{ "uniprot_canonical_ac": "Q9Z183-1", "uniprot_ac": "Q9Z183", "uniprot_id": "PADI4_MOUSE", "mass": { "chemical_mass": 74415.0, "monoisotopic_mass": 74415.0 }, "refseq": { "ac": "NP_035191", "name": "protein-arginine deiminase type-4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035191" }, "gene_names": [ { "name": "Padi4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9Z183", "id": "Q9Z183" }, { "name": "Pad4; Pdi4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035191", "id": "NP_035191" }, { "name": "Pad4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9Z183", "id": "Q9Z183" }, { "name": "Padi4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035191", "id": "NP_035191" }, { "name": "Pdi4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9Z183", "id": "Q9Z183" } ], "protein_names": [ { "name": "Protein-arginine deiminase type-4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9Z183" }, { "name": "3.5.3.15", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z183" }, { "name": "Peptidylarginine deiminase IV", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z183" }, { "name": "Protein-arginine deiminase type IV", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z183" }, { "name": "peptidylarginine deiminase IV; protein-arginine deiminase type IV; PAD type IV", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035191", "id": "NP_035191" }, { "name": "protein-arginine deiminase type-4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035191", "id": "NP_035191" } ], "function": [ { "annotation": "An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.", "evidence": [ { "database": "RefSeq", "id": "NP_035191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035191" }, { "database": "PubMed", "id": "37140445", "url": "https://glygen.org/publication/PubMed/37140445" } ] }, { "annotation": "Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance (PubMed:15339660, PubMed:32528174). Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci) (PubMed:15339660). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance (PubMed:24463520, PubMed:32528174). Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci (PubMed:20733033, PubMed:23650392). Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:20733033, PubMed:32528174). Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription (By similarity). Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183#function" }, { "database": "PubMed", "id": "15339660", "url": "https://glygen.org/publication/PubMed/15339660" }, { "database": "PubMed", "id": "23650392", "url": "https://glygen.org/publication/PubMed/23650392" }, { "database": "PubMed", "id": "20733033", "url": "https://glygen.org/publication/PubMed/20733033" }, { "database": "PubMed", "id": "24463520", "url": "https://glygen.org/publication/PubMed/24463520" }, { "database": "UniProtKB", "id": "Q9UM07", "url": "https://www.uniprot.org/uniprot/Q9UM07#function" }, { "database": "PubMed", "id": "32528174", "url": "https://glygen.org/publication/PubMed/32528174" } ] }, { "annotation": "Transcriptomic analysis of PADI4 target genes during multi-lineage differentiation of embryonic stem cells.", "evidence": [ { "database": "RefSeq", "id": "NP_035191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035191" }, { "database": "PubMed", "id": "37778387", "url": "https://glygen.org/publication/PubMed/37778387" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Padi4", "url": "https://www.uniprot.org/uniprot/Q9Z183", "locus": { "chromosome": "4", "start_pos": 140473176, "end_pos": 140501547, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000025330", "url": "https://www.ensembl.org/id/ENSMUSG00000025330" } ] } } ], "crossref": [ { "id": "ENSMUSG00000025330", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000025330", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.5.3.15", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.3.15&UniProtAcc=Q9Z183", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd04214", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04214", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL3407322", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3407322", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "18602", "url": "https://www.ncbi.nlm.nih.gov/gene/18602", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004303", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004303", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013530", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013530", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013733", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013733", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036556", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036556", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038685", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038685", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:18602", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18602", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1338898", "url": "http://www.informatics.jax.org/marker/MGI:1338898", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "DQRTWTW", "url": "https://omabrowser.org/oma/group/DQRTWTW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3956477at2759", "url": "http://www.orthodb.org/?query=3956477at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10837", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10837", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10837:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10837:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "6MKD", "url": "https://www.rcsb.org/structure/6MKD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6MKR", "url": "https://www.rcsb.org/structure/6MKR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6MNG", "url": "https://www.rcsb.org/structure/6MNG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6MNM", "url": "https://www.rcsb.org/structure/6MNM", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6MNN", "url": "https://www.rcsb.org/structure/6MNN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6MNO", "url": "https://www.rcsb.org/structure/6MNO", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF03068", "url": "http://pfam.xfam.org/family/PF03068", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08526", "url": "http://pfam.xfam.org/family/PF08526", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08527", "url": "http://pfam.xfam.org/family/PF08527", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9Z183", "url": "http://purl.obolibrary.org/obo/PR_Q9Z183", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-3247509", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3247509", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_035191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035191", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "18089", "url": "https://www.rhea-db.org/rhea/18089", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Z183-1", "url": "https://www.uniprot.org/uniprot/Q9Z183-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQGAVIHVAPEQPTHAVCVVGTATPLDVRGSAPKGYTTFGITASPGVIVDVIHGPPVKKSTMGASKWPLDPELEVTLQVKAASSRTDDEKVRVSYYGPKTSPVQALIYITGVELSLSADVTRTGRVKPAQAGKDQSTWTWGPGGRGAILLVNCDKEDPQASGMDFEDDKILDNKDLQDMSPMTLSTKTPKDFFEKYQLVLEVPKAKMNRVRVFRATRGKLPSRYKVALGPQQFSYCLELPGGQHSTDFYVEGLAFPDADFKGLIPLTISLLDKSNPELPEALVFQDSVTFRVAPWIMTPNTQPPQEVYVCRVSDNEDFLKSLATLTKKAKCKLTVCPEEENIDDQWMQDEMEIGYIQAPHKTLPVVFDSPRDRGLKDFPVKRVMGPNFGYVTRKLYMSELTGLDAFGNLEVSPPVTVRGKEYPLGRILIGNSGYSSSESRDMHQALQDFLSAQQVQAPVRLFSDWLFVGHVDEFLSFVPARDKQGFRLLLSSPRACYQLFQELQSQGHGEATLFEGLKRKRQTINEILSNKKLRDQNAYVESCIDWNRAVLKRELGLAEGDIIDIPQLFKLAGNSRGNSKAQAFFPNMVNMLVLGKYLGIPKPFGPIIDGHCCLEEEVRSHLEPLGLHCTFINDFYTYHVYNGEVHCGTNVRRKPFTFKWWHMVP", "length": 666, "header": "sp|Q9Z183-1|PADI4_MOUSE Isoform 1 of Protein-arginine deiminase type-4 OS=Mus musculus OX=10090 GN=Padi4 PE=1 SV=3 CANONICAL=Q9Z183-1" }, "isoforms": [ { "isoform_ac": "Q9Z183-1", "url": "", "sequence": { "sequence": "MAQGAVIHVAPEQPTHAVCVVGTATPLDVRGSAPKGYTTFGITASPGVIVDVIHGPPVKKSTMGASKWPLDPELEVTLQVKAASSRTDDEKVRVSYYGPKTSPVQALIYITGVELSLSADVTRTGRVKPAQAGKDQSTWTWGPGGRGAILLVNCDKEDPQASGMDFEDDKILDNKDLQDMSPMTLSTKTPKDFFEKYQLVLEVPKAKMNRVRVFRATRGKLPSRYKVALGPQQFSYCLELPGGQHSTDFYVEGLAFPDADFKGLIPLTISLLDKSNPELPEALVFQDSVTFRVAPWIMTPNTQPPQEVYVCRVSDNEDFLKSLATLTKKAKCKLTVCPEEENIDDQWMQDEMEIGYIQAPHKTLPVVFDSPRDRGLKDFPVKRVMGPNFGYVTRKLYMSELTGLDAFGNLEVSPPVTVRGKEYPLGRILIGNSGYSSSESRDMHQALQDFLSAQQVQAPVRLFSDWLFVGHVDEFLSFVPARDKQGFRLLLSSPRACYQLFQELQSQGHGEATLFEGLKRKRQTINEILSNKKLRDQNAYVESCIDWNRAVLKRELGLAEGDIIDIPQLFKLAGNSRGNSKAQAFFPNMVNMLVLGKYLGIPKPFGPIIDGHCCLEEEVRSHLEPLGLHCTFINDFYTYHVYNGEVHCGTNVRRKPFTFKWWHMVP", "length": 666, "header": "sp|Q9Z183-1|PADI4_MOUSE Isoform 1 of Protein-arginine deiminase type-4 OS=Mus musculus OX=10090 GN=Padi4 PE=1 SV=3 CANONICAL=Q9Z183-1" }, "locus": { "chromosome": "4", "start_pos": 140501491, "end_pos": 140473438, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000026381", "url": "https://www.ensembl.org/id/ENSMUST00000026381" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000026381", "url": "https://www.ensembl.org/id/ENSMUSP00000026381" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse.", "journal": "Eur. J. Biochem.", "date": "1999", "authors": "Rus'd AA, Ikejiri Y, Ono H, Yonekawa T, Shiraiwa M, Kawada A, Takahara H", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "reference": [ { "type": "PubMed", "id": "10092850", "url": "https://glygen.org/publication/PubMed/10092850" } ] }, { "title": "Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.", "journal": "Gene", "date": "2004", "authors": "Chavanas S, Mechin MC, Takahara H, Kawada A, Nachat R, Serre G, Simon M", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "reference": [ { "type": "PubMed", "id": "15087120", "url": "https://glygen.org/publication/PubMed/15087120" } ] }, { "title": "Histone deimination antagonizes arginine methylation.", "journal": "Cell", "date": "2004", "authors": "Cuthbert GL, Daujat S, Snowden AW, Erdjument-Bromage H, Hagiwara T, Yamada M, Schneider R, Gregory PD, Tempst P, Bannister AJ, Kouzarides T", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "reference": [ { "type": "PubMed", "id": "15339660", "url": "https://glygen.org/publication/PubMed/15339660" } ] }, { "title": "PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps.", "journal": "J. Exp. Med.", "date": "2010", "authors": "Li M., Li P., Wang Y., Xiong N., Kennett M.J., Lindberg M.R.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "reference": [ { "type": "PubMed", "id": "20733033", "url": "https://glygen.org/publication/PubMed/20733033" } ] }, { "title": "Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2013", "authors": "Wang Y., Hu J., Wong S.L., Gallant M., Wagner D.D., Demers M., Brill A., Fuchs T.A., Martinod K.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "reference": [ { "type": "PubMed", "id": "23650392", "url": "https://glygen.org/publication/PubMed/23650392" } ] }, { "title": "Citrullination regulates pluripotency and histone H1 binding to chromatin.", "journal": "Nature", "date": "2014", "authors": "Christophorou MA, Castelo-Branco G, Halley-Stott RP, Oliveira CS, Loos R, Radzisheuskaya A, Mowen KA, Bertone P, Silva JC, Zernicka-Goetz M, Nielsen ML, Gurdon JB, Kouzarides T", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "reference": [ { "type": "PubMed", "id": "24463520", "url": "https://glygen.org/publication/PubMed/24463520" } ] }, { "title": "DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.", "journal": "Nature", "date": "2020", "authors": "Yang L, Liu Q, Zhang X, Liu X, Zhou B, Chen J, Huang D, Li J, Li H, Chen F, Liu J, Xing Y, Chen X, Su S, Song E", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "reference": [ { "type": "PubMed", "id": "32528174", "url": "https://glygen.org/publication/PubMed/32528174" } ] }, { "title": "An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.", "journal": "Cancer discovery", "date": "2023-07-07", "authors": "Indeglia Alexandra, Leung Jessica C, Miller Sven A, Leu Julia I-Ju, Dougherty James F, Clarke Nicole L, Kirven Nicole A, Shao Chunlei, Ke Lei, Lovell Scott, Barnoud Thibaut, Lu David Y, Lin Cindy, Kannan Toshitha, Battaile Kevin P, Yang Tyler Hong Loong, Batista Oliva Isabela, Claiborne Daniel T, Vogel Peter, Liu Lijun, Liu Qin, Nefedova Yulia, Cassel Joel, Auslander Noam, Kossenkov Andrew V, Karanicolas John, Murphy Maureen E", "evidence": [ { "database": "RefSeq", "id": "NP_035191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035191" } ], "reference": [ { "type": "PubMed", "id": "37140445", "url": "https://glygen.org/publication/PubMed/37140445" } ] }, { "title": "Transcriptomic analysis of PADI4 target genes during multi-lineage differentiation of embryonic stem cells.", "journal": "Philosophical transactions of the Royal Society of London. Series B, Biological sciences", "date": "2023-11-20", "authors": "Singh Anup Kumar, Khan Soumen, Moore Daniel, Andrews Simon, Christophorou Maria A", "evidence": [ { "database": "RefSeq", "id": "NP_035191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035191" } ], "reference": [ { "type": "PubMed", "id": "37778387", "url": "https://glygen.org/publication/PubMed/37778387" } ] } ], "pathway": [ { "id": "mmu:18602", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18602", "resource": "KEGG Pathway" }, { "id": "R-MMU-3247509", "name": "Chromatin modifying enzymes", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3247509", "resource": "Reactome", "description": "Chromatin modifying enzymes" } ], "orthologs": [ { "uniprot_canonical_ac": "O88807-1", "protein_name": "Protein-arginine deiminase type-4", "gene_name": "Padi4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQGAVIHVAPEEPTHAVCVVGTATPLDIRGSAPRGSTSFSITASPEVVVDVIHGPPSKKSTTGASKWPLDPKLEVTLQMKAASSRIDDQKVRISYYGPKTSSTQALLYLTGVELSLSADVTRTGKAKPAPAGKDQSTWTWGPDGHGAILLVNCDKEDPKSSGMDFEDDKVLDNKDLQDMSPMTLSTKTPKDFFDKYQLVLQVPKAKMNKVRVFRATRGKLPSRYKVVLGPQQFSHRLELLGGQHSTDFYVEGLAFPDADFKGLIPLTISLLDKSNPELPEALVFQDTVMFRVAPWIMTPNTQPPQEVYVCRFSDNEDFLKSLATFTKKAKCKLTVCPEEENQDDQWMQDEMEIGYIQAPHKTLPVVFDSPRDRGLKDFPVKRVMGPNFGYVTRGLYRAEVTGLDAFGNLEVSPPVTVRGKEYPLGRILIGSSGYSSSESRDMHQILQDFLGAQQVQAPVRLFSDWLFVGHVDEFLSFVPARGKQGFRLLLSSPRACYQMFQELQTEGHGEASLFEGLKRKRQTISDILSSQKLRDQNAYVESCIDWNREVLKRELGLTEGDIIDIPQLFRIVGNSRGNPKAEAFFPNMVNMLVLGKHLGIPKPFGPIINGRCCLEEKVCSLLEPLGLHCTFINDFYSYHMYHGEVHCGTNVRRKPFAFKWWHMVP", "length": 666 }, "evidence": [ { "id": "45235170", "url": "http://www.informatics.jax.org/homology/45235170", "database": "MGI" }, { "id": "Q9Z183", "url": "https://omabrowser.org/oma/group/Q9Z183/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UM07-1", "protein_name": "Protein-arginine deiminase type-4", "gene_name": "PADI4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIAHGPPAKKKSTGSSTWPLDPGVEVTLTMKVASGSTGDQKVQISYYGPKTPPVKALLYLTGVEISLCADITRTGKVKPTRAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDMSLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATRGKLSSKCSVVLGPKWPSHYLMVPGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTPNTQPPQEVYACSIFENEDFLKSVTTLAMKAKCKLTICPEEENMDDQWMQDEMEIGYIQAPHKTLPVVFDSPRNRGLKEFPIKRVMGPDFGYVTRGPQTGGISGLDSFGNLEVSPPVTVRGKEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIRHGEVHCGTNVRRKPFSFKWWNMVP", "length": 663 }, "evidence": [ { "id": "45235170", "url": "http://www.informatics.jax.org/homology/45235170", "database": "MGI" }, { "id": "Q9Z183", "url": "https://omabrowser.org/oma/group/Q9Z183/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "protein-arginine deiminase activity", "id": "GO:0004668", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004668", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" }, { "name": "histone arginine deiminase activity", "id": "GO:0140794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140794", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" }, { "name": "histone H3R2 arginine deiminase activity", "id": "GO:0140795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140795", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" }, { "name": "histone H3R8 arginine deiminase activity", "id": "GO:0140796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140796", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" }, { "name": "histone H3R17 arginine deiminase activity", "id": "GO:0140797", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140797", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" }, { "name": "histone H3R26 arginine deiminase activity", "id": "GO:0140798", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140798", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" }, { "name": "post-translational protein modification", "id": "GO:0043687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043687", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" }, { "name": "stem cell population maintenance", "id": "GO:0019827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019827", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" }, { "name": "nucleosome assembly", "id": "GO:0006334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006334", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [ { "annotation": "Autocitrullination at Arg-372 and Arg-374 inactivates the enzyme.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z183", "url": "https://www.uniprot.org/uniprot/Q9Z183" }, { "database": "PubMed", "id": "Q9UM07", "url": "https://glygen.org/publication/PubMed/Q9UM07" } ] } ], "interactions": [], "reactions": [ { "id": "18089", "name": "", "equation": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O88806-1", "O88807-1", "P20717-1", "P70708-1", "D4ABN7-1", "Q9Y2J8-1", "Q9ULC6-1", "Q9UM07-1", "Q9ULW8-1", "Q6TGC4-1", "Q8K3V4-1", "Q9Z183-1", "Q08642-1", "Q9Z185-1", "Q9Z184-1" ], "evidence": [ { "id": "18089", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18089" } ] }, { "id": "R-MMU-1183128", "name": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-1183111" ], "output_participant_list": [ "R-ALL-1183191" ], "enzyme_list": [ "Q08642-1", "Q9Z183-1", "Q9Z184-1", "Q9Z185-1", "Q8K3V4-1" ], "evidence": [ { "id": "R-MMU-1183128", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1183128" } ] }, { "id": "R-MMU-3247569", "name": "PADI4 deiminates Histones", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-ALL-113518" ], "output_participant_list": [ "R-ALL-76230" ], "enzyme_list": [ "Q08642-1", "Q9Z183-1", "Q9Z184-1", "Q9Z185-1", "Q8K3V4-1" ], "evidence": [ { "id": "R-MMU-3247569", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3247569" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-113518", "participant_name": "H2O [nucleoplasm]", "crossref": [ { "id": "8145132", "database": "PubChem Substance", "url": "" }, { "id": "C00001", "database": "COMPOUND", "url": "" }, { "id": "HMDB0002111", "database": "HMDB Metabolite", "url": "" }, { "id": "15377", "database": "ChEBI", "url": "" }, { "id": "8145132", "database": "PubChem Substance", "url": "" }, { "id": "C00001", "database": "COMPOUND", "url": "" }, { "id": "HMDB0002111", "database": "HMDB Metabolite", "url": "" }, { "id": "15377", "database": "ChEBI", "url": "" }, { "id": "15377", "database": "ChEBI", "url": "" }, { "id": "HMDB0002111", "database": "HMDB Metabolite", "url": "" }, { "id": "8145132", "database": "PubChem Substance", "url": "" }, { "id": "C00001", "database": "COMPOUND", "url": "" }, { "id": "15377", "database": "ChEBI", "url": "" }, { "id": "8145132", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0002111", "database": "HMDB Metabolite", "url": "" }, { "id": "C00001", "database": "COMPOUND", "url": "" }, { "id": "C00001", "database": "COMPOUND", "url": "" }, { "id": "15377", "database": "ChEBI", "url": "" }, { "id": "8145132", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0002111", "database": "HMDB Metabolite", "url": "" }, { "id": "8145132", "database": "PubChem Substance", "url": "" }, { "id": "C00001", "database": "COMPOUND", "url": "" }, { "id": "15377", "database": "ChEBI", "url": "" }, { "id": "HMDB0002111", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-1183111", "participant_name": "Protein-L-arginine [cytosol]", "crossref": [ { "id": "33708", "database": "ChEBI", "url": "" }, { "id": "33708", "database": "ChEBI", "url": "" }, { "id": "33708", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1183191", "participant_name": "Protein-L-citrulline [cytosol]", "crossref": [ { "id": "33708", "database": "ChEBI", "url": "" }, { "id": "33708", "database": "ChEBI", "url": "" }, { "id": "33708", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-76230", "participant_name": "NH3 [nucleoplasm]", "crossref": [ { "id": "C00014", "database": "COMPOUND", "url": "" }, { "id": "16134", "database": "ChEBI", "url": "" }, { "id": "8145696", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000051", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0033934", "database": "HMDB Metabolite", "url": "" }, { "id": "C00014", "database": "COMPOUND", "url": "" }, { "id": "16134", "database": "ChEBI", "url": "" }, { "id": "8145696", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000051", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0033934", "database": "HMDB Metabolite", "url": "" }, { "id": "C00014", "database": "COMPOUND", "url": "" }, { "id": "8145696", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0033934", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0000051", "database": "HMDB Metabolite", "url": "" }, { "id": "16134", "database": "ChEBI", "url": "" }, { "id": "C00014", "database": "COMPOUND", "url": "" }, { "id": "16134", "database": "ChEBI", "url": "" }, { "id": "8145696", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000051", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0033934", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "D4ABN7", "gene_name": "Padi6", "activity": [ { "ec_number": "3.5.3.15", "activity": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "D4ABN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ABN7" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "D4ABN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ABN7" } ] } ] }, { "uniprot_ac": "O88806", "gene_name": "Padi1", "activity": [ { "ec_number": "3.5.3.15", "activity": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "O88806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88806" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "O88806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88806" } ] } ] }, { "uniprot_ac": "O88807", "gene_name": "Padi4", "activity": [ { "ec_number": "3.5.3.15", "activity": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "O88807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88807" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "O88807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88807" } ] } ] }, { "uniprot_ac": "P20717", "gene_name": "Padi2", "activity": [ { "ec_number": "3.5.3.15", "activity": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "P20717", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20717" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "P20717", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20717" } ] } ] }, { "uniprot_ac": "P70708", "gene_name": "Padi3", "activity": [ { "ec_number": "3.5.3.15", "activity": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "P70708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70708" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "P70708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70708" } ] } ] }, { "uniprot_ac": "Q08642", "gene_name": "Padi2", "activity": [ { "ec_number": "3.5.3.15", "activity": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "Q08642", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08642" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "Q08642", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08642" } ] } ] }, { "uniprot_ac": "Q6TGC4", "gene_name": "PADI6", "activity": [ { "ec_number": "3.5.3.15", "activity": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "Q6TGC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6TGC4" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "Q6TGC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6TGC4" } ] } ] }, { "uniprot_ac": "Q8K3V4", "gene_name": "Padi6", "activity": [ { "ec_number": "3.5.3.15", "activity": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "Q8K3V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K3V4" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "Q8K3V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K3V4" } ] } ] }, { "uniprot_ac": "Q9ULC6", "gene_name": "PADI1", "activity": [ { "ec_number": "3.5.3.15", "activity": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "Q9ULC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ULC6" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "Q9ULC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ULC6" } ] } ] }, { "uniprot_ac": "Q9ULW8", "gene_name": "PADI3", "activity": [ { "ec_number": "3.5.3.15", "activity": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "Q9ULW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ULW8" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "Q9ULW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ULW8" } ] } ] }, { "uniprot_ac": "Q9UM07", "gene_name": "PADI4", "activity": [ { "ec_number": "3.5.3.15", "activity": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "Q9UM07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UM07" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "Q9UM07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UM07" } ] } ] }, { "uniprot_ac": "Q9Y2J8", "gene_name": "PADI2", "activity": [ { "ec_number": "3.5.3.15", "activity": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "Q9Y2J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2J8" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { 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