{ "uniprot_canonical_ac": "Q9Z0F4-1", "uniprot_ac": "Q9Z0F4", "uniprot_id": "CIB1_MOUSE", "mass": { "chemical_mass": 21763.0, "monoisotopic_mass": 21763.0 }, "refseq": { "ac": "NP_001278205", "name": "calcium and integrin-binding protein 1 isoform 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278205" }, "gene_names": [ { "name": "Cib1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9Z0F4", "id": "Q9Z0F4" }, { "name": "Cib1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278205", "id": "NP_001278205" }, { "name": "Cibkip; Kip; Prkdcip", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278205", "id": "NP_001278205" }, { "name": "Cib", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9Z0F4", "id": "Q9Z0F4" }, { "name": "Kip", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9Z0F4", "id": "Q9Z0F4" }, { "name": "Prkdcip", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9Z0F4", "id": "Q9Z0F4" } ], "protein_names": [ { "name": "Calcium and integrin-binding protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9Z0F4" }, { "name": "CIB", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z0F4" }, { "name": "Calmyrin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z0F4" }, { "name": "DNA-PKcs-interacting protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z0F4" }, { "name": "KIP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z0F4" }, { "name": "Kinase-interacting protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Z0F4" }, { "name": "calcium and integrin-binding protein 1 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278204", "id": "NP_001278204" }, { "name": "calcium and integrin-binding protein 1 isoform 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278205", "id": "NP_001278205" }, { "name": "protein kinase, DNA activated, catalytic polypeptide interacting protein; calcium and integrin binding, protein kinase interacting protein; calmyrin; calcium and integrin-binding protein 1; CIB; kinase-interacting protein; DNA-PKcs-interacting protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278204", "id": "NP_001278204" } ], "function": [ { "annotation": "Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4#function" }, { "database": "PubMed", "id": "19691476", "url": "https://glygen.org/publication/PubMed/19691476" }, { "database": "PubMed", "id": "22128142", "url": "https://glygen.org/publication/PubMed/22128142" }, { "database": "PubMed", "id": "20804551", "url": "https://glygen.org/publication/PubMed/20804551" }, { "database": "PubMed", "id": "16982698", "url": "https://glygen.org/publication/PubMed/16982698" }, { "database": "PubMed", "id": "17975111", "url": "https://glygen.org/publication/PubMed/17975111" } ] }, { "annotation": "Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components.", "evidence": [ { "database": "RefSeq", "id": "NP_001278205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278205" }, { "database": "PubMed", "id": "32917726", "url": "https://glygen.org/publication/PubMed/32917726" }, { "database": "RefSeq", "id": "NP_001278204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278204" } ] }, { "annotation": "Identification of calcium and integrin-binding protein 1 as a novel regulator of production of amyloid beta peptide using CRISPR/Cas9-based screening system.", "evidence": [ { "database": "RefSeq", "id": "NP_001278205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278205" }, { "database": "PubMed", "id": "32307772", "url": "https://glygen.org/publication/PubMed/32307772" }, { "database": "RefSeq", "id": "NP_001278204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278204" } ] }, { "annotation": "Mouse erythrocyte calmyrin is an interacting molecule of the rodent malaria parasite Plasmodium yoelii RhopH complex.", "evidence": [ { "database": "RefSeq", "id": "NP_001278205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278205" }, { "database": "PubMed", "id": "29653104", "url": "https://glygen.org/publication/PubMed/29653104" }, { "database": "RefSeq", "id": "NP_001278204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278204" } ] } ], "disease": [ { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "evidence": [ { "id": "10652", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] }, { "disease_id": "DOID:13777", "recommended_name": { "id": "DOID:13777", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13777", "name": "epidermodysplasia verruciformis", "description": "A primary immunodeficiency disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body." }, "synonyms": [ { "id": "MONDO:0100045", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100045", "name": "epidermodysplasia verruciformis, susceptibility to, 1", "description": "" }, { "id": "MONDO:0100045", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100045", "name": "EV1", "description": "" }, { "id": "MONDO:0100045", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100045", "name": "epidermodysplasia verruciformis 1", "description": "" }, { "id": "MIM:226400", "resource": "MIM", "url": "https://www.omim.org/entry/226400", "name": "Epidermodysplasia verruciformis 1", "description": "Epidermodysplasia verruciformis 1" } ], "evidence": [ { "id": "13777", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13777" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Cib1", "url": "https://www.uniprot.org/uniprot/Q9Z0F4", "locus": { "chromosome": "7", "start_pos": 79876895, "end_pos": 79882561, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000030538", "url": "https://www.ensembl.org/id/ENSMUSG00000030538" } ] } } ], "crossref": [ { "id": "ENSMUSG00000030538", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000030538", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "23991", "url": "https://www.ncbi.nlm.nih.gov/gene/23991", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:23991", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:23991", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1344418", "url": "http://www.informatics.jax.org/marker/MGI:1344418", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "LYAHQKF", "url": "https://omabrowser.org/oma/group/LYAHQKF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5472814at2759", "url": "http://www.orthodb.org/?query=5472814at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45791", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45791", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45791:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45791:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13405", "url": "http://pfam.xfam.org/family/PF13405", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13499", "url": "http://pfam.xfam.org/family/PF13499", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9Z0F4", "url": "http://purl.obolibrary.org/obo/PR_Q9Z0F4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001278204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278204", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0U1RNH3", "url": "https://www.uniprot.org/uniprot/A0A0U1RNH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0U1RNH3-1", "url": "https://www.uniprot.org/uniprot/A0A0U1RNH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0U1RPF3", "url": "https://www.uniprot.org/uniprot/A0A0U1RPF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0U1RPF3-1", "url": "https://www.uniprot.org/uniprot/A0A0U1RPF3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0U1RPW6", "url": "https://www.uniprot.org/uniprot/A0A0U1RPW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0U1RPW6-1", "url": "https://www.uniprot.org/uniprot/A0A0U1RPW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3YY46", "url": "https://www.uniprot.org/uniprot/D3YY46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3YY46-1", "url": "https://www.uniprot.org/uniprot/D3YY46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C2K4", "url": "https://www.uniprot.org/uniprot/Q8C2K4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C2K4-1", "url": "https://www.uniprot.org/uniprot/Q8C2K4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Z0F4-1", "url": "https://www.uniprot.org/uniprot/Q9Z0F4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPPEQRTVEESLHTRVSFEQILSLPELKANPFKERICMVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL", "length": 191, "header": "sp|Q9Z0F4-1|CIB1_MOUSE Isoform 1 of Calcium and integrin-binding protein 1 OS=Mus musculus OX=10090 GN=Cib1 PE=1 SV=3 CANONICAL=Q9Z0F4-1" }, "isoforms": [ { "isoform_ac": "A0A0U1RNH3-1", "url": "", "sequence": { "sequence": "MGGSGSRLSKELLAEYQDLTFLTKQEILLRKDCLWIERRQTWT", "length": 43, "header": "tr|A0A0U1RNH3-1|A0A0U1RNH3_MOUSE Computationally mapped isoform of Calcium and integrin binding 1 (calmyrin) OS=Mus musculus OX=10090 GN=Cib1 PE=1 SV=1 CANONICAL=Q9Z0F4-1" }, "locus": { "chromosome": "7", "start_pos": 79882308, "end_pos": 79880696, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000206802.2", "url": "https://www.ensembl.org/id/ENSMUST00000206802.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000145564.2", "url": "https://www.ensembl.org/id/ENSMUSP00000145564.2" } ] } }, { "isoform_ac": "A0A0U1RPF3-1", "url": "", "sequence": { "sequence": "MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPPEQRTVEESLHTRVSFEQILSLPELKERICMVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL", "length": 186, "header": "tr|A0A0U1RPF3-1|A0A0U1RPF3_MOUSE Computationally mapped isoform of Calcium and integrin binding 1 (calmyrin) OS=Mus musculus OX=10090 GN=Cib1 PE=1 SV=1 CANONICAL=Q9Z0F4-1" }, "locus": { "chromosome": "7", "start_pos": 79882308, "end_pos": 79877116, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000206084.2", "url": "https://www.ensembl.org/id/ENSMUST00000206084.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000145961.2", "url": "https://www.ensembl.org/id/ENSMUSP00000145961.2" } ] } }, { "isoform_ac": "A0A0U1RPW6-1", "url": "", "sequence": { "sequence": "MVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEESD", "length": 87, "header": "tr|A0A0U1RPW6-1|A0A0U1RPW6_MOUSE Computationally mapped isoform of Calcium and integrin binding 1 (calmyrin) OS=Mus musculus OX=10090 GN=Cib1 PE=1 SV=1 CANONICAL=Q9Z0F4-1" }, "locus": { "chromosome": "7", "start_pos": 79878269, "end_pos": 79877813, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000205996.2", "url": "https://www.ensembl.org/id/ENSMUST00000205996.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000146153.2", "url": "https://www.ensembl.org/id/ENSMUSP00000146153.2" } ] } }, { "isoform_ac": "D3YY46-1", "url": "", "sequence": { "sequence": "MVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSF", "length": 113, "header": "tr|D3YY46-1|D3YY46_MOUSE Computationally mapped isoform of Calcium and integrin binding 1 (calmyrin) OS=Mus musculus OX=10090 GN=Cib1 PE=1 SV=2 CANONICAL=Q9Z0F4-1" }, "locus": { "chromosome": "7", "start_pos": 79878269, "end_pos": 79877128, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000123279.8", "url": "https://www.ensembl.org/id/ENSMUST00000123279.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000118926.3", "url": "https://www.ensembl.org/id/ENSMUSP00000118926.3" } ] } }, { "isoform_ac": "Q8C2K4-1", "url": "", "sequence": { "sequence": "MGGSGSRLSKELLAEYQANPFKERICMVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL", "length": 143, "header": "tr|Q8C2K4-1|Q8C2K4_MOUSE Computationally mapped isoform of Calcium and integrin binding 1 (calmyrin) OS=Mus musculus OX=10090 GN=Cib1 PE=1 SV=1 CANONICAL=Q9Z0F4-1" }, "locus": { "chromosome": "7", "start_pos": 79882308, "end_pos": 79877116, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000071457.12", "url": "https://www.ensembl.org/id/ENSMUST00000071457.12" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000071401.6", "url": "https://www.ensembl.org/id/ENSMUSP00000071401.6" } ] } }, { "isoform_ac": "Q9Z0F4-1", "url": "", "sequence": { "sequence": "MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPPEQRTVEESLHTRVSFEQILSLPELKANPFKERICMVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL", "length": 191, "header": "sp|Q9Z0F4-1|CIB1_MOUSE Isoform 1 of Calcium and integrin-binding protein 1 OS=Mus musculus OX=10090 GN=Cib1 PE=1 SV=3 CANONICAL=Q9Z0F4-1" }, "locus": { "chromosome": "7", "start_pos": 79882308, "end_pos": 79877116, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000065163", "url": "https://www.ensembl.org/id/ENSMUST00000065163" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000070901", "url": "https://www.ensembl.org/id/ENSMUSP00000070901" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structure, expression profile, and chromosomal location of a mouse gene homologous to human DNA-PKcs interacting protein (KIP) gene.", "journal": "Mamm. Genome", "date": "1999", "authors": "Abe M., Matsuda Y., Saito T., Seki N., Hattori A., Hayashi A., Kozuma S., Fukumura R., Fujimori A., Araki R.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "reference": [ { "type": "PubMed", "id": "10051332", "url": "https://glygen.org/publication/PubMed/10051332" } ] }, { "title": "Genomic structure of mouse and human genes for DNA-PKcs interacting protein (KIP).", "journal": "DNA Seq.", "date": "2000", "authors": "Hattori A, Seki N, Hayashi A, Kozuma S, Saito T", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "reference": [ { "type": "PubMed", "id": "10826701", "url": "https://glygen.org/publication/PubMed/10826701" } ] }, { "title": "CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation.", "journal": "J. Cell Biol.", "date": "2006", "authors": "Yuan W, Leisner TM, McFadden AW, Wang Z, Larson MK, Clark S, Boudignon-Proudhon C, Lam SC, Parise LV", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "reference": [ { "type": "PubMed", "id": "16418530", "url": "https://glygen.org/publication/PubMed/16418530" } ] }, { "title": "CIB1 is essential for mouse spermatogenesis.", "journal": "Mol. Cell. Biol.", "date": "2006", "authors": "Clark S., Maeda N., Yuan W., Leisner T.M., McFadden A.W., Parise L.V., O'Brien D.A., Hiller S.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "reference": [ { "type": "PubMed", "id": "16982698", "url": "https://glygen.org/publication/PubMed/16982698" } ] }, { "title": "CIB1 regulates endothelial cells and ischemia-induced pathological and adaptive angiogenesis.", "journal": "Circ. Res.", "date": "2007", "authors": "Yuan W., Leisner T.M., McFadden A.W., Parise L.V., Schaller M.D., Chalothorn D., Faber J.E., Hartnett M.E., Zayed M.A.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "reference": [ { "type": "PubMed", "id": "17975111", "url": "https://glygen.org/publication/PubMed/17975111" } ] }, { "title": "CIB1 and CaBP1 bind to the myo1c regulatory domain.", "journal": "J. Muscle Res. Cell Motil.", "date": "2007", "authors": "Yang J., Foskett J.K., Lin T., Ostap E.M., Tang N.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "reference": [ { "type": "PubMed", "id": "17994197", "url": "https://glygen.org/publication/PubMed/17994197" } ] }, { "title": "Characterization of calcium- and integrin-binding protein 1 (CIB1) knockout platelets: potential compensation by CIB family members.", "journal": "Thromb. Haemost.", "date": "2008", "authors": "Yuan W., Gentry H.R., Parise L.V., Temple B.R., Denofrio J.C.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "reference": [ { "type": "PubMed", "id": "18989529", "url": "https://glygen.org/publication/PubMed/18989529" } ] }, { "title": "CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin alpha IIb beta 3.", "journal": "J. Thromb. Haemost.", "date": "2009", "authors": "Naik M.U., Naik U.P., Sullivan M., Czymmek K., Manrai P., Millili P., Nigam A.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "reference": [ { "type": "PubMed", "id": "19691476", "url": "https://glygen.org/publication/PubMed/19691476" } ] }, { "title": "CIB1 is a regulator of pathological cardiac hypertrophy.", "journal": "Nat. Med.", "date": "2010", "authors": "Xu J., Yuan W., Molkentin J.D., Auger-Messier M., Benard M.J., Correll R.N., Drexler H., Heineke J., Parise L.V.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "reference": [ { "type": "PubMed", "id": "20639889", "url": "https://glygen.org/publication/PubMed/20639889" } ] }, { "title": "Tumor growth and angiogenesis is impaired in CIB1 knockout mice.", "journal": "J. Angiog. Res.", "date": "2010", "authors": "Yuan W., Parise L.V., Chalothorn D., Faber J.E., Zayed M.A.", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "reference": [ { "type": "PubMed", "id": "20804551", "url": "https://glygen.org/publication/PubMed/20804551" } ] }, { "title": "Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration.", "journal": "Blood", "date": "2012", "authors": "Kostyak JC, Naik MU, Naik UP", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "reference": [ { "type": "PubMed", "id": "22128142", "url": "https://glygen.org/publication/PubMed/22128142" } ] }, { "title": "CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival.", "journal": "EMBO Mol. Med.", "date": "2017", "authors": "Michel V, Booth KT, Patni P, Cortese M, Azaiez H, Bahloul A, Kahrizi K, Labbe M, Emptoz A, Lelli A, Degardin J, Dupont T, Aghaie A, Oficjalska-Pham D, Picaud S, Najmabadi H, Smith RJ, Bowl MR, Brown SD, Avan P, Petit C, El-Amraoui A", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "reference": [ { "type": "PubMed", "id": "29084757", "url": "https://glygen.org/publication/PubMed/29084757" } ] }, { "title": "Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice.", "journal": "Front. Mol. Neurosci.", "date": "2017", "authors": "Wang Y, Li J, Yao X, Li W, Du H, Tang M, Xiong W, Chai R, Xu Z", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "reference": [ { "type": "PubMed", "id": "29255404", "url": "https://glygen.org/publication/PubMed/29255404" } ] }, { "title": "The malaria parasite RhopH protein complex interacts with erythrocyte calmyrin identified from a comprehensive erythrocyte protein library.", "journal": "Biochemical and biophysical research communications", "date": "2018", "authors": "Miura T, Takeo S, Ntege EH, Otsuki H, Sawasaki T, Ishino T, Takashima E, Tsuboi T", "evidence": [ { "database": "RefSeq", "id": "NP_001278205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278205" }, { "database": "RefSeq", "id": "NP_001278204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278204" } ], "reference": [ { "type": "PubMed", "id": "29653104", "url": "https://glygen.org/publication/PubMed/29653104" } ] }, { "title": "Identification of calcium and integrin-binding protein 1 as a novel regulator of production of amyloid beta peptide using CRISPR/Cas9-based screening system.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2020", "authors": "Chiu YW, Hori Y, Ebinuma I, Sato H, Hara N, Ikeuchi T, Tomita T", "evidence": [ { "database": "RefSeq", "id": "NP_001278205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278205" }, { "database": "RefSeq", "id": "NP_001278204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278204" } ], "reference": [ { "type": "PubMed", "id": "32307772", "url": "https://glygen.org/publication/PubMed/32307772" } ] }, { "title": "Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components.", "journal": "The Journal of biological chemistry", "date": "2020", "authors": "Wu CJ, Li X, Sommers CL, Kurima K, Huh S, Bugos G, Dong L, Li W, Griffith AJ, Samelson LE", "evidence": [ { "database": "RefSeq", "id": "NP_001278204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278204" }, { "database": "RefSeq", "id": "NP_001278205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278205" } ], "reference": [ { "type": "PubMed", "id": "32917726", "url": "https://glygen.org/publication/PubMed/32917726" } ] } ], "pathway": [ { "id": "mmu:23991", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:23991", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q99828-1", "protein_name": "Calcium and integrin-binding protein 1", "gene_name": "CIB1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPQEQRSVESSLRAQVPFEQILSLPELKANPFKERICRVFSTSPAKDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL", "length": 191 }, 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damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "pmid": "" }, { "name": "cellular response to growth factor stimulus", "id": "GO:0071363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071363", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "pmid": "" }, { "name": "positive regulation of cell migration involved in sprouting angiogenesis", "id": "GO:0090050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090050", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "pmid": "" }, { "name": "positive regulation of substrate adhesion-dependent cell spreading", "id": "GO:1900026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900026", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "pmid": "" }, { "name": "positive regulation of protein localization to plasma membrane", "id": "GO:1903078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903078", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "pmid": "" }, { "name": "positive regulation of protein serine/threonine kinase activity", "id": "GO:0071902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071902", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "pmid": "" }, { "name": "negative regulation of microtubule depolymerization", "id": "GO:0007026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007026", "evidence": [ { "database": "UniProtKB", "id": "Q9Z0F4", "url": "https://www.uniprot.org/uniprot/Q9Z0F4" } ], "pmid": "" }, { "name": "negative regulation of megakaryocyte differentiation", "id": "GO:0045653", "url": 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