{ "uniprot_canonical_ac": "Q9WVE9-3", "uniprot_ac": "Q9WVE9", "uniprot_id": "ITSN1_RAT", "mass": { "chemical_mass": 194197.0, "monoisotopic_mass": 194197.0 }, "refseq": { "ac": "NP_001129568", "name": "intersectin-1 isoform a", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129568" }, "gene_names": [ { "name": "Itsn1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9WVE9", "id": "Q9WVE9" }, { "name": "EHSH1; Itsn", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129568", "id": "NP_001129568" }, { "name": "Ehsh1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9WVE9", "id": "Q9WVE9" }, { "name": "Itsn1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129568", "id": "NP_001129568" }, { "name": "Itsn", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9WVE9", "id": "Q9WVE9" } ], "protein_names": [ { "name": "Intersectin-1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9WVE9" }, { "name": "EH domain and SH3 domain regulator of endocytosis 1; intersectin 1 (SH3 domain protein 1A); intersectin 1 (SH3 domain protein); intersectin-1-like", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129568", "id": "NP_001129568" }, { "name": "EH domain and SH3 domain regulator of endocytosis 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9WVE9" }, { "name": "intersectin-1 isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129568", "id": "NP_001129568" } ], "function": [ { "annotation": "Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin-coated vesicles (PubMed:20448150). Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (By similarity). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines (By similarity). Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (PubMed:23633571). Inhibits ARHGAP31 activity toward RAC1 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9#function" }, { "database": "PubMed", "id": "23633571", "url": "https://glygen.org/publication/PubMed/23633571" }, { "database": "PubMed", "id": "20448150", "url": "https://glygen.org/publication/PubMed/20448150" }, { "database": "UniProtKB", "id": "Q15811", "url": "https://www.uniprot.org/uniprot/Q15811#function" }, { "database": "UniProtKB", "id": "Q9Z0R4", "url": "https://www.uniprot.org/uniprot/Q9Z0R4#function" } ] }, { "annotation": "Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1 in fresh exudates swabbed from critically colonised and infected full-thickness wounds in rats.", "evidence": [ { "database": "RefSeq", "id": "NP_001129568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129568" }, { "database": "PubMed", "id": "36307995", "url": "https://glygen.org/publication/PubMed/36307995" } ] }, { "annotation": "Plays a role in synaptic vesicle endocytosis in brain neurons.", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9#function" }, { "database": "UniProtKB", "id": "Q9Z0R4", "url": "https://www.uniprot.org/uniprot/Q9Z0R4#function" } ] }, { "annotation": "The intersectin1-L protein was primarily expressed in neurons in brain tissue. Its expression was remarkably increased in patients with refractory epilepsy and in epilepsy model rats.", "evidence": [ { "database": "RefSeq", "id": "NP_001129568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129568" }, { "database": "PubMed", "id": "25783631", "url": "https://glygen.org/publication/PubMed/25783631" } ] }, { "annotation": "These results highlight a role of Numb for dendritic spine development and synaptic functions with intersectin and EphB2.", "evidence": [ { "database": "RefSeq", "id": "NP_001129568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129568" }, { "database": "PubMed", "id": "16394100", "url": "https://glygen.org/publication/PubMed/16394100" } ] } ], "disease": [ { "disease_id": "DOID:1059", "recommended_name": { "id": "DOID:1059", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1059", "name": "intellectual disability", "description": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills." }, "synonyms": [], "evidence": [ { "id": "1059", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1059" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" } ], "common_name": "Rat" } ], "gene": [ { "name": "Itsn1", "url": "https://www.uniprot.org/uniprot/Q9WVE9", "locus": { "chromosome": "11", "start_pos": 31160645, "end_pos": 30978590, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000002001", "url": "https://www.ensembl.org/id/ENSRNOG00000002001" } ] } } ], "crossref": [ { "id": "ENSRNOG00000002001", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000002001", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00052", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00052", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08375", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08375", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11987", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11987", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11989", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11989", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11993", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11993", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11995", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11995", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13264", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13264", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "29491", "url": "https://www.ncbi.nlm.nih.gov/gene/29491", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9WVE9", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9WVE9*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:29491", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:29491", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2910300at2759", "url": "http://www.orthodb.org/?query=2910300at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46006", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46006", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46006:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46006:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "3HS9", "url": "https://www.rcsb.org/structure/3HS9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00018", "url": "http://pfam.xfam.org/family/PF00018", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "http://pfam.xfam.org/family/PF00168", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00621", "url": "http://pfam.xfam.org/family/PF00621", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07653", "url": "http://pfam.xfam.org/family/PF07653", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12763", "url": "http://pfam.xfam.org/family/PF12763", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14604", "url": "http://pfam.xfam.org/family/PF14604", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16617", "url": "http://pfam.xfam.org/family/PF16617", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16652", "url": "http://pfam.xfam.org/family/PF16652", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9WVE9", "url": "http://purl.obolibrary.org/obo/PR_Q9WVE9", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-193648", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193648", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3928662", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-416482", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416482", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8856825", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8856828", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013148", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9013406", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013406", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9013408", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013408", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001129568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129568", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "2935", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=2935", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9WVE9-1", "url": "https://www.uniprot.org/uniprot/Q9WVE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9WVE9-2", "url": "https://www.uniprot.org/uniprot/Q9WVE9-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9WVE9-3", "url": "https://www.uniprot.org/uniprot/Q9WVE9-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQFPTPFGGSLDIWAITVEERAKHDQQFQSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNKDGRMDQVEFSIAMKLIKLKLQGYQLPPALPPVMKQQPAAISSAPAFGIGGMAGMPPLTAVAPVPMGSIPVVGMSPPLVSSVPQAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASAPAAAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGMSVISSSSADQRLPEEPSSEDEQQVEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLTQRNKDQEGIVVLKARRKTLEFELEALNDKKHQLEGKLQDIRCRLATQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILSDQLKQVQQNSLHRDSLLTLKRALEAKELARQQLREQLDEVEKETRSKLQEIDVFNNQLKELREIHSKQQLQKQRSIEAERLKQKEQERKSLELEKQKEEGQRRVQERDKQWQEHVQQEEQQRPRKPHEEDKLKREDSVKKKEAEERAKPEVQDKQSRLFHPHQEPAKPAQAPWPTTEKGPLTISAQESAKVVYYRALYPFESRSHDEITIQPGDIVMVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEIPTPAKPVTDLTSAPAPKLALRETPAPLPVTSSEPSTTPNNWADFSSTWPSSTNEKPETDNWDTWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKSDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPVRKSTSIDTGPTEAPSSLKRVASPAAKPAIPGEEFVAMYTYESSEHGDLTFQQGDVIVVTKKDGDWWTGTVGETSGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTELPKTAVQPAVCQVIGMYDYTAQNDDELAFSKGQIINVLSKEDPDWWKGEVSGQVGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLTESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSCQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSSTDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNPYCEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP", "length": 1713, "header": "sp|Q9WVE9-3|ITSN1_RAT Isoform 3 of Intersectin-1 OS=Rattus norvegicus OX=10116 GN=Itsn1 PE=1 SV=2 CANONICAL=Q9WVE9-3" }, "isoforms": [ { "isoform_ac": "Q9WVE9-1", "url": "", "sequence": { "sequence": "MAQFPTPFGGSLDIWAITVEERAKHDQQFQSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNKDGRMDQVEFSIAMKLIKLKLQGYQLPPALPPVMKQQPAAISSAPAFGIGGMAGMPPLTAVAPVPMGSIPVVGMSPPLVSSVPQAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASAPAAAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGMSVISSSSADQRLPEEPSSEDEQQVEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLTQRNKDQEGIVVLKARRKTLEFELEALNDKKHQLEGKLQDIRCRLATQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILSDQLKQVQQNSLHRDSLLTLKRALEAKELARQQLREQLDEVEKETRSKLQEIDVFNNQLKELREIHSKQQLQKQRSIEAERLKQKEQERKSLELEKQKEEGQRRVQERDKQWQEHVQQEEQQRPRKPHEEDKLKREDSVKKKEAEERAKPEVQDKQSRLFHPHQEPAKPAQAPWPTTEKGPLTISAQESAKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEIPTPAKPVTDLTSAPAPKLALRETPAPLPVTSSEPSTTPNNWADFSSTWPSSTNEKPETDNWDTWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKSDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPVRKSTSIDTGPTEAPSSLKRVASPAAKPAIPGEEFVAMYTYESSEHGDLTFQQGDVIVVTKKDGDWWTGTVGETSGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTELPKTAVQPAVCQVIGMYDYTAQNDDELAFSKGQIINVLSKEDPDWWKGEVSGQVGLFPSNYVKLTTDMDPSQQ", "length": 1217, "header": "sp|Q9WVE9-1|ITSN1_RAT Isoform 1 of Intersectin-1 OS=Rattus norvegicus OX=10116 GN=Itsn1 PE=1 SV=2 CANONICAL=Q9WVE9-3" }, "locus": {} }, { "isoform_ac": "Q9WVE9-2", "url": "", "sequence": { "sequence": "MAQFPTPFGGSLDIWAITVEERAKHDQQFQSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNKDGRMDQVEFSIAMKLIKLKLQGYQLPPALPPVMKQQPAAISSAPAFGIGGMAGMPPLTAVAPVPMGSIPVVGMSPPLVSSVPQAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASAPAAAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGMSVISSSSADQRLPEEPSSEDEQQVEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLTQRNKDQEGIVVLKARRKTLEFELEALNDKKHQLEGKLQDIRCRLATQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILSDQLKQVQQNSLHRDSLLTLKRALEAKELARQQLREQLDEVEKETRSKLQEIDVFNNQLKELREIHSKQQLQKQRSIEAERLKQKEQERKSLELEKQKEEGQRRVQERDKQWQEHVQQEEQQRPRKPHEEDKLKREDSVKKKEAEERAKPEVQDKQSRLFHPHQEPAKPAQAPWPTTEKGPLTISAQESAKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEIPTPAKPVTDLTSAPAPKLALRETPAPLPVTSSEPSTTPNNWADFSSTWPSSTNEKPETDNWDTWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKSDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPVRKSTSIDTGPTEAPSSLKRVASPAAKPAIPGEEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTELPKTAVQPAVCQVIGMYDYTAQNDDELAFSKGQIINVLSKEDPDWWKGEVSGQVGLFPSNYVKLTTDMDPSQQ", "length": 1146, "header": "sp|Q9WVE9-2|ITSN1_RAT Isoform 2 of Intersectin-1 OS=Rattus norvegicus OX=10116 GN=Itsn1 PE=1 SV=2 CANONICAL=Q9WVE9-3" }, "locus": {} }, { "isoform_ac": "Q9WVE9-3", "url": "", "sequence": { "sequence": "MAQFPTPFGGSLDIWAITVEERAKHDQQFQSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNKDGRMDQVEFSIAMKLIKLKLQGYQLPPALPPVMKQQPAAISSAPAFGIGGMAGMPPLTAVAPVPMGSIPVVGMSPPLVSSVPQAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASAPAAAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGMSVISSSSADQRLPEEPSSEDEQQVEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLTQRNKDQEGIVVLKARRKTLEFELEALNDKKHQLEGKLQDIRCRLATQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILSDQLKQVQQNSLHRDSLLTLKRALEAKELARQQLREQLDEVEKETRSKLQEIDVFNNQLKELREIHSKQQLQKQRSIEAERLKQKEQERKSLELEKQKEEGQRRVQERDKQWQEHVQQEEQQRPRKPHEEDKLKREDSVKKKEAEERAKPEVQDKQSRLFHPHQEPAKPAQAPWPTTEKGPLTISAQESAKVVYYRALYPFESRSHDEITIQPGDIVMVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEIPTPAKPVTDLTSAPAPKLALRETPAPLPVTSSEPSTTPNNWADFSSTWPSSTNEKPETDNWDTWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKSDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPVRKSTSIDTGPTEAPSSLKRVASPAAKPAIPGEEFVAMYTYESSEHGDLTFQQGDVIVVTKKDGDWWTGTVGETSGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTELPKTAVQPAVCQVIGMYDYTAQNDDELAFSKGQIINVLSKEDPDWWKGEVSGQVGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLTESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSCQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSSTDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNPYCEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP", "length": 1713, "header": "sp|Q9WVE9-3|ITSN1_RAT Isoform 3 of Intersectin-1 OS=Rattus norvegicus OX=10116 GN=Itsn1 PE=1 SV=2 CANONICAL=Q9WVE9-3" }, "locus": { "chromosome": "11", "start_pos": 31152857, "end_pos": 31027264, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000096792", "url": "https://www.ensembl.org/id/ENSRNOT00000096792" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000095645", "url": "https://www.ensembl.org/id/ENSRNOP00000095645" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1129, "end_pos": 1129, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q9WVE9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVE9" } ], "site_lbl": "Ser1129" }, { "start_pos": 1136, "end_pos": 1136, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q9WVE9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVE9" } ], "site_lbl": "Thr1136" }, { "start_pos": 203, "end_pos": 203, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q9WVE9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVE9" } ], "site_lbl": "Ser203" }, { "start_pos": 318, "end_pos": 318, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" } ], "site_lbl": "Ser318" }, { "start_pos": 334, "end_pos": 334, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q9WVE9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVE9" } ], "site_lbl": "Ser334" }, { "start_pos": 335, "end_pos": 335, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q9WVE9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVE9" } ], "site_lbl": "Ser335" }, { "start_pos": 685, "end_pos": 685, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q9WVE9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVE9" } ], "site_lbl": "Ser685" }, { "start_pos": 889, "end_pos": 889, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" } ], "site_lbl": "Thr889" }, { "start_pos": 893, "end_pos": 893, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" } ], "site_lbl": "Ser893" }, { "start_pos": 894, "end_pos": 894, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q9WVE9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVE9" } ], "site_lbl": "Ser894" }, { "start_pos": 896, "end_pos": 896, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q9WVE9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVE9" } ], "site_lbl": "Ser896" }, { "start_pos": 970, "end_pos": 970, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q9WVE9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVE9" } ], "site_lbl": "Ser970" }, { "start_pos": 976, "end_pos": 976, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" } ], "site_lbl": "Thr976" }, { "start_pos": 987, "end_pos": 987, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" } ], "site_lbl": "Ser987" } ], "glycation": [], "keywords": [], "publication": [ { "title": "EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?", "journal": "J. Biol. Chem.", "date": "1999", "authors": "Okamoto M, Schoch S, Sudhof TC", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" } ], "reference": [ { "type": "PubMed", "id": "10373452", "url": "https://glygen.org/publication/PubMed/10373452" } ] }, { "title": "Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP.", "journal": "Nat. Cell Biol.", "date": "2001", "authors": "Hussain NK, Jenna S, Glogauer M, Quinn CC, Wasiak S, Guipponi M, Antonarakis SE, Kay BK, Stossel TP, Lamarche-Vane N, McPherson PS", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" } ], "reference": [ { "type": "PubMed", "id": "11584276", "url": "https://glygen.org/publication/PubMed/11584276" } ] }, { "title": "Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2.", "journal": "Molecular biology of the cell", "date": "2006", "authors": "Nishimura T, Yamaguchi T, Tokunaga A, Hara A, Hamaguchi T, Kato K, Iwamatsu A, Okano H, Kaibuchi K", "evidence": [ { "database": "RefSeq", "id": "NP_001129568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129568" } ], "reference": [ { "type": "PubMed", "id": "16394100", "url": "https://glygen.org/publication/PubMed/16394100" } ] }, { "title": "FCHo proteins are nucleators of clathrin-mediated endocytosis.", "journal": "Science", "date": "2010", "authors": "Henne WM, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, McMahon HT", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" } ], "reference": [ { "type": "PubMed", "id": "20448150", "url": "https://glygen.org/publication/PubMed/20448150" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" }, { "database": "iPTMnet", "id": "Q9WVE9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WVE9" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "Fast neurotransmitter release regulated by the endocytic scaffold intersectin.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2013", "authors": "Sakaba T, Kononenko NL, Bacetic J, Pechstein A, Schmoranzer J, Yao L, Barth H, Shupliakov O, Kobler O, Aktories K, Haucke V", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" } ], "reference": [ { "type": "PubMed", "id": "23633571", "url": "https://glygen.org/publication/PubMed/23633571" } ] }, { "title": "Altered Expression of Intersectin1-L in Patients with Refractory Epilepsy and in Experimental Epileptic Rats.", "journal": "Cellular and molecular neurobiology", "date": "2015", "authors": "Yang X, Xu X, Zhang Y, Wang S, Li M, Wang X", "evidence": [ { "database": "RefSeq", "id": "NP_001129568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129568" } ], "reference": [ { "type": "PubMed", "id": "25783631", "url": "https://glygen.org/publication/PubMed/25783631" } ] }, { "title": "A Novel Topology of Proline-rich Transmembrane Protein 2 (PRRT2): hints for an intracellular function at the synapse.", "journal": "J. Biol. Chem.", "date": "2016", "authors": "Rossi P, Sterlini B, Castroflorio E, Marte A, Onofri F, Valtorta F, Maragliano L, Corradi A, Benfenati F", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" } ], "reference": [ { "type": "PubMed", "id": "26797119", "url": "https://glygen.org/publication/PubMed/26797119" } ] }, { "title": "Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1 in fresh exudates swabbed from critically colonised and infected full-thickness wounds in rats.", "journal": "International wound journal", "date": "2022-10-28", "authors": "Takizawa Chihiro, Minematsu Takeo, Nakagami Gojiro, Kitamura Aya, Koudounas Sofoklis, Kunimitsu Mao, Sanada Hiromi", "evidence": [ { "database": "RefSeq", "id": "NP_001129568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129568" } ], "reference": [ { "type": "PubMed", "id": "36307995", "url": "https://glygen.org/publication/PubMed/36307995" } ] } ], "pathway": [ { "id": "rno:29491", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:29491", "resource": "KEGG Pathway" }, { "id": "R-RNO-193648", "name": "NRAGE signals death through JNK", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193648", "resource": "Reactome", "description": "NRAGE signals death through JNK" }, { "id": "R-RNO-3928662", "name": "EPHB-mediated forward signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3928662", "resource": "Reactome", "description": "EPHB-mediated forward signaling" }, { "id": "R-RNO-416482", "name": "G alpha (12/13) signalling events", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" }, { "id": "R-RNO-8856825", "name": "Cargo recognition for clathrin-mediated endocytosis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8856825", "resource": "Reactome", "description": "Cargo recognition for clathrin-mediated endocytosis" }, { "id": "R-RNO-8856828", "name": "Clathrin-mediated endocytosis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8856828", "resource": "Reactome", "description": "Clathrin-mediated endocytosis" }, { "id": "R-RNO-9013148", "name": "CDC42 GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-RNO-9013406", "name": "RHOQ GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013406", "resource": "Reactome", "description": "RHOQ GTPase cycle" }, { "id": "R-RNO-9013408", "name": "RHOG GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013408", "resource": "Reactome", "description": "RHOG GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "Q15811-1", "protein_name": "Intersectin-1", "gene_name": "ITSN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"length": 1721 }, "evidence": [ { "id": "45226008", "url": "http://www.informatics.jax.org/homology/45226008", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z0R4-1", "protein_name": "Intersectin-1", "gene_name": "Itsn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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} ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "kinase activator activity", "id": "GO:0019209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019209", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" } ], "pmid": "" }, { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": "https://www.uniprot.org/uniprot/Q9WVE9" } ], "pmid": "" }, { "name": "proline-rich region binding", "id": "GO:0070064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070064", "evidence": [ { "database": "UniProtKB", "id": "Q9WVE9", "url": 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