{ "uniprot_canonical_ac": "Q9W3C7-1", "uniprot_ac": "Q9W3C7", "uniprot_id": "PPT1_DROME", "mass": { "chemical_mass": 35780.0, "monoisotopic_mass": 35780.0 }, "refseq": { "ac": "NP_001285024", "name": "Palmitoyl-protein thioesterase 1, isoform B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285024" }, "gene_names": [ { "name": "Ppt1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9W3C7", "id": "Q9W3C7" }, { "name": "CG12108; Dmel\\CG12108; DmPpt1; ppt1; PPT1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285024", "id": "NP_001285024" }, { "name": "CG12108", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W3C7", "id": "Q9W3C7" }, { "name": "DmPpt1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W3C7", "id": "Q9W3C7" }, { "name": "Dmel\\CG12108", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W3C7", "id": "Q9W3C7" }, { "name": "Dmel_CG12108", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W3C7", "id": "Q9W3C7" }, { "name": "PPT1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W3C7", "id": "Q9W3C7" }, { "name": "Ppt1-RA", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W3C7", "id": "Q9W3C7" }, { "name": "Ppt1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285024", "id": "NP_001285024" }, { "name": "ppt1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W3C7", "id": "Q9W3C7" } ], "protein_names": [ { "name": "Palmitoyl-protein thioesterase 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9W3C7" }, { "name": "3.1.2.22", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9W3C7" }, { "name": "CG12108-PB; Ppt1-PB; palmitoyl-protein thioesterase 1; palmitoyl protein thioesterase 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285024", "id": "NP_001285024" }, { "name": "PPT-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9W3C7" }, { "name": "Palmitoyl-protein hydrolase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9W3C7" }, { "name": "Palmitoyl-protein thioesterase 1, isoform B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285024", "id": "NP_001285024" } ], "function": [ { "annotation": "Cleaves thioester-linked long fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides.", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7#function" }, { "database": "PubMed", "id": "16452138", "url": "https://glygen.org/publication/PubMed/16452138" }, { "database": "PubMed", "id": "12909364", "url": "https://glygen.org/publication/PubMed/12909364" } ] } ], "disease": [ { "disease_id": "DOID:0110721", "recommended_name": { "id": "DOID:0110721", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110721", "name": "neuronal ceroid lipofuscinosis 1", "description": "A neuronal ceroid lipofuscinosis that is characterized by variable age of onset of symptoms (progressive dementia, seizures, and progressive visual failure) and lipopigment pattern of granular osmiophilic deposits, and has_material_basis_in homozygous or compound heterozygous mutation in the PPT1 gene on chromosome 1p34." }, "synonyms": [ { "id": "DOID:0110721", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110721", "name": "CLN1", "description": "" }, { "id": "DOID:0110721", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110721", "name": "neuronal ceroid lipofuscinosis 1 variable age of onset", "description": "" }, { "id": "MONDO:0009744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009744", "name": "neuronal ceroid lipofuscinosis 1", "description": "A condition associated with mutation(s) in the PPT1 gene, encoding palmitoyl-protein thioesterase 1. 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"MONDO:0009744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009744", "name": "congenital neuronal ceroid lipofuscinosis", "description": "" }, { "id": "MONDO:0009744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009744", "name": "lipofuscin storage disease", "description": "" }, { "id": "MIM:256730", "resource": "MIM", "url": "https://www.omim.org/entry/256730", "name": "Ceroid lipofuscinosis, neuronal, 1", "description": "Ceroid lipofuscinosis, neuronal, 1" } ], "evidence": [ { "id": "0110721", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110721" } ] }, { "disease_id": "DOID:0110731", "recommended_name": { "id": "DOID:0110731", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110731", "name": "neuronal ceroid lipofuscinosis 3", "description": "A neuronal ceroid lipofuscinosis that is characterized by juvenile-onset of progressive dementia, 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"https://monarchinitiative.org/disease/MONDO:0009744", "name": "classic late infantile CLN (type of CLN1)", "description": "" }, { "id": "MONDO:0009744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009744", "name": "infantile CLN (type of CLN1)", "description": "" }, { "id": "MONDO:0009744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009744", "name": "infantile neuronal ceroid lipofuscinosis", "description": "" }, { "id": "MONDO:0009744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009744", "name": "juvenile CLN (type of CLN1)", "description": "" }, { "id": "MONDO:0009744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009744", "name": "neuronal ceroid lipofuscinosis, infantile", "description": "" }, { "id": "MONDO:0009744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009744", "name": "congenital NCL", "description": "" }, { "id": "MONDO:0009744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009744", "name": "congenital neuronal ceroid lipofuscinosis", "description": "" }, { "id": "MONDO:0009744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009744", "name": "lipofuscin storage disease", "description": "" }, { "id": "MIM:256730", "resource": "MIM", "url": "https://www.omim.org/entry/256730", "name": "Ceroid lipofuscinosis, neuronal, 1", "description": "Ceroid lipofuscinosis, neuronal, 1" } ], "evidence": [ { "id": "14503", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:14503" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Ppt1", "url": "https://www.uniprot.org/uniprot/Q9W3C7", "locus": { "chromosome": "X", "start_pos": 8688627, "end_pos": 8690227, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0030057", "url": "https://www.ensembl.org/id/FBgn0030057" } ] } } ], "crossref": [ { "id": "FBgn0030057", "url": "https://bgee.org/?page=gene&gene_id=FBgn0030057", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.1.2.22", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.2.22&UniProtAcc=Q9W3C7", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "FBgn0030057", "url": "https://flybase.org/reports/FBgn0030057", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "31805", "url": "https://www.ncbi.nlm.nih.gov/gene/31805", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9W3C7", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9W3C7*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG12108", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG12108", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KFVMVMF", "url": "https://omabrowser.org/oma/group/KFVMVMF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "760135at2759", "url": "http://www.orthodb.org/?query=760135at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11247", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11247", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11247:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11247:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02089", "url": "http://pfam.xfam.org/family/PF02089", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9W3C7", "url": "http://purl.obolibrary.org/obo/PR_Q9W3C7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DME-75105", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-75105", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001285024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285024", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19233", "url": "https://www.rhea-db.org/rhea/19233", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9W3C7-1", "url": "https://www.uniprot.org/uniprot/Q9W3C7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "S5WMX5", "url": "https://www.uniprot.org/uniprot/S5WMX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "S5WMX5-1", "url": "https://www.uniprot.org/uniprot/S5WMX5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MISICCSRFSCILFLLFLIFSLVLSYIWWSPTKGGTNPEVLPVVLWHGMGDTCCVPFSLGAIMNLIVEQTKGGYVRSLQIGGNVLIDWQSGFFIHPNEQVDYVCKQLLQDEHLAKGYHAIGFSQGGQFLRAVAERCPNPPMRNLITLGGQHQGIFGLPMCPTLTEKPCDYITRLLDNAAYAPEVQKALVQATYWHDPIMENKYRLGSTFLADINNELFINKFYIENLQKLKKFVMVQFLNDTIVQPKESQWFQYYTTGQNKVIQPFTESKVYQDLGLDKMHRQGQLVFLGVEGDHLAISKAWFIQNIVPLLLEK", "length": 314, "header": "sp|Q9W3C7-1|PPT1_DROME Isoform 1 of Palmitoyl-protein thioesterase 1 OS=Drosophila melanogaster OX=7227 GN=Ppt1 PE=2 SV=2 CANONICAL=Q9W3C7-1" }, "isoforms": [ { "isoform_ac": "Q9W3C7-1", "url": "", "sequence": { "sequence": "MISICCSRFSCILFLLFLIFSLVLSYIWWSPTKGGTNPEVLPVVLWHGMGDTCCVPFSLGAIMNLIVEQTKGGYVRSLQIGGNVLIDWQSGFFIHPNEQVDYVCKQLLQDEHLAKGYHAIGFSQGGQFLRAVAERCPNPPMRNLITLGGQHQGIFGLPMCPTLTEKPCDYITRLLDNAAYAPEVQKALVQATYWHDPIMENKYRLGSTFLADINNELFINKFYIENLQKLKKFVMVQFLNDTIVQPKESQWFQYYTTGQNKVIQPFTESKVYQDLGLDKMHRQGQLVFLGVEGDHLAISKAWFIQNIVPLLLEK", "length": 314, "header": "sp|Q9W3C7-1|PPT1_DROME Isoform 1 of Palmitoyl-protein thioesterase 1 OS=Drosophila melanogaster OX=7227 GN=Ppt1 PE=2 SV=2 CANONICAL=Q9W3C7-1" }, "locus": { "chromosome": "X", "start_pos": 8689979, "end_pos": 8688783, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0071225", "url": "https://www.ensembl.org/id/FBtr0071225" }, { "database": "Ensembl Peptide", "id": "FBpp0071170", "url": "https://www.ensembl.org/id/FBpp0071170" } ] } }, { "isoform_ac": "S5WMX5-1", "url": "", "sequence": { "sequence": "MISICCSRFSCILFLLFLIFSLVLSYIWWSPTKGGTNPEVLPVVLWHGMGDTCCVPFSLGAIMNLIVEQTKGGYVRSLQIGGNVLIDWQSGFFIHPNEQVDYVCKQLLQDEHLAKGYHAIGFSQGGQFLRAVAERCPNPPMRNLITLGGQHQGIFGLPMCPTLTEKPCDYITRLLDNAAYAPEVQKALVQATYWHDPIMENKYRLGSTFLADINNELFINKFYIENLQKLKKFVMVQFLNDTIVQPKESQWFQYYTTGQNKVIQPFTESKVYQDLGLDKMHRQGQLVFLGVEGDHLAISKAWFIQNIVPLLLEK", "length": 314, "header": "tr|S5WMX5-1|PPT1_DROME Computationally mapped isoform of Palmitoyl-protein thioesterase 1 OS=Drosophila melanogaster OX=7227 GN=Ppt1 PE=2 SV=1 CANONICAL=Q9W3C7-1" }, "locus": { "chromosome": "X", "start_pos": 8689979, "end_pos": 8688783, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0071225", "url": "https://www.ensembl.org/id/FBtr0071225" }, { "database": "Ensembl Peptide", "id": "FBpp0071170", "url": "https://www.ensembl.org/id/FBpp0071170" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 240, "start_aa": "Asn", "end_pos": 240, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn240", "evidence": [ { "id": "Q9W3C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W3C7#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "S5WMX5", "url": "https://www.uniprot.org/uniprot/S5WMX5" }, { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.", "journal": "Genome Biol.", "date": "2002", "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM", "evidence": [ { "database": "UniProtKB", "id": "S5WMX5", "url": "https://www.uniprot.org/uniprot/S5WMX5" } ], "reference": [ { "type": "PubMed", "id": "12537568", "url": "https://glygen.org/publication/PubMed/12537568" } ] }, { "title": "A Drosophila full-length cDNA resource.", "journal": "Genome Biol.", "date": "2002", "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "reference": [ { "type": "PubMed", "id": "12537569", "url": "https://glygen.org/publication/PubMed/12537569" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "S5WMX5", "url": "https://www.uniprot.org/uniprot/S5WMX5" }, { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.", "journal": "Genome Biol.", "date": "2002", "authors": "Kaminker JS, Bergman CM, Kronmiller B, Carlson J, Svirskas R, Patel S, Frise E, Wheeler DA, Lewis SE, Rubin GM, Ashburner M, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "S5WMX5", "url": "https://www.uniprot.org/uniprot/S5WMX5" } ], "reference": [ { "type": "PubMed", "id": "12537573", "url": "https://glygen.org/publication/PubMed/12537573" } ] }, { "title": "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.", "journal": "Genome Biol.", "date": "2002", "authors": "Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, Kaminker JS, Kennedy C, Mungall CJ, Sullivan BA, Sutton GG, Yasuhara JC, Wakimoto BT, Myers EW, Celniker SE, Rubin GM, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "S5WMX5", "url": "https://www.uniprot.org/uniprot/S5WMX5" } ], "reference": [ { "type": "PubMed", "id": "12537574", "url": "https://glygen.org/publication/PubMed/12537574" } ] }, { "title": "Characterization of Drosophila palmitoyl-protein thioesterase 1.", "journal": "Gene", "date": "2003", "authors": "Glaser R.L., Chotkowski H.L., Chu-LaGraff Q., Hickey A.J.", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "reference": [ { "type": "PubMed", "id": "12909364", "url": "https://glygen.org/publication/PubMed/12909364" } ] }, { "title": "Combined evidence annotation of transposable elements in genome sequences.", "journal": "PLoS Comput. Biol.", "date": "2005", "authors": "Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D", "evidence": [ { "database": "UniProtKB", "id": "S5WMX5", "url": "https://www.uniprot.org/uniprot/S5WMX5" } ], "reference": [ { "type": "PubMed", "id": "16110336", "url": "https://glygen.org/publication/PubMed/16110336" } ] }, { "title": "Palmitoyl-protein thioesterase 1 deficiency in Drosophila melanogaster causes accumulation of abnormal storage material and reduced life span.", "journal": "Genetics", "date": "2006", "authors": "Singh N., MacDonald M.E., Glaser R.L., Ault J.G., Korey C.A., Chotkowski H.L., Hickey A.J.", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "reference": [ { "type": "PubMed", "id": "16452138", "url": "https://glygen.org/publication/PubMed/16452138" } ] }, { "title": "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Smith CD, Shu S, Mungall CJ, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "S5WMX5", "url": "https://www.uniprot.org/uniprot/S5WMX5" } ], "reference": [ { "type": "PubMed", "id": "17569856", "url": "https://glygen.org/publication/PubMed/17569856" } ] }, { "title": "Sequence finishing and mapping of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "S5WMX5", "url": "https://www.uniprot.org/uniprot/S5WMX5" } ], "reference": [ { "type": "PubMed", "id": "17569867", "url": "https://glygen.org/publication/PubMed/17569867" } ] }, { "title": "The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases.", "journal": "Fly", "date": "2008", "authors": "Glaser R.L., Van Etten J., Ault J.G., Bannan B.A., Buff H., Fowler E., Hansen N.M., Kohler J.A., Korey C.A., Sigmon S., Tsoi Y., Williams T.S.", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "reference": [ { "type": "PubMed", "id": "18719403", "url": "https://glygen.org/publication/PubMed/18719403" } ] }, { "title": "The Release 6 reference sequence of the Drosophila melanogaster genome.", "journal": "Genome Res.", "date": "2015", "authors": "Hoskins RA, Carlson JW, Wan KH, Park S, Mendez I, Galle SE, Booth BW, Pfeiffer BD, George RA, Svirskas R, Krzywinski M, Schein J, Accardo MC, Damia E, Messina G, Mendez-Lago M, de Pablos B, Demakova OV, Andreyeva EN, Boldyreva LV, Marra M, Carvalho AB, Dimitri P, Villasante A, Zhimulev IF, Rubin GM, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "S5WMX5", "url": "https://www.uniprot.org/uniprot/S5WMX5" } ], "reference": [ { "type": "PubMed", "id": "25589440", "url": "https://glygen.org/publication/PubMed/25589440" } ] }, { "title": "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.", "journal": "G3 (Bethesda)", "date": "2015", "authors": "Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM", "evidence": [ { "database": "UniProtKB", "id": "S5WMX5", "url": "https://www.uniprot.org/uniprot/S5WMX5" } ], "reference": [ { "type": "PubMed", "id": "26109356", "url": "https://glygen.org/publication/PubMed/26109356" } ] }, { "title": "Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.", "journal": "G3 (Bethesda)", "date": "2015", "authors": "Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM", "evidence": [ { "database": "UniProtKB", "id": "S5WMX5", "url": "https://www.uniprot.org/uniprot/S5WMX5" } ], "reference": [ { "type": "PubMed", "id": "26109357", "url": "https://glygen.org/publication/PubMed/26109357" } ] } ], "pathway": [ { "id": "dme:Dmel_CG12108", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG12108", "resource": "KEGG Pathway" }, { "id": "R-DME-75105", "name": "Fatty acyl-CoA biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-75105", "resource": "Reactome", "description": "Fatty acyl-CoA biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "O88531-1", "protein_name": "Palmitoyl-protein thioesterase 1", "gene_name": "Ppt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASSCSRRLLAAALLPWCCAAWALGHLDPPSPPPLVIWHGMGDSCCNPMSMGVIKKMVEKEIPGIYVLSLEIGKNMMEDVENSFFLNVNVQVNMVCQILEKDPKLQQGYNAIGFSQGGQFLRAVAQRCPTPPMMTLISVGGQHQGVFGLPRCPGESSHICDFIRKSLNAGAYSKLVQERLVQAQYWHDPIKESVYRNYSIFLADINQERCVNESYKKNLMALKKFVMVKFFNDSIVDPVDSEWFGFYRSGQAKETIPLQESTLYTEDRLGLKKMDKAGKLVFLAKEGDHLQISKEWFTAHIIPFLK", "length": 306 }, "evidence": [ { "id": "Q9W3C7", "url": "https://omabrowser.org/oma/group/Q9W3C7/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P45479-1", "protein_name": "Palmitoyl-protein thioesterase 1", "gene_name": "Ppt1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASPGYRRLLAAALLPWCCAAWALGHLDPPSPPPLVIWHGMGDSCCNPMSMGSIKKMVEKEIPGIYVLSLEIGKNMVEDVENSFFLNVNLQVGMACQILEKDPKLQHGYNAIGFSQGGQFLRAVAQRCPTPPMMTLISVGGQHQGVFGLPRCPGESSHICDFIRKSLNAGAYSKVVQERLVQAQYWHDPIKEEVYRNCSIFLADINQERHINESYKENLMALKKFVMVKFFNDSIVDPVDSEWFGFYRSGQAKETIPLQETTLYTEDRLGLKKMDKAGKLVFLAKEGDHLQISKEWFTAHIIPFLK", "length": 306 }, "evidence": [ { "id": "Q9W3C7", "url": "https://omabrowser.org/oma/group/Q9W3C7/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P50897-1", "protein_name": "Palmitoyl-protein thioesterase 1", "gene_name": "PPT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLSMGAIKKMVEKKIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQFLRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERLVQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVDSEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAHIIPFLG", "length": 306 }, "evidence": [ { "id": "Q9W3C7", "url": "https://omabrowser.org/oma/group/Q9W3C7/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "palmitoyl-(protein) hydrolase activity", "id": "GO:0008474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008474", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "pmid": "" }, { "name": "serine hydrolase activity", "id": "GO:0017171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017171", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "regulation of axon guidance", "id": "GO:1902667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902667", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "pmid": "" }, { "name": "positive regulation of synaptic vesicle endocytosis", "id": "GO:1900244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900244", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "pmid": "" }, { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "pmid": "" }, { "name": "receptor-mediated endocytosis", "id": "GO:0006898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "pmid": "" }, { "name": "neuron fate specification", "id": "GO:0048665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048665", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "pmid": "" }, { "name": "protein depalmitoylation", "id": "GO:0002084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002084", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "pmid": "" }, { "name": "determination of adult lifespan", "id": "GO:0008340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008340", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "pmid": "" }, { "name": "macromolecule depalmitoylation", "id": "GO:0098734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098734", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprot/Q9W3C7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 240, "end_pos": 242, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19233", "name": "", "equation": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B5DFK7-1", "Q5XIJ5-1", "Q6AY17-1", "P45479-1", "Q5I0K5-1", "P70470-1", "Q9QYL8-1", "Q5VST6-1", "Q6PCB6-1", "Q96GS6-1", "P50897-1", "Q9NUJ1-1", "Q5VWZ2-1", "O95372-1", "O75608-1", "Q99JW1-1", "Q8VCV1-1", "Q7M759-1", "O88531-1", "Q6PE15-1", "Q9WTL7-1", "Q3UFF7-1", "P97823-1", "Q12354-1", "Q54T49-1", "Q55FK4-1", "Q54CM0-1", "Q9W3C7-1" ], "evidence": [ { "id": "19233", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19233" } ] }, { "id": "R-DME-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [], "output_participant_list": [ "R-ALL-6785219" ], "enzyme_list": [ "Q9W3C7-1" ], "evidence": [ { "id": "R-DME-5690517", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5690517" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-6785219", "participant_name": "protein [lysosomal lumen]", "crossref": [ { "id": "36080", "database": "ChEBI", "url": "" }, { "id": "36080", "database": "ChEBI", "url": "" }, { "id": "36080", "database": "ChEBI", "url": "" }, { "id": "36080", "database": "ChEBI", "url": "" }, { "id": "36080", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "B5DFK7", "gene_name": "Abhd17c", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "B5DFK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFK7" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "B5DFK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFK7" } ] } ] }, { "uniprot_ac": "O75608", "gene_name": "LYPLA1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] } ] }, { "uniprot_ac": "O88531", "gene_name": "Ppt1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "O88531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88531" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "O88531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88531" } ] } ] }, { "uniprot_ac": "O95372", "gene_name": "LYPLA2", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] } ] }, { "uniprot_ac": "P45479", "gene_name": "Ppt1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "P45479", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45479" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P45479", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45479" } ] } ] }, { "uniprot_ac": "P50897", "gene_name": "PPT1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "P50897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50897" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P50897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50897" } ] } ] }, { "uniprot_ac": "P70470", "gene_name": "Lypla1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] } ] }, { "uniprot_ac": "P97823", "gene_name": "Lypla1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] } ] }, { "uniprot_ac": "Q12354", "gene_name": "", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q12354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12354" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q12354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12354" } ] } ] }, { "uniprot_ac": "Q3UFF7", "gene_name": "Lyplal1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q3UFF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UFF7" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q3UFF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UFF7" } ] } ] }, { "uniprot_ac": "Q54CM0", "gene_name": "ppt3", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q54CM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54CM0" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q54CM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54CM0" } ] } ] }, { "uniprot_ac": "Q54T49", "gene_name": "", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q54T49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54T49" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q54T49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54T49" } ] } ] }, { "uniprot_ac": "Q55FK4", "gene_name": "", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q55FK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FK4" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q55FK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FK4" } ] } ] }, { "uniprot_ac": "Q5I0K5", "gene_name": "Abhd10", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q5I0K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5I0K5" } ] }, { "ec_number": "3.1.1.93", "activity": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide = D-glucuronate + H(+) + mycophenolate.", "evidence": [ { "id": "Q5I0K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5I0K5" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q5I0K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5I0K5" } ] } ] }, { "uniprot_ac": "Q5VST6", "gene_name": "ABHD17B", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q5VST6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VST6" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q5VST6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VST6" } ] } ] }, { "uniprot_ac": "Q5VWZ2", "gene_name": "LYPLAL1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q5VWZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VWZ2" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q5VWZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VWZ2" } ] } ] }, { "uniprot_ac": "Q5XIJ5", "gene_name": "Abhd17a", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q5XIJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIJ5" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q5XIJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIJ5" } ] } ] }, { "uniprot_ac": "Q6AY17", "gene_name": "Abhd17b", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q6AY17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AY17" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q6AY17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AY17" } ] } ] }, { "uniprot_ac": "Q6PCB6", "gene_name": "ABHD17C", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q6PCB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCB6" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q6PCB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCB6" } ] } ] }, { "uniprot_ac": "Q6PE15", "gene_name": "Abhd10", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q6PE15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PE15" } ] }, { "ec_number": "3.1.1.93", "activity": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide = D-glucuronate + H(+) + 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