{
    "uniprot_canonical_ac": "Q9WVG9-1",
    "uniprot_ac": "Q9WVG9",
    "uniprot_id": "MS3L1_MOUSE",
    "mass": {
        "chemical_mass": 60292.0,
        "monoisotopic_mass": 60292.0
    },
    "refseq": {
        "ac": "NP_034962",
        "name": "male-specific lethal 3 homolog isoform 5",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034962"
    },
    "gene_names": [
        {
            "name": "Msl3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q9WVG9",
            "id": "Q9WVG9"
        },
        {
            "name": "Msl31; Msl3l1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034962",
            "id": "NP_034962"
        },
        {
            "name": "Msl31",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9WVG9",
            "id": "Q9WVG9"
        },
        {
            "name": "Msl3l1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9WVG9",
            "id": "Q9WVG9"
        },
        {
            "name": "Msl3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034962",
            "id": "NP_034962"
        }
    ],
    "protein_names": [
        {
            "name": "Male-specific lethal 3 homolog",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q9WVG9"
        },
        {
            "name": "MSL3-like 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9WVG9"
        },
        {
            "name": "Male-specific lethal-3 homolog 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9WVG9"
        },
        {
            "name": "Male-specific lethal-3 protein-like 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9WVG9"
        },
        {
            "name": "male-specific lethal 3 homolog isoform 5",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034962",
            "id": "NP_034962"
        },
        {
            "name": "male-specific lethal-3 protein-like 1; male-specific lethal-3 homolog 1; male-specific lethal 3 homolog",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034962",
            "id": "NP_034962"
        }
    ],
    "function": [
        {
            "annotation": "Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_034962",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034962"
                },
                {
                    "database": "PubMed",
                    "id": "11668396",
                    "url": "https://glygen.org/publication/PubMed/11668396"
                }
            ]
        },
        {
            "annotation": "Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1) and male-specific lethal 3 (Msl3). Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_034962",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034962"
                },
                {
                    "database": "PubMed",
                    "id": "28609438",
                    "url": "https://glygen.org/publication/PubMed/28609438"
                }
            ]
        },
        {
            "annotation": "Has a role in chromatin remodeling and transcriptional regulation. Has a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9WVG9",
                    "url": "https://www.uniprot.org/uniprot/Q9WVG9#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q8N5Y2",
                    "url": "https://www.uniprot.org/uniprot/Q8N5Y2#function"
                }
            ]
        },
        {
            "annotation": "Msl1 interacts with Msl3 as an extended chain forming an extensive hydrophobic interface, whereas the Msl1-MOF interface involves electrostatic interactions between the HAT domain and a long helix of Msl1.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_034962",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034962"
                },
                {
                    "database": "PubMed",
                    "id": "21217699",
                    "url": "https://glygen.org/publication/PubMed/21217699"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0111838",
            "recommended_name": {
                "id": "DOID:0111838",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111838",
                "name": "Basilicata-Akhtar syndrome",
                "description": "A syndromic X-linked intellectual disability characterized by global developmental delay apparent from infancy, feeding difficulties, hypotonia, and poor or absent speech that has_material_basis_in hemizygous or heterozygous mutation in the MSL3 gene on chromosome Xp22.2."
            },
            "synonyms": [
                {
                    "id": "DOID:0111838",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111838",
                    "name": "MRXS36",
                    "description": ""
                },
                {
                    "id": "DOID:0111838",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111838",
                    "name": "X-linked syndromic mental retardation 36",
                    "description": ""
                },
                {
                    "id": "DOID:0111838",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111838",
                    "name": "X-linked syndromic mental retardation Basilicata-Akhtar type",
                    "description": ""
                },
                {
                    "id": "MONDO:0026730",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0026730",
                    "name": "Basilicata-Akhtar syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0026730",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0026730",
                    "name": "Basilicata-Akhtar syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0026730",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0026730",
                    "name": "Basilicata-Akhtar syndrome, X-linked dominant",
                    "description": ""
                },
                {
                    "id": "MONDO:0026730",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0026730",
                    "name": "MRXSBA",
                    "description": ""
                },
                {
                    "id": "MONDO:0026730",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0026730",
                    "name": "Mental Retardation, X-Linked, Syndromic 36",
                    "description": ""
                },
                {
                    "id": "MONDO:0026730",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0026730",
                    "name": "Mental Retardation, X-Linked, Syndromic, Basilicata-Akhtar Type",
                    "description": ""
                },
                {
                    "id": "MIM:301032",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/301032",
                    "name": "Basilicata-Akhtar syndrome",
                    "description": "Basilicata-Akhtar syndrome"
                }
            ],
            "evidence": [
                {
                    "id": "0111838",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111838"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9WVG9",
                    "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Msl3",
            "url": "https://www.uniprot.org/uniprot/Q9WVG9",
            "locus": {
                "chromosome": "X",
                "start_pos": 167437113,
                "end_pos": 167456894,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000031358",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000031358"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000031358",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031358",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd18983",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18983",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "17692",
            "url": "https://www.ncbi.nlm.nih.gov/gene/17692",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q9WVG9",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9WVG9*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000953",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000953",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR008676",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008676",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR016197",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016197",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR025995",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR025995",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR026541",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026541",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR038217",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038217",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:17692",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:17692",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1341851",
            "url": "http://www.informatics.jax.org/marker/MGI:1341851",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "DTEYAHL",
            "url": "https://omabrowser.org/oma/group/DTEYAHL/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2878816at2759",
            "url": "http://www.orthodb.org/?query=2878816at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10880",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10880",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10880:SF47",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10880:SF47",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF05712",
            "url": "http://pfam.xfam.org/family/PF05712",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF11717",
            "url": "http://pfam.xfam.org/family/PF11717",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q9WVG9",
            "url": "http://purl.obolibrary.org/obo/PR_Q9WVG9",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-3214847",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3214847",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_034962",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034962",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9WVG9",
            "url": "https://www.uniprot.org/uniprot/Q9WVG9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9WVG9-1",
            "url": "https://www.uniprot.org/uniprot/Q9WVG9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9WVG9-2",
            "url": "https://www.uniprot.org/uniprot/Q9WVG9-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSASEGMKFQFHSGEKVLCFEPDPTKARVLYDAKIIDVIIGKDEKGRKIPEYLIHFNGWNRSWDRWAAEEHVLHDTDENRRLQRKLAKKAIARLRGTGKKKRRCRLPGVDSVLKSVPVKEKSKNDENSVSSTCHESCGEKNGGIKEHRQRRIKVKAKAKKKVLSLRSRKEMDERTITIDIPDVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHAMMHTHMNVHYVPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQTQYKRVTSSKFFLPIKESTTTTNRSQEELSPSPPLLNPSTPQSTESQPPTGEPATPKRRKAEPEALQSLRRSTRHSTNCDRLSESSSSPQPKRRQQDTSASMPKLFLHLEKKTPVHSRSSSPIPLTPSKDGSAVFAGFEGRRPNEINEVLSWKLVPDNYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY",
        "length": 525,
        "header": "sp|Q9WVG9-1|MS3L1_MOUSE Isoform 1 of Male-specific lethal 3 homolog  OS=Mus musculus OX=10090 GN=Msl3 PE=1 SV=3 CANONICAL=Q9WVG9-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q9WVG9-1",
            "url": "",
            "sequence": {
                "sequence": "MSASEGMKFQFHSGEKVLCFEPDPTKARVLYDAKIIDVIIGKDEKGRKIPEYLIHFNGWNRSWDRWAAEEHVLHDTDENRRLQRKLAKKAIARLRGTGKKKRRCRLPGVDSVLKSVPVKEKSKNDENSVSSTCHESCGEKNGGIKEHRQRRIKVKAKAKKKVLSLRSRKEMDERTITIDIPDVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHAMMHTHMNVHYVPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQTQYKRVTSSKFFLPIKESTTTTNRSQEELSPSPPLLNPSTPQSTESQPPTGEPATPKRRKAEPEALQSLRRSTRHSTNCDRLSESSSSPQPKRRQQDTSASMPKLFLHLEKKTPVHSRSSSPIPLTPSKDGSAVFAGFEGRRPNEINEVLSWKLVPDNYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY",
                "length": 525,
                "header": "sp|Q9WVG9-1|MS3L1_MOUSE Isoform 1 of Male-specific lethal 3 homolog  OS=Mus musculus OX=10090 GN=Msl3 PE=1 SV=3 CANONICAL=Q9WVG9-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 167456825,
                "end_pos": 167437868,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000033725",
                        "url": "https://www.ensembl.org/id/ENSMUST00000033725"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000033725",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000033725"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q9WVG9-2",
            "url": "",
            "sequence": {
                "sequence": "MPSWDRWAAEEHVLHDTDENRRLQRKLAKKAIARLRGTGKKKRRCRLPGVDSVLKSVPVKEKSKNDENSVSSTCHESCGEKNGGIKEHRQRRIKVKAKAKKKVLSLRSRKEMDERTITIDIPDVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHAMMHTHMNVHYVPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQTQYKRVTSSKFFLPIKESTTTTNRSQEELSPSPPLLNPSTPQSTESQPPTGEPATPKRRKAEPEALQSLRRSTRHSTNCDRLSESSSSPQPKRRQQDTSASMPKLFLHLEKKTPVHSRSSSPIPLTPSKDGSAVFAGFEGRRPNEINEVLSWKLVPDNYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY",
                "length": 466,
                "header": "sp|Q9WVG9-2|MS3L1_MOUSE Isoform 2 of Male-specific lethal 3 homolog  OS=Mus musculus OX=10090 GN=Msl3 PE=1 SV=3 CANONICAL=Q9WVG9-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 167456731,
                "end_pos": 167437868,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000112137",
                        "url": "https://www.ensembl.org/id/ENSMUST00000112137"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000107765",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000107765"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 313,
            "end_pos": 313,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9WVG9",
                    "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9WVG9",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVG9"
                }
            ],
            "site_lbl": "Ser313"
        },
        {
            "start_pos": 315,
            "end_pos": 315,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9WVG9",
                    "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9WVG9",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVG9"
                }
            ],
            "site_lbl": "Ser315"
        },
        {
            "start_pos": 371,
            "end_pos": 371,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9WVG9",
                    "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                }
            ],
            "site_lbl": "Ser371"
        },
        {
            "start_pos": 404,
            "end_pos": 404,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9WVG9",
                    "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                }
            ],
            "site_lbl": "Ser404"
        },
        {
            "start_pos": 409,
            "end_pos": 409,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9WVG9",
                    "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9WVG9",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVG9"
                }
            ],
            "site_lbl": "Thr409"
        },
        {
            "start_pos": 411,
            "end_pos": 411,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9WVG9",
                    "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9WVG9",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVG9"
                }
            ],
            "site_lbl": "Ser411"
        },
        {
            "start_pos": 415,
            "end_pos": 415,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9WVG9",
                    "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9WVG9",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVG9"
                }
            ],
            "site_lbl": "Ser415"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Characterization of a novel chromo domain gene in Xp22.3 with homology to Drosophila msl-3.",
            "journal": "Genomics",
            "date": "1999",
            "authors": "Prakash SK, Van den Veyver IB, Franco B, Volta M, Ballabio A, Zoghbi HY",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9WVG9",
                    "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10395802",
                    "url": "https://glygen.org/publication/PubMed/10395802"
                }
            ]
        },
        {
            "title": "Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice.",
            "journal": "Mammalian genome : official journal of the International Mammalian Genome Society",
            "date": "2001",
            "authors": "Cormier TA, Prakash SK, Magner DB, Zoghbi HY, Van den Veyver IB",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_034962",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034962"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11668396",
                    "url": "https://glygen.org/publication/PubMed/11668396"
                }
            ]
        },
        {
            "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.",
            "journal": "Cell",
            "date": "2010",
            "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9WVG9",
                    "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9WVG9",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVG9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "title": "Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1.",
            "journal": "Nat. Struct. Mol. Biol.",
            "date": "2011",
            "authors": "Kadlec J, Hallacli E, Lipp M, Holz H, Sanchez-Weatherby J, Cusack S, Akhtar A",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9WVG9",
                    "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_034962",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034962"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21217699",
                    "url": "https://glygen.org/publication/PubMed/21217699"
                }
            ]
        },
        {
            "title": "PEG3 control on the mammalian MSL complex.",
            "journal": "PloS one",
            "date": "2017",
            "authors": "Ye A, Kim H, Kim J",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_034962",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034962"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28609438",
                    "url": "https://glygen.org/publication/PubMed/28609438"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:17692",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:17692",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-3214847",
            "name": "HATs acetylate histones",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3214847",
            "resource": "Reactome",
            "description": "HATs acetylate histones"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A8I6A9H7-1",
            "protein_name": "MSL complex subunit 3",
            "gene_name": "Msl3",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MSASKGMKFQFHSGEKVLCFEPDPTKARVLYDAKIIDVIIGKDEKGRKIPEYLIHFNGWNSSSWDRWAAEDHVLHDTDENRRLQRKLAKKAIARLRGTGKKKRRCRLPGVDSVLKSVPVKEKTKNDENSISSTCHESCGEKNGGIKEHRQRRIKVKTKGKKKVLSLRSRKDMDERTITIEIPEVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHAMMHAHMNVHYVPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQTQYKRVTSSKFFLPIKESTTTTNRSQEELSPSPPLLNPSTPQSTESQPPTGEPATPKRRKAEPEALQSLRRSTRHSTNCDRLSESSSSPQPKRRQQDTSTSMPKLFLHLEKKTPVHSRSSSPIPLTPSKDGSAVFAGFEGRRTNEINEVLSWKLVPDNYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY",
                "length": 526
            },
            "evidence": [
                {
                    "id": "45242458",
                    "url": "http://www.informatics.jax.org/homology/45242458",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q8N5Y2-1",
            "protein_name": "Male-specific lethal 3 homolog",
            "gene_name": "MSL3",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSASEGMKFKFHSGEKVLCFEPDPTKARVLYDAKIVDVIVGKDEKGRKIPEYLIHFNGWNRSWDRWAAEDHVLRDTDENRRLQRKLARKAVARLRSTGRKKKRCRLPGVDSVLKGLPTEEKDENDENSLSSSSDCSENKDEEISEESDIEEKTEVKEEPELQTRREMEERTITIEIPEVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHVMPHANMNVHYIPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQAQYKKVTSSKFFLPIKESATSTNRSQEELSPSPPLLNPSTPQSTESQPTTGEPATPKRRKAEPEALQSLRRSTRHSANCDRLSESSASPQPKRRQQDTSASMPKLFLHLEKKTPVHSRSSSPIPLTPSKEGSAVFAGFEGRRTNEINEVLSWKLVPDNYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY",
                "length": 521
            },
            "evidence": [
                {
                    "id": "45242458",
                    "url": "http://www.informatics.jax.org/homology/45242458",
                    "database": "MGI"
                },
                {
                    "id": "Q9WVG9",
                    "url": "https://omabrowser.org/oma/group/Q9WVG9/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "regulation of dosage compensation by inactivation of X chromosome",
                        "id": "GO:1900095",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900095",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9WVG9",
                                "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "histone H2A acetylation",
                        "id": "GO:0043968",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043968",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9WVG9",
                                "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of DNA-templated transcription",
                        "id": "GO:0006355",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9WVG9",
                                "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of DNA-templated transcription",
                        "id": "GO:0045893",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9WVG9",
                                "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "histone H4-K16 acetylation",
                        "id": "GO:0043984",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043984",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9WVG9",
                                "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9WVG9",
                                "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "histone H4K16 acetyltransferase activity",
                        "id": "GO:0046972",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046972",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9WVG9",
                                "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "methylated histone binding",
                        "id": "GO:0035064",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035064",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9WVG9",
                                "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9WVG9",
                                "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "NuA4 histone acetyltransferase complex",
                        "id": "GO:0035267",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035267",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9WVG9",
                                "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "MSL complex",
                        "id": "GO:0072487",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072487",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9WVG9",
                                "url": "https://www.uniprot.org/uniprot/Q9WVG9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 306,
            "end_pos": 308,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 60,
            "end_pos": 62,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 7
                },
                {
                    "field": "total_sites",
                    "count": 7
                }
            ],
            "sort_fields": [
                "start_pos",
                "end_pos",
                "kinase_uniprot_canonical_ac",
                "kinase_gene_name",
                "residue",
                "comment",
                "site_lbl"
            ]
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 5
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "date",
                "authors"
            ]
        }
    ]
}