{
    "uniprot_canonical_ac": "Q9Z200-1",
    "uniprot_ac": "Q9Z200",
    "uniprot_id": "SH2B2_RAT",
    "mass": {
        "chemical_mass": 66708.0,
        "monoisotopic_mass": 66708.0
    },
    "refseq": {
        "ac": "NP_446121",
        "name": "SH2B adapter protein 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446121"
    },
    "gene_names": [
        {
            "name": "Sh2b2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q9Z200",
            "id": "Q9Z200"
        },
        {
            "name": "Aps",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446121",
            "id": "NP_446121"
        },
        {
            "name": "Aps",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9Z200",
            "id": "Q9Z200"
        },
        {
            "name": "Sh2b2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446121",
            "id": "NP_446121"
        }
    ],
    "protein_names": [
        {
            "name": "SH2B adapter protein 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q9Z200"
        },
        {
            "name": "Adapter protein with pleckstrin homology and Src homology 2 domains",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9Z200"
        },
        {
            "name": "SH2 and PH domain-containing adapter protein APS",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9Z200"
        },
        {
            "name": "SH2B adapter protein 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446121",
            "id": "NP_446121"
        },
        {
            "name": "adaptor protein with pleckstrin homology and src homology 2 domains; SH2 and PH domain-containing adapter protein APS; adapter protein with pleckstrin homology and Src homology 2 domains",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446121",
            "id": "NP_446121"
        }
    ],
    "function": [
        {
            "annotation": "APS was identified as a novel substrate for protein kinase B/Akt.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_446121",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446121"
                },
                {
                    "database": "PubMed",
                    "id": "16141217",
                    "url": "https://glygen.org/publication/PubMed/16141217"
                }
            ]
        },
        {
            "annotation": "Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis (By similarity). Involved in stimulation of glucose uptake by insulin. Involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Induces cytoskeletal reorganization and neurite outgrowth in cultured neurons.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z200",
                    "url": "https://www.uniprot.org/uniprot/Q9Z200#function"
                },
                {
                    "database": "PubMed",
                    "id": "10854852",
                    "url": "https://glygen.org/publication/PubMed/10854852"
                },
                {
                    "database": "PubMed",
                    "id": "15031295",
                    "url": "https://glygen.org/publication/PubMed/15031295"
                },
                {
                    "database": "PubMed",
                    "id": "9856458",
                    "url": "https://glygen.org/publication/PubMed/9856458"
                },
                {
                    "database": "PubMed",
                    "id": "11997497",
                    "url": "https://glygen.org/publication/PubMed/11997497"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 437,
            "end_pos": 437,
            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "Abolishes interaction with phosphorylated INSR.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z200",
                    "url": "https://www.uniprot.org/uniprot/Q9Z200"
                },
                {
                    "database": "PubMed",
                    "id": "14690593",
                    "url": "https://glygen.org/publication/PubMed/14690593"
                }
            ]
        },
        {
            "start_pos": 455,
            "end_pos": 455,
            "sequence_org": "K",
            "sequence_mut": "A",
            "comment": "Reduces interaction with phosphorylated INSR.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z200",
                    "url": "https://www.uniprot.org/uniprot/Q9Z200"
                },
                {
                    "database": "PubMed",
                    "id": "14690593",
                    "url": "https://glygen.org/publication/PubMed/14690593"
                }
            ]
        },
        {
            "start_pos": 457,
            "end_pos": 457,
            "sequence_org": "K",
            "sequence_mut": "N",
            "comment": "Abolishes interaction with phosphorylated INSR.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z200",
                    "url": "https://www.uniprot.org/uniprot/Q9Z200"
                },
                {
                    "database": "PubMed",
                    "id": "14690593",
                    "url": "https://glygen.org/publication/PubMed/14690593"
                }
            ]
        },
        {
            "start_pos": 618,
            "end_pos": 618,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Abolishes phosphorylation in response to insulin.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z200",
                    "url": "https://www.uniprot.org/uniprot/Q9Z200"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z200",
                    "url": "https://www.uniprot.org/uniprot/Q9Z200"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Sh2b2",
            "url": "https://www.uniprot.org/uniprot/Q9Z200",
            "locus": {
                "chromosome": "12",
                "start_pos": 20456844,
                "end_pos": 20429043,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000001425",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000001425"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000001425",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000001425",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd01231",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01231",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd10411",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10411",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "114203",
            "url": "https://www.ncbi.nlm.nih.gov/gene/114203",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q9Z200",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9Z200*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000980",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001849",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011993",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015012",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015012",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR030523",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR030523",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR035058",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035058",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036290",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036290",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036860",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:114203",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:114203",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "YHRMEGT",
            "url": "https://omabrowser.org/oma/group/YHRMEGT/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2995825at2759",
            "url": "http://www.orthodb.org/?query=2995825at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10872",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10872",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10872:SF4",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10872:SF4",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1RPY",
            "url": "https://www.rcsb.org/structure/1RPY",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "1RQQ",
            "url": "https://www.rcsb.org/structure/1RQQ",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "1YVH",
            "url": "https://www.rcsb.org/structure/1YVH",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "PF00017",
            "url": "http://pfam.xfam.org/family/PF00017",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00169",
            "url": "http://pfam.xfam.org/family/PF00169",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF08916",
            "url": "http://pfam.xfam.org/family/PF08916",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q9Z200",
            "url": "http://purl.obolibrary.org/obo/PR_Q9Z200",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-RNO-1433559",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1433559",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-983231",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983231",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_446121",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446121",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "69284",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=69284",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A8I6GLF9",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GLF9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6GLF9-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GLF9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6GLZ7",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GLZ7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6GLZ7-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GLZ7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9Z200",
            "url": "https://www.uniprot.org/uniprot/Q9Z200",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9Z200-1",
            "url": "https://www.uniprot.org/uniprot/Q9Z200-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MNGATPGSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANFLAVFSEEVRRVLGTAADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHVATKARVRKGFSLRNMSLCVVDGVRDLWHRRASPEPEGGATPKTTEPVSEPRDKWTRRLRLARTLAAKVELVDIQREGALRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVTSCSCELLTEADMPRPPETMTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSESNNTGDEGAELDPDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPTSPSNGAGASSSSGSSSSATSVPPRPAEGPLSARSRSNSTEHLLEAASGATEEPADATLGRARAVENQYSFY",
        "length": 621,
        "header": "sp|Q9Z200-1|SH2B2_RAT Isoform 1 of SH2B adapter protein 2  OS=Rattus norvegicus OX=10116 GN=Sh2b2 PE=1 SV=1 CANONICAL=Q9Z200-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I6GLF9-1",
            "url": "",
            "sequence": {
                "sequence": "MNGATPGSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANFLAVFSEEVRRVLGTAADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHVATKARVRKGFSLRNMSLCVVDGVRDLWHRRASPEPEGGATPKTTEPVSEPRDKWTRRLRLARTLAAKVELVDIQREGALRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVTSCSCELLTEADMPRPPETMTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSESNNTGTIGVPSPYKDLCGASEVVIFPIVLTVVLVF",
                "length": 418,
                "header": "tr|A0A8I6GLF9-1|A0A8I6GLF9_RAT Computationally mapped isoform of SH2B adaptor protein 2  OS=Rattus norvegicus OX=10116 GN=Sh2b2 PE=4 SV=1 CANONICAL=Q9Z200-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 20450691,
                "end_pos": 20441837,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000093990.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000093990.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000095058.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000095058.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6GLZ7-1",
            "url": "",
            "sequence": {
                "sequence": "MNGATPGSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANFLAVFSEEVRRVLGTAADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHVATKARVRKGFSLRNMSLCVVDGVRDLWHRRASPEPEGGATPKTTEPVSEPRDKWTRRLRLARTLAAKVELVDIQREGALRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVTSCSCELLTEADMPRPPETMTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSESNNTGDEGAELDPDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPGKTPHPEPGIWLRLQKVCLVCSKPGFDTQHFINWVWWFTPVIPALWR",
                "length": 561,
                "header": "tr|A0A8I6GLZ7-1|SH2B2_RAT Computationally mapped isoform of SH2B adapter protein 2  OS=Rattus norvegicus OX=10116 GN=Sh2b2 PE=1 SV=1 CANONICAL=Q9Z200-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 20455346,
                "end_pos": 20441837,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000102136.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000102136.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000097265.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000097265.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q9Z200-1",
            "url": "",
            "sequence": {
                "sequence": "MNGATPGSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANFLAVFSEEVRRVLGTAADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHVATKARVRKGFSLRNMSLCVVDGVRDLWHRRASPEPEGGATPKTTEPVSEPRDKWTRRLRLARTLAAKVELVDIQREGALRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVTSCSCELLTEADMPRPPETMTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSESNNTGDEGAELDPDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPTSPSNGAGASSSSGSSSSATSVPPRPAEGPLSARSRSNSTEHLLEAASGATEEPADATLGRARAVENQYSFY",
                "length": 621,
                "header": "sp|Q9Z200-1|SH2B2_RAT Isoform 1 of SH2B adapter protein 2  OS=Rattus norvegicus OX=10116 GN=Sh2b2 PE=1 SV=1 CANONICAL=Q9Z200-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 20456164,
                "end_pos": 20441837,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000001935",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000001935"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000001935",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000001935"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 130,
            "end_pos": 130,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z200",
                    "url": "https://www.uniprot.org/uniprot/Q9Z200"
                }
            ],
            "site_lbl": "Ser130"
        },
        {
            "start_pos": 303,
            "end_pos": 303,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z200",
                    "url": "https://www.uniprot.org/uniprot/Q9Z200"
                }
            ],
            "site_lbl": "Ser303"
        },
        {
            "start_pos": 47,
            "end_pos": 47,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z200",
                    "url": "https://www.uniprot.org/uniprot/Q9Z200"
                }
            ],
            "site_lbl": "Tyr47"
        },
        {
            "start_pos": 597,
            "end_pos": 597,
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