{ "uniprot_canonical_ac": "Q9Z1M7-1", "uniprot_ac": "Q9Z1M7", "uniprot_id": "LARG1_MOUSE", "mass": { "chemical_mass": 87964.0, "monoisotopic_mass": 87964.0 }, "refseq": { "ac": "NP_001304320", "name": "xylosyl- and glucuronyltransferase LARGE1 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304320" }, "gene_names": [ { "name": "Large1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9Z1M7", "id": "Q9Z1M7" }, { "name": "BPFD#36; enr; fg; froggy; Gyltl1a; Large; Mbp-1; Mbp1; myd", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304320", "id": "NP_001304320" }, { "name": "Kiaa0609", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9Z1M7", "id": "Q9Z1M7" }, { "name": "Large1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304320", "id": "NP_001304320" }, { "name": "Large", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9Z1M7", "id": "Q9Z1M7" } ], "protein_names": [ { "name": "Xylosyl- and glucuronyltransferase LARGE1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9Z1M7" }, { "name": "2.4.-.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z1M7" }, { "name": "Acetylglucosaminyltransferase-like 1A", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z1M7" }, { "name": "Glycosyltransferase-like protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z1M7" }, { "name": "LARGE xylosyl- and glucuronyltransferase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z1M7" }, { "name": "glycosyltransferase-like protein LARGE1; acetylglucosaminyltransferase-like 1A; myodystrophy; like-glycosyltransferase; xylosyl- and glucuronyltransferase LARGE1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304320", "id": "NP_001304320" }, { "name": "xylosyl- and glucuronyltransferase LARGE1 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304320", "id": "NP_001304320" } ], "function": [ { "annotation": "Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity (PubMed:23125099, PubMed:23135544, PubMed:25138275, PubMed:32975514). Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity). Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer (PubMed:32975514). Plays a key role in skeletal muscle function and regeneration (PubMed:15184894, PubMed:24132234).", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7#function" }, { "database": "PubMed", "id": "23135544", "url": "https://glygen.org/publication/PubMed/23135544" }, { "database": "UniProtKB", "id": "O95461", "url": "https://www.uniprot.org/uniprot/O95461#function" }, { "database": "PubMed", "id": "24132234", "url": "https://glygen.org/publication/PubMed/24132234" }, { "database": "PubMed", "id": "15184894", "url": "https://glygen.org/publication/PubMed/15184894" }, { "database": "PubMed", "id": "23125099", "url": "https://glygen.org/publication/PubMed/23125099" }, { "database": "PubMed", "id": "32975514", "url": "https://glygen.org/publication/PubMed/32975514" }, { "database": "PubMed", "id": "25138275", "url": "https://glygen.org/publication/PubMed/25138275" } ] }, { "annotation": "N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on alpha-dystroglycan and prevents muscular dystrophy. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001304320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304320" }, { "database": "PubMed", "id": "36723429", "url": "https://glygen.org/publication/PubMed/36723429" } ] }, { "annotation": "POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001304320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304320" }, { "database": "PubMed", "id": "32975514", "url": "https://glygen.org/publication/PubMed/32975514" } ] } ], "disease": [ { "disease_id": "DOID:0050588", "recommended_name": { "id": "DOID:0050588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050588", "name": "muscular dystrophy-dystroglycanopathy type B1", "description": "A congenital muscular dystrophy characterized by muscle weakness, cognitive impairment and brain abnormalities and has_material_basis_in mutation to the POMT1 gene that encodes O-mannosyltransferase." }, "synonyms": [ { "id": "DOID:0050588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050588", "name": "CMD due to dystroglycanopathy", "description": "" }, { "id": "DOID:0050588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050588", "name": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B1", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B1", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "congenital muscular dystrophy-POMT1 related", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "MDDGB1", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "muscular dystrophy, congenital, Pomt1-related", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B, 1", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type B, 1", "description": "" }, { "id": "MIM:613155", "resource": "MIM", "url": "https://www.omim.org/entry/613155", "name": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B1", "description": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B1" } ], "evidence": [ { "id": "0050588", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050588" } ] }, { "disease_id": "DOID:0110637", "recommended_name": { "id": "DOID:0110637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110637", "name": "muscular dystrophy-dystroglycanopathy type B6", "description": "A congenital muscular dystrophy characterized by autosomal recessive inheritance of muscular dystrophy with mental retardation and structural brain abnormalities that has_material_basis_in homozygous or compound heterozygous mutation in the LARGE gene on chromosome 22q12." }, "synonyms": [ { "id": "DOID:0110637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110637", "name": "MDC1D", "description": "" }, { "id": "DOID:0110637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110637", "name": "MDDGB6", "description": "" }, { "id": "DOID:0110637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110637", "name": "congenital muscular dystrophy LARGE-related", "description": "" }, { "id": "DOID:0110637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110637", "name": "congenital muscular dystrophy type 1D", "description": "" }, { "id": "DOID:0110637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110637", "name": "muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type B, 6", "description": "" }, { "id": "DOID:0110637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110637", "name": "muscular dystrophy-dystroglycanopathy (congenital with impaired intellectual development), type B, 6", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "muscular dystrophy-dystroglycanopathy type B6", "description": "A congenital muscular dystrophy characterized by autosomal recessive inheritance of muscular dystrophy with mental retardation and structural brain abnormalities that has material basis in homozygous or compound heterozygous mutation in the LARGE gene on chromosome 22q12." }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "MDC1D", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "MDDGB6", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "congenital muscular dystrophy large-related", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "congenital muscular dystrophy type 1D", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B, 6", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type B, 6", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "muscular dystrophy, congenital, large-related", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "muscular dystrophy, congenital, type 1D", "description": "" }, { "id": "MIM:608840", "resource": "MIM", "url": "https://www.omim.org/entry/608840", "name": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B6", "description": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B6" } ], "evidence": [ { "id": "0110637", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110637" } ] }, { "disease_id": "DOID:0111242", "recommended_name": { "id": "DOID:0111242", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111242", "name": "congenital muscular dystrophy-dystroglycanopathy type A6", "description": "A congenital muscular dystrophy-dystroglycanopathy type A that has_material_basis_in homozygous or compound heterozygous mutation in LARGE on 22q12.3." }, "synonyms": [ { "id": "DOID:0111242", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111242", "name": "Walker-Warburg syndrome or muscle-eye-brain disease, LARGE-related", "description": "" }, { "id": "DOID:0111242", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111242", "name": "MDDGA6", "description": "" }, { "id": "DOID:0111242", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111242", "name": "congenital muscular dystrophy-dystroglycanopathy with brain and eye anomalies type A6", "description": "" }, { "id": "MONDO:0013158", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013158", "name": "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A6", "description": "An autosomal recessive muscular dystrophy caused by mutations in the LARGE gene. It is associated with characteristic brain and eye malformations, profound mental retardation, and death usually in the first years of life." }, { "id": "MONDO:0013158", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013158", "name": "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies) type A, 6", "description": "" }, { "id": "MONDO:0013158", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013158", "name": "MDDGA6", "description": "" }, { "id": "MONDO:0013158", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013158", "name": "Walker-Warburg syndrome or muscle-eye-brain disease, large-related", "description": "" }, { "id": "MONDO:0013158", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013158", "name": "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 6", "description": "" }, { "id": "MIM:613154", "resource": "MIM", "url": "https://www.omim.org/entry/613154", "name": "Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A6", "description": "Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A6" } ], "evidence": [ { "id": "0111242", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111242" } ] }, { "disease_id": "DOID:11727", "recommended_name": { "id": "DOID:11727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11727", "name": "facioscapulohumeral muscular dystrophy", "description": "" }, "synonyms": [ { "id": "DOID:11727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11727", "name": "Landouzy Dejerine muscular dystrophy", "description": "" }, { "id": "DOID:11727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11727", "name": "Landouzy-Dejerine muscular dystrophy", "description": "" }, { "id": "DOID:11727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11727", "name": "Muscular dystrophy, Landouzy-Dejerine", "description": "" } ], "evidence": [ { "id": "11727", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11727" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Large1", "url": "https://www.uniprot.org/uniprot/Q9Z1M7", "locus": { "chromosome": "8", "start_pos": 73541227, "end_pos": 74080168, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000004383", "url": "https://www.ensembl.org/id/ENSMUSG00000004383" } ] } } ], "crossref": [ { "id": "ENSMUSG00000004383", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000004383", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "2.4.1.B80", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.1.B80&UniProtAcc=Q9Z1M7", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "2.4.2.B18", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.2.B18&UniProtAcc=Q9Z1M7", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "GT49", "url": "http://www.cazy.org/GT49.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "GT8", "url": "http://www.cazy.org/GT8.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "cd06431", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06431", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "16795", "url": "https://www.ncbi.nlm.nih.gov/gene/16795", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "GPDB0007843", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0007843", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "IPR002495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:16795", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16795", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1342270", "url": "http://www.informatics.jax.org/marker/MGI:1342270", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "GWNKVSY", "url": "https://omabrowser.org/oma/group/GWNKVSY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1363389at2759", "url": "http://www.orthodb.org/?query=1363389at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12270", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12270", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12270:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12270:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01501", "url": "http://pfam.xfam.org/family/PF01501", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13896", "url": "http://pfam.xfam.org/family/PF13896", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9Z1M7", "url": "http://purl.obolibrary.org/obo/PR_Q9Z1M7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-5173105", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5173105", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001304320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304320", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "57336", "url": "https://www.rhea-db.org/rhea/57336", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67924", "url": "https://www.rhea-db.org/rhea/67924", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "68368", "url": "https://www.rhea-db.org/rhea/68368", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Z1M7-1", "url": "https://www.uniprot.org/uniprot/Q9Z1M7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGICRGRRKFLAASLTLLCIPAITWIYLFAGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGQSPAHHRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPAVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSETDVNNENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEFEPSADNTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRQNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYQVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFTVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 756, "header": "sp|Q9Z1M7-1|LARG1_MOUSE Isoform 1 of Xylosyl- and glucuronyltransferase LARGE1 OS=Mus musculus OX=10090 GN=Large1 PE=1 SV=1 CANONICAL=Q9Z1M7-1" }, "isoforms": [ { "isoform_ac": "Q9Z1M7-1", "url": "", "sequence": { "sequence": "MLGICRGRRKFLAASLTLLCIPAITWIYLFAGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGQSPAHHRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPAVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSETDVNNENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEFEPSADNTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRQNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYQVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFTVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 756, "header": "sp|Q9Z1M7-1|LARG1_MOUSE Isoform 1 of Xylosyl- and glucuronyltransferase LARGE1 OS=Mus musculus OX=10090 GN=Large1 PE=1 SV=1 CANONICAL=Q9Z1M7-1" }, "locus": { "chromosome": "8", "start_pos": 73940858, "end_pos": 73542455, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000004497", "url": "https://www.ensembl.org/id/ENSMUST00000004497" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000004497", "url": "https://www.ensembl.org/id/ENSMUSP00000004497" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 122, "start_aa": "Asn", "end_pos": 122, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn122", "evidence": [ { "id": "Q9Z1M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z1M7#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 148, "start_aa": "Asn", "end_pos": 148, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn148", "evidence": [ { "id": "Q9Z1M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z1M7#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 272, "start_aa": "Asn", "end_pos": 272, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn272", "evidence": [ { "id": "Q9Z1M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z1M7#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 97, "start_aa": "Asn", "end_pos": 97, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn97", "evidence": [ { "id": "Q9Z1M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z1M7#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Mutant glycosyltransferase and altered glycosylation of alpha-dystroglycan in the myodystrophy mouse.", "journal": "Nat. Genet.", "date": "2001", "authors": "Hewitt J.E., Bittner R.E., Grewal P.K., Holzfeind P.J.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "reference": [ { "type": "PubMed", "id": "11381262", "url": "https://glygen.org/publication/PubMed/11381262" } ] }, { "title": "Molecular recognition by LARGE is essential for expression of functional dystroglycan.", "journal": "Cell", "date": "2004", "authors": "Dumanski J.P., Saito F., Campbell K.P., Yoshida-Moriguchi T., Kunz S., Barresi R., Kanagawa M., Kobayashi Y.M., Michele D.E., Oldstone M.B., Muschler J.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "reference": [ { "type": "PubMed", "id": "15210115", "url": "https://glygen.org/publication/PubMed/15210115" } ] }, { "title": "Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies.", "journal": "Glycobiology", "date": "2005", "authors": "Grewal PK, McLaughlan JM, Moore CJ, Browning CA, Hewitt JE", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "reference": [ { "type": "PubMed", "id": "15958417", "url": "https://glygen.org/publication/PubMed/15958417" } ] }, { "title": "Xylosyl- and glucuronyltransferase functions of LARGE in alpha-dystroglycan modification are conserved in LARGE2.", "journal": "Glycobiology", "date": "2013", "authors": "Inamori K, Hara Y, Willer T, Anderson ME, Zhu Z, Yoshida-Moriguchi T, Campbell KP", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "reference": [ { "type": "PubMed", "id": "23125099", "url": "https://glygen.org/publication/PubMed/23125099" } ] }, { "title": "LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE.", "journal": "Glycobiology", "date": "2013", "authors": "Bakker H., Ashikov A., Buettner F.F., Gerardy-Schahn R., Tiemann B.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "reference": [ { "type": "PubMed", "id": "23135544", "url": "https://glygen.org/publication/PubMed/23135544" } ] }, { "title": "LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy.", "journal": "Nature", "date": "2013", "authors": "Goddeeris MM, Wu B, Venzke D, Yoshida-Moriguchi T, Saito F, Matsumura K, Moore SA, Campbell KP", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "reference": [ { "type": "PubMed", "id": "24132234", "url": "https://glygen.org/publication/PubMed/24132234" } ] }, { "title": "Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of alpha-dystroglycan in cells and tissues.", "journal": "J. Biol. Chem.", "date": "2014", "authors": "Inamori K, Willer T, Hara Y, Venzke D, Anderson ME, Clarke NF, Guicheney P, Bonnemann CG, Moore SA, Campbell KP", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "reference": [ { "type": "PubMed", "id": "25138275", "url": "https://glygen.org/publication/PubMed/25138275" } ] }, { "title": "POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan.", "journal": "eLife", "date": "2020", "authors": "Walimbe AS, Okuma H, Joseph S, Yang T, Yonekawa T, Hord JM, Venzke D, Anderson ME, Torelli S, Manzur A, Devereaux M, Cuellar M, Prouty S, Ocampo Landa S, Yu L, Xiao J, Dixon JE, Muntoni F, Campbell KP", "evidence": [ { "database": "RefSeq", "id": "NP_001304320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304320" } ], "reference": [ { "type": "PubMed", "id": "32975514", "url": "https://glygen.org/publication/PubMed/32975514" } ] }, { "title": "N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on \u03b1-dystroglycan and prevents muscular dystrophy.", "journal": "eLife", "date": "2023-02-01", "authors": "Okuma Hidehiko, Hord Jeffrey M, Chandel Ishita, Venzke David, Anderson Mary E, Walimbe Ameya S, Joseph Soumya, Gastel Zeita, Hara Yuji, Saito Fumiaki, Matsumura Kiichiro, Campbell Kevin P", "evidence": [ { "database": "RefSeq", "id": "NP_001304320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304320" } ], "reference": [ { "type": "PubMed", "id": "36723429", "url": "https://glygen.org/publication/PubMed/36723429" } ] }, { "title": "The human LARGE gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1999", "authors": "Collins J.E., Dumanski J.P., Dunham I., Fransson I., Peyrard M., Seroussi E., Han F.-Y., Xie Y.-G., Kost-Alimova M., Imreh S., Sandberg-Nordqvist A.-C.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "reference": [ { "type": "PubMed", "id": "9892679", "url": "https://glygen.org/publication/PubMed/9892679" } ] } ], "pathway": [ { "id": "mmu:16795", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16795", "resource": "KEGG Pathway" }, { "id": "R-MMU-5173105", "name": "O-linked glycosylation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5173105", "resource": "Reactome", "description": "O-linked glycosylation" } ], "orthologs": [ { "uniprot_canonical_ac": "O95461-1", "protein_name": "Xylosyl- and glucuronyltransferase LARGE1", "gene_name": "LARGE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 756 }, "evidence": [ { "id": "45228332", "url": "http://www.informatics.jax.org/homology/45228332", "database": "MGI" }, { "id": "Q9Z1M7", "url": "https://omabrowser.org/oma/group/Q9Z1M7/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 73, "go_terms": [ { "name": "skeletal muscle tissue regeneration", "id": "GO:0043403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043403", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "skeletal muscle organ development", "id": "GO:0060538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060538", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "protein modification process", "id": "GO:0036211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036211", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "astrocyte differentiation", "id": "GO:0048708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048708", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "protein phosphorylation", "id": "GO:0006468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "protein glycosylation", "id": "GO:0006486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006486", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "plasma membrane organization", "id": "GO:0007009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007009", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "neuromuscular synaptic transmission", "id": "GO:0007274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007274", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "neuromuscular junction development", "id": "GO:0007528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007528", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "memory", "id": "GO:0007613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007613", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "post-translational protein modification", "id": "GO:0043687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043687", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "muscle cell cellular homeostasis", "id": "GO:0046716", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046716", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "synapse organization", "id": "GO:0050808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050808", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "synaptic assembly at neuromuscular junction", "id": "GO:0051124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051124", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "acetylcholine receptor signaling pathway", "id": "GO:0095500", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0095500", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "neuron migration", "id": "GO:0001764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "protein O-linked glycosylation", "id": "GO:0006493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006493", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "protein targeting to membrane", "id": "GO:0006612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006612", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "glycoprotein biosynthetic process", "id": "GO:0009101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009101", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "myelination", "id": "GO:0042552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042552", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "regulation of synaptic plasticity", "id": "GO:0048167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048167", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "multicellular organism growth", "id": "GO:0035264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035264", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "muscle organ development", "id": "GO:0007517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007517", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "response to mechanical stimulus", "id": "GO:0009612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009612", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "skeletal muscle fiber development", "id": "GO:0048741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048741", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "retina development in camera-type eye", "id": "GO:0060041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060041", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "blood vessel development", "id": "GO:0001568", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001568", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "cardiac muscle tissue development", "id": "GO:0048738", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048738", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "behavioral fear response", "id": "GO:0001662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001662", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "retina vasculature development in camera-type eye", "id": "GO:0061298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061298", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "retina layer formation", "id": "GO:0010842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010842", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "limb development", "id": "GO:0060173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060173", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "bone development", "id": "GO:0060348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060348", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "protein localization to membrane", "id": "GO:0072657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072657", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "striated muscle contraction", "id": "GO:0006941", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006941", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "cardiac muscle cell development", "id": "GO:0055013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055013", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "regulation of protein binding", "id": "GO:0043393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043393", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "nerve development", "id": "GO:0021675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021675", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "water transport", "id": "GO:0006833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006833", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "response to light stimulus", "id": "GO:0009416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009416", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "long-term synaptic potentiation", "id": "GO:0060291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060291", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "protein deglycosylation", "id": "GO:0006517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006517", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "glycoprotein metabolic process", "id": "GO:0009100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009100", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "protein O-linked mannosylation", "id": "GO:0035269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035269", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "neuromuscular process controlling posture", "id": "GO:0050884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050884", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "principal sensory nucleus of trigeminal nerve development", "id": "GO:0021740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021740", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "connective tissue development", "id": "GO:0061448", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061448", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "striated muscle cell development", "id": "GO:0055002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055002", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "walking behavior", "id": "GO:0090659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090659", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "determination of adult lifespan", "id": "GO:0008340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008340", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "myotube differentiation", "id": "GO:0014902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014902", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "gene expression", "id": "GO:0010467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010467", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "dentate gyrus development", "id": "GO:0021542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021542", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "macrophage differentiation", "id": "GO:0030225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030225", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "basement membrane organization", "id": "GO:0071711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071711", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "skeletal muscle fiber differentiation", "id": "GO:0098528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098528", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "protein-containing complex assembly", "id": "GO:0065003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "regulation of kinase activity", "id": "GO:0043549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043549", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "cellular component organization", "id": "GO:0016043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016043", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "reactive gliosis", "id": "GO:0150103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150103", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "multicellular organism reproduction", "id": "GO:0032504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032504", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "post-embryonic hindlimb morphogenesis", "id": "GO:0035129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035129", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "localization of cell", "id": "GO:0051674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051674", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "xylosyltransferase activity", "id": "GO:0042285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042285", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "manganese ion binding", "id": "GO:0030145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030145", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "glycosyltransferase activity", "id": "GO:0016757", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016757", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "glucuronosyltransferase activity", "id": "GO:0015020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015020", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "hexosyltransferase activity", "id": "GO:0016758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016758", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q9Z1M7", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 754, "end_pos": 756, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "57336", "name": "", "equation": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P7A1-1", "O95461-1", "Q8N3Y3-1", "Q9Z1M7-1", "Q5XPT3-1" ], "evidence": [ { "id": "57336", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/57336" } ] }, { "id": "67924", "name": "", "equation": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P7A1-1", "O95461-1", "Q8N3Y3-1", "Q9Z1M7-1", "Q5XPT3-1" ], "evidence": [ { "id": "67924", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67924" } ] }, { "id": "68368", "name": "", "equation": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose = 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P7A1-1", "O95461-1", "Q8N3Y3-1", "Q9Z1M7-1", "Q5XPT3-1" ], "evidence": [ { "id": "68368", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/68368" } ] }, { "id": "R-MMU-9638090", "name": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9Z1M7-1", "Q8BWP8-1" ], "evidence": [ { "id": "R-MMU-9638090", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9638090" } ] }, { "id": "R-MMU-9638097", "name": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9Z1M7-1", "Q8BWP8-1" ], "evidence": [ { "id": "R-MMU-9638097", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9638097" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O95461", "gene_name": "LARGE1", "activity": [ { "ec_number": "2.4.-.-", "activity": "", "evidence": [ { "id": "O95461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95461" } ] }, { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "O95461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95461" } ] }, { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "O95461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95461" } ] } ] }, { "uniprot_ac": "Q5XPT3", "gene_name": "Large2", "activity": [ { "ec_number": "2.4.-.-", "activity": "", "evidence": [ { "id": "Q5XPT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPT3" } ] }, { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q5XPT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPT3" } ] }, { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q5XPT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPT3" } ] } ] }, { "uniprot_ac": "Q6P7A1", "gene_name": "Large2", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q6P7A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7A1" } ] }, { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q6P7A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7A1" } ] }, { "ec_number": "2.4.-.-", "activity": "", "evidence": [ { "id": "Q6P7A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7A1" } ] } ] }, { "uniprot_ac": "Q8BWP8", "gene_name": "B4gat1", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q8BWP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWP8" } ] } ] }, { "uniprot_ac": "Q8N3Y3", "gene_name": "LARGE2", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q8N3Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N3Y3" } ] }, { "ec_number": "2.4.-.-", "activity": "", "evidence": [ { "id": "Q8N3Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N3Y3" } ] }, { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q8N3Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N3Y3" } ] } ] }, { "uniprot_ac": "Q9Z1M7", "gene_name": "Large1", "activity": [ { "ec_number": "2.4.-.-", "activity": "", "evidence": [ { "id": "Q9Z1M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ] }, { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q9Z1M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ] }, { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q9Z1M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z1M7" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 4 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": 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