{ "uniprot_canonical_ac": "Q9W5E0-1", "uniprot_ac": "Q9W5E0", "uniprot_id": "SUV42_DROME", "mass": { "chemical_mass": 137525.0, "monoisotopic_mass": 137525.0 }, "refseq": { "ac": "NP_001245453", "name": "histone methyltransferase 4-20, isoform B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245453" }, "gene_names": [ { "name": "Hmt4-20", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9W5E0", "id": "Q9W5E0" }, { "name": "BcDNA:LD36415; CG13363; Dmel\\CG13363; dSuv4-20; EG:115C2.10; hmt4-20; Su(var)4-20; Suv4-20; SUV4-20; Suv4.20", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245453", "id": "NP_001245453" }, { "name": "BcDNA:LD36415", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W5E0", "id": "Q9W5E0" }, { "name": "CG13363", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W5E0", "id": "Q9W5E0" }, { "name": "Dmel\\CG13363", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W5E0", "id": "Q9W5E0" }, { "name": "Dmel_CG13363", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W5E0", "id": "Q9W5E0" }, { "name": "EG:115C2.10", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W5E0", "id": "Q9W5E0" }, { "name": "Hmt4-20", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245453", "id": "NP_001245453" }, { "name": "SUV4-20", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W5E0", "id": "Q9W5E0" }, { "name": "Su(var)4-20", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W5E0", "id": "Q9W5E0" }, { "name": "Suv4-20", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W5E0", "id": "Q9W5E0" }, { "name": "Suv4.20", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W5E0", "id": "Q9W5E0" }, { "name": "dSuv4-20", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W5E0", "id": "Q9W5E0" }, { "name": "hmt4-20", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W5E0", "id": "Q9W5E0" } ], "protein_names": [ { "name": "Histone-lysine N-methyltransferase Suv4-20", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9W5E0" }, { "name": "2.1.1.361", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9W5E0" }, { "name": "2.1.1.362", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9W5E0" }, { "name": "CG13363-PB; Hmt4-20-PB; histone methyltransferase 4-20; Suv4-20", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245453", "id": "NP_001245453" }, { "name": "Su(var)4-20", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9W5E0" }, { "name": "Suppressor of variegation 4-20", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9W5E0" }, { "name": "histone methyltransferase 4-20, isoform B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245453", "id": "NP_001245453" } ], "function": [ { "annotation": "Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. Acts as a dominant suppressor of position-effect variegation.", "evidence": [ { "database": "UniProtKB", "id": "Q9W5E0", "url": "https://www.uniprot.org/uniprot/Q9W5E0#function" }, { "database": "PubMed", "id": "15145825", "url": "https://glygen.org/publication/PubMed/15145825" } ] } ], "disease": [ { "disease_id": "DOID:0060041", "recommended_name": { "id": "DOID:0060041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060041", "name": "autism spectrum disorder", "description": "A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior." }, "synonyms": [], "evidence": [ { "id": "0060041", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060041" } ] }, { "disease_id": "DOID:0080232", "recommended_name": { "id": "DOID:0080232", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080232", "name": "autosomal dominant intellectual developmental disorder 51", "description": "An autosomal dominant intellectual developmental disorder that has_material_basis_in heterozygous mutation in the KMT5B gene on chromosome 11q13." }, "synonyms": [ { "id": "DOID:0080232", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080232", "name": "autosomal dominant mental retardation 51", "description": "" }, { "id": "MONDO:0030917", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030917", "name": "intellectual disability, autosomal dominant 51", "description": "" }, { "id": "MONDO:0030917", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030917", "name": "intellectual disability, autosomal dominant 51", "description": "" }, { "id": "MONDO:0030917", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030917", "name": "MRD51", "description": "" }, { "id": "MONDO:0030917", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030917", "name": "autosomal dominant intellectual disability 51", "description": "" }, { "id": "MONDO:0030917", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030917", "name": "autosomal dominant mental retardation 51", "description": "" }, { "id": "MONDO:0030917", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030917", "name": "mental retardation, autosomal dominant 51", "description": "" }, { "id": "MIM:617788", "resource": "MIM", "url": "https://www.omim.org/entry/617788", "name": "Intellectual developmental disorder, autosomal dominant 51", "description": "Intellectual developmental disorder, autosomal dominant 51" } ], "evidence": [ { "id": "0080232", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080232" } ] }, { "disease_id": "DOID:916", "recommended_name": { "id": "DOID:916", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:916", "name": "liver benign neoplasm", "description": "" }, "synonyms": [ { "id": "DOID:916", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:916", "name": "epithelial hepatic and intrahepatic bile duct neoplasm", "description": "" } ], "evidence": [ { "id": "916", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:916" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9W5E0", "url": "https://www.uniprot.org/uniprot/Q9W5E0" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Hmt4-20", "url": "https://www.uniprot.org/uniprot/Q9W5E0", "locus": { "chromosome": "X", "start_pos": 648483, "end_pos": 656033, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0025639", "url": "https://www.ensembl.org/id/FBgn0025639" } ] } } ], "crossref": [ { "id": "FBgn0025639", "url": "https://bgee.org/?page=gene&gene_id=FBgn0025639", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "2.1.1.361", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.361&UniProtAcc=Q9W5E0", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "FBgn0025639", "url": "https://flybase.org/reports/FBgn0025639", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "31015", "url": "https://www.ncbi.nlm.nih.gov/gene/31015", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9W5E0", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9W5E0*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG13363", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG13363", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AAQHIHC", "url": "https://omabrowser.org/oma/group/AAQHIHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5396777at2759", "url": "http://www.orthodb.org/?query=5396777at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12977", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12977", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12977:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12977:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00856", "url": "http://pfam.xfam.org/family/PF00856", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9W5E0", "url": "http://purl.obolibrary.org/obo/PR_Q9W5E0", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001245453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245453", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "60344", "url": "https://www.rhea-db.org/rhea/60344", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60348", "url": "https://www.rhea-db.org/rhea/60348", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "61992", "url": "https://www.rhea-db.org/rhea/61992", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "M9NE25", "url": "https://www.uniprot.org/uniprot/M9NE25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M9NE25-1", "url": "https://www.uniprot.org/uniprot/M9NE25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9W5E0", "url": "https://www.uniprot.org/uniprot/Q9W5E0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9W5E0-1", "url": "https://www.uniprot.org/uniprot/Q9W5E0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9W5E0-2", "url": "https://www.uniprot.org/uniprot/Q9W5E0-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVVGSNHTRRGETGSRFTNSSSSSSTSGGPTASASSTTSVTSSLATNSTSTSTAAALLSSMSHKSHGPPPSAPPSAHHQTNQQHHQVAHSQPHATHYQQTNQHPSHHHQSHQSSNGSGGGSAGSGSGSGSVVSGLNGCNGSAVSRLSQSTGMSPRELSENDDLATSLILDPHLGFQTHKMNIRFRPLKVDTQQLKAIVDDFIHTQNYDIAIQRIYEGPWIPRHLKNKNKIATKRLHDHIVRYLRVFDKDSGFAIEACYRYTLEEQRGAKISSTKRWSKNDKIECLVGCIAELTEAEEAALLHSGKNDFSVMYSCRKNCAQLWLGPAAYINHDCRANCKFLATGRDTACVKVLRDIEVGEEITCFYGEDFFGDSNRYCECETCERRGTGAFAGKDDGLMLGLSMGLGLASSGPGNNGGYRLRETDNRINRIKSRANSTNSTSNSNSNTNDSTGPSETSSTNGLVASGGAGGATGAAMLPTPSQQSTGGKEATAAVSLLEKKLPNVVVSPLTMKELRQKGMTKYDAEMIMANAAYQQQHHHQHHFHHHHHHHHHHHNHGQHASTGAEATAAVQQMAAMQKPGVGGTGAAGNAGATTVSSVAAGAGSEVNGGRSTSLRKSMRVNSTSSSISTASADEVIAPVVAASISLPSKAPVVLMPRCKPAQMAIAALHQSQQRQLRRSERQKEKLTDGESSDTSSEQQKKEQKQQDHQLPQKMFSLAEEPQPEKSEEKQQEQQKRVTRNSAGRVGLVARLATAHNNNIATTTNSSSSSNKATTITNCNNHNSNNSSRINHNSNLSSRLSVKSRKPAPSEASSIPSSTSSENQQQQATRRSCSPTPAYKKNLLASFDPDPPSTQGIKEQLKDESVTYSPVKQKRSRRAAALAAAQSIHCEALGGFPTGSTGSQRKRAQAGEPTTSCSSTTISNVEPLLKTPERRLKLTLRMKRSPILDEVIELGTSLSNGGAGRGAPGSHREGTAGEGSVRSALNLTGSSSNGIEYEILRMEGISEHGNDDDEDEEEDDEEPAAEEEEEPPPKEELQLVNKKQRKKQRSRSRSSQRRSPAPSSVYGTPQKKRLRLIFGNESHTIDIPPAAAEGSGSGLDDLNSSGGGGDESFNASYASSTSLTVNTSSSSTSSSSGVGGATSTSAEPVDSSTVGPPIAAQSPSSTTSSSFQSACTSTTNSNSYFPNGKQRAAGEDSYAMHYYQLGKFAGTPSPGQGQAIVSSSSGSSGGGGSGAGFLSMPKHTFGTCALLAPTSFACLQNQPQISQQKTSSGGGAGVVPTSTSTGAVTSHHHTNNHHGQK", "length": 1300, "header": "sp|Q9W5E0-1|SUV42_DROME Isoform 1 of Histone-lysine N-methyltransferase Suv4-20 OS=Drosophila melanogaster OX=7227 GN=Hmt4-20 PE=1 SV=1 CANONICAL=Q9W5E0-1" }, "isoforms": [ { "isoform_ac": "M9NE25-1", "url": "", "sequence": { "sequence": "MVVGSNHTRRGETGSRFTNSSSSSSTSGGPTASASSTTSVTSSLATNSTSTSTAAALLSSMSHKSHGPPPSAPPSAHHQTNQQHHQVAHSQPHATHYQQTNQHPSHHHQSHQSSNGSGGGSAGSGSGSGSVVSGLNGCNGSAVSRLSQSTGMSPRELSENDDLATSLILDPHLGFQTHKMNIRFRPLKVDTQQLKAIVDDFIHTQNYDIAIQRIYEGPWIPRHLKNKNKIATKRLHDHIVRYLRVFDKDSGFAIEACYRYTLEEQRGAKISSTKRWSKNDKIECLVGCIAELTEAEEAALLHSGKNDFSVMYSCRKNCAQLWLGPAAYINHDCRANCKFLATGRDTACVKVLRDIEVGEEITCFYGEDFFGDSNRYCECETCERRGTGAFAGKDDGLMLGLSMGLGLASSGPGNNGGYRLRETDNRINRIKSRANSTNSTSNSNSNTNDSTGPSETSSTNGLVASGGAGGATGAAMLPTPSQQSTGGKEATAAVSLLEKKLPNVVVSPLTMKELRQKGMTKYDAEMIMANAAYQQQHHHQHHFHHHHHHHHHHHNHGQHASTGAEATAAVQQMAAMQKPGVGGTGAAGNAGATTVSSVAAGAGSEVNGGRSTSLRKSMRVNSTSSSISTASADEVIAPVVAASISLPSKAPVVLMPRCKPAQMAIAALHQSQQRQLRRSERQKEKLTDGESSDTSSEQQKKEQKQQDHQLPQKMFSLAEEPQPEKSEEKQQEQQKRVTRNSAGRVGLVARLATAHNNNIATTTNSSSSSNKATTITNCNNHNSNNSSRINHNSNLSSRLSVKSRKPAPSEASSIPSSTSSENQQQQATRRSCSPTPAYKKNLLASFDPDPPSTQGIKEQLKDESVTYSPVKQKRSRRAAALAAAQSIHCEALGGFPTGSTGSQRKRAQAGEPTTSCSSTTISNVEPLLKTPERRLKLTLRMKRSPILDEVIELGTSLSNGGAGRGAPGSHREGTAGEGSVRSALNLTGSSSNGIEYEILRMEGISEHGNDDDEDEEEDDEEPAAEEEEEPPPKEELQLVNKKQRKKQRSRSRSSQRRSPAPSSVYGTPQKKRLRLIFGNESHTIDIPPAAAEGSGSGLDDLNSSGGGGDESFNASYASSTSLTVNTSSSSTSSSSGVGGATSTSAEPVDSSTVGPPIAAQSPSSTTSSSFQSACTSTTNSNSYFPNGKQRAAGEDSYAMHYYQLGKFAGTPSPGQGQAIVSSSSGSSGGGGSGAGFLSMPKHTFGTCALLAPTSFACLQNQPQISQQKTSSGGGAGVVPTSTSTGAVTSHHHTNNHHGQK", "length": 1300, "header": "tr|M9NE25-1|M9NE25_DROME Computationally mapped isoform of [histone H4]-N-methyl-L-lysine(20) N-methyltransferase OS=Drosophila melanogaster OX=7227 GN=Hmt4-20 PE=4 SV=1 CANONICAL=Q9W5E0-1" }, "locus": {} }, { "isoform_ac": "Q9W5E0-1", "url": "", "sequence": { "sequence": "MVVGSNHTRRGETGSRFTNSSSSSSTSGGPTASASSTTSVTSSLATNSTSTSTAAALLSSMSHKSHGPPPSAPPSAHHQTNQQHHQVAHSQPHATHYQQTNQHPSHHHQSHQSSNGSGGGSAGSGSGSGSVVSGLNGCNGSAVSRLSQSTGMSPRELSENDDLATSLILDPHLGFQTHKMNIRFRPLKVDTQQLKAIVDDFIHTQNYDIAIQRIYEGPWIPRHLKNKNKIATKRLHDHIVRYLRVFDKDSGFAIEACYRYTLEEQRGAKISSTKRWSKNDKIECLVGCIAELTEAEEAALLHSGKNDFSVMYSCRKNCAQLWLGPAAYINHDCRANCKFLATGRDTACVKVLRDIEVGEEITCFYGEDFFGDSNRYCECETCERRGTGAFAGKDDGLMLGLSMGLGLASSGPGNNGGYRLRETDNRINRIKSRANSTNSTSNSNSNTNDSTGPSETSSTNGLVASGGAGGATGAAMLPTPSQQSTGGKEATAAVSLLEKKLPNVVVSPLTMKELRQKGMTKYDAEMIMANAAYQQQHHHQHHFHHHHHHHHHHHNHGQHASTGAEATAAVQQMAAMQKPGVGGTGAAGNAGATTVSSVAAGAGSEVNGGRSTSLRKSMRVNSTSSSISTASADEVIAPVVAASISLPSKAPVVLMPRCKPAQMAIAALHQSQQRQLRRSERQKEKLTDGESSDTSSEQQKKEQKQQDHQLPQKMFSLAEEPQPEKSEEKQQEQQKRVTRNSAGRVGLVARLATAHNNNIATTTNSSSSSNKATTITNCNNHNSNNSSRINHNSNLSSRLSVKSRKPAPSEASSIPSSTSSENQQQQATRRSCSPTPAYKKNLLASFDPDPPSTQGIKEQLKDESVTYSPVKQKRSRRAAALAAAQSIHCEALGGFPTGSTGSQRKRAQAGEPTTSCSSTTISNVEPLLKTPERRLKLTLRMKRSPILDEVIELGTSLSNGGAGRGAPGSHREGTAGEGSVRSALNLTGSSSNGIEYEILRMEGISEHGNDDDEDEEEDDEEPAAEEEEEPPPKEELQLVNKKQRKKQRSRSRSSQRRSPAPSSVYGTPQKKRLRLIFGNESHTIDIPPAAAEGSGSGLDDLNSSGGGGDESFNASYASSTSLTVNTSSSSTSSSSGVGGATSTSAEPVDSSTVGPPIAAQSPSSTTSSSFQSACTSTTNSNSYFPNGKQRAAGEDSYAMHYYQLGKFAGTPSPGQGQAIVSSSSGSSGGGGSGAGFLSMPKHTFGTCALLAPTSFACLQNQPQISQQKTSSGGGAGVVPTSTSTGAVTSHHHTNNHHGQK", "length": 1300, "header": "sp|Q9W5E0-1|SUV42_DROME Isoform 1 of Histone-lysine N-methyltransferase Suv4-20 OS=Drosophila melanogaster OX=7227 GN=Hmt4-20 PE=1 SV=1 CANONICAL=Q9W5E0-1" }, "locus": { "chromosome": "X", "start_pos": 654083, "end_pos": 650053, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0070151", "url": "https://www.ensembl.org/id/FBtr0070151" }, { "database": "Ensembl Peptide", "id": "FBpp0070146", "url": "https://www.ensembl.org/id/FBpp0070146" } ] } }, { "isoform_ac": "Q9W5E0-2", "url": "", "sequence": { "sequence": "MVVGSNHTRRGETGSRFTNSSSSSSTSGGPTASASSTTSVTSSLATNSTSTSTAAALLSSMSHKSHGPPPSAPPSAHHQTNQQHHQVAHSQPHATHYQQTNQHPSHHHQSHQSSNGSGGGSAGSGSGSGSVVSGLNGCNGSAVSRLSQSTGMSPRELSENDDLATSLILDPHLGFQTHKMNIRFRPLKVDTQQLKAIVDDFIHTQNYDIAIQRIYEGPWIPRHLKNKNKIATKRLHDHIVRYLRVFDKDSGFAIEACYRYTLEEQRGAKISSTKRWSKNDKIECLVGCIAELTEAEEAALLHSGKNDFSVMYSCRKNCAQLWLGPAAYINHDCRANCKFLATGRDTACVKVLRDIEVGEEITCFYGEDFFGDSNRYCECETCERRGTGAFAGKDDGLMLGLSMGLGLASSGPGNNGGYRLRETDNRINRIKSRANSTNSTSNSNSNTNDSTGPSETSSTNGLVASGGAGGATGAAMLPTPSQQSTGGKEATAAVSLLEKKLPNVVVSPLTMKELRQKGMTKYDAEMIMANAAYQQQHHHQHHFHHHHHHHHHHHNHGQHASTGAEATAAVQQMAAMQKPGVGGTGAAGNAGATTVSSVAAGAGSEVNGGRSTSLRKSMRVNSTSSSISTASADEVIAPVVAASISLPSKAPVVLMPRCKPAQMAIAALHQSQQRQLRRSERQKEKLTDGESSDTSSEQQKKEQKQQDHQLPQKMFSLAEEPQPEKSEEKQQEQQKRVTRNSAGRVGLVARLATAHNNNIATTTIAVDHHNSSTRMCINIFAT", "length": 782, "header": "sp|Q9W5E0-2|SUV42_DROME Isoform 2 of Histone-lysine N-methyltransferase Suv4-20 OS=Drosophila melanogaster OX=7227 GN=Hmt4-20 PE=1 SV=1 CANONICAL=Q9W5E0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 831, "end_pos": 831, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9W5E0", "url": "https://www.uniprot.org/uniprot/Q9W5E0" }, { "database": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" }, { "database": "phospho.ELM", "id": "Q9W5E0", "url": "http://phospho.elm.eu.org/byAccession/Q9W5E0.html" }, { "database": "iPTMnet", "id": "Q9W5E0", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9W5E0" } ], "site_lbl": "Ser831" }, { "start_pos": 833, "end_pos": 833, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9W5E0", "url": "https://www.uniprot.org/uniprot/Q9W5E0" }, { "database": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" }, { 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"2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q9W5E0", "url": "https://www.uniprot.org/uniprot/Q9W5E0" }, { "database": "UniProtKB", "id": "M9NE25", "url": "https://www.uniprot.org/uniprot/M9NE25" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "From sequence to chromosome: the tip of the X chromosome of D. melanogaster.", "journal": "Science", "date": "2000", "authors": "Galibert F., Barrell B.G., Schaefer U., Harris D., Werner M., Glover D.M., Cox S., Dreano S., Mottier S., Jaeckle H., Vidal S., Ferraz C., Brun C., Gatt M.K., Dowe G., Minana B., Modolell J., Campbell L.A., Ashburner M., Kafatos F.C., Valenti P., Louis C., Saunders R.D.C., Benos P.V., Bolshakov S., Borkova D., Cadieu E., Murphy L., Salles C., Siden-Kiamos I., de Pablos B., Beinert N., Bucheton A., Callister D.M., Darlamitsou A., Demailles J., Gloux S., Henderson N.S., Lelaure V., Madueno E., McMillan P.J., Mourkioti F., Papagiannakis G., Peter A., Schoettler P., Spanos L., Tait E.A.", "evidence": [ { "database": "UniProtKB", "id": "Q9W5E0", "url": "https://www.uniprot.org/uniprot/Q9W5E0" } ], "reference": [ { "type": "PubMed", "id": "10731137", "url": "https://glygen.org/publication/PubMed/10731137" } ] }, { "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.", "journal": "Genome Biol.", "date": "2002", "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM", "evidence": [ { "database": "UniProtKB", "id": "M9NE25", "url": "https://www.uniprot.org/uniprot/M9NE25" } ], "reference": [ { "type": "PubMed", "id": "12537568", "url": "https://glygen.org/publication/PubMed/12537568" } ] }, { "title": "A Drosophila full-length cDNA resource.", "journal": "Genome Biol.", "date": "2002", "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "Q9W5E0", "url": "https://www.uniprot.org/uniprot/Q9W5E0" } ], "reference": [ { "type": "PubMed", "id": "12537569", "url": "https://glygen.org/publication/PubMed/12537569" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q9W5E0", "url": "https://www.uniprot.org/uniprot/Q9W5E0" }, { "database": "UniProtKB", "id": "M9NE25", "url": "https://www.uniprot.org/uniprot/M9NE25" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.", "journal": "Genome Biol.", "date": "2002", "authors": "Kaminker JS, Bergman CM, Kronmiller B, Carlson J, Svirskas R, Patel S, Frise E, Wheeler DA, Lewis SE, Rubin GM, Ashburner M, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "M9NE25", "url": "https://www.uniprot.org/uniprot/M9NE25" } ], "reference": [ { "type": "PubMed", "id": "12537573", "url": "https://glygen.org/publication/PubMed/12537573" } ] }, { "title": "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.", "journal": "Genome Biol.", "date": "2002", "authors": "Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, Kaminker JS, Kennedy C, Mungall CJ, Sullivan BA, Sutton GG, Yasuhara JC, Wakimoto BT, Myers EW, Celniker SE, Rubin GM, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "M9NE25", "url": "https://www.uniprot.org/uniprot/M9NE25" } ], "reference": [ { "type": "PubMed", "id": "12537574", "url": "https://glygen.org/publication/PubMed/12537574" } ] }, { "title": "A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.", "journal": "Genes Dev.", "date": "2004", "authors": "Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T", "evidence": [ { "database": "UniProtKB", "id": "Q9W5E0", "url": "https://www.uniprot.org/uniprot/Q9W5E0" } ], "reference": [ { "type": "PubMed", "id": "15145825", "url": "https://glygen.org/publication/PubMed/15145825" } ] }, { "title": "Combined evidence annotation of transposable elements in genome sequences.", "journal": "PLoS Comput. Biol.", "date": "2005", "authors": "Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D", "evidence": [ { "database": "UniProtKB", "id": "M9NE25", "url": "https://www.uniprot.org/uniprot/M9NE25" } ], "reference": [ { "type": "PubMed", "id": "16110336", "url": "https://glygen.org/publication/PubMed/16110336" } ] }, { "title": "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Smith CD, Shu S, Mungall CJ, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "M9NE25", "url": "https://www.uniprot.org/uniprot/M9NE25" } ], "reference": [ { "type": "PubMed", "id": "17569856", "url": "https://glygen.org/publication/PubMed/17569856" } ] }, { "title": "Sequence finishing and mapping of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "M9NE25", "url": "https://www.uniprot.org/uniprot/M9NE25" } ], "reference": [ { "type": "PubMed", "id": "17569867", "url": "https://glygen.org/publication/PubMed/17569867" } ] }, { "title": "Phosphoproteome analysis of Drosophila melanogaster embryos.", "journal": "Journal of proteome research", "date": "2008", "authors": "Zhai B, Villen J, Beausoleil SA, Mintseris J, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q9W5E0", "url": "https://www.uniprot.org/uniprot/Q9W5E0" }, { "database": "iPTMnet", "id": "Q9W5E0", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9W5E0" } ], "reference": [ { "type": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" } ] } ], "pathway": [ { "id": "dme:Dmel_CG13363", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG13363", "resource": "KEGG Pathway" } ], "orthologs": 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"annotation": "n_glycosylation_sequon" }, { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" }, { "start_pos": 621, "end_pos": 623, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" }, { "start_pos": 764, "end_pos": 766, "annotation": "n_glycosylation_sequon" }, { "start_pos": 784, "end_pos": 786, "annotation": "n_glycosylation_sequon" }, { "start_pos": 785, "end_pos": 787, "annotation": "n_glycosylation_sequon" }, { "start_pos": 794, "end_pos": 796, "annotation": "n_glycosylation_sequon" }, { "start_pos": 985, "end_pos": 987, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "60344", "name": "", "equation": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P0C2N5-1", "P0C6Y7-1", "P0C2N6-1", "A0A0G2JTW4-1", "A0A0G2JW37-1", "D3ZEB9-1", "M0R767-1", "A0A8I6AL52-1", "Q9NVD3-1", "Q4FZB7-1", "Q9NQR1-1", "Q86Y97-1", "Q9NQX0-3", "Q9NQV7-1", "Q3U8K7-1", "P58467-1", "Q2YDW7-1", "Q6Q783-1", "Q3UZD5-1", "Q96EQ9-1", "Q9VFK6-1", "Q9W5E0-1" ], "evidence": [ { "id": "60344", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60344" } ] }, { "id": "60348", "name": "", "equation": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P0C2N5-1", "P0C6Y7-1", "P0C2N6-1", "Q9NVD3-1", "Q4FZB7-1", "Q86Y97-1", "Q9NQV7-1", "P58467-1", "Q3U8K7-1", "Q6Q783-1", "Q96EQ9-1", "Q9W5E0-1" ], "evidence": [ { "id": "60348", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60348" } ] }, { "id": "61992", "name": "", "equation": "N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P0C2N5-1", "P0C2N6-1", "Q9NVD3-1", "Q4FZB7-1", "Q86Y97-1", "P58467-1", "Q3U8K7-1", "Q6Q783-1", "Q9W5E0-1" ], "evidence": [ { "id": "61992", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/61992" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JTW4", "gene_name": "AABR07010705.1", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "A0A0G2JTW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JTW4" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "A0A0G2JTW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JTW4" } ] } ] }, { "uniprot_ac": "A0A0G2JW37", "gene_name": "RGD1561318", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "A0A0G2JW37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW37" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "A0A0G2JW37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW37" } ] } ] }, { "uniprot_ac": "A0A8I6AL52", "gene_name": "ENSRNOG00000067141", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "A0A8I6AL52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AL52" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "A0A8I6AL52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AL52" } ] } ] }, { "uniprot_ac": "D3ZEB9", "gene_name": "Kmt5a", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "D3ZEB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "D3ZEB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ] } ] }, { "uniprot_ac": "M0R767", "gene_name": "AABR07033047.1", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "M0R767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R767" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "M0R767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R767" } ] } ] }, { "uniprot_ac": "P0C2N5", "gene_name": "Kmt5b", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C2N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N5" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C2N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N5" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "P0C2N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N5" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "P0C2N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N5" } ] } ] }, { "uniprot_ac": "P0C2N6", "gene_name": "Kmt5c", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C2N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N6" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C2N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N6" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "P0C2N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N6" } ] } ] }, { "uniprot_ac": "P0C6Y7", "gene_name": "Prdm9", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.355", "activity": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] } ] }, { "uniprot_ac": "P58467", "gene_name": "Setd4", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "P58467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58467" } ] }, { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P58467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58467" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "P58467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58467" } ] } ] }, { "uniprot_ac": "Q2YDW7", "gene_name": "Kmt5a", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q2YDW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2YDW7" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q2YDW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2YDW7" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q2YDW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2YDW7" } ] } ] }, { "uniprot_ac": "Q3U8K7", "gene_name": "Kmt5b", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q3U8K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U8K7" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q3U8K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U8K7" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q3U8K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U8K7" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "Q3U8K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U8K7" } ] } ] }, { "uniprot_ac": "Q3UZD5", "gene_name": "Prdm6", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q3UZD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UZD5" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q3UZD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UZD5" } ] } ] }, { "uniprot_ac": "Q4FZB7", "gene_name": "KMT5B", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q4FZB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4FZB7" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q4FZB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4FZB7" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q4FZB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4FZB7" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "Q4FZB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4FZB7" } ] } ] }, { "uniprot_ac": "Q6Q783", "gene_name": "Kmt5c", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q6Q783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q783" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q6Q783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q783" } ] } ] }, { "uniprot_ac": "Q86Y97", "gene_name": "KMT5C", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q86Y97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y97" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q86Y97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y97" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "Q86Y97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y97" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q86Y97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y97" } ] } ] }, { "uniprot_ac": "Q96EQ9", "gene_name": "Prdm9", "activity": [ { "ec_number": "2.1.1.43", "activity": "", "evidence": [ { "id": "Q96EQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96EQ9" } ] }, { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q96EQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96EQ9" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q96EQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96EQ9" } ] }, { "ec_number": "2.1.1.355", "activity": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q96EQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96EQ9" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q96EQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96EQ9" } ] }, { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q96EQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96EQ9" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q96EQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96EQ9" } ] } ] }, { "uniprot_ac": "Q9NQR1", "gene_name": "KMT5A", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q9NQR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQR1" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NQR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQR1" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q9NQR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQR1" } ] } ] }, { "uniprot_ac": "Q9NQV7", "gene_name": "PRDM9", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NQV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQV7" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q9NQV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQV7" } ] }, { "ec_number": "2.1.1.355", "activity": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NQV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQV7" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NQV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQV7" } ] }, { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NQV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQV7" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NQV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQV7" } ] } ] }, { "uniprot_ac": "Q9NQX0", "gene_name": "PRDM6", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NQX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQX0" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q9NQX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQX0" } ] } ] }, { "uniprot_ac": "Q9NVD3", "gene_name": "SETD4", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q9NVD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NVD3" } ] }, { "ec_number": "2.1.1.364", 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