{ "uniprot_canonical_ac": "Q9Y3Q0-1", "uniprot_ac": "Q9Y3Q0", "uniprot_id": "NALD2_HUMAN", "mass": { "chemical_mass": 83592.0, "monoisotopic_mass": 83592.0 }, "refseq": { "ac": "NP_001287859", "name": "N-acetylated-alpha-linked acidic dipeptidase 2 isoform 2", "summary": "This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287859" }, "gene_names": [ { "name": "NAALAD2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9Y3Q0", "id": "Q9Y3Q0" }, { "name": "GCP3; GCPIII; GPCIII", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287859", "id": "NP_001287859" }, { "name": "NAALAD2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287859", "id": "NP_001287859" } ], "protein_names": [ { "name": "N-acetylated-alpha-linked acidic dipeptidase 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9Y3Q0" }, { "name": "3.4.17.21", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y3Q0" }, { "name": "GCPIII", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y3Q0" }, { "name": "Glutamate carboxypeptidase III", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y3Q0" }, { "name": "N-acetylated alpha-linked acidic dipeptidase II; NAALADase II; glutamate carboxypeptidase III; NAALADASE2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287859", "id": "NP_001287859" }, { "name": "N-acetylated-alpha-linked acidic dipeptidase 2 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287859", "id": "NP_001287859" }, { "name": "N-acetylated-alpha-linked acidic dipeptidase II", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y3Q0" }, { "name": "NAALADase II", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y3Q0" } ], "function": [ { "annotation": "GCPII has been recognized as a neuropeptidase in the central nervous system, as a folate hydrolase participating in absorption of folates in the jejunum and, most importantly, as a prostate-specific membrane antigen that is highly expressed in prostate adenocarcinoma; GCPIII has not been associated with any specific physiolological functions [review] Review article Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001287859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287859" }, { "database": "PubMed", "id": "30844704", "url": "https://glygen.org/publication/PubMed/30844704" } ] }, { "annotation": "Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate.", "evidence": [ { "database": "UniProtKB", "id": "Q9Y3Q0", "url": "https://www.uniprot.org/uniprot/Q9Y3Q0#function" }, { "database": "PubMed", "id": "10085079", "url": "https://glygen.org/publication/PubMed/10085079" } ] }, { "annotation": "Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus.", "evidence": [ { "database": "RefSeq", "id": "NP_001287859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287859" }, { "database": "PubMed", "id": "34850884", "url": "https://glygen.org/publication/PubMed/34850884" } ] }, { "annotation": "Promoter Methylation of PRKCB, ADAMTS12, and NAALAD2 Is Specific to Prostate Cancer and Predicts Biochemical Disease Recurrence. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001287859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287859" }, { "database": "PubMed", "id": "34198725", "url": "https://glygen.org/publication/PubMed/34198725" } ] }, { "annotation": "This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].", "evidence": [ { "database": "RefSeq", "id": "NP_001287859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287859" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs140306822", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs140306822" }, { "id": "rs140306822", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs140306822" } ], "glycoeffect": [ "n-glyco-sequon-gain", "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 316, "end_pos": 316, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SYS->NYS); n-glyco-sequon-loss (NVS->NVN).", "chr_id": "11", "chr_pos": "90159295", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S316", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs754739862", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs754739862" }, { "id": "rs754739862", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs754739862" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 111, "end_pos": 111, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NET->SET).", "chr_id": "11", "chr_pos": "90147467", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N111", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs201108621", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201108621" }, { "id": "rs201108621", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs201108621" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 145, "end_pos": 145, "sequence_org": "T", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVT->NVK).", "chr_id": "11", "chr_pos": "90149058", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T145", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs77745866", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs77745866" }, { "id": "rs77745866", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs77745866" }, { "id": "rs77745866", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs77745866" }, { "id": "rs77745866", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs77745866#frequency_tab" }, { "id": "rs77745866", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs77745866" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 187, "end_pos": 187, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NCT->NCI).", "chr_id": "11", "chr_pos": "90150558", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "0.03035", "site_lbl": "T187", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs563183977", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs563183977" }, { "id": "rs563183977", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs563183977" }, { "id": "rs563183977", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs563183977" }, { "id": "rs563183977", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs563183977#frequency_tab" }, { "id": "rs563183977", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs563183977" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 208, "end_pos": 208, "sequence_org": "M", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NAM->NAT).", "chr_id": "11", "chr_pos": "90152311", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "M208", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs950711606", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs950711606" }, { "id": "rs950711606", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs950711606#frequency_tab" }, { "id": "rs950711606", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs950711606" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 252, "end_pos": 252, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLN->NLS).", "chr_id": "11", "chr_pos": "90152443", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N252", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs780072682", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780072682" }, { "id": "rs780072682", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780072682" }, { "id": "rs780072682", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780072682" }, { "id": "rs780072682", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs780072682" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 306, "end_pos": 306, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DKS->NKS).", "chr_id": "11", "chr_pos": "90159264", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D306", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1212342356", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1212342356" }, { "id": "rs1212342356", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1212342356#frequency_tab" }, { "id": "rs1212342356", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1212342356" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 314, "end_pos": 314, "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVS->DVS).", "chr_id": "11", "chr_pos": "90162998", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N314", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs774792618", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs774792618" }, { "id": "rs774792618", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs774792618" }, { "id": "rs774792618", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs774792618#frequency_tab" }, { "id": "rs774792618", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs774792618" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 314, "end_pos": 314, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVS->SVS).", "chr_id": "11", "chr_pos": "90162999", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N314", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1459910891", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1459910891" }, { "id": "rs1459910891", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1459910891" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 316, "end_pos": 316, "sequence_org": "S", "sequence_mut": "G", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVS->NVG).", "chr_id": "11", "chr_pos": "90159294", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S316", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1406474383", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1406474383" }, { "id": "rs1406474383", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1406474383#frequency_tab" }, { "id": "rs1406474383", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1406474383" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 340, "end_pos": 340, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NIN->NIS).", "chr_id": "11", "chr_pos": "90162978", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N340", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1590993189", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1590993189" }, { "id": "rs1590993189", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1590993189" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 341, "end_pos": 341, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KIT->NIT).", "chr_id": "11", "chr_pos": "90162982", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K341", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1270502693", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1270502693" }, { "id": "rs1270502693", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1270502693" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 342, "end_pos": 342, "sequence_org": "I", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NKI->NKS).", "chr_id": "11", "chr_pos": "90162984", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I342", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1391066130", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1391066130" }, { "id": "rs1391066130", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1391066130" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 449, "end_pos": 449, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NYT->SYT).", "chr_id": "11", "chr_pos": "90170072", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N449", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs905775892", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs905775892" }, { "id": "rs905775892", "database": 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"MAESRGRLYLWMCLAAALASFLMGFMVGWFIKPLKETTTSVRYHQSIRWKLVSEMKAENIKSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYISIVDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVNYARTEDFFKLEREMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPEVQPYPKGWNLPGTAAQRGNVLNLNGAGDPLTPGYPAKEYTFRLDVEEGVGIPRIPVHPIGYNDAEILLRYLGGIAPPDKSWKGALNVSYSIGPGFTGSDSFRKVRMHVYNINKITRIYNVVGTIRGSVEPDRYVILGGHRDSWVFGAIDPTSGVAVLQEIARSFGKLMSKGWRPRRTIIFASWDAEEFGLLGSTEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTPLLYQLVYKLTKEIPSPDDGFESKSLYESWLEKDPSPENKNLPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYPVYHTIYETFELVEKFYDPTFKKQLSVAQLRGALVYELVDSKIIPFNIQDYAEALKNYAASIYNLSKKHDQQLTDHGVSFDSLFSAVKNFSEAASDFHKRLIQVDLNNPIAVRMMNDQLMLLERAFIDPLGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIFDIENKANSRLAWKEVKKHISIAAFTIQAAAGTLKEVL", "length": 740, "header": "sp|Q9Y3Q0-1|NALD2_HUMAN Isoform 1 of N-acetylated-alpha-linked acidic dipeptidase 2 OS=Homo sapiens OX=9606 GN=NAALAD2 PE=1 SV=1 CANONICAL=Q9Y3Q0-1" }, "isoforms": [ { "isoform_ac": "E9PII2-1", "url": "", "sequence": { "sequence": "MAESRGRLYLWMCLAAALASFLMGFMVGWFIKPLKETTTSVRYHQSIRWKLVSEMKAENIKSFLRSFTKLPHLAGTEQNFLLAKKIQT", "length": 88, "header": "tr|E9PII2-1|NALD2_HUMAN Computationally mapped isoform of N-acetylated-alpha-linked acidic dipeptidase 2 OS=Homo sapiens OX=9606 GN=NAALAD2 PE=1 SV=1 CANONICAL=Q9Y3Q0-1" }, "locus": { "chromosome": "11", "start_pos": 90147399, "end_pos": 90134759, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000525497.5", "url": "https://www.ensembl.org/id/ENST00000525497.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000431989.1", "url": "https://www.ensembl.org/id/ENSP00000431989.1" } ] } }, { "isoform_ac": "E9PJ53-1", "url": "", "sequence": { "sequence": "MKAENIKSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYISIVDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPE", "length": 107, "header": "tr|E9PJ53-1|NALD2_HUMAN Computationally mapped isoform of N-acetylated-alpha-linked acidic dipeptidase 2 OS=Homo sapiens OX=9606 GN=NAALAD2 PE=1 SV=1 CANONICAL=Q9Y3Q0-1" }, "locus": { "chromosome": "11", "start_pos": 90149107, "end_pos": 90135639, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000526637.1", "url": "https://www.ensembl.org/id/ENST00000526637.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000435670.1", "url": "https://www.ensembl.org/id/ENSP00000435670.1" } ] } }, { "isoform_ac": "E9PJV2-1", "url": "", "sequence": { "sequence": "MAESRGRLYLWMCLAAALASFLMGFMVGWFIKPLKETTTSVRYHQSIRWKLVSEMKAENIKSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYISIVDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVNYARTEDFFKLEREMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPEVQPYPKGWNLPGTAAQRGNVLNLNGAGDPLTPGYPAKATWEELLHQIRVGREPLM", "length": 283, "header": "tr|E9PJV2-1|E9PJV2_HUMAN Computationally mapped isoform of N-acetylated-alpha-linked acidic dipeptidase 2 OS=Homo sapiens OX=9606 GN=NAALAD2 PE=1 SV=1 CANONICAL=Q9Y3Q0-1" }, "locus": { "chromosome": "11", "start_pos": 90159291, "end_pos": 90134759, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000527493.5", "url": "https://www.ensembl.org/id/ENST00000527493.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000433710.1", "url": "https://www.ensembl.org/id/ENSP00000433710.1" } ] } }, { "isoform_ac": "E9PKX5-1", "url": "", "sequence": { "sequence": "MAESRGRLYLWMCLAAALASFLMGFMVGWFIKPLKETTTSVRYHQSIRWKLVSEMKAENIKSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYISIVDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVNYARTEDFFKLEREMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPEVQPYPKGWNLPGTAAQRGNVLNLNGAGDPLTPGYPAKDRYVILGGHRDSWVFGAIDPTSGVAVLQEIARSFGKLMSKGWRPRRTIIFASWDAEEFGLLGSTEWAEVNKTKKVLIIFLVNREQICMCLRMIKNIFHYLIWFCFGE", "length": 372, "header": "tr|E9PKX5-1|NALD2_HUMAN Computationally mapped isoform of N-acetylated-alpha-linked acidic dipeptidase 2 OS=Homo sapiens OX=9606 GN=NAALAD2 PE=1 SV=1 CANONICAL=Q9Y3Q0-1" }, "locus": { "chromosome": "CHR_HSCHR11_2_CTG8", "start_pos": 90163734, "end_pos": 90134759, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000642929.1", "url": "https://www.ensembl.org/id/ENST00000642929.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000494592.1", "url": "https://www.ensembl.org/id/ENSP00000494592.1" } ] } }, { "isoform_ac": "J3KNJ3-1", "url": "", "sequence": { "sequence": "MAESRGRLYLWMCLAAALASFLMGFMVGWFIKPLKETTTSVRYHQSIRWKLVSEMKAENIKSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYISIVDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVNYARTEDFFKLEREMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPEVQPYPKGWNLPGTAAQRGNVLNLNGAGDPLTPGYPAKEYTFRLDVEEGVGIPRIPVHPIGYNDAEILLRKVRMHVYNINKITRIYNVVGTIRGSVEPDRYVILGGHRDSWVFGAIDPTSGVAVLQEIARSFGKLMSKGWRPRRTIIFASWDAEEFGLLGSTEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTPLLYQLVYKLTKEIPSPDDGFESKSLYESWLEKDPSPENKNLPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYPVYHTIYETFELVEKFYDPTFKKQLSVAQLRGALVYELVDSKIIPFNIQDYAEALKNYAASIYNLSKKHDQQLTDHGVSFDSLFSAVKNFSEAASDFHKRLIQVDLNNPIAVRMMNDQLMLLERAFIDPLGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIFDIENKANSRLAWKEVKKHISIAAFTIQAAAGTLKEVL", "length": 707, "header": "tr|J3KNJ3-1|J3KNJ3_HUMAN Computationally mapped isoform of N-acetylated-alpha-linked acidic dipeptidase 2 OS=Homo sapiens OX=9606 GN=NAALAD2 PE=1 SV=1 CANONICAL=Q9Y3Q0-1" }, "locus": { "chromosome": "11", "start_pos": 90191744, "end_pos": 90134759, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000321955.8", "url": "https://www.ensembl.org/id/ENST00000321955.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000320083.4", "url": "https://www.ensembl.org/id/ENSP00000320083.4" } ] } }, { "isoform_ac": "Q9Y3Q0-1", "url": "", "sequence": { "sequence": "MAESRGRLYLWMCLAAALASFLMGFMVGWFIKPLKETTTSVRYHQSIRWKLVSEMKAENIKSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYISIVDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVNYARTEDFFKLEREMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPEVQPYPKGWNLPGTAAQRGNVLNLNGAGDPLTPGYPAKEYTFRLDVEEGVGIPRIPVHPIGYNDAEILLRYLGGIAPPDKSWKGALNVSYSIGPGFTGSDSFRKVRMHVYNINKITRIYNVVGTIRGSVEPDRYVILGGHRDSWVFGAIDPTSGVAVLQEIARSFGKLMSKGWRPRRTIIFASWDAEEFGLLGSTEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTPLLYQLVYKLTKEIPSPDDGFESKSLYESWLEKDPSPENKNLPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYPVYHTIYETFELVEKFYDPTFKKQLSVAQLRGALVYELVDSKIIPFNIQDYAEALKNYAASIYNLSKKHDQQLTDHGVSFDSLFSAVKNFSEAASDFHKRLIQVDLNNPIAVRMMNDQLMLLERAFIDPLGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIFDIENKANSRLAWKEVKKHISIAAFTIQAAAGTLKEVL", "length": 740, "header": "sp|Q9Y3Q0-1|NALD2_HUMAN Isoform 1 of N-acetylated-alpha-linked acidic dipeptidase 2 OS=Homo sapiens OX=9606 GN=NAALAD2 PE=1 SV=1 CANONICAL=Q9Y3Q0-1" }, "locus": { "chromosome": "11", "start_pos": 90191744, "end_pos": 90134759, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000534061.6", "url": "https://www.ensembl.org/id/ENST00000534061.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000432481.1", "url": "https://www.ensembl.org/id/ENSP00000432481.1" } ] } }, { "isoform_ac": "Q9Y3Q0-2", "url": "", "sequence": { "sequence": "MAESRGRLYLWMCLAAALASFLMGFMVGWFIKPLKETTTSVRYHQSIRWKLVSEMKAENIKSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYISIVDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVNYARTEDFFKLEREMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPEVQPYPKGWNLPGTAAQRGNVLNLNGAGDPLTPGYPAKGTSYLLQVATTNMLENHFLESMMLSLILKIKPTLVWPGKK", "length": 305, "header": "sp|Q9Y3Q0-2|NALD2_HUMAN Isoform 2 of N-acetylated-alpha-linked acidic dipeptidase 2 OS=Homo sapiens OX=9606 GN=NAALAD2 PE=1 SV=1 CANONICAL=Q9Y3Q0-1" }, "locus": { "chromosome": "11", "start_pos": 90191676, "end_pos": 90134759, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000375944.7", "url": "https://www.ensembl.org/id/ENST00000375944.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000365111.3", "url": "https://www.ensembl.org/id/ENSP00000365111.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 111, "start_aa": "Asn", "end_pos": 111, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn111", "evidence": [ { "id": "Q9Y3Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y3Q0#ptm_processing" }, { "id": "19678840", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19678840" }, { "id": "3FF3", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FF3" }, { "id": "3FEE", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FEE" }, { "id": "3FED", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FED" }, { "id": "3FEC", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FEC" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 143, "start_aa": "Asn", "end_pos": 143, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn143", "evidence": [ { "id": "Q9Y3Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y3Q0#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 185, "start_aa": "Asn", "end_pos": 185, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn185", "evidence": [ { "id": "Q9Y3Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y3Q0#ptm_processing" }, { "id": "19678840", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19678840" }, { "id": "3FF3", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FF3" }, { "id": "3FEE", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FEE" }, { "id": "3FED", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FED" }, { "id": "3FEC", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FEC" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 314, "start_aa": "Asn", "end_pos": 314, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn314", "evidence": [ { "id": "Q9Y3Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y3Q0#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 449, "start_aa": "Asn", "end_pos": 449, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn449", "evidence": [ { "id": "Q9Y3Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y3Q0#ptm_processing" }, { "id": "19678840", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19678840" }, { "id": "3FF3", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FF3" }, { "id": "3FEE", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FEE" }, { "id": "3FED", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FED" }, { "id": "3FEC", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FEC" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 603, "start_aa": "Asn", "end_pos": 603, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn603", "evidence": [ { "id": "Q9Y3Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y3Q0#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 628, "start_aa": "Asn", "end_pos": 628, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn628", "evidence": [ { "id": "Q9Y3Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y3Q0#ptm_processing" }, { "id": "19678840", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19678840" }, { "id": "3FF3", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FF3" }, { "id": "3FEE", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FEE" }, { "id": "3FED", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FED" }, { "id": "3FEC", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3FEC" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported" ], "publication": [ { "title": "Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity.", "journal": "J. Biol. Chem.", "date": "1999", "authors": "Pangalos MN, Neefs JM, Somers M, Verhasselt P, Bekkers M, van der Helm L, Fraiponts E, Ashton D, Gordon RD", "evidence": [ { "database": "UniProtKB", "id": "Q9Y3Q0", "url": "https://www.uniprot.org/uniprot/Q9Y3Q0" }, { "database": "Reactome", "id": "R-HSA-8963693", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8963693" } ], "reference": [ { "type": "PubMed", "id": "10085079", "url": "https://glygen.org/publication/PubMed/10085079" } ] }, { "title": "Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene.", "journal": "The Prostate", "date": "2004", "authors": "O'Keefe DS, Bacich DJ, Heston WD", "evidence": [ { "database": "Reactome", "id": "R-HSA-8963693", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8963693" } ], "reference": [ { "type": "PubMed", "id": "14716746", "url": "https://glygen.org/publication/PubMed/14716746" } ] }, { "title": "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.", "journal": "DNA Res.", "date": "2005", "authors": "Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T", "evidence": [ { "database": "UniProtKB", "id": "Q9Y3Q0", "url": "https://www.uniprot.org/uniprot/Q9Y3Q0" } ], "reference": [ { "type": "PubMed", "id": "16303743", "url": "https://glygen.org/publication/PubMed/16303743" } ] }, { "title": "Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.", "journal": "The EMBO journal", "date": "2006", "authors": "Mesters JR, Barinka C, Li W, Tsukamoto T, Majer P, Slusher BS, Konvalinka J, Hilgenfeld R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8963693", "url": 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}