{ "uniprot_canonical_ac": "Q9Y237-1", "uniprot_ac": "Q9Y237", "uniprot_id": "PIN4_HUMAN", "mass": { "chemical_mass": 13810.0, "monoisotopic_mass": 13810.0 }, "refseq": { "ac": "NP_001164218", "name": "peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 2", "summary": "This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164218" }, "gene_names": [ { "name": "PIN4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9Y237", "id": "Q9Y237" }, { "name": "EPVH; hEPVH; hPar14; hPar17; PAR14; PAR17", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164218", "id": "NP_001164218" }, { "name": "PIN4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164218", "id": "NP_001164218" } ], "protein_names": [ { "name": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9Y237" }, { "name": "5.2.1.8", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y237" }, { "name": "PPIase Pin4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y237" }, { "name": "Par14", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y237" }, { "name": "Par17", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y237" }, { "name": "Parvulin-14", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y237" }, { "name": "Parvulin-17", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y237" }, { "name": "Peptidyl-prolyl cis-trans isomerase Pin4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y237" }, { "name": "Peptidyl-prolyl cis/trans isomerase EPVH", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y237" }, { "name": "Rotamase Pin4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y237" }, { "name": "hEPVH", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y237" }, { "name": "hPar14", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y237" }, { "name": "hPar17", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9Y237" }, { "name": "peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164218", "id": "NP_001164218" }, { "name": "peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; rotamase PIN4; PPIase PIN4; parvulin-14; parvulin-17; eukaryotic parvulin homolog; protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin); peptidyl-prolyl cis-trans isomerase Pin4; peptidyl-prolyl cis/trans isomerase EPVH", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164218", "id": "NP_001164218" } ], "function": [ { "annotation": "Identification of a longer Parvulin isoform (Par17) that has an extension at the 5' end including a 75 bp extended open reading frame. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001164218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164218" }, { "database": "PubMed", "id": "16522211", "url": "https://glygen.org/publication/PubMed/16522211" } ] }, { "annotation": "In the presence of HBx, the Par14 and Par17 proteins bound to cccDNA. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001164218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164218" }, { "database": "PubMed", "id": "30567987", "url": "https://glygen.org/publication/PubMed/30567987" } ] }, { "annotation": "Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237#function" }, { "database": "PubMed", "id": "19369196", "url": "https://glygen.org/publication/PubMed/19369196" } ] }, { "annotation": "Isoform 2 binds to double-stranded DNA.", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237#function" }, { "database": "PubMed", "id": "19369196", "url": "https://glygen.org/publication/PubMed/19369196" } ] }, { "annotation": "Par14 interacts with the androgen receptor, augmenting both its transcriptional activity and prostate cancer proliferation.", "evidence": [ { "database": "RefSeq", "id": "NP_001164218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164218" }, { "database": "PubMed", "id": "36583514", "url": "https://glygen.org/publication/PubMed/36583514" } ] }, { "annotation": "The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding.", "evidence": [ { "database": "RefSeq", "id": "NP_001164218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164218" }, { "database": "PubMed", "id": "12144781", "url": "https://glygen.org/publication/PubMed/12144781" } ] }, { "annotation": "This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009].", "evidence": [ { "database": "RefSeq", "id": "NP_001164218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164218" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 19, "end_pos": 19, "sequence_org": "S", "sequence_mut": "A", "comment": "Abolishes phosphorylation and strongly reduces nuclear localization.", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" }, { "database": "PubMed", "id": "12860119", "url": "https://glygen.org/publication/PubMed/12860119" } ] }, { "start_pos": 19, "end_pos": 19, "sequence_org": "S", "sequence_mut": "E", "comment": "Does not abolish nuclear localization and reduces DNA-binding ability.", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" }, { "database": "PubMed", "id": "12860119", "url": "https://glygen.org/publication/PubMed/12860119" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "92.56", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102309", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102309" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "91.68", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102309", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102309" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "85.36", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102309", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102309" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "92.6", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102309", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102309" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "89.15", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102309", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102309" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "86.23", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102309", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102309" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "88.98", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102309", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102309" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "89.35", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102309", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102309" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "88.24", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102309", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102309" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "88.39", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102309", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102309" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "87.8", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102309", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102309" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "87.43", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102309", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102309" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "87.82", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102309", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102309" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q9Y237", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y237" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "Q9Y237", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y237" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "Q9Y237", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y237" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "Q9Y237", "url": 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This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "Q9Y237", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y237" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "Q9Y237", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y237" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "Q9Y237", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y237" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y237" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "Q9Y237", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9Y237" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": 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}, { "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Y237-1", "url": "https://www.uniprot.org/uniprot/Q9Y237-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Y237-2", "url": "https://www.uniprot.org/uniprot/Q9Y237-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Y237-3", "url": "https://www.uniprot.org/uniprot/Q9Y237-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKFGYHIIMVEGRK", "length": 131, "header": "sp|Q9Y237-1|PIN4_HUMAN Isoform 1 of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1 CANONICAL=Q9Y237-1" }, "isoforms": [ { "isoform_ac": "A0A494C021-1", "url": "", "sequence": { "sequence": "MGAGEERREGTDSPSPESGTDAAGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGIPSLQQHAGHHRDLRSTLISLVSYLQTTP", "length": 117, "header": "tr|A0A494C021-1|PIN4_HUMAN Computationally mapped isoform of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=2 CANONICAL=Q9Y237-1" }, "locus": { "chromosome": "X", "start_pos": 72262793, "end_pos": 72181856, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000652108.2", "url": "https://www.ensembl.org/id/ENST00000652108.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000498324.2", "url": "https://www.ensembl.org/id/ENSP00000498324.2" } ] } }, { "isoform_ac": "D6RFY5-1", "url": "", "sequence": { "sequence": "MPPKGKSGSGKAGKACQLSLVLAYFVWPKIILPLWPREAERLDTLVVKCLAEFPFEVWRYDGNIHSGCVLDLSVNMEVQFK", "length": 81, "header": "tr|D6RFY5-1|D6RFY5_HUMAN Computationally mapped isoform of Peptidylprolyl cis/trans isomerase, NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=2 CANONICAL=Q9Y237-1" }, "locus": { "chromosome": "X", "start_pos": 72186433, "end_pos": 72181786, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000373662.4", "url": "https://www.ensembl.org/id/ENST00000373662.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000421392.2", "url": "https://www.ensembl.org/id/ENSP00000421392.2" } ] } }, { "isoform_ac": "H0Y4T6-1", "url": "", "sequence": { "sequence": "MPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGAFRLR", "length": 84, "header": "tr|H0Y4T6-1|H0Y4T6_HUMAN Computationally mapped isoform of peptidylprolyl isomerase OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=2 CANONICAL=Q9Y237-1" }, "locus": { "chromosome": "X", "start_pos": 72298996, "end_pos": 72181786, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000439980.7", "url": "https://www.ensembl.org/id/ENST00000439980.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000394066.3", "url": "https://www.ensembl.org/id/ENSP00000394066.3" } ] } }, { "isoform_ac": "H0Y610-1", "url": "", "sequence": { "sequence": "MGAGEERREGTDSPSPESGTDAAGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGVCCSYYL", "length": 95, "header": "tr|H0Y610-1|H0Y610_HUMAN Computationally mapped isoform of peptidylprolyl isomerase OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=2 CANONICAL=Q9Y237-1" }, "locus": { "chromosome": "X", "start_pos": 72196925, "end_pos": 72181856, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000446576.2", "url": "https://www.ensembl.org/id/ENST00000446576.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000402330.2", "url": "https://www.ensembl.org/id/ENSP00000402330.2" } ] } }, { "isoform_ac": "H0Y8P6-1", "url": "", "sequence": { "sequence": "MPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGIPSLQQHAGHHRDLRSTLISLVSYLQTTP", "length": 108, "header": "tr|H0Y8P6-1|H0Y8P6_HUMAN Computationally mapped isoform of peptidylprolyl isomerase OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=2 CANONICAL=Q9Y237-1" }, "locus": { "chromosome": "X", "start_pos": 72262793, "end_pos": 72181786, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000496835.7", "url": "https://www.ensembl.org/id/ENST00000496835.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000421676.2", "url": "https://www.ensembl.org/id/ENSP00000421676.2" } ] } }, { "isoform_ac": "J3KMW3-1", "url": "", "sequence": { "sequence": "MPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGVCCSYYL", "length": 86, "header": "tr|J3KMW3-1|J3KMW3_HUMAN Computationally mapped isoform of peptidylprolyl isomerase OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=2 CANONICAL=Q9Y237-1" }, "locus": { "chromosome": "X", "start_pos": 72196925, "end_pos": 72181786, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000218432.10", "url": "https://www.ensembl.org/id/ENST00000218432.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000218432.6", "url": "https://www.ensembl.org/id/ENSP00000218432.6" } ] } }, { "isoform_ac": "Q9Y237-1", "url": "", "sequence": { "sequence": "MPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKFGYHIIMVEGRK", "length": 131, "header": "sp|Q9Y237-1|PIN4_HUMAN Isoform 1 of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1 CANONICAL=Q9Y237-1" }, "locus": { "chromosome": "X", "start_pos": 72197523, "end_pos": 72181786, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000373669.8", "url": "https://www.ensembl.org/id/ENST00000373669.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000362773.3", "url": "https://www.ensembl.org/id/ENSP00000362773.3" } ] } }, { "isoform_ac": "Q9Y237-2", "url": "", "sequence": { "sequence": "MPMAGLLKGLVRQLERFSVQQQASKMPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKFGYHIIMVEGRK", "length": 156, "header": "sp|Q9Y237-2|PIN4_HUMAN Isoform 2 of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1 CANONICAL=Q9Y237-1" }, "locus": { "chromosome": "X", "start_pos": 72197523, "end_pos": 72181711, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000664196.1", "url": "https://www.ensembl.org/id/ENST00000664196.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000499466.1", "url": "https://www.ensembl.org/id/ENSP00000499466.1" } ] } }, { "isoform_ac": "Q9Y237-3", "url": "", "sequence": { "sequence": "MPMAGLLKGLVRQLERFSVQQQASKMPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGIPSLQQHAGHHRDLRSTLISLVSYLQTTP", "length": 133, "header": "sp|Q9Y237-3|PIN4_HUMAN Isoform 3 of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1 CANONICAL=Q9Y237-1" }, "locus": { "chromosome": "X", "start_pos": 72262793, "end_pos": 72181711, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000423432.6", "url": "https://www.ensembl.org/id/ENST00000423432.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000409154.2", "url": "https://www.ensembl.org/id/ENSP00000409154.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q9Y237", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Y237" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "34229054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34229054" } ] } ], "phosphorylation": [ { "start_pos": 19, "end_pos": 19, "kinase_uniprot_canonical_ac": "P68400-1", "kinase_gene_name": "CSNK2A1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9Y237", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Y237" }, { "database": "PubMed", "id": "12860119", "url": "https://glygen.org/publication/PubMed/12860119" } ], "site_lbl": "Ser19" }, { "start_pos": 19, "end_pos": 19, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CK2", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" }, { "database": "phospho.ELM", "id": "Q9Y237", "url": "http://phospho.elm.eu.org/byAccession/Q9Y237.html" }, { "database": "iPTMnet", "id": "Q9Y237", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Y237" }, { "database": "PubMed", "id": "12860119", "url": "https://glygen.org/publication/PubMed/12860119" } ], "site_lbl": "Ser19" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Identification and characterization of a 14 kDa human protein as a novel parvulin-like peptidyl prolyl cis/trans isomerase.", "journal": "FEBS Lett.", "date": "1999", "authors": "Uchida T, Fujimori F, Tradler T, Fischer G, Rahfeld JU", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "reference": [ { "type": "PubMed", "id": "10100858", "url": "https://glygen.org/publication/PubMed/10100858" } ] }, { "title": "Identification of eukaryotic parvulin homologues: a new subfamily of peptidylprolyl cis-trans isomerases.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1999", "authors": "Rulten S, Thorpe J, Kay J", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "reference": [ { "type": "PubMed", "id": "10364457", "url": "https://glygen.org/publication/PubMed/10364457" } ] }, { "title": "NMR solution structure of hPar14 reveals similarity to the peptidyl prolyl cis/trans isomerase domain of the mitotic regulator hPin1 but indicates a different functionality of the protein.", "journal": "J. Mol. Biol.", "date": "2000", "authors": "Bayer P., Fischer G., Mueller J., Fanghaenel J., Rahfeld J.-U., Rascher C., Sekerina E.", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "reference": [ { "type": "PubMed", "id": "10966801", "url": "https://glygen.org/publication/PubMed/10966801" } ] }, { "title": "Solution structure of the human parvulin-like peptidyl prolyl cis/trans isomerase, hPar14.", "journal": "J. Mol. Biol.", "date": "2001", "authors": "Terada T, Shirouzu M, Fukumori Y, Fujimori F, Ito Y, Kigawa T, Yokoyama S, Uchida T", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "reference": [ { "type": "PubMed", "id": "11162102", "url": "https://glygen.org/publication/PubMed/11162102" } ] }, { "title": "The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding.", "journal": "J. Mol. Biol.", "date": "2002", "authors": "Surmacz TA, Bayer E, Rahfeld JU, Fischer G, Bayer P", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" }, { "database": "RefSeq", "id": "NP_001164218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164218" } ], "reference": [ { "type": "PubMed", "id": "12144781", "url": "https://glygen.org/publication/PubMed/12144781" } ] }, { "title": "Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14.", "journal": "J. Mol. Biol.", "date": "2003", "authors": "Reimer T, Weiwad M, Schierhorn A, Ruecknagel PK, Rahfeld JU, Bayer P, Fischer G", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" }, { "database": "iPTMnet", "id": "Q9Y237", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Y237" } ], "reference": [ { "type": "PubMed", "id": "12860119", "url": "https://glygen.org/publication/PubMed/12860119" } ] }, { "title": "Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation.", "journal": "BMC Mol. Biol.", "date": "2006", "authors": "Mueller JW, Kessler D, Neumann D, Stratmann T, Papatheodorou P, Hartmann-Fatu C, Bayer P", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" }, { "database": "RefSeq", "id": "NP_001164218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164218" } ], "reference": [ { "type": "PubMed", "id": "16522211", "url": "https://glygen.org/publication/PubMed/16522211" } ] }, { "title": "The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae.", "journal": "BMC Biol.", "date": "2007", "authors": "Kessler D, Papatheodorou P, Stratmann T, Dian EA, Hartmann-Fatu C, Rassow J, Bayer P, Mueller JW", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "reference": [ { "type": "PubMed", "id": "17875217", "url": "https://glygen.org/publication/PubMed/17875217" } ] }, { "title": "Parvulin (Par14), a peptidyl-prolyl cis-trans isomerase, is a novel rRNA processing factor that evolved in the metazoan lineage.", "journal": "Mol. Cell. Proteomics", "date": "2009", "authors": "Fujiyama-Nakamura S, Yoshikawa H, Homma K, Hayano T, Tsujimura-Takahashi T, Izumikawa K, Ishikawa H, Miyazawa N, Yanagida M, Miura Y, Shinkawa T, Yamauchi Y, Isobe T, Takahashi N", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "reference": [ { "type": "PubMed", "id": "19369196", "url": "https://glygen.org/publication/PubMed/19369196" } ] }, { "title": "Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9Y237", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Y237" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] }, { "title": "Parvulin 14 and Parvulin 17 Bind to HBx and cccDNA and Upregulate Hepatitis B Virus Replication from cccDNA to Virion in an HBx-Dependent Manner.", "journal": "Journal of virology", "date": "2019", "authors": "Saeed U, Kim J, Piracha ZZ, Kwon H, Jung J, Chwae YJ, Park S, Shin HJ, Kim K", "evidence": [ { "database": "RefSeq", "id": "NP_001164218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164218" } ], "reference": [ { "type": "PubMed", "id": "30567987", "url": "https://glygen.org/publication/PubMed/30567987" } ] }, { "title": "Synthesis of Na2S2O4 mediated cleavable affinity tag for labeling of O-GlcNAc modified proteins via azide-alkyne cycloaddition.", "journal": "Bioorganic & medicinal chemistry letters", "date": "2021", "authors": "Wang J, Dou B, Zheng L, Cao W, Zeng X, Wen Y, Ma J, Li X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9Y237", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9Y237" } ], "reference": [ { "type": "PubMed", "id": "34229054", "url": "https://glygen.org/publication/PubMed/34229054" } ] }, { "title": "Par14 interacts with the androgen receptor, augmenting both its transcriptional activity and prostate cancer proliferation.", "journal": "Cancer medicine", "date": "2023-04", "authors": "Naito Miki, Ikeda Kenichiro, Aoyama Shunya, Kanamoto Mayu, Akasaka Yasuyuki, Kido Yuri, Nakanishi Mikako, Kanna Machi, Yamamotoya Takeshi, Matsubara Akio, Hinata Nobuyuki, Asano Tomoichiro, Nakatsu Yusuke", "evidence": [ { "database": "RefSeq", "id": "NP_001164218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164218" } ], "reference": [ { "type": "PubMed", "id": "36583514", "url": "https://glygen.org/publication/PubMed/36583514" } ] } ], "pathway": [ { "id": "hsa:5303", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5303", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "M0RCP9-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase", "gene_name": "Pin4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPPKGKSGSGKGGKGRPAETVRELRGGAASGSDSADKKSQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFSEVATQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKFGYHIIMVEGRK", "length": 142 }, "evidence": [ { "id": "45233718", "url": "http://www.informatics.jax.org/homology/45233718", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CWW6-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4", "gene_name": "Pin4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPPKGKSGSGKGGKGGAASGSDSADKKSQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFSEVATQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKFGYHIIMVEGRK", "length": 131 }, "evidence": [ { "id": "45233718", "url": "http://www.informatics.jax.org/homology/45233718", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" }, { "name": "peptidyl-prolyl cis-trans isomerase activity", "id": "GO:0003755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003755", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" }, { "name": "bent DNA binding", "id": "GO:0003681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003681", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" }, { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" }, { "name": "localization", "id": "GO:0051179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051179", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "preribosome", "id": "GO:0030684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030684", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [ { "annotation": "Isoform 2 is sumoylated with SUMO2 and SUMO3.", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" }, { "database": "PubMed", "id": "16522211", "url": "https://glygen.org/publication/PubMed/16522211" } ] }, { "annotation": "Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus.", "evidence": [ { "database": "UniProtKB", "id": "Q9Y237", "url": "https://www.uniprot.org/uniprot/Q9Y237" }, { "database": "PubMed", "id": "19369196", "url": "https://glygen.org/publication/PubMed/19369196" }, { "database": "PubMed", "id": "12860119", "url": "https://glygen.org/publication/PubMed/12860119" } ] } ], "interactions": [], "reactions": [ { "id": "16237", "name": "", "equation": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "M0RCP9-1", "P24368-1", "Q9QVC8-1", "P97534-1", "Q3B7U9-1", "Q66H94-1", "Q62658-1", "Q812D3-1", "O55035-1", "Q6DGG0-1", "P10111-1", "P29117-1", "G3V7V5-1", "Q5U2V1-1", "A0A0G2K869-1", "A0A8I6GGK9-1", "A0A8I6AE14-1", "A0A8I6GH88-1", "A0A8I5ZMT9-1", "Q4KLI4-1", "M0RCZ9-1", "G3V6L9-1", "A0A8I6A7U0-1", "D4AEG3-1", "Q6AYQ9-1", "A0A8I6A7W4-1", "A0A8I5ZR77-1", "A0A8I5ZPZ9-1", "A0A8I6A3L4-1", "A0A8I6AK73-1", "A0A8I6AP42-1", "A0A8I6GE67-1", "A0A8I6GJ67-1", "A0A8I6AFJ6-1", "A0A8I6GB94-1", "D3ZQF4-1", "A0A8I6A629-1", "A0A8I5ZVA3-1", "A0A8I5Y1J2-1", "A0A8I6AIC0-1", "A0A8I6ADW5-1", "F7EYK0-1", "A0A8I5ZNP3-1", "Q14318-1", "P68106-1", "Q5VVH2-1", "O75344-1", "O00170-1", "Q02790-1", "Q96AY3-1", "P0DN26-1", "O95302-1", "Q15257-1", "Q13526-1", "P62942-1", "Q9NWM8-1", "Q9NYL4-1", "P26885-1", "Q00688-1", "Q9Y680-2", "Q13451-1", "P0DN37-1", "A0A075B759-1", "Q9Y536-1", "F5H284-1", "P30414-1", "O43447-1", "Q9H2H8-1", "Q8WUA2-1", "Q9Y237-1", "A0A0B4J2A2-1", "Q08752-1", "P30405-1", "Q9Y3C6-1", "P23284-1", "P62937-1", "Q9UNP9-1", "P45877-1", "Q13427-1", "Q96BP3-1", "Q8IXY8-1", "A0A075B767-1", "Q5T1M5-1", "Q6UX04-1", "Q6P9Q6-1", "Q64378-1", "Q3ULQ2-1", "Q62446-1", "P30416-1", "Q9Z2I2-1", "O35465-1", "O54998-1", "Q9Z247-1", "P45878-1", "Q9D1M7-1", "Q61576-1", "P26883-1", "P59024-1", "Q9CXG3-1", "Q9CWW6-1", "P30415-1", "Q9QUR7-1", "Q9CR16-1", "P58389-1", "Q9D6L8-1", "P17742-1", "P24369-1", "Q8CEC6-1", "A2AR02-1", "P30412-1", "Q9D868-1", "Q9QZH3-1", "Q99KR7-1", "Q9D0W5-1", "Q9D6D8-1", "Q3TKY6-1", "P14832-1", "P20081-1", "P25719-1", "P40454-1", "Q12461-1", "P22696-1", "P47103-1", "P53691-1", "Q06205-1", "P32472-1", "P25334-1", "P23285-1", "P35176-1", "P38911-1", "P53728-1", "Q02770-1", "Q54E95-1", "Q54LG6-1", "Q54RW5-1", "Q54Z53-1", "Q554J3-1", "Q54CU3-1", "Q54G21-1", "Q54N80-1", "Q54NB6-1", "Q54SR7-1", "Q54WH6-1", "Q54Y27-1", "Q55CJ3-1", "Q55EZ0-1", "B0G119-1", "Q86J17-1", "Q54QI6-1", "Q54UR2-1", "Q9UA41-1", "Q54SM3-1", "Q9NI62-1", "Q9TW32-1", "P25007-1", "Q9V3G3-1", "P15425-1", "P54353-1", "P54397-1", "P48375-1", "Q9VL78-1", "A0A0B4K7C5-1", "Q4V5H1-1", "Q7K2I4-1", "Q8MKJ6-1", "Q9VNG7-1", "Q9VXN8-1", "Q9VGK3-1", "Q9VBU4-1", "Q9VQQ0-1", "Q9XYZ6-1", "Q7K3D4-1", "Q9W227-1", "Q9W0Q2-1" ], "evidence": [ { "id": "16237", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16237" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A075B759", "gene_name": "PPIAL4E", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A075B759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A075B759" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A075B759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A075B759" } ] } ] }, { "uniprot_ac": "A0A075B767", "gene_name": "PPIAL4H", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A075B767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A075B767" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A075B767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A075B767" } ] } ] }, { "uniprot_ac": "A0A0B4J2A2", 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"ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A0G2K869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K869" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A0G2K869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K869" } ] } ] }, { "uniprot_ac": "A0A8I5Y1J2", "gene_name": "ENSRNOG00000067128", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I5Y1J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y1J2" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I5Y1J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y1J2" } ] } ] }, { "uniprot_ac": "A0A8I5ZMT9", "gene_name": "Ppih", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I5ZMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I5ZMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT9" } ] } ] }, { "uniprot_ac": "A0A8I5ZNP3", "gene_name": "Fkbp14", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I5ZNP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZNP3" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I5ZNP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZNP3" } ] } ] }, { "uniprot_ac": "A0A8I5ZPZ9", "gene_name": "Ptpa", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I5ZPZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZPZ9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I5ZPZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZPZ9" } ] } ] }, { "uniprot_ac": "A0A8I5ZR77", "gene_name": "ENSRNOG00000071104", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I5ZR77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZR77" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I5ZR77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZR77" } ] } ] }, { "uniprot_ac": "A0A8I5ZVA3", "gene_name": "ENSRNOG00000068459", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I5ZVA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVA3" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I5ZVA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVA3" } ] } ] }, { "uniprot_ac": "A0A8I6A3L4", "gene_name": "ENSRNOG00000067890", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6A3L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A3L4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6A3L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A3L4" } ] } ] }, { "uniprot_ac": "A0A8I6A629", "gene_name": "LOC100911252", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": 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"evidence": [ { "id": "G3V7V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V7V5" } ] } ] }, { "uniprot_ac": "M0RCP9", "gene_name": "Pin4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "M0RCP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCP9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "M0RCP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCP9" } ] } ] }, { "uniprot_ac": "M0RCZ9", "gene_name": "Ppial4g", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "M0RCZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCZ9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "M0RCZ9", "database": "UniProtKB", "url": 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[protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O55035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55035" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O55035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55035" } ] } ] }, { "uniprot_ac": "O75344", "gene_name": "FKBP6", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O75344", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75344" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O75344", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75344" } ] } ] }, { "uniprot_ac": "O95302", "gene_name": "FKBP9", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O95302", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95302" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O95302", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95302" } ] } ] }, { "uniprot_ac": "P0DN26", "gene_name": "PPIAL4F", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P0DN26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN26" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P0DN26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN26" } ] } ] }, { "uniprot_ac": "P0DN37", "gene_name": "PPIAL4G", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P0DN37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN37" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P0DN37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN37" } ] } ] }, { "uniprot_ac": "P10111", "gene_name": "Ppia", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P10111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10111" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P10111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10111" } ] } ] }, { "uniprot_ac": "P14832", "gene_name": "CPR1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P14832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14832" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P14832", "database": "UniProtKB", "url": 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"url": "https://www.uniprot.org/uniprot/P24368" } ] } ] }, { "uniprot_ac": "P24369", "gene_name": "Ppib", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P24369", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24369" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P24369", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24369" } ] } ] }, { "uniprot_ac": "P25007", "gene_name": "Cyp1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P25007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25007" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P25007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25007" } ] } ] }, { "uniprot_ac": "P25334", "gene_name": 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[protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26883" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26883" } ] } ] }, { "uniprot_ac": "P26885", "gene_name": "FKBP2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26885" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26885" } ] } ] }, { "uniprot_ac": "P29117", "gene_name": "Ppif", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P29117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29117" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P29117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29117" } ] } ] }, { "uniprot_ac": "P30405", "gene_name": "PPIF", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30405" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30405" } ] } ] }, { "uniprot_ac": "P30412", "gene_name": "Ppic", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30412" } ] }, { "ec_number": "5.2.1.8", "activity": "", 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[protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P40454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40454" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P40454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40454" } ] } ] }, { "uniprot_ac": "P45877", "gene_name": "PPIC", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P45877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45877" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P45877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45877" } ] } ] }, { "uniprot_ac": "P45878", "gene_name": "Fkbp2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P45878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45878" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P45878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45878" } ] } ] }, { "uniprot_ac": "P47103", "gene_name": "CPR7", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P47103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47103" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P47103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47103" } ] } ] }, { "uniprot_ac": "P48375", "gene_name": "Fkbp12", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P48375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48375" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P48375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48375" } ] } ] }, { "uniprot_ac": "P53691", "gene_name": "CPR6", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P53691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53691" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P53691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53691" } ] } ] }, { "uniprot_ac": "P53728", "gene_name": "CPR8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P53728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53728" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P53728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53728" } ] } ] }, { "uniprot_ac": "P54353", "gene_name": "dod", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P54353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54353" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P54353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54353" } ] } ] }, { "uniprot_ac": "P54397", "gene_name": "Fkbp39", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P54397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54397" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P54397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54397" } ] } ] }, { "uniprot_ac": "P58389", "gene_name": "Ptpa", 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[protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62937" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62937" } ] } ] }, { "uniprot_ac": "P62942", "gene_name": "FKBP1A", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62942", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62942" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62942", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62942" } ] } ] }, { "uniprot_ac": "P68106", "gene_name": "FKBP1B", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P68106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68106" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P68106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68106" } ] } ] }, { "uniprot_ac": "P97534", "gene_name": "Fkbp1b", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P97534", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97534" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P97534", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97534" } ] } ] }, { "uniprot_ac": "Q00688", "gene_name": "FKBP3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q00688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00688" } ] }, { "ec_number": "5.2.1.8", "activity": "", 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