{
    "uniprot_canonical_ac": "Q9W2H9-1",
    "uniprot_ac": "Q9W2H9",
    "uniprot_id": "PANX_DROME",
    "mass": {
        "chemical_mass": 61148.0,
        "monoisotopic_mass": 61148.0
    },
    "refseq": {
        "ac": "NP_611576",
        "name": "panoramix",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611576"
    },
    "gene_names": [
        {
            "name": "Panx",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q9W2H9",
            "id": "Q9W2H9"
        },
        {
            "name": "CG9754; Dmel\\CG9754; pan; panx",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611576",
            "id": "NP_611576"
        },
        {
            "name": "CG9754",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9W2H9",
            "id": "Q9W2H9"
        },
        {
            "name": "Panx",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611576",
            "id": "NP_611576"
        }
    ],
    "protein_names": [
        {
            "name": "Protein panoramix",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q9W2H9"
        },
        {
            "name": "CG9754-PA; Panx-PA; silencio",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611576",
            "id": "NP_611576"
        },
        {
            "name": "Protein silencio",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9W2H9"
        },
        {
            "name": "panoramix",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611576",
            "id": "NP_611576"
        }
    ],
    "function": [
        {
            "annotation": "Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:26472911, PubMed:26494711). Required for transcriptional silencing of transposons targeted by piwi and confers its effects by interacting with nascent RNA transcripts (PubMed:26472911, PubMed:26494711). Likely to be recruited to nascent transcripts cotranscriptionally by piwi and to recruit additional factors involved in transcriptional silencing (PubMed:26472911). In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31570835, PubMed:31384064). The interaction with nxf2 stabilizes the nuclear protein complex (PubMed:31384064).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9W2H9",
                    "url": "https://www.uniprot.org/uniprot/Q9W2H9#function"
                },
                {
                    "database": "PubMed",
                    "id": "31384064",
                    "url": "https://glygen.org/publication/PubMed/31384064"
                },
                {
                    "database": "PubMed",
                    "id": "31570835",
                    "url": "https://glygen.org/publication/PubMed/31570835"
                },
                {
                    "database": "PubMed",
                    "id": "31219034",
                    "url": "https://glygen.org/publication/PubMed/31219034"
                },
                {
                    "database": "PubMed",
                    "id": "26494711",
                    "url": "https://glygen.org/publication/PubMed/26494711"
                },
                {
                    "database": "PubMed",
                    "id": "31368590",
                    "url": "https://glygen.org/publication/PubMed/31368590"
                },
                {
                    "database": "PubMed",
                    "id": "26472911",
                    "url": "https://glygen.org/publication/PubMed/26472911"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 328,
            "end_pos": 335,
            "sequence_org": "AELVLEQI",
            "sequence_mut": "DEVDDEQD",
            "comment": "Abolishes interaction with nxf2 and decreases protein stability.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9W2H9",
                    "url": "https://www.uniprot.org/uniprot/Q9W2H9"
                },
                {
                    "database": "PubMed",
                    "id": "31384064",
                    "url": "https://glygen.org/publication/PubMed/31384064"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9W2H9",
                    "url": "https://www.uniprot.org/uniprot/Q9W2H9"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "gene": [
        {
            "name": "Panx",
            "url": "https://www.uniprot.org/uniprot/Q9W2H9",
            "locus": {
                "chromosome": "2R",
                "start_pos": 21310368,
                "end_pos": 21312354,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "FBgn0034617",
                        "url": "https://www.ensembl.org/id/FBgn0034617"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "FBgn0034617",
            "url": "https://bgee.org/?page=gene&gene_id=FBgn0034617",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "FBgn0034617",
            "url": "https://flybase.org/reports/FBgn0034617",
            "database": "FlyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "37434",
            "url": "https://www.ncbi.nlm.nih.gov/gene/37434",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q9W2H9",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9W2H9*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "dme:Dmel_CG9754",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG9754",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "SPICNNM",
            "url": "https://omabrowser.org/oma/group/SPICNNM/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3577474at2759",
            "url": "http://www.orthodb.org/?query=3577474at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "6IEW",
            "url": "https://www.rcsb.org/structure/6IEW",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "6OPF",
            "url": "https://www.rcsb.org/structure/6OPF",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "7K3J",
            "url": "https://www.rcsb.org/structure/7K3J",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "7K3K",
            "url": "https://www.rcsb.org/structure/7K3K",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "7K3L",
            "url": "https://www.rcsb.org/structure/7K3L",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "7MKK",
            "url": "https://www.rcsb.org/structure/7MKK",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "PR_Q9W2H9",
            "url": "http://purl.obolibrary.org/obo/PR_Q9W2H9",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_611576",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611576",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9W2H9",
            "url": "https://www.uniprot.org/uniprot/Q9W2H9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9W2H9-1",
            "url": "https://www.uniprot.org/uniprot/Q9W2H9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MEAPMKLEVKVENYVECGINEDEATPLREGTGETPPHAFACGVPMSGSGWCSDPEDGNLVHHSATPTSDEHLQPSLDTIEPKMEPKIKEDADNAMLDSLLADPFENNSPATLQTPADVKPNAMLDSVEQGSRSCELLPSEFSKRENLDDMDLFSLKAAKTLVPDEQQSFPQNDTPIDDPEAADLIAQKREILKMLEMTAENRKVKHKKKKHKKERSHRSNKHQEESRKRNHSNSSSDEGADDKNQFDCDYRGHKKYKNRRGSASSQNESSKERKLRDTELDYVPVRPDEHFIRPIKFSNLIERRPPQVEFNTVNLSKADKRSLAVARAELVLEQIQQKANKEEPPEFHMVDTICKLPVNESFRNQDCFENPSPICNNMNVVYKFNSTPGTRIDLSKWGLETVPEATKRLLRLLGIDVARLKELQSTVKPSQRILKLKKEQLEQGLAPTEEQETATLYKNAATQTERRTATRDAGTQVRLESKLNGAFWQNPHFDPMNLTQHQSNVMLALQEIYQTLPSATMAVKLSRALAPALAIIKGRQP",
        "length": 541,
        "header": "sp|Q9W2H9-1|PANX_DROME Isoform 1 of Protein panoramix  OS=Drosophila melanogaster OX=7227 GN=Panx PE=1 SV=1 CANONICAL=Q9W2H9-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q9W2H9-1",
            "url": "",
            "sequence": {
                "sequence": "MEAPMKLEVKVENYVECGINEDEATPLREGTGETPPHAFACGVPMSGSGWCSDPEDGNLVHHSATPTSDEHLQPSLDTIEPKMEPKIKEDADNAMLDSLLADPFENNSPATLQTPADVKPNAMLDSVEQGSRSCELLPSEFSKRENLDDMDLFSLKAAKTLVPDEQQSFPQNDTPIDDPEAADLIAQKREILKMLEMTAENRKVKHKKKKHKKERSHRSNKHQEESRKRNHSNSSSDEGADDKNQFDCDYRGHKKYKNRRGSASSQNESSKERKLRDTELDYVPVRPDEHFIRPIKFSNLIERRPPQVEFNTVNLSKADKRSLAVARAELVLEQIQQKANKEEPPEFHMVDTICKLPVNESFRNQDCFENPSPICNNMNVVYKFNSTPGTRIDLSKWGLETVPEATKRLLRLLGIDVARLKELQSTVKPSQRILKLKKEQLEQGLAPTEEQETATLYKNAATQTERRTATRDAGTQVRLESKLNGAFWQNPHFDPMNLTQHQSNVMLALQEIYQTLPSATMAVKLSRALAPALAIIKGRQP",
                "length": 541,
                "header": "sp|Q9W2H9-1|PANX_DROME Isoform 1 of Protein panoramix  OS=Drosophila melanogaster OX=7227 GN=Panx PE=1 SV=1 CANONICAL=Q9W2H9-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 21312072,
                "end_pos": 21310450,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0071615",
                        "url": "https://www.ensembl.org/id/FBtr0071615"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0071541",
                        "url": "https://www.ensembl.org/id/FBpp0071541"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "The genome sequence of Drosophila melanogaster.",
            "journal": "Science",
            "date": "2000",
            "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9W2H9",
                    "url": "https://www.uniprot.org/uniprot/Q9W2H9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10731132",
                    "url": "https://glygen.org/publication/PubMed/10731132"
                }
            ]
        },
        {
            "title": "A Drosophila full-length cDNA resource.",
            "journal": "Genome Biol.",
            "date": "2002",
            "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9W2H9",
                    "url": "https://www.uniprot.org/uniprot/Q9W2H9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12537569",
                    "url": "https://glygen.org/publication/PubMed/12537569"
                }
            ]
        },
        {
            "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.",
            "journal": "Genome Biol.",
            "date": "2002",
            "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9W2H9",
                    "url": "https://www.uniprot.org/uniprot/Q9W2H9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12537572",
                    "url": "https://glygen.org/publication/PubMed/12537572"
                }
            ]
        },
        {
            "title": "The genetic makeup of the Drosophila piRNA pathway.",
            "journal": "Mol. Cell",
            "date": "2013",
            "authors": "Handler D, Meixner K, Pizka M, Lauss K, Schmied C, Gruber FS, Brennecke J",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9W2H9",
                    "url": "https://www.uniprot.org/uniprot/Q9W2H9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23665231",
                    "url": "https://glygen.org/publication/PubMed/23665231"
                }
            ]
        },
        {
            "title": "Panoramix enforces piRNA-dependent cotranscriptional silencing.",
            "journal": "Science",
            "date": "2015",
            "authors": "Gu J., Jin Y., Ma J., Yu Y., Luo Y., Hannon G.J., Preall J.B., Czech B.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9W2H9",
                    "url": "https://www.uniprot.org/uniprot/Q9W2H9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26472911",
                    "url": "https://glygen.org/publication/PubMed/26472911"
                }
            ]
        },
        {
            "title": "Silencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery.",
            "journal": "Genes Dev.",
            "date": "2015",
            "authors": "Tirian L., Batki J., Brennecke J., Doenertas D., Meixner K., Senti K.A., Sienski G.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9W2H9",
                    "url": "https://www.uniprot.org/uniprot/Q9W2H9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26494711",
                    "url": "https://glygen.org/publication/PubMed/26494711"
                }
            ]
        },
        {
            "title": "Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing.",
            "journal": "EMBO J.",
            "date": "2019",
            "authors": "Saito K., Suzuki S., Natsume T., Shibuya A., Ishizu H., Adachi S., Kondo S., Siomi H., Siomi M.C., Iwasaki Y.W., Mashiko A., Murano K.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9W2H9",
                    "url": "https://www.uniprot.org/uniprot/Q9W2H9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31368590",
                    "url": "https://glygen.org/publication/PubMed/31368590"
                }
            ]
        },
        {
            "title": "The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.",
            "journal": "Nat. Struct. Mol. Biol.",
            "date": "2019",
            "authors": "Batki J, Schnabl J, Wang J, Handler D, Andreev VI, Stieger CE, Novatchkova M, Lampersberger L, Kauneckaite K, Xie W, Mechtler K, Patel DJ, Brennecke J",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9W2H9",
                    "url": "https://www.uniprot.org/uniprot/Q9W2H9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31384064",
                    "url": "https://glygen.org/publication/PubMed/31384064"
                }
            ]
        },
        {
            "title": "A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation.",
            "journal": "Nat. Cell Biol.",
            "date": "2019",
            "authors": "Zhao K, Cheng S, Miao N, Xu P, Lu X, Zhang Y, Wang M, Ouyang X, Yuan X, Liu W, Lu X, Zhou P, Gu J, Zhang Y, Qiu D, Jin Z, Su C, Peng C, Wang JH, Dong MQ, Wan Y, Ma J, Cheng H, Huang Y, Yu Y",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9W2H9",
                    "url": "https://www.uniprot.org/uniprot/Q9W2H9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31570835",
                    "url": "https://glygen.org/publication/PubMed/31570835"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "dme:Dmel_CG9754",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG9754",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "positive regulation of DNA methylation-dependent heterochromatin formation",
                        "id": "GO:0090309",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090309",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9W2H9",
                                "url": "https://www.uniprot.org/uniprot/Q9W2H9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of gene expression",
                        "id": "GO:0010629",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9W2H9",
                                "url": "https://www.uniprot.org/uniprot/Q9W2H9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "piRNA-mediated heterochromatin formation",
                        "id": "GO:0140966",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140966",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9W2H9",
                                "url": "https://www.uniprot.org/uniprot/Q9W2H9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "gene silencing by RNA-directed DNA methylation",
                        "id": "GO:0080188",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080188",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9W2H9",
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