural killer (NK) cells and in CD8+ T cells (PubMed:34326534). Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses. Required for sustained transcription of anti-inflammatory genes, including IL1RN (PubMed:34326534, PubMed:35266071). Is a negative regulator of pro-inflammatory cytokines expression, including IL17A, IL1B, IL6, TNFA and CXCL1 (PubMed:34326534, PubMed:35266071). Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses (PubMed:34326534, PubMed:35266071).", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4#function" }, { "database": "PubMed", "id": "19412182", "url": "https://glygen.org/publication/PubMed/19412182" }, { "database": "PubMed", "id": "34326534", "url": "https://glygen.org/publication/PubMed/34326534" }, { "database": "PubMed", "id": "35266071", "url": "https://glygen.org/publication/PubMed/35266071" }, { "database": "PubMed", "id": "12387738", "url": "https://glygen.org/publication/PubMed/12387738" }, { "database": "PubMed", "id": "19380490", "url": "https://glygen.org/publication/PubMed/19380490" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 230, "end_pos": 230, "sequence_org": "W", "sequence_mut": "R", "comment": "Higher TNFA, IL1B and IL6 expression in bone marrow-derived and peritoneal macrophages from mutant mice compared to wild-type, after VSV infection. Decreased viral clearance in mutant mice compared to wild-type. Loss of transcriptional activity shown in IFNB1 promoter-driven luciferase assay.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" }, { "database": "PubMed", "id": "35266071", "url": "https://glygen.org/publication/PubMed/35266071" } ] }, { "start_pos": 250, "end_pos": 250, "sequence_org": "W", "sequence_mut": "S", "comment": "Higher IL17A, IL1B, IL6, CXCL1 and TREM1 expression in bone marrow-derived macrophages from mutant mice compared to wild-type, after LPS stimulation. CD8+ T cells from mutant mice have reduced PRF1 expression when activated with IL-2 compared to cells from wild-type littermates.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" }, { "database": "PubMed", "id": "34326534", "url": "https://glygen.org/publication/PubMed/34326534" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Elf4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4", "locus": { "chromosome": "X", "start_pos": 47499923, "end_pos": 47552009, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000031103", "url": "https://www.ensembl.org/id/ENSMUSG00000031103" } ] } } ], "crossref": [ { "id": "ENSMUSG00000031103", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031103", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "56501", "url": "https://www.ncbi.nlm.nih.gov/gene/56501", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:56501", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:56501", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1928377", "url": "http://www.informatics.jax.org/marker/MGI:1928377", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "DDQEGHC", "url": "https://omabrowser.org/oma/group/DDQEGHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4245771at2759", "url": "http://www.orthodb.org/?query=4245771at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849:SF170", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849:SF170", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00178", "url": "http://pfam.xfam.org/family/PF00178", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12310", "url": "http://pfam.xfam.org/family/PF12310", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9Z2U4", "url": "http://purl.obolibrary.org/obo/PR_Q9Z2U4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_006541589", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006541589", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3U1U8", "url": "https://www.uniprot.org/uniprot/Q3U1U8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3U1U8-1", "url": "https://www.uniprot.org/uniprot/Q3U1U8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Z2U4-1", "url": "https://www.uniprot.org/uniprot/Q9Z2U4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAIALQPSDLVFEFASNGMDDIHQLEDPSVFPAVIVEQVPYPELVHLCSGLDLDEVHNGIIRDRTLCMTQDQILEGSILLTDDDVSTSNNVSSTEVLFNVATPSDVLDEKQIFSSPEVLSDSNSVQAINLPNFLLSTPEPDDLKKTSDAGDQKEHSEEEKVSREENLRKMGKARKRNRKTKNNRSTSPVTDPSMPIRKKSKDGKGSTIYLWEFLLALLQDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLVVIDDEEESPETPEDSSQASTSSTPSTSTIRRASSRVGTRASPEDKDNPPWEKPKVQHTGLQPSASLELGLSVDEEVPTTSTMLASPLQSQARLTKTVSSSPAPSNIHLGVAPVGPGSTVTLQTIPLTTVLTNGPPASTTAPTQLVLQSVPQVSTFKDTFTLQTSFPLNTNLQENQVATQGAPLILSGLPQLLAGANPQSNPAPSQVIGAGSAGPSSQPPGTVIAAFIRTSSGTSVPVVKEGPLRSSSYVQGVVTGAPVEGLLVPEETLRELLRDQGHLQPLPSQVLSRGSHNLSLVGNQTLSPPSHPTVGLTPVAELELSSGSGPLFVTEPSVTRSPTQAPFSPFNPTSLIKMEPQDI", "length": 655, "header": "sp|Q9Z2U4-1|ELF4_MOUSE Isoform 1 of ETS-related transcription factor Elf-4 OS=Mus musculus OX=10090 GN=Elf4 PE=1 SV=2 CANONICAL=Q9Z2U4-1" }, "isoforms": [ { "isoform_ac": "Q3U1U8-1", "url": "", "sequence": { "sequence": "MAIALQPSDLVFEFASNGMDDIHQLEDPSVFPAVIVEQVPYPELVHLCSGLDLDEVHNGIIRDRTLCMTQDQILEGSILLTDDDVSTSNNVSSTEVLFNVATPSDVLDEKQIFSSPEVLSDSNSVQAINLPNFLLSTPEPDDLKKTSDAGDQKEHSEEEKVSREENLRKMGKARKRNRKTKNNRSTSPVTDPSMPIRKKSKDGKGSTIYLWEFLLALLQDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLVVIDDEEESPETPEDSSQASTSSTPSTSTIRRASSRVGTRASPEDKDNPPWEKPKVQHTGLQPSASLELGLSVDEEVPTTSTMLASPLQSQARLT", "length": 391, "header": "tr|Q3U1U8-1|Q3U1U8_MOUSE Computationally mapped isoform of E74-like factor 4 (ets domain transcription factor) OS=Mus musculus OX=10090 GN=Elf4 PE=1 SV=1 CANONICAL=Q9Z2U4-1" }, "locus": { "chromosome": "X", "start_pos": 47513026, "end_pos": 47505535, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000140486.2", "url": "https://www.ensembl.org/id/ENSMUST00000140486.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000118436.2", "url": "https://www.ensembl.org/id/ENSMUSP00000118436.2" } ] } }, { "isoform_ac": "Q9Z2U4-1", "url": "", "sequence": { "sequence": "MAIALQPSDLVFEFASNGMDDIHQLEDPSVFPAVIVEQVPYPELVHLCSGLDLDEVHNGIIRDRTLCMTQDQILEGSILLTDDDVSTSNNVSSTEVLFNVATPSDVLDEKQIFSSPEVLSDSNSVQAINLPNFLLSTPEPDDLKKTSDAGDQKEHSEEEKVSREENLRKMGKARKRNRKTKNNRSTSPVTDPSMPIRKKSKDGKGSTIYLWEFLLALLQDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLVVIDDEEESPETPEDSSQASTSSTPSTSTIRRASSRVGTRASPEDKDNPPWEKPKVQHTGLQPSASLELGLSVDEEVPTTSTMLASPLQSQARLTKTVSSSPAPSNIHLGVAPVGPGSTVTLQTIPLTTVLTNGPPASTTAPTQLVLQSVPQVSTFKDTFTLQTSFPLNTNLQENQVATQGAPLILSGLPQLLAGANPQSNPAPSQVIGAGSAGPSSQPPGTVIAAFIRTSSGTSVPVVKEGPLRSSSYVQGVVTGAPVEGLLVPEETLRELLRDQGHLQPLPSQVLSRGSHNLSLVGNQTLSPPSHPTVGLTPVAELELSSGSGPLFVTEPSVTRSPTQAPFSPFNPTSLIKMEPQDI", "length": 655, "header": "sp|Q9Z2U4-1|ELF4_MOUSE Isoform 1 of ETS-related transcription factor Elf-4 OS=Mus musculus OX=10090 GN=Elf4 PE=1 SV=2 CANONICAL=Q9Z2U4-1" }, "locus": { "chromosome": "X", "start_pos": 47513026, "end_pos": 47503543, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114958", "url": "https://www.ensembl.org/id/ENSMUST00000114958" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110608", "url": "https://www.ensembl.org/id/ENSMUSP00000110608" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 187, "end_pos": 187, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "site_lbl": "Ser187" }, { "start_pos": 633, "end_pos": 633, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "site_lbl": "Ser633" }, { "start_pos": 640, "end_pos": 640, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "site_lbl": "Ser640" } ], "glycation": [], "keywords": [], "publication": [ { "title": "The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells.", "journal": "Immunity", "date": "2002", "authors": "Lacorazza HD, Miyazaki Y, Di Cristofano A, Deblasio A, Hedvat C, Zhang J, Cordon-Cardo C, Mao S, Pandolfi PP, Nimer SD", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "reference": [ { "type": "PubMed", "id": "12387738", "url": "https://glygen.org/publication/PubMed/12387738" } ] }, { "title": "ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation.", "journal": "Mol. Cell. Biol.", "date": "2009", "authors": "Liu Y., Izumi M., Ohyashiki K., Miyata Y., Elf S., Menendez S., Nimer S.D., Sashida G.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "reference": [ { "type": "PubMed", "id": "19380490", "url": "https://glygen.org/publication/PubMed/19380490" } ] }, { "title": "Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2.", "journal": "Nat. Immunol.", "date": "2009", "authors": "Yamada T., Mamonkin M., Park C.S., Lacorazza H.D.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "reference": [ { "type": "PubMed", "id": "19412182", "url": "https://glygen.org/publication/PubMed/19412182" } ] }, { "title": "Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation.", "journal": "Nat. Immunol.", "date": "2021", "authors": "Tyler PM, Bucklin ML, Zhao M, Maher TJ, Rice AJ, Ji W, Warner N, Pan J, Morotti R, McCarthy P, Griffiths A, van Rossum AMC, Hollink IHIM, Dalm VASH, Catanzaro J, Lakhani SA, Muise AM, Lucas CL", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "reference": [ { "type": "PubMed", "id": "34326534", "url": "https://glygen.org/publication/PubMed/34326534" } ] }, { "title": "Loss of Function Mutation in ELF4 Causes Autoinflammatory and Immunodeficiency Disease in Human.", "journal": "J. Clin. Immunol.", "date": "2022", "authors": "Sun G, Qiu L, Yu L, An Y, Ding Y, Zhou L, Wu J, Yang X, Zhang Z, Tang X, Xia H, Cao L, You F, Zhao X, Du H", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "reference": [ { "type": "PubMed", "id": "35266071", "url": "https://glygen.org/publication/PubMed/35266071" } ] } ], "pathway": [ { "id": "mmu:56501", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:56501", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZWM8-1", "protein_name": "E74-like factor 4 (ets domain transcription factor)", "gene_name": "Elf4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAIALQPSDLVFEFASNGMDDIHQLEDPSVFPAVIVEQVPYPELVHLYSGLDLDEVHSGIIRDRTLCMTQDQILEGSILLTDDNVSTSNNSSSTEVLFNVATPSDVLDEKQIFSTPEVLPDSNSVQAINLPNFLLSTPEPDDPKKTSDAGDQKEYSLEEVSREENLRKIGKSRKRNRKTKNNRSTSPVTDPSVPIRKKSKDGKGSTIYLWEFLLALLQDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLVVIDDEEESTETPEDSSQASTSSTPSTSTTRRPSSRVVTRASPEDKDSPSWEKPKVEHTGLQPSASLELGLSVDEEVPTTSTMIVSPLQSQAKPAKTVSTSAPSNIHLGVAPVGPGSTVTLQTIPLTTVLTNGPPAGTTAPAQLVLQSVPQVSTFKDTLTLQTSFPLNASLQENQVATQGTPLILSGLPQLLAGANHQSNPVTSQVIGAGSAGPSSQPPGTVIAAFIRTSNGTSVPVVKEGPLRSSSYVQGVVTGAPVEGLLVPEETLRELLRDQAHLQPLQSQALSRGSHNLSLVGNQTLSPPSHPTVGLTPVAELELSSSSGSLLVTEPNMTTSGSLLTRSPTQAPFSPFNPTSLIKMEPHDI", "length": 660 }, "evidence": [ { "id": "45225035", "url": "http://www.informatics.jax.org/homology/45225035", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99607-1", "protein_name": "ETS-related transcription factor Elf-4", "gene_name": "ELF4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAITLQPSDLIFEFASNGMDDDIHQLEDPSVFPAVIVEQVPYPDLLHLYSGLELDDVHNGIITDGTLCMTQDQILEGSFLLTDDNEATSHTMSTAEVLLNMESPSDILDEKQIFSTSEMLPDSDPAPAVTLPNYLFPASEPDALNRAGDTSDQEGHSLEEKASREESAKKTGKSKKRIRKTKGNRSTSPVTDPSIPIRKKSKDGKGSTIYLWEFLLALLQDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLVVIEDEDESSEATAAPPQASTASVASASTTRRTSSRVSSRSAPQGKGSSSWEKPKIQHVGLQPSASLELGPSLDEEIPTTSTMLVSPAEGQVKLTKAVSASSVPSNIHLGVAPVGSGSALTLQTIPLTTVLTNGPPASTTAPTQLVLQSVPAASTFKDTFTLQASFPLNASFQDSQVAAPGAPLILSGLPQLLAGANRPTNPAPPTVTGAGPAGPSSQPPGTVIAAFIRTSGTTAAPRVKEGPLRSSSYVQGMVTGAPMEGLLVPEETLRELLRDQAHLQPLPTQVVSRGSHNPSLLGNQTLSPPSRPTVGLTPVAELELSSGSGSLLMAEPSVTTSGSLLTRSPTPAPFSPFNPTSLIKMEPHDI", "length": 663 }, "evidence": [ { "id": "45225035", "url": "http://www.informatics.jax.org/homology/45225035", "database": "MGI" }, { "id": "Q9Z2U4", "url": "https://omabrowser.org/oma/group/Q9Z2U4/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "pmid": "" }, { "name": "PML body", "id": "GO:0016605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "pmid": "" }, { "name": "negative regulation of interleukin-1 beta production", "id": "GO:0032691", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032691", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "pmid": "" }, { "name": "negative regulation of interleukin-6 production", "id": "GO:0032715", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032715", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "pmid": "" }, { "name": "negative regulation of tumor necrosis factor production", "id": "GO:0032720", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032720", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "pmid": "" }, { "name": "negative regulation of inflammatory response", "id": "GO:0050728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q9Z2U4", "url": "https://www.uniprot.org/uniprot/Q9Z2U4" } ], "pmid": "" }, { "name": "natural killer cell proliferation", "id": "GO:0001787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001787", "evidence": [ { 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