{
    "uniprot_canonical_ac": "Q9Z1X1-1",
    "uniprot_ac": "Q9Z1X1",
    "uniprot_id": "ESYT1_RAT",
    "mass": {
        "chemical_mass": 121159.0,
        "monoisotopic_mass": 121159.0
    },
    "refseq": {
        "ac": "NP_058945",
        "name": "extended synaptotagmin-1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058945"
    },
    "gene_names": [
        {
            "name": "Esyt1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q9Z1X1",
            "id": "Q9Z1X1"
        },
        {
            "name": "Esyt1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058945",
            "id": "NP_058945"
        },
        {
            "name": "Fam62a; Mbc2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058945",
            "id": "NP_058945"
        },
        {
            "name": "Fam62a",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9Z1X1",
            "id": "Q9Z1X1"
        },
        {
            "name": "Mbc2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9Z1X1",
            "id": "Q9Z1X1"
        }
    ],
    "protein_names": [
        {
            "name": "Extended synaptotagmin-1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q9Z1X1"
        },
        {
            "name": "E-Syt1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9Z1X1"
        },
        {
            "name": "Membrane-bound C2 domain-containing protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9Z1X1"
        },
        {
            "name": "extended synaptotagmin-1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058945",
            "id": "NP_058945"
        },
        {
            "name": "membrane bound C2 domain containing protein; E-Syt1; vp115; family with sequence similarity 62 (C2 domain containing), member A; extended synaptotagmin-like protein 1; extended synaptotagmin protein 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058945",
            "id": "NP_058945"
        },
        {
            "name": "vp115",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9Z1X1"
        }
    ],
    "function": [
        {
            "annotation": "Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z1X1",
                    "url": "https://www.uniprot.org/uniprot/Q9Z1X1#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z1X1",
                    "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Esyt1",
            "url": "https://www.uniprot.org/uniprot/Q9Z1X1",
            "locus": {
                "chromosome": "7",
                "start_pos": 928848,
                "end_pos": 946199,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000060753",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000060753"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000060753",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000060753",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd04030",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04030",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd04050",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04050",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd08391",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08391",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "29579",
            "url": "https://www.ncbi.nlm.nih.gov/gene/29579",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q9Z1X1",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9Z1X1*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000008",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR031468",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR031468",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR035892",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR037733",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037733",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR037749",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037749",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR037752",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037752",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR039010",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039010",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:29579",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:29579",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "HPGQSKE",
            "url": "https://omabrowser.org/oma/group/HPGQSKE/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "944695at2759",
            "url": "http://www.orthodb.org/?query=944695at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR45761",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45761",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR45761:SF3",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45761:SF3",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00168",
            "url": "http://pfam.xfam.org/family/PF00168",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF17047",
            "url": "http://pfam.xfam.org/family/PF17047",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q9Z1X1",
            "url": "http://purl.obolibrary.org/obo/PR_Q9Z1X1",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-RNO-9013149",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013149",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9013404",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013404",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9013405",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013405",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9013408",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013408",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9013423",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013423",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9035034",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9035034",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9840309",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9840309",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_058945",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058945",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "3053",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=3053",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2JXJ7",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JXJ7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2JXJ7-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JXJ7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9Z1X1",
            "url": "https://www.uniprot.org/uniprot/Q9Z1X1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9Z1X1-1",
            "url": "https://www.uniprot.org/uniprot/Q9Z1X1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MERSPEEGAGPEPSGQSPATDSTRERDGGSGVPPAGPGAASEALAVLTSFGRRLLVLVPVYLAGAAGLSVGFVLFGLALYLGWRRVRDGKERSLRAARQLLDDEERITAETLYMSHRELPAWVSFPDVEKAEWLNKIVVQVWPFLGQYMEKLLAETVAPAVRGANPHLQTFTFTRVELGEKPVRIIGVKVHPSQRKDQILLDLNVSYVGDLQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLIGDLPIVGAVSMFFIKRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRVGTQTFCSRVIDEELNPHWGETYEVIVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQAGVLDNWYPLQGGQGQVHLRLEWLSLLPDAEKLDQVLQWNRGITSRPEPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSVQDVTQESKATYSTNCPVWEEAFRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASELTLDQWFQLSSSGPNSRLYMKLVMRILYLDSSEMRLPTEPGAQDWDSESPETGSSVDAPPRPYHTTPNSHFGTENVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKVAGRSLRTHVVREDLNPRWNEVFEVIVTSIPGQELDIEVFDKDLDKDDFLGRYKVGLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLSPRPTAAELEEVLQVNSLIQTQKSSELAAALLSVYLERSEDLPLRKGTKPPSPYAILTVGETSHKTKTVSQTSAPIWEESASFLIRKPHAESLELQVRGEGTGTLGSISLPLSELLQEEQLCLDRWFALSGQGQVLMRVQLGILVSQHSGVEAHSHSSSSLNEEPEVLGDPTHTASPVLEVRHRLTHGDSPSEALIGPLGQVKLTVWYHSDEQKLISIIHSCRALRQNGRDLPDPYVSVLLLPDKNRGTKRKTSQKKRTLNPEFNERFEWDLPLDGTLRRKLDVSVKSNSSFMSRERELLGKVQLDLAEIDLSQGAAQWYDLIDDRDKGGS",
        "length": 1088,
        "header": "sp|Q9Z1X1-1|ESYT1_RAT Isoform 1 of Extended synaptotagmin-1  OS=Rattus norvegicus OX=10116 GN=Esyt1 PE=1 SV=1 CANONICAL=Q9Z1X1-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2JXJ7-1",
            "url": "",
            "sequence": {
                "sequence": "MERSPEEGAGPEPSGQSPATDSTRERDGGSGVPPAGPGAASEALAVLTSFGRRLLVLVPVYLAGAAGLSVGFVLFGLALYLGWRRVRDGKERSLRAARQLLDDEERITAETLYMSHRELPAWVSFPDVEKAEWLNKIVVQVWPFLGQYMEKLLAETVAPAVRGANPHLQTFTFTRVELGEKPVRIIGVKVHPSQRKDQILLDLNVSYVGDLQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLIGDLPIVGAVSMFFIKRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRVGTQTFCSRVIDEELNPRWGETYEVIVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQAGVLDNWYPLQGGQGQVHLRLEWLSLLPDAEKLDQVLQWNRGITSRPEPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSVQDVTQESKATYSTNCPVWEEAFRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASELTLDQWFQLSSSGPNSRLYMKLVMRILYLDSSEMRLPTEPGAQDWDSESPETGSSVDAPPRPYHTTPNSHFGTENVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKVAGRSLRTHVVREDLNPRWNEVFEVIVTSIPGQELDIEVFDKDLDKDDFLGRYKVGLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLSPRPTAAELEEVLQVNSLIQTQKSSELAAALLSVYLERSEDLPLRKGTKPPSPYAILTVGETSHKTKTVSQTSAPIWEESASFLIRKPHAESLELQVRGEGTGTLGSISLPLSELLQEEQLCLDRWFALSGQGQVLMRVQLGILVSQHSGVEAHSHSSSSLNEEPEVLGDPTHTASPVLEVRHRLTHGDSPSEALIGPLGQVKLTVWYHSDEQKLISIIHSCRALRQNGRDLPDPYVSVLLLPDKNRGTKRKTSQKKRTLNPEFNERFEWDLPLDGTLRRKLDVSVKSNSSFMSRERELLGKVQLDLAEIDLSQGAAQWYDLIDDRDKGGS",
                "length": 1088,
                "header": "tr|A0A0G2JXJ7-1|A0A0G2JXJ7_RAT Computationally mapped isoform of Extended synaptotagmin 1  OS=Rattus norvegicus OX=10116 GN=Esyt1 PE=1 SV=2 CANONICAL=Q9Z1X1-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 946108,
                "end_pos": 929238,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000082107.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000082107.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000070299.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000070299.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q9Z1X1-1",
            "url": "",
            "sequence": {
                "sequence": "MERSPEEGAGPEPSGQSPATDSTRERDGGSGVPPAGPGAASEALAVLTSFGRRLLVLVPVYLAGAAGLSVGFVLFGLALYLGWRRVRDGKERSLRAARQLLDDEERITAETLYMSHRELPAWVSFPDVEKAEWLNKIVVQVWPFLGQYMEKLLAETVAPAVRGANPHLQTFTFTRVELGEKPVRIIGVKVHPSQRKDQILLDLNVSYVGDLQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLIGDLPIVGAVSMFFIKRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRVGTQTFCSRVIDEELNPHWGETYEVIVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQAGVLDNWYPLQGGQGQVHLRLEWLSLLPDAEKLDQVLQWNRGITSRPEPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSVQDVTQESKATYSTNCPVWEEAFRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASELTLDQWFQLSSSGPNSRLYMKLVMRILYLDSSEMRLPTEPGAQDWDSESPETGSSVDAPPRPYHTTPNSHFGTENVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKVAGRSLRTHVVREDLNPRWNEVFEVIVTSIPGQELDIEVFDKDLDKDDFLGRYKVGLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLSPRPTAAELEEVLQVNSLIQTQKSSELAAALLSVYLERSEDLPLRKGTKPPSPYAILTVGETSHKTKTVSQTSAPIWEESASFLIRKPHAESLELQVRGEGTGTLGSISLPLSELLQEEQLCLDRWFALSGQGQVLMRVQLGILVSQHSGVEAHSHSSSSLNEEPEVLGDPTHTASPVLEVRHRLTHGDSPSEALIGPLGQVKLTVWYHSDEQKLISIIHSCRALRQNGRDLPDPYVSVLLLPDKNRGTKRKTSQKKRTLNPEFNERFEWDLPLDGTLRRKLDVSVKSNSSFMSRERELLGKVQLDLAEIDLSQGAAQWYDLIDDRDKGGS",
                "length": 1088,
                "header": "sp|Q9Z1X1-1|ESYT1_RAT Isoform 1 of Extended synaptotagmin-1  OS=Rattus norvegicus OX=10116 GN=Esyt1 PE=1 SV=1 CANONICAL=Q9Z1X1-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 316,
            "end_pos": 316,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine; by CDK5",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z1X1",
                    "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                }
            ],
            "site_lbl": "Ser316"
        },
        {
            "start_pos": 809,
            "end_pos": 809,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z1X1",
                    "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                }
            ],
            "site_lbl": "Ser809"
        },
        {
            "start_pos": 933,
            "end_pos": 933,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z1X1",
                    "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                }
            ],
            "site_lbl": "Ser933"
        },
        {
            "start_pos": 947,
            "end_pos": 947,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z1X1",
                    "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                }
            ],
            "site_lbl": "Ser947"
        },
        {
            "start_pos": 993,
            "end_pos": 993,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z1X1",
                    "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                },
                {
                    "database": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9Z1X1",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Z1X1"
                }
            ],
            "site_lbl": "Tyr993"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Cloning and preliminary characterization of a 121 kDa protein with multiple predicted C2 domains.",
            "journal": "Biochim. Biophys. Acta",
            "date": "1999",
            "authors": "Morris NJ, Ross SA, Neveu JM, Lane WS, Lienhard GE",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z1X1",
                    "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10350628",
                    "url": "https://glygen.org/publication/PubMed/10350628"
                }
            ]
        },
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nature communications",
            "date": "2012",
            "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z1X1",
                    "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JXJ7",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JXJ7"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9Z1X1",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Z1X1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:29579",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:29579",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-9013149",
            "name": "RAC1 GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013149",
            "resource": "Reactome",
            "description": "RAC1 GTPase cycle"
        },
        {
            "id": "R-RNO-9013404",
            "name": "RAC2 GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013404",
            "resource": "Reactome",
            "description": "RAC2 GTPase cycle"
        },
        {
            "id": "R-RNO-9013405",
            "name": "RHOD GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013405",
            "resource": "Reactome",
            "description": "RHOD GTPase cycle"
        },
        {
            "id": "R-RNO-9013408",
            "name": "RHOG GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013408",
            "resource": "Reactome",
            "description": "RHOG GTPase cycle"
        },
        {
            "id": "R-RNO-9013423",
            "name": "RAC3 GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013423",
            "resource": "Reactome",
            "description": "RAC3 GTPase cycle"
        },
        {
            "id": "R-RNO-9035034",
            "name": "RHOF GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9035034",
            "resource": "Reactome",
            "description": "RHOF GTPase cycle"
        },
        {
            "id": "R-RNO-9840309",
            "name": "Glycosphingolipid biosynthesis",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9840309",
            "resource": "Reactome",
            "description": "Glycosphingolipid biosynthesis"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q3U7R1-1",
            "protein_name": "Extended synaptotagmin-1",
            "gene_name": "Esyt1",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MEHSPEEGASPEPSGQPPATDSTRDGGSGVPPAGPGAASEALAVLTSFGRRLLVLVPVYLAGAAGLSVGFVLFGLALYLGWRRVRDGKERSLRAARQLLDDEERITAETLYMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGANPHLQTFTFTRVELGEKPLRIIGVKVHPSQRKDQILLDLNVSYVGDVQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLTGDLPIVGAVSMFFIKRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRVGTQTFCSRVIDEELNPHWGETYEVIVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQAGVLDNWYPLQGGQGQVHLRLEWLSLLPDAEKLDQVLQWNRGITSRPEPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSVQDVTRESKATYSTNSPVWEEAFRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASELTLDQWFQLSSSGPNSRLYMKLVMRILYLDYSEIRFPTVPGAQDWDRESLETGSSVDAPPRPYHTTPNSHFGTENVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKVAGKSFRTHVVREDLNPRWNEVFEVIVTSIPGQELEIEVFDKDLDKDDFLGRYKVSLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSSELAAALLSVFLERAEDLPLRKGTKPPSPYATITVGETSHKTKTVSQSSAPVWEESASFLIRKPHAESLELQVRGEGTGTLGSVSLPLSELLQEDQLCLDHWFALSGQGQVLMRAQLGILVSQHSGVEAHSHSYSHSHSSSSLNDEPEALGGPTHPASPVLEVRHRLTHGDSPSEAPVGPLGQVKLTVWYHSDEQKLISIIHSCRALRQNGRDLPDPYVSVLLLPDKNRSTKRKTPQKKRTLNPEFNERFEWDLPLDGTLRRKLDVSVKSNSSFMSRERELLGKVQLDLAEIDLSQGAAQWYDLMDDRDKGGS",
                "length": 1092
            },
            "evidence": [
                {
                    "id": "45226662",
                    "url": "http://www.informatics.jax.org/homology/45226662",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9BSJ8-1",
            "protein_name": "Extended synaptotagmin-1",
            "gene_name": "ESYT1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MERSPGEGPSPSPMDQPSAPSDPTDQPPAAHAKPDPGSGGQPAGPGAAGEALAVLTSFGRRLLVLIPVYLAGAVGLSVGFVLFGLALYLGWRRVRDEKERSLRAARQLLDDEEQLTAKTLYMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQTFTFTRVELGEKPLRIIGVKVHPGQRKEQILLDLNISYVGDVQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLIGDLPFVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQASVLDDWFPLQGGQGQVHLRLEWLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRILYLDSSEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQELEVEVFDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAEDLPLRKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQVRGEGTGVLGSLSLPLSELLVADQLCLDRWFTLSSGQGQVLLRAQLGILVSQHSGVEAHSHSYSHSSSSLSEEPELSGGPPHITSSAPELRQRLTHVDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVARWYDLMDNKDKGSS",
                "length": 1104
            },
            "evidence": [
                {
                    "id": "45226662",
                    "url": "http://www.informatics.jax.org/homology/45226662",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum membrane",
                        "id": "GO:0005789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "extrinsic component of cytoplasmic side of plasma membrane",
                        "id": "GO:0031234",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031234",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "lipid transport",
                        "id": "GO:0006869",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum-plasma membrane tethering",
                        "id": "GO:0061817",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061817",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "intermembrane lipid transfer",
                        "id": "GO:0120009",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120009",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 9,
                "go_terms": [
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "lipid binding",
                        "id": "GO:0008289",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "identical protein binding",
                        "id": "GO:0042802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "calcium ion binding",
                        "id": "GO:0005509",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "calcium-dependent phospholipid binding",
                        "id": "GO:0005544",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005544",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phosphatidylethanolamine binding",
                        "id": "GO:0008429",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008429",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phosphatidylcholine binding",
                        "id": "GO:0031210",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031210",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phosphatidylinositol binding",
                        "id": "GO:0035091",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phospholipid transfer activity",
                        "id": "GO:0120014",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120014",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z1X1",
                                "url": "https://www.uniprot.org/uniprot/Q9Z1X1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 1046,
            "end_pos": 1048,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 204,
            "end_pos": 206,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 265,
            "end_pos": 267,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
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                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                },
                {
                    "field": "n_linked_glycans",
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                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
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                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                {
                    "field": "n_linked_glycan_sites",
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                {
                    "field": "o_linked_glycans",
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                {
                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
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                    "field": "total",
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                },
                {
                    "field": "total_sites",
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                {
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                {
                    "field": "n_linked_glycan_sites",
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                {
                    "field": "o_linked_glycans",
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                {
                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
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                    "field": "total",
                    "count": 0
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                {
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                    "field": "n_linked_glycans",
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                {
                    "field": "n_linked_glycan_sites",
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                {
                    "field": "o_linked_glycans",
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                {
                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
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                    "field": "total",
                    "count": 5
                },
                {
                    "field": "total_sites",
                    "count": 5
                }
            ],
            "sort_fields": [
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                "kinase_uniprot_canonical_ac",
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        },
        {
            "table_id": "snv",
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                    "field": "total",
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                {
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            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
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            ],
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        {
            "table_id": "snv_non_disease",
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            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
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                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": [
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        }
    ]
}