{ "uniprot_canonical_ac": "Q9Y676-1", "uniprot_ac": "Q9Y676", "uniprot_id": "RT18B_HUMAN", "mass": { "chemical_mass": 29396.0, "monoisotopic_mass": 29396.0 }, "refseq": { "ac": "NP_054765", "name": "small ribosomal subunit protein mS40", "summary": "Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054765" }, "gene_names": [ { "name": "MRPS18B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9Y676", "id": "Q9Y676" }, { "name": "C6orf14; HSPC183; HumanS18a; MRP-S18-2; MRPS18-2; mS40; PTD017; S18amt", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054765", "id": "NP_054765" }, { "name": "C6orf14", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9Y676", "id": "Q9Y676" }, { "name": "HSPC183", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9Y676", "id": "Q9Y676" }, { "name": "MRPS18B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054765", "id": "NP_054765" }, { "name": "PTD017", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9Y676", "id": "Q9Y676" } ], "protein_names": [ { "name": "Small ribosomal subunit protein mS40", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9Y676" }, { "name": "28S ribosomal protein S18-2, mitochondrial", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y676" }, { "name": "28S ribosomal protein S18b, mitochondrial", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y676" }, { "name": "MRP-S18-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y676" }, { "name": "MRP-S18-b", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y676" }, { "name": "Mrps18-b", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y676" }, { "name": "S18mt-b", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y676" }, { "name": "Small ribosomal subunit protein bS18b", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y676" }, { "name": "mitochondrial ribosomal protein S18-2; 28S ribosomal protein S18b, mitochondrial; S18mt-b; mrps18-b; MRP-S18-b; 28S ribosomal protein S18-2, mitochondrial; mitochondrial small ribosomal subunit protein mS40; mitochondrial small ribosomal subunit protein bS18m-B; mitochondrial small ribosomal subunit protein bS18b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054765", "id": "NP_054765" }, { "name": "small ribosomal subunit protein mS40", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054765", "id": "NP_054765" } ], "function": [ { "annotation": "EBNA-6 {ebna-3c} binds to MRPS18-2 , and targets it to the nucleus; binding targets the small pocket of pRb, which is a site of interaction with E2F1. The MRPS18-2 competes with the binding of E2F1 to pRb, thereby raising the level of free E2F1", "evidence": [ { "database": "RefSeq", "id": "NP_054765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054765" }, { "database": "PubMed", "id": "18391203", "url": "https://glygen.org/publication/PubMed/18391203" } ] }, { "annotation": "Expression pattern of MRPS18 family genes in gliomas.", "evidence": [ { "database": "RefSeq", "id": "NP_054765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054765" }, { "database": "PubMed", "id": "34591434", "url": "https://glygen.org/publication/PubMed/34591434" } ] }, { "annotation": "Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_054765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054765" } ] }, { "annotation": "Together, these data suggest that the S18-2 protein induces epithelial to mesenchymal cell transition through the TWIST2/E-cadherin signalling and, consequently, CXCR4-mediated migration of prostate cancer cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_054765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054765" }, { "database": "PubMed", "id": "29396484", "url": "https://glygen.org/publication/PubMed/29396484" } ] }, { "annotation": "Trend for increasing expression of the S18-2 protein in tumors correlates with the aggressiveness of malignant breast cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_054765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054765" }, { "database": "PubMed", "id": "30593750", "url": "https://glygen.org/publication/PubMed/30593750" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "94.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204568" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "96.44", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204568" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "95.29", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204568" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "91.8", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204568" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "94.33", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204568" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "96.07", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204568" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "96.2", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204568" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "95.15", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204568" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "93.76", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204568" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "93.62", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204568" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "94.05", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204568" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "91.95", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204568" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "94.41", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204568" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q9Y676", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y676" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "Q9Y676", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y676" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { 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"name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour 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"categories": [ "3D Structure" ] }, { "id": "8CSR", "url": "https://www.rcsb.org/structure/8CSR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8CSS", "url": "https://www.rcsb.org/structure/8CSS", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8CST", "url": "https://www.rcsb.org/structure/8CST", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8CSU", "url": "https://www.rcsb.org/structure/8CSU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF01084", "url": "http://pfam.xfam.org/family/PF01084", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "Q9Y676", "url": "https://pharos.nih.gov/targets/Q9Y676", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_Q9Y676", "url": "http://purl.obolibrary.org/obo/PR_Q9Y676", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-5368286", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5368286", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5389840", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5419276", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_054765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054765", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0G2JIC6", "url": "https://www.uniprot.org/uniprot/A0A0G2JIC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JIC6-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JIC6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Y676", "url": "https://www.uniprot.org/uniprot/Q9Y676", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Y676-1", "url": "https://www.uniprot.org/uniprot/Q9Y676-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASVLNTVLRRLPMLSLFRGSHRVQVPLQTLCTKAPSEEDSLSSVPISPYKDEPWKYLESEEYQERYGSRPVWADYRRNHKGGVPPQRTRKTCIRRNKVVGNPCPICRDHKLHVDFRNVKLLEQFVCAHTGIIFYAPYTGVCVKQHKRLTQAIQKARDHGLLIYHIPQVEPRDLDFSTSHGAVSATPPAPTLVSGDPWYPWYNWKQPPERELSRLRRLYQGHLQEESGPPPESMPKMPPRTPAEASSTGQTGPQSAL", "length": 258, "header": "sp|Q9Y676-1|RT18B_HUMAN Isoform 1 of Small ribosomal subunit protein mS40 OS=Homo sapiens OX=9606 GN=MRPS18B PE=1 SV=1 CANONICAL=Q9Y676-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JIC6-1", "url": "", "sequence": { "sequence": "MAASVLNTVLRRLPMLSLFRGSHRVQVPLQTLCTKAPSEEDSLSSVPISPYKDEPWKYLESEEYQERYGSRPVWADYRRNHKGGVPPQRTRKTCINVKLLEQFVCAHTGIIFYAPYTGLLIYHIPQVEPRDLDFSTSHGAVSATPPAPTLVSGDPWYPWYNWKQPPERELSRLRRLYQGHLQEESGPPPESMPKMPPRTPAEASSTGQTGPQSAL", "length": 215, "header": "tr|A0A0G2JIC6-1|RT18B_HUMAN Computationally mapped isoform of Small ribosomal subunit protein mS40 OS=Homo sapiens OX=9606 GN=MRPS18B PE=1 SV=1 CANONICAL=Q9Y676-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MANN_CTG1", "start_pos": 30670430, "end_pos": 30662502, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000440992.2", "url": "https://www.ensembl.org/id/ENST00000440992.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000390930.2", "url": "https://www.ensembl.org/id/ENSP00000390930.2" } ] } }, { "isoform_ac": "Q9Y676-1", "url": "", "sequence": { "sequence": "MAASVLNTVLRRLPMLSLFRGSHRVQVPLQTLCTKAPSEEDSLSSVPISPYKDEPWKYLESEEYQERYGSRPVWADYRRNHKGGVPPQRTRKTCIRRNKVVGNPCPICRDHKLHVDFRNVKLLEQFVCAHTGIIFYAPYTGVCVKQHKRLTQAIQKARDHGLLIYHIPQVEPRDLDFSTSHGAVSATPPAPTLVSGDPWYPWYNWKQPPERELSRLRRLYQGHLQEESGPPPESMPKMPPRTPAEASSTGQTGPQSAL", "length": 258, "header": "sp|Q9Y676-1|RT18B_HUMAN Isoform 1 of Small ribosomal subunit protein mS40 OS=Homo sapiens OX=9606 GN=MRPS18B PE=1 SV=1 CANONICAL=Q9Y676-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MANN_CTG1", "start_pos": 30670430, "end_pos": 30662502, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000451032.6", "url": "https://www.ensembl.org/id/ENST00000451032.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000415703.2", "url": "https://www.ensembl.org/id/ENSP00000415703.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q9Y676", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Y676" }, { "id": "29485866", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29485866" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" } ] } ], "phosphorylation": [ { "start_pos": 38, "end_pos": 38, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9Y676", "url": "https://www.uniprot.org/uniprot/Q9Y676" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q9Y676", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Y676" } ], "site_lbl": "Ser38" }, { "start_pos": 49, "end_pos": 49, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9Y676", "url": "https://www.uniprot.org/uniprot/Q9Y676" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q9Y676", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Y676" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Ser49" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL", "evidence": [ { "database": "UniProtKB", "id": "Q9Y676", "url": "https://www.uniprot.org/uniprot/Q9Y676" } ], "reference": [ { "type": "PubMed", "id": "11279123", "url": "https://glygen.org/publication/PubMed/11279123" } ] }, { "title": "Expression and characterization of isoform 1 of human mitochondrial elongation factor G.", "journal": "Protein expression and purification", "date": "2004", "authors": "Bhargava K, Templeton P, Spremulli LL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5389840" } ], "reference": [ { "type": "PubMed", "id": "15358359", "url": "https://glygen.org/publication/PubMed/15358359" } ] }, { "title": "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.", "journal": "Genetics", "date": "2006", "authors": "Kikkawa E., Shimizu S., Tokunaga K., Inoko H., Kulski J.K., Sano K., Shiina T., Watanabe A., Hashimoto N., Katsuyama Y., Ota M., Bahram S., Meyer A., Kimura N., Anzai T., Gojobori T., Hosomichi K., Ikeo K., Iwamoto C., Kohara S., Macquin C., Naruse T., Takasu M., Umehara Y., Wanner V., Yanagiya K.", "evidence": [ { "database": "UniProtKB", "id": "Q9Y676", "url": "https://www.uniprot.org/uniprot/Q9Y676" } ], "reference": [ { "type": "PubMed", "id": "16702430", "url": "https://glygen.org/publication/PubMed/16702430" } ] }, { "title": "mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG.", "journal": "Molecular cell", "date": "2007", "authors": "Soleimanpour-Lichaei HR, Kuhl I, Gaisne M, Passos JF, Wydro M, Rorbach J, Temperley R, Bonnefoy N, Tate W, Lightowlers R, Chrzanowska-Lightowlers Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5419276" } ], "reference": [ { "type": "PubMed", "id": "17803939", "url": "https://glygen.org/publication/PubMed/17803939" } ] }, { "title": "EBV-encoded EBNA-6 binds and targets MRS18-2 to the nucleus, resulting in the disruption of pRb-E2F1 complexes.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Kashuba E, Yurchenko M, Yenamandra SP, Snopok B, Isaguliants M, Szekely L, Klein G", "evidence": [ { "database": "RefSeq", "id": "NP_054765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054765" } ], "reference": [ { "type": "PubMed", "id": "18391203", "url": "https://glygen.org/publication/PubMed/18391203" } ] }, { "title": "HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG.", "journal": "Genes to cells : devoted to molecular & cellular mechanisms", "date": "2008", "authors": "Nozaki Y, Matsunaga N, Ishizawa T, Ueda T, Takeuchi N", "evidence": [ { "database": "Reactome", "id": "R-HSA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5419276" } ], "reference": [ { "type": "PubMed", "id": "18429816", "url": "https://glygen.org/publication/PubMed/18429816" } ] }, { "title": "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.", "journal": "Mol. Cell", "date": "2008", "authors": "Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JIC6", "url": "https://www.uniprot.org/uniprot/A0A0G2JIC6" }, { "database": "UniProtKB", "id": "Q9Y676", "url": "https://www.uniprot.org/uniprot/Q9Y676" }, { "database": "iPTMnet", "id": "Q9Y676", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Y676" } ], "reference": [ { "type": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ] }, { "title": "The human mitochondrial ribosome recycling factor is essential for cell viability.", "journal": "Nucleic acids research", "date": "2008", "authors": "Rorbach J, Richter R, Wessels HJ, Wydro M, Pekalski M, Farhoud M, Kuhl I, Gaisne M, Bonnefoy N, Smeitink JA, Lightowlers RN, Chrzanowska-Lightowlers ZM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5419276" } ], "reference": [ { "type": "PubMed", "id": "18782833", "url": "https://glygen.org/publication/PubMed/18782833" } ] }, { "title": "The R336Q mutation in human mitochondrial EFTu prevents the formation of an active mt-EFTu.GTP.aa-tRNA ternary complex.", "journal": "Biochimica et biophysica acta", "date": "2009", "authors": "Valente L, Shigi N, Suzuki T, Zeviani M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5389840" } ], "reference": [ { "type": "PubMed", "id": "19524667", "url": "https://glygen.org/publication/PubMed/19524667" } ] }, { "title": "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis.", "journal": "Molecular cell", "date": "2009", "authors": "Tsuboi M, Morita H, Nozaki Y, Akama K, Ueda T, Ito K, Nierhaus KH, Takeuchi N", "evidence": [ { "database": "Reactome", "id": "R-HSA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5389840" } ], "reference": [ { "type": "PubMed", "id": "19716793", "url": "https://glygen.org/publication/PubMed/19716793" } ] }, { "title": "Hungry codons promote frameshifting in human mitochondrial ribosomes.", "journal": "Science (New York, N.Y.)", "date": "2010", "authors": "Temperley R, Richter R, Dennerlein S, Lightowlers RN, Chrzanowska-Lightowlers ZM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5419276" } ], "reference": [ { "type": "PubMed", "id": "20075246", "url": "https://glygen.org/publication/PubMed/20075246" } ] }, { "title": "A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome.", "journal": "The EMBO journal", "date": "2010", "authors": "Richter R, Rorbach J, Pajak A, Smith PM, Wessels HJ, Huynen MA, Smeitink JA, Lightowlers RN, Chrzanowska-Lightowlers ZM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5419276" } ], "reference": [ { "type": "PubMed", "id": "20186120", "url": "https://glygen.org/publication/PubMed/20186120" } ] }, { "title": "Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria.", "journal": "RNA (New York, N.Y.)", "date": "2010", "authors": "Young DJ, Edgar CD, Murphy J, Fredebohm J, Poole ES, Tate WP", "evidence": [ { "database": "Reactome", "id": "R-HSA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5419276" } ], "reference": [ { "type": "PubMed", "id": "20421313", "url": "https://glygen.org/publication/PubMed/20421313" } ] }, { "title": "Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation.", "journal": "Cell metabolism", "date": "2011", "authors": "Tucker EJ, Hershman SG, Kohrer C, Belcher-Timme CA, Patel J, Goldberger OA, Christodoulou J, Silberstein JM, McKenzie M, Ryan MT, Compton AG, Jaffe JD, Carr SA, Calvo SE, RajBhandary UL, Thorburn DR, Mootha VK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5368286", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5368286" } ], "reference": [ { "type": "PubMed", "id": "21907147", "url": "https://glygen.org/publication/PubMed/21907147" } ] }, { "title": "Mechanism of protein biosynthesis in mammalian mitochondria.", "journal": "Biochimica et biophysica acta", "date": "2012", "authors": "Christian BE, Spremulli LL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5389840" } ], "reference": [ { "type": "PubMed", "id": "22172991", "url": "https://glygen.org/publication/PubMed/22172991" } ] }, { "title": "Purification and characterization of elongation factor G from bovine liver mitochondria.", "journal": "The Journal of biological chemistry", "date": "1990", "authors": "Chung HK, Spremulli LL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5389840" } ], "reference": [ { "type": "PubMed", "id": "2250005", "url": "https://glygen.org/publication/PubMed/2250005" } ] }, { "title": "Structure based hypothesis of a mitochondrial ribosome rescue mechanism.", "journal": "Biology direct", "date": "2012", "authors": "Huynen MA, Duarte I, Chrzanowska-Lightowlers ZM, Nabuurs SB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5419276" } ], "reference": [ { "type": "PubMed", "id": "22569235", "url": "https://glygen.org/publication/PubMed/22569235" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "Q9Y676", "url": "https://www.uniprot.org/uniprot/Q9Y676" }, { "database": "iPTMnet", "id": "Q9Y676", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Y676" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons.", "journal": "Nature communications", "date": "2013", "authors": "Lind C, Sund J, Aqvist J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5419276" } ], "reference": [ { "type": "PubMed", "id": "24352605", "url": "https://glygen.org/publication/PubMed/24352605" } ] }, { "title": "Ribosome rescue and translation termination at non-standard stop codons by ICT1 in mammalian mitochondria.", "journal": "PLoS genetics", "date": "2014", "authors": "Akabane S, Ueda T, Nierhaus KH, Takeuchi N", "evidence": [ { "database": "Reactome", "id": "R-HSA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5419276" } ], "reference": [ { "type": "PubMed", "id": "25233460", "url": "https://glygen.org/publication/PubMed/25233460" } ] }, { "title": "Ribosome. The structure of the human mitochondrial ribosome.", "journal": "Science", "date": "2015", "authors": "Amunts A, Brown A, Toots J, Scheres SHW, Ramakrishnan V", "evidence": [ { "database": "UniProtKB", "id": "Q9Y676", "url": "https://www.uniprot.org/uniprot/Q9Y676" } ], "reference": [ { "type": "PubMed", "id": "25838379", "url": "https://glygen.org/publication/PubMed/25838379" } ] }, { "title": "Structure and function of the mitochondrial ribosome.", "journal": "Annu. Rev. Biochem.", "date": "2016", "authors": "Ban N., Greber B.J.", "evidence": [ { "database": "UniProtKB", "id": "Q9Y676", "url": "https://www.uniprot.org/uniprot/Q9Y676" } ], "reference": [ { "type": "PubMed", "id": "27023846", "url": "https://glygen.org/publication/PubMed/27023846" } ] }, { "title": "Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9Y676", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Y676" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] }, { "title": "The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells.", "journal": "Scientific reports", "date": "2018", "authors": "Mushtaq M, Jensen L, Davidsson S, Grygoruk OV, Andren O, Kashuba V, Kashuba E", "evidence": [ { "database": "RefSeq", "id": "NP_054765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054765" } ], "reference": [ { "type": "PubMed", "id": "29396484", "url": "https://glygen.org/publication/PubMed/29396484" } ] }, { "title": "O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix.", "journal": "Journal of the American Chemical Society", "date": "2018", "authors": "Levine ZG, Fan C, Melicher MS, Orman M, Benjamin T, Walker S", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9Y676", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Y676" } ], "reference": [ { "type": "PubMed", "id": "29485866", "url": "https://glygen.org/publication/PubMed/29485866" } ] }, { "title": "Overexpression of the mitochondrial ribosomal protein 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