{
    "uniprot_canonical_ac": "Q9Z0S2-1",
    "uniprot_ac": "Q9Z0S2",
    "uniprot_id": "LHX2_MOUSE",
    "mass": {
        "chemical_mass": 44419.0,
        "monoisotopic_mass": 44419.0
    },
    "refseq": {
        "ac": "NP_034840",
        "name": "LIM/homeobox protein Lhx2 isoform a",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034840"
    },
    "gene_names": [
        {
            "name": "Lhx2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q9Z0S2",
            "id": "Q9Z0S2"
        },
        {
            "name": "Lhx2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034840",
            "id": "NP_034840"
        },
        {
            "name": "ap; apterous; Lh-2; LH2A; Lim2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034840",
            "id": "NP_034840"
        }
    ],
    "protein_names": [
        {
            "name": "LIM/homeobox protein Lhx2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q9Z0S2"
        },
        {
            "name": "Homeobox protein LH-2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9Z0S2"
        },
        {
            "name": "LIM homeobox protein 2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9Z0S2"
        },
        {
            "name": "LIM/homeobox protein Lhx2 isoform a",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034840",
            "id": "NP_034840"
        },
        {
            "name": "LIM/homeobox protein Lhx2 isoform b",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277575",
            "id": "NP_001277575"
        },
        {
            "name": "LIM/homeobox protein Lhx2; homeobox protein LH-2; LIM homeo box protein 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277575",
            "id": "NP_001277575"
        }
    ],
    "function": [
        {
            "annotation": "Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z0S2",
                    "url": "https://www.uniprot.org/uniprot/Q9Z0S2#function"
                },
                {
                    "database": "PubMed",
                    "id": "10593900",
                    "url": "https://glygen.org/publication/PubMed/10593900"
                }
            ]
        },
        {
            "annotation": "Regulation of chromatin accessibility and gene expression in the developing hippocampal primordium by LIM-HD transcription factor LHX2. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_034840",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034840"
                },
                {
                    "database": "PubMed",
                    "id": "37594984",
                    "url": "https://glygen.org/publication/PubMed/37594984"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001277575",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277575"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:9649",
            "recommended_name": {
                "id": "DOID:9649",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:9649",
                "name": "congenital nystagmus",
                "description": "A pathologic nystagmus, present at birth, characterized by involuntary, rhythmic eye movements; oscillations are usually horizontal in direction."
            },
            "synonyms": [
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "nystagmus 1, congenital, X-linked",
                    "description": "Any congenital nystagmus in which the cause of the disease is a mutation in the FRMD7 gene."
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "FRMD7 congenital nystagmus",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "congenital nystagmus caused by mutation in FRMD7",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "nystagmus 1, congenital, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "NYS1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "NYSTAGMUS 1, congenital, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "Nystagmus 1, congenital, X- linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "Nystagmus 1, infantile, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "Nystagmus, congenital motor, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "Nystagmus, infantile idiopathic",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "Nystagmus, infantile idiopathic, formerly",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "Nystagmus, infantile periodic alternating, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "Xlpan",
                    "description": ""
                },
                {
                    "id": "MIM:310700",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/310700",
                    "name": "Nystagmus 1, congenital, X-linked",
                    "description": "Nystagmus 1, congenital, X-linked"
                }
            ],
            "evidence": [
                {
                    "id": "9649",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:9649"
                }
            ]
        },
        {
            "disease_id": "DOID:9650",
            "recommended_name": {
                "id": "DOID:9650",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:9650",
                "name": "pathologic nystagmus",
                "description": ""
            },
            "synonyms": [],
            "evidence": [
                {
                    "id": "9650",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:9650"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 53,
            "end_pos": 53,
            "sequence_org": "C",
            "sequence_mut": "A",
            "comment": "Reduces transcriptional activation; when associated with A-56.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z0S2",
                    "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                },
                {
                    "database": "PubMed",
                    "id": "10593900",
                    "url": "https://glygen.org/publication/PubMed/10593900"
                }
            ]
        },
        {
            "start_pos": 56,
            "end_pos": 56,
            "sequence_org": "C",
            "sequence_mut": "A",
            "comment": "Reduces transcriptional activation; when associated with A-53.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z0S2",
                    "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                },
                {
                    "database": "PubMed",
                    "id": "10593900",
                    "url": "https://glygen.org/publication/PubMed/10593900"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z0S2",
                    "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Lhx2",
            "url": "https://www.uniprot.org/uniprot/Q9Z0S2",
            "locus": {
                "chromosome": "2",
                "start_pos": 38259745,
                "end_pos": 38229293,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000000247",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000000247"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000000247",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000000247",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00086",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd09377",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09377",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd09469",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09469",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "16870",
            "url": "https://www.ncbi.nlm.nih.gov/gene/16870",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q9Z0S2",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9Z0S2*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001356",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001781",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR009057",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017970",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:16870",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16870",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "96785",
            "url": "http://www.informatics.jax.org/marker/MGI:96785",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "CSTCAKM",
            "url": "https://omabrowser.org/oma/group/CSTCAKM/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24208",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24208",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24208:SF80",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24208:SF80",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00046",
            "url": "http://pfam.xfam.org/family/PF00046",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00412",
            "url": "http://pfam.xfam.org/family/PF00412",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q9Z0S2",
            "url": "http://purl.obolibrary.org/obo/PR_Q9Z0S2",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_034840",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034840",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0A0MQK9",
            "url": "https://www.uniprot.org/uniprot/A0A0A0MQK9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0A0MQK9-1",
            "url": "https://www.uniprot.org/uniprot/A0A0A0MQK9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6SM03",
            "url": "https://www.uniprot.org/uniprot/F6SM03",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6SM03-1",
            "url": "https://www.uniprot.org/uniprot/F6SM03-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6Z9H5",
            "url": "https://www.uniprot.org/uniprot/F6Z9H5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6Z9H5-1",
            "url": "https://www.uniprot.org/uniprot/F6Z9H5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "H3BKI3",
            "url": "https://www.uniprot.org/uniprot/H3BKI3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "H3BKI3-1",
            "url": "https://www.uniprot.org/uniprot/H3BKI3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9Z0S2",
            "url": "https://www.uniprot.org/uniprot/Q9Z0S2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9Z0S2-1",
            "url": "https://www.uniprot.org/uniprot/Q9Z0S2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MLFHSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETTMPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGSAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKTSDATLQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHSPSQTTLTNLF",
        "length": 406,
        "header": "sp|Q9Z0S2-1|LHX2_MOUSE Isoform 1 of LIM/homeobox protein Lhx2  OS=Mus musculus OX=10090 GN=Lhx2 PE=1 SV=1 CANONICAL=Q9Z0S2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0A0MQK9-1",
            "url": "",
            "sequence": {
                "sequence": "MPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKM",
                "length": 108,
                "header": "tr|A0A0A0MQK9-1|A0A0A0MQK9_MOUSE Computationally mapped isoform of LIM homeobox protein 2  OS=Mus musculus OX=10090 GN=Lhx2 PE=4 SV=1 CANONICAL=Q9Z0S2-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 38244584,
                "end_pos": 38243326,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000155964.3",
                        "url": "https://www.ensembl.org/id/ENSMUST00000155964.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000121462.4",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000121462.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F6SM03-1",
            "url": "",
            "sequence": {
                "sequence": "MPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGSAGANPLGLPYYNGVGTVQKGRPRKRKSPGP",
                "length": 192,
                "header": "tr|F6SM03-1|F6SM03_MOUSE Computationally mapped isoform of LIM homeobox protein 2  OS=Mus musculus OX=10090 GN=Lhx2 PE=1 SV=1 CANONICAL=Q9Z0S2-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 38244836,
                "end_pos": 38243326,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000133661.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000133661.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000115179.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000115179.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F6Z9H5-1",
            "url": "",
            "sequence": {
                "sequence": "MPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGSAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKTSDATLQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHSPSQTTLTNLF",
                "length": 365,
                "header": "tr|F6Z9H5-1|F6Z9H5_MOUSE Computationally mapped isoform of LIM homeobox protein 2  OS=Mus musculus OX=10090 GN=Lhx2 PE=1 SV=2 CANONICAL=Q9Z0S2-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 38259138,
                "end_pos": 38243326,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000143783.9",
                        "url": "https://www.ensembl.org/id/ENSMUST00000143783.9"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000114797.3",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000114797.3"
                    }
                ]
            }
        },
        {
            "isoform_ac": "H3BKI3-1",
            "url": "",
            "sequence": {
                "sequence": "MLFHSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETVGARLWSWG",
                "length": 49,
                "header": "tr|H3BKI3-1|H3BKI3_MOUSE Computationally mapped isoform of LIM homeobox protein 2  OS=Mus musculus OX=10090 GN=Lhx2 PE=1 SV=1 CANONICAL=Q9Z0S2-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "Q9Z0S2-1",
            "url": "",
            "sequence": {
                "sequence": "MLFHSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETTMPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGSAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKTSDATLQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHSPSQTTLTNLF",
                "length": 406,
                "header": "sp|Q9Z0S2-1|LHX2_MOUSE Isoform 1 of LIM/homeobox protein Lhx2  OS=Mus musculus OX=10090 GN=Lhx2 PE=1 SV=1 CANONICAL=Q9Z0S2-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 38259138,
                "end_pos": 38241786,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000000253",
                        "url": "https://www.ensembl.org/id/ENSMUST00000000253"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000000253",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000000253"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Conservation of the expression and function of apterous orthologs in Drosophila and mammals.",
            "journal": "Proc. Natl. Acad. Sci. U.S.A.",
            "date": "1999",
            "authors": "Botas J., Canal I., Izpisua-Belmonte J.-C., Rincon-Limas D.E., Calleja M., Lu C.-H., Rodriguez-Esteban C.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z0S2",
                    "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10051612",
                    "url": "https://glygen.org/publication/PubMed/10051612"
                }
            ]
        },
        {
            "title": "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression.",
            "journal": "J. Biol. Chem.",
            "date": "1999",
            "authors": "Glenn DJ, Maurer RA",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z0S2",
                    "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10593900",
                    "url": "https://glygen.org/publication/PubMed/10593900"
                }
            ]
        },
        {
            "title": "Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells.",
            "journal": "PLoS ONE",
            "date": "2014",
            "authors": "Li R., Wu F., Hu Z., Mu X., Sapkota D., Ruonala R.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Z0S2",
                    "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24643061",
                    "url": "https://glygen.org/publication/PubMed/24643061"
                }
            ]
        },
        {
            "title": "Regulation of chromatin accessibility and gene expression in the developing hippocampal primordium by LIM-HD transcription factor LHX2.",
            "journal": "PLoS genetics",
            "date": "2023-08",
            "authors": "Suresh Varun, Muralidharan Bhavana, Pradhan Saurabh J, Bose Mahima, D'Souza Leora, Parichha Arpan, Reddy Puli Chandramouli, Galande Sanjeev, Tole Shubha",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001277575",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277575"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_034840",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034840"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "37594984",
                    "url": "https://glygen.org/publication/PubMed/37594984"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:16870",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16870",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P36198-1",
            "protein_name": "LIM/homeobox protein Lhx2",
            "gene_name": "Lhx2",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MLFHSLSGPEVHGVIDEMDRRQERGSGISSAIDRGDTETTMPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISESEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPPHFNHADVARAAAAAEQLRVQDWAQLGLTLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKTSDATLQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEATSPTALHKRLLPTFSNDSPPPSPLSPHDFFKKEIIFS",
                "length": 426
            },
            "evidence": [
                {
                    "id": "45227462",
                    "url": "http://www.informatics.jax.org/homology/45227462",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "P50458-1",
            "protein_name": "LIM/homeobox protein Lhx2",
            "gene_name": "LHX2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MLFHSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETTMPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHSPSQTTLTNLF",
                "length": 406
            },
            "evidence": [
                {
                    "id": "45227462",
                    "url": "http://www.informatics.jax.org/homology/45227462",
                    "database": "MGI"
                },
                {
                    "id": "Q9Z0S2",
                    "url": "https://omabrowser.org/oma/group/Q9Z0S2/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 7,
                "go_terms": [
                    {
                        "name": "chromatin binding",
                        "id": "GO:0003682",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding",
                        "id": "GO:0000977",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding",
                        "id": "GO:0000978",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription factor activity, RNA polymerase II-specific",
                        "id": "GO:0000981",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sequence-specific DNA binding",
                        "id": "GO:0043565",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription activator activity, RNA polymerase II-specific",
                        "id": "GO:0001228",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 25,
                "go_terms": [
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nervous system development",
                        "id": "GO:0007399",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cerebral cortex development",
                        "id": "GO:0021987",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021987",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "brain development",
                        "id": "GO:0007420",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of DNA-templated transcription",
                        "id": "GO:0045893",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "retina development in camera-type eye",
                        "id": "GO:0060041",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060041",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "neural tube closure",
                        "id": "GO:0001843",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "neuron differentiation",
                        "id": "GO:0030182",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "hair follicle development",
                        "id": "GO:0001942",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001942",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of neural precursor cell proliferation",
                        "id": "GO:2000179",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000179",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of transcription regulatory region DNA binding",
                        "id": "GO:2000678",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000678",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dorsal/ventral pattern formation",
                        "id": "GO:0009953",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009953",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "maintenance of epithelial cell apical/basal polarity",
                        "id": "GO:0045199",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045199",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of gene expression, epigenetic",
                        "id": "GO:0045814",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045814",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "axon guidance",
                        "id": "GO:0007411",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of neurogenesis",
                        "id": "GO:0050768",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050768",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "neurogenesis",
                        "id": "GO:0022008",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022008",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "axon extension",
                        "id": "GO:0048675",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048675",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "anatomical structure formation involved in morphogenesis",
                        "id": "GO:0048646",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048646",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mesoderm development",
                        "id": "GO:0007498",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007498",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "telencephalon development",
                        "id": "GO:0021537",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021537",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "telencephalon regionalization",
                        "id": "GO:0021978",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021978",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "olfactory bulb development",
                        "id": "GO:0021772",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021772",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "system development",
                        "id": "GO:0048731",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048731",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9Z0S2",
                                "url": "https://www.uniprot.org/uniprot/Q9Z0S2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 355,
            "end_pos": 357,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
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