{ "uniprot_canonical_ac": "Q9Z1T1-1", "uniprot_ac": "Q9Z1T1", "uniprot_id": "AP3B1_MOUSE", "mass": { "chemical_mass": 122740.0, "monoisotopic_mass": 122740.0 }, "refseq": { "ac": "NP_033810", "name": "AP-3 complex subunit beta-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033810" }, "gene_names": [ { "name": "Ap3b1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9Z1T1", "id": "Q9Z1T1" }, { "name": "AP-3; beta3A; Hps2; pe; pearl; rim2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033810", "id": "NP_033810" }, { "name": "Ap3b1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033810", "id": "NP_033810" } ], "protein_names": [ { "name": "AP-3 complex subunit beta-1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9Z1T1" }, { "name": "AP-3 complex subunit beta-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033810", "id": "NP_033810" }, { "name": "Adaptor protein complex AP-3 subunit beta-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z1T1" }, { "name": "Adaptor-related protein complex 3 subunit beta-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z1T1" }, { "name": "Beta-3A-adaptin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z1T1" }, { "name": "Clathrin assembly protein complex 3 beta-1 large chain", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z1T1" }, { "name": "beta3A-adaptin; adaptor protein complex AP-3 beta-1 subunit; adapter-related protein complex 3 subunit beta-1; clathrin assembly protein complex 3 beta-1 large chain; beta-3A-adaptin; adaptor protein complex AP-3 subunit beta-1; recombination induced mutation 2; adaptor-related protein complex 3 subunit beta-1; adaptor-related protein complex AP-3 beta 1 subunit", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033810", "id": "NP_033810" } ], "function": [ { "annotation": "Adaptor protein AP-3 produces synaptic vesicles that release at high frequency by recruiting phospholipid flippase ATP8A1.", "evidence": [ { "database": "RefSeq", "id": "NP_033810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033810" }, { "database": "PubMed", "id": "37723322", "url": "https://glygen.org/publication/PubMed/37723322" } ] }, { "annotation": "Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_033810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033810" }, { "database": "PubMed", "id": "33557836", "url": "https://glygen.org/publication/PubMed/33557836" } ] }, { "annotation": "Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1#function" }, { "database": "PubMed", "id": "21998198", "url": "https://glygen.org/publication/PubMed/21998198" } ] } ], "disease": [ { "disease_id": "DOID:0060540", "recommended_name": { "id": "DOID:0060540", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060540", "name": "Hermansky-Pudlak syndrome 2", "description": "A Hermansky-Pudlak syndrome that has_material_basis_in homozygous or compound heterozygous mutation in the gene encoding the beta-3A subunit of the AP3 complex (AP3B1) on chromosome 5q14.1." }, "synonyms": [ { "id": "MONDO:0011997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011997", "name": "Hermansky-Pudlak syndrome 2", "description": "A type of Hermansky-Pudlak syndrome (HPS), a multi-system disorder characterized by oculocutaneous albinism, bleeding diathesis and neutropenia." }, { "id": "MONDO:0011997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011997", "name": "AP3B1 Hermansky-Pudlak syndrome", "description": "" }, { "id": "MONDO:0011997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011997", "name": "HPS-2", "description": "" }, { "id": "MONDO:0011997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011997", "name": "HPS2", "description": "" }, { "id": "MONDO:0011997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011997", "name": "Hermansky-Pudlak syndrome 2", "description": "" }, { "id": "MONDO:0011997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011997", "name": "Hermansky-Pudlak syndrome caused by mutation in AP3B1", "description": "" }, { "id": "MONDO:0011997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011997", "name": "Hermansky-Pudlak syndrome type 2", "description": "" }, { "id": "MONDO:0011997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011997", "name": "Hermansky Pudlak syndrome 2", "description": "" }, { "id": "MONDO:0011997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011997", "name": "Hermansky-Pudlak syndrome with neutropenia", "description": "" }, { "id": "MONDO:0011997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011997", "name": "Platelet defects and oculocutaneous albinism", "description": "" }, { "id": "MIM:608233", "resource": "MIM", "url": "https://www.omim.org/entry/608233", "name": "Hermansky-Pudlak syndrome 2", "description": "Hermansky-Pudlak syndrome 2" } ], "evidence": [ { "id": "0060540", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060540" } ] }, { "disease_id": "DOID:1227", "recommended_name": { "id": "DOID:1227", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1227", "name": "neutropenia", "description": "" }, "synonyms": [], "evidence": [ { "id": "1227", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1227" } ] }, { "disease_id": "DOID:2223", "recommended_name": { "id": "DOID:2223", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2223", "name": "platelet storage pool deficiency", "description": "" }, "synonyms": [ { "id": "DOID:2223", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2223", "name": "Dense body defect", "description": "" }, { "id": "DOID:2223", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2223", "name": "Platelet dense granule deficiency", "description": "" }, { "id": "DOID:2223", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2223", "name": "Platelet storage pool defect", "description": "" }, { "id": "MONDO:0008495", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008495", "name": "platelet storage pool deficiency", "description": "Platelet storage pool deficiency refers to a group of conditions that are caused by problems with the platelet granules. Platelet granules are tiny storage sacs found within the platelets which release various substances to help stop bleeding. Platelet storage pool deficiencies occur when platelet granules are absent, reduced in number, or unable to empty their contents into the bloodstream. The signs and symptoms include frequent nosebleeds; abnormally heavy or prolonged menstruation ; easy bruising; recurrent anemia ; and abnormal bleeding after surgery, dental work or childbirth. Platelet storage pool deficiencies may be genetic or acquired (non-genetic). They can also be part of an inherited genetic syndrome such as Hermansky-Pudlak syndrome, Chediak-Higashi syndrome, thrombocytopenia-absent radius (TAR) syndrome, and Wiskott-Aldrich syndrome. Treatment is symptomatic." }, { "id": "MONDO:0008495", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008495", "name": "alpha dense granule deficiency", "description": "" }, { "id": "MONDO:0008495", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008495", "name": "combined alpha-delta platelet storage pool deficiency", "description": "" }, { "id": "MONDO:0008495", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008495", "name": "dense body defect", "description": "" }, { "id": "MONDO:0008495", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008495", "name": "platelet dense granule deficiency", "description": "" }, { "id": "MONDO:0008495", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008495", "name": "platelet storage pool defect", "description": "" }, { "id": "MONDO:0008495", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008495", "name": "alpha delta granule deficiency", "description": "" }, { "id": "MONDO:0008495", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008495", "name": "platelet storage pool diseases", "description": "" }, { "id": "MONDO:0008495", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008495", "name": "storage pool platelet disease", "description": "" } ], "evidence": [ { "id": "2223", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2223" } ] }, { "disease_id": "DOID:3082", "recommended_name": { "id": "DOID:3082", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3082", "name": "interstitial lung disease", "description": "A lung disease that is characterized by inflammation and altered lung interstitium compromising pulmonary function and often has_symptom shortness of breath, dyspnea, and/or cough." }, "synonyms": [ { "id": "DOID:3082", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3082", "name": "ILD", "description": "" } ], "evidence": [ { "id": "3082", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3082" } ] }, { "disease_id": "DOID:3753", "recommended_name": { "id": "DOID:3753", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3753", "name": "Hermansky-Pudlak syndrome", "description": "A syndrome characterized by oculocutaneous albinism, bleeding problems due to platelet storage pool defect, visual impairment and lysosomal accumulation of ceroid lipofuscin." }, "synonyms": [ { "id": "MONDO:0008748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008748", "name": "Hermansky-Pudlak syndrome 1", "description": "Any Hermansky-Pudlak syndrome in which the cause of the disease is a mutation in the HPS1 gene." }, { "id": "MONDO:0008748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008748", "name": "HPS1 Hermansky-Pudlak syndrome", "description": "" }, { "id": "MONDO:0008748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008748", "name": "Hermansky-Pudlak syndrome 1", "description": "" }, { "id": "MONDO:0008748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008748", "name": "Hermansky-Pudlak syndrome caused by mutation in HPS1", "description": "" }, { "id": "MONDO:0008748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008748", "name": "Hermansky-Pudlak syndrome type 1", "description": "" }, { "id": "MONDO:0008748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008748", "name": "Delta storage pool disease", "description": "" }, { "id": "MONDO:0008748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008748", "name": "HPS1", "description": "" }, { "id": "MONDO:0008748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008748", "name": "albinism with hemorrhagic diathesis and pigmented reticuloendothelial cells", "description": "" }, { "id": "MIM:203300", "resource": "MIM", "url": "https://www.omim.org/entry/203300", "name": "Hermansky-Pudlak syndrome 1", "description": "Hermansky-Pudlak syndrome 1" } ], "evidence": [ { "id": "3753", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3753" } ] }, { "disease_id": "DOID:3770", "recommended_name": { "id": "DOID:3770", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3770", "name": "pulmonary fibrosis", "description": "An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation." }, "synonyms": [ { "id": "DOID:3770", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3770", "name": "Fibrosis of lung", "description": "" } ], "evidence": [ { "id": "3770", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3770" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ap3b1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1", "locus": { "chromosome": "13", "start_pos": 94702825, "end_pos": 94495468, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000021686", "url": "https://www.ensembl.org/id/ENSMUSG00000021686" } ] } } ], "crossref": [ { "id": "ENSMUSG00000021686", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000021686", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "11774", "url": "https://www.ncbi.nlm.nih.gov/gene/11774", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9Z1T1", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9Z1T1*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002553", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026740", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026740", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:11774", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:11774", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1333879", "url": "http://www.informatics.jax.org/marker/MGI:1333879", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q9Z1T1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Z1T1", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "ETSERCM", "url": "https://omabrowser.org/oma/group/ETSERCM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "7857at2759", "url": "http://www.orthodb.org/?query=7857at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11134", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11134", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11134:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11134:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01602", "url": "http://pfam.xfam.org/family/PF01602", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14796", "url": "http://pfam.xfam.org/family/PF14796", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14797", "url": "http://pfam.xfam.org/family/PF14797", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9Z1T1", "url": "http://purl.obolibrary.org/obo/PR_Q9Z1T1", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-432722", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-432722", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_033810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033810", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A338P6V5", "url": "https://www.uniprot.org/uniprot/A0A338P6V5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A338P6V5-1", "url": "https://www.uniprot.org/uniprot/A0A338P6V5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Z1T1-1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSNSFAYNEQSGGGEAAELGQEATSTISPSGAFGLFSSDWKKNEDLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPVMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHRNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWREDGGLEDNEKNFYESEEEEEEKEKSSRKKSYAMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGVISKSLVRLLRSNREVQYIVLQNIATMSIERKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVRSQDKQFAAATIQTIGRCATSISEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIRHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLAAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNEKSGALSKYAKKIFLAPKPAPLLESPFKDRDRFQLGTLSHTLNIKASGYLELSNWPEVAPDPSVRNVEVIESAKEWTPLGKTKKEKPMKKFYSESEEEEDEDEDEDEEEEEKEDEDENPSDSSSDSESGSGSESGDTGTEDSSEDSSSGQDSETGSQAEAERQKVAKRNSKTKRKSDSENREKKNENSKASESSSEESSSMEDSSSESESESGSDSEPAPRNVAPAKERKPQQERHPPSKDVFLLDLDDFNPVSTPVALPTPALSPSLIADLEGLNLSTSSSVINVSTPVFVPTKTHELLHRMHGKGLAAHYCFPRQPCIFSDKMVSVQITLTNTSDRKIENIHIGGKGLPVGMQMHAFHPIDSLEPKGSVTVSVGIDFCDSTQTASFQLCTKDDCFNVTLQPPVGELLSPVAMSEKDFKKEQGTLTGMNETSATLIAAPQNFTPSMILQKVVNVANLGAVPSSQDNVHRFAARTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELKPVLSQG", "length": 1105, "header": "sp|Q9Z1T1-1|AP3B1_MOUSE Isoform 1 of AP-3 complex subunit beta-1 OS=Mus musculus OX=10090 GN=Ap3b1 PE=1 SV=2 CANONICAL=Q9Z1T1-1" }, "isoforms": [ { "isoform_ac": "A0A338P6V5-1", "url": "", "sequence": { "sequence": "XELSNWPEVAPDPSVRNVEVIESAKEWTPLGKTKKEKPMKKFYSESEEEEDEDEDEDEEEEEKEDEDENPSDSSSDSESGSGSESGDTGTEDSSEDSSSGQDSETGSQAEAERQKVAKRNSKTKRKSDSENREKKNENSKASESSSEESSSMEDSSSESESESGSDSEPAPRNVAPAKERKPQQERHPPSKDVFLLDLDDFNPVSTPVALPTPALSPSLIADLEGLNLSTSSSVINVSTPVFVPTKTHELLHRMHGKGLAAHYCFPRQPCIFSDKMVSVQITLTNTSDRKIENIHIGGKGLPVGMQMHAFHPIDSLEPKGSVTVSVGIDFCDSTQTASFQLCTKDDCFNVTLQPPVGELLSPVAMSEKDFKKEQACLCFTSVCSANQGTLTGMNETSATLIAAPQNFTPSMILQKVVNVANLGAVPSSQDNVHRFAARTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELKPVLSQG", "length": 484, "header": "tr|A0A338P6V5-1|AP3B1_MOUSE Computationally mapped isoform of AP-3 complex subunit beta-1 OS=Mus musculus OX=10090 GN=Ap3b1 PE=1 SV=1 CANONICAL=Q9Z1T1-1" }, "locus": { "chromosome": "13", "start_pos": 94702265, "end_pos": 94609371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000231916.2", "url": "https://www.ensembl.org/id/ENSMUST00000231916.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000155984.2", "url": "https://www.ensembl.org/id/ENSMUSP00000155984.2" } ] } }, { "isoform_ac": "Q9Z1T1-1", "url": "", "sequence": { "sequence": "MSSNSFAYNEQSGGGEAAELGQEATSTISPSGAFGLFSSDWKKNEDLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPVMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHRNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWREDGGLEDNEKNFYESEEEEEEKEKSSRKKSYAMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGVISKSLVRLLRSNREVQYIVLQNIATMSIERKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVRSQDKQFAAATIQTIGRCATSISEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIRHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLAAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNEKSGALSKYAKKIFLAPKPAPLLESPFKDRDRFQLGTLSHTLNIKASGYLELSNWPEVAPDPSVRNVEVIESAKEWTPLGKTKKEKPMKKFYSESEEEEDEDEDEDEEEEEKEDEDENPSDSSSDSESGSGSESGDTGTEDSSEDSSSGQDSETGSQAEAERQKVAKRNSKTKRKSDSENREKKNENSKASESSSEESSSMEDSSSESESESGSDSEPAPRNVAPAKERKPQQERHPPSKDVFLLDLDDFNPVSTPVALPTPALSPSLIADLEGLNLSTSSSVINVSTPVFVPTKTHELLHRMHGKGLAAHYCFPRQPCIFSDKMVSVQITLTNTSDRKIENIHIGGKGLPVGMQMHAFHPIDSLEPKGSVTVSVGIDFCDSTQTASFQLCTKDDCFNVTLQPPVGELLSPVAMSEKDFKKEQGTLTGMNETSATLIAAPQNFTPSMILQKVVNVANLGAVPSSQDNVHRFAARTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELKPVLSQG", "length": 1105, "header": "sp|Q9Z1T1-1|AP3B1_MOUSE Isoform 1 of AP-3 complex subunit beta-1 OS=Mus musculus OX=10090 GN=Ap3b1 PE=1 SV=2 CANONICAL=Q9Z1T1-1" }, "locus": { "chromosome": "13", "start_pos": 94702263, "end_pos": 94495612, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000022196", "url": "https://www.ensembl.org/id/ENSMUST00000022196" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000022196", "url": "https://www.ensembl.org/id/ENSMUSP00000022196" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q9Z1T1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Z1T1" }, { "id": "33300544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33300544" } ] } ], "phosphorylation": [ { "start_pos": 276, "end_pos": 276, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" }, { "database": "phospho.ELM", "id": "Q9Z1T1", "url": "http://phospho.elm.eu.org/byAccession/Q9Z1T1.html" }, { "database": "iPTMnet", "id": "Q9Z1T1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Z1T1" }, { "database": "PubMed", "id": "17203969", "url": "https://glygen.org/publication/PubMed/17203969" } ], "site_lbl": "Ser276" }, { "start_pos": 610, "end_pos": 610, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "site_lbl": "Ser610" }, { "start_pos": 761, "end_pos": 761, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "site_lbl": "Ser761" }, { "start_pos": 763, "end_pos": 763, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "site_lbl": "Ser763" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Genomic structure of the mouse ap3b1 gene in normal and pearl mice.", "journal": "Genomics", "date": "2000", "authors": "Feng L., Gorin M.B., Novak E.K., Swank R.T., Rigatti B.W.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "reference": [ { "type": "PubMed", "id": "11056055", "url": "https://glygen.org/publication/PubMed/11056055" } ] }, { "title": "Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.", "journal": "Journal of proteome research", "date": "2007", "authors": "Dai J, Jin WH, Sheng QH, Shieh CH, Wu JR, Zeng R", "evidence": [ { "database": "iPTMnet", "id": "Q9Z1T1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Z1T1" } ], "reference": [ { "type": "PubMed", "id": "17203969", "url": "https://glygen.org/publication/PubMed/17203969" } ] }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" }, { "database": "iPTMnet", "id": "Q9Z1T1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Z1T1" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2007", "authors": "Bhandari R, Saiardi A, Ahmadibeni Y, Snowman AM, Resnick AC, Kristiansen TZ, Molina H, Pandey A, Werner JK Jr, Juluri KR, Xu Y, Prestwich GD, Parang K, Snyder SH", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "reference": [ { "type": "PubMed", "id": "17873058", "url": "https://glygen.org/publication/PubMed/17873058" } ] }, { "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "date": "2009", "authors": "Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" }, { "database": "iPTMnet", "id": "Q9Z1T1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Z1T1" } ], "reference": [ { "type": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" }, { "database": "iPTMnet", "id": "Q9Z1T1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Z1T1" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.", "journal": "Mol. Biol. Cell", "date": "2011", "authors": "Larimore J, Tornieri K, Ryder PV, Gokhale A, Zlatic SA, Craige B, Lee JD, Talbot K, Pare JF, Smith Y, Faundez V", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "reference": [ { "type": "PubMed", "id": "21998198", "url": "https://glygen.org/publication/PubMed/21998198" } ] }, { "title": "O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease.", "journal": "Brain : a journal of neurology", "date": "2020", "authors": "Lee BE, Kim HY, Kim HJ, Jeong H, Kim BG, Lee HE, Lee J, Kim HB, Lee SE, Yang YR, Yi EC, Hanover JA, Myung K, Suh PG, Kwon T, Kim JI", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9Z1T1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Z1T1" } ], "reference": [ { "type": "PubMed", "id": "33300544", "url": "https://glygen.org/publication/PubMed/33300544" } ] }, { "title": "Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung.", "journal": "Respiratory research", "date": "2021", "authors": "Cuevas-Mora K, Roque W, Shaghaghi H, Gochuico BR, Rosas IO, Summer R, Romero F", "evidence": [ { "database": "RefSeq", "id": "NP_033810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033810" } ], "reference": [ { "type": "PubMed", "id": "33557836", "url": "https://glygen.org/publication/PubMed/33557836" } ] }, { "title": "Adaptor protein AP-3 produces synaptic vesicles that release at high frequency by recruiting phospholipid flippase ATP8A1.", "journal": "Nature neuroscience", "date": "2023-10", "authors": "Xu Hongfei, Oses-Prieto Juan A, Khvotchev Mikhail, Jain Shweta, Liang Jocelyn, Burlingame Alma, Edwards Robert H", "evidence": [ { "database": "RefSeq", "id": "NP_033810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033810" } ], "reference": [ { "type": "PubMed", "id": "37723322", "url": "https://glygen.org/publication/PubMed/37723322" } ] }, { "title": "The beta-3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness.", "journal": "Hum. Mol. Genet.", "date": "1999", "authors": "Feng L, Seymour AB, Jiang S, To A, Peden AA, Novak EK, Zhen L, Rusiniak ME, Eicher EM, Robinson MS, Gorin MB, Swank RT", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "reference": [ { "type": "PubMed", "id": "9931340", "url": "https://glygen.org/publication/PubMed/9931340" } ] } ], "pathway": [ { "id": "mmu:11774", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:11774", "resource": "KEGG Pathway" }, { "id": "R-MMU-432722", "name": "Golgi Associated Vesicle Biogenesis", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-432722", "resource": "Reactome", "description": "Golgi Associated Vesicle Biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "O00203-1", "protein_name": "AP-3 complex subunit beta-1", "gene_name": "AP3B1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSNSFPYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVIELAKEWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLDLDDFNPVSTPVALPTPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDKMVSIQITLNNTTDRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSAVIIAAPQNFTPSVIFQKVVNVANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELKPVLSQG", "length": 1094 }, "evidence": [ { "id": "45239862", "url": "http://www.informatics.jax.org/homology/45239862", "database": "MGI" }, { "id": "Q9Z1T1", "url": "https://omabrowser.org/oma/group/Q9Z1T1/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 37, "go_terms": [ { "name": "melanosome assembly", "id": "GO:1903232", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903232", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "protein modification process", "id": "GO:0036211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036211", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "granulocyte differentiation", "id": "GO:0030851", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030851", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "skin epidermis development", "id": "GO:0098773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098773", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "establishment of protein localization to mitochondrial membrane involved in mitochondrial fission", "id": "GO:0090152", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090152", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "zinc ion transport", "id": "GO:0006829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006829", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "respiratory system process", "id": "GO:0003016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003016", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "lung development", "id": "GO:0030324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030324", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "membrane organization", "id": "GO:0061024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061024", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "cell morphogenesis", "id": "GO:0000902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000902", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "single fertilization", "id": "GO:0007338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007338", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "regulation of catalytic activity", "id": "GO:0050790", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050790", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "lysosome organization", "id": "GO:0007040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007040", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "platelet dense granule organization", "id": "GO:0060155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060155", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "anterograde axonal transport", "id": "GO:0008089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008089", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "melanosome organization", "id": "GO:0032438", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032438", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "antigen processing and presentation, exogenous lipid antigen via MHC class Ib", "id": "GO:0048007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048007", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": 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"hematopoietic progenitor cell differentiation", "id": "GO:0002244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002244", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "protein localization to cell surface", "id": "GO:0034394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034394", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "toll-like receptor signaling pathway", "id": "GO:0002224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002224", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "pigmentation", "id": "GO:0043473", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043473", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "mRNA transcription by RNA polymerase II", "id": "GO:0042789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042789", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "intracellular zinc ion homeostasis", "id": "GO:0006882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006882", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "homeostasis of number of cells", "id": "GO:0048872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048872", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "lung morphogenesis", "id": "GO:0060425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060425", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "antigen processing and 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"name": "clathrin-coated vesicle membrane", "id": "GO:0030665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030665", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "AP-3 adaptor complex", "id": "GO:0030123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030123", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "clathrin adaptor complex", "id": "GO:0030131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030131", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1T1", "url": "https://www.uniprot.org/uniprot/Q9Z1T1" } ], "pmid": "" }, { "name": "axon cytoplasm", "id": "GO:1904115", 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