{ "uniprot_canonical_ac": "Q9W1X7-1", "uniprot_ac": "Q9W1X7", "uniprot_id": "MED23_DROME", "mass": { "chemical_mass": 167065.0, "monoisotopic_mass": 167065.0 }, "refseq": { "ac": "NP_611735", "name": "mediator complex subunit 23", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611735" }, "gene_names": [ { "name": "MED23", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9W1X7", "id": "Q9W1X7" }, { "name": "CG3695; Dmel\\CG3695; dSUR2; dTRAP150beta; Gal11/SUR2; Med23; Trap150; Trap150beta", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611735", "id": "NP_611735" }, { "name": "CG3695", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W1X7", "id": "Q9W1X7" }, { "name": "MED23", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611735", "id": "NP_611735" }, { "name": "Trap150", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W1X7", "id": "Q9W1X7" } ], "protein_names": [ { "name": "Mediator of RNA polymerase II transcription subunit 23", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9W1X7" }, { "name": "CG3695-PA; MED23-PA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611735", "id": "NP_611735" }, { "name": "Mediator complex subunit 23", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9W1X7" }, { "name": "dSUR2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9W1X7" }, { "name": "dTRAP150", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9W1X7" }, { "name": "mediator complex subunit 23", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611735", "id": "NP_611735" } ], "function": [ { "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for transcriptional activation in response to heat shock.", "evidence": [ { "database": "UniProtKB", "id": "Q9W1X7", "url": "https://www.uniprot.org/uniprot/Q9W1X7#function" }, { "database": "PubMed", "id": "15297616", "url": "https://glygen.org/publication/PubMed/15297616" } ] } ], "disease": [ { "disease_id": "DOID:0081190", "recommended_name": { "id": "DOID:0081190", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0081190", "name": "autosomal recessive intellectual developmental disorder 18", "description": "An autosomal recessive intellectual developmental disorder that is characterized by impaired intellectual development with or without epilepsy and that has_material_basis_in homozygous or compound heterozygous mutation in the MED23 gene on chromosome 6q23." }, "synonyms": [ { "id": "MONDO:0013651", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013651", "name": "intellectual disability, autosomal recessive 18", "description": "Any autosomal recessive non-syndromic intellectual disability in which the cause of the disease is a mutation in the MED23 gene." }, { "id": "MONDO:0013651", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013651", "name": "MED23 autosomal recessive non-syndromic intellectual disability", "description": "" }, { "id": "MONDO:0013651", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013651", "name": "autosomal recessive non-syndromic intellectual disability caused by mutation in MED23", "description": "" }, { "id": "MONDO:0013651", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013651", "name": "intellectual developmental disorder, autosomal recessive 18, with or without epilepsy", "description": "" }, { "id": "MONDO:0013651", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013651", "name": "intellectual disability, autosomal recessive 18", "description": "" }, { "id": "MONDO:0013651", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013651", "name": "intellectual disability, autosomal recessive type 18", "description": "" }, { "id": "MONDO:0013651", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013651", "name": "mental retardation, autosomal recessive type 18", "description": "" }, { "id": "MONDO:0013651", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013651", "name": "MED23", "description": "" }, { "id": "MONDO:0013651", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013651", "name": "MRT18", "description": "" }, { "id": "MONDO:0013651", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013651", "name": "autosomal recessive nonsyndromic intellectual disability-18", "description": "" }, { "id": "MONDO:0013651", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013651", "name": "autosomal recessive nonsyndromic mental retardation-18", "description": "" }, { "id": "MONDO:0013651", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013651", "name": "mental retardation, autosomal recessive 18", "description": "" }, { "id": "MIM:614249", "resource": "MIM", "url": "https://www.omim.org/entry/614249", "name": "Intellectual developmental disorder, autosomal recessive 18, with or without epilepsy", "description": "Intellectual developmental disorder, autosomal recessive 18, with or without epilepsy" } ], "evidence": [ { "id": "0081190", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0081190" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9W1X7", "url": "https://www.uniprot.org/uniprot/Q9W1X7" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "MED23", "url": "https://www.uniprot.org/uniprot/Q9W1X7", "locus": { "chromosome": "2R", "start_pos": 22894425, "end_pos": 22888928, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0034795", "url": "https://www.ensembl.org/id/FBgn0034795" } ] } } ], "crossref": [ { "id": "FBgn0034795", "url": "https://bgee.org/?page=gene&gene_id=FBgn0034795", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0034795", "url": "https://flybase.org/reports/FBgn0034795", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "37639", "url": "https://www.ncbi.nlm.nih.gov/gene/37639", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG3695", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG3695", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WVWLHLS", "url": "https://omabrowser.org/oma/group/WVWLHLS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2899461at2759", "url": "http://www.orthodb.org/?query=2899461at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12691", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12691", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12691:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12691:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11573", "url": "http://pfam.xfam.org/family/PF11573", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9W1X7", "url": "http://purl.obolibrary.org/obo/PR_Q9W1X7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_611735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611735", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9W1X7", "url": "https://www.uniprot.org/uniprot/Q9W1X7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9W1X7-1", "url": "https://www.uniprot.org/uniprot/Q9W1X7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METQVIDTVNEFLKVDSLDEAFVSVIVFKPNTEQERATRFANDLVTAFGNVAQENREQVLRLYLLRAAGASGYHIKVLMAALVKLVDAHVITARMLCDKVLMCEKLDFEHRTFWIESFRLIKRVIVQVDYKGVREIMKVCRDKAQWFPLNVNVTYMPQLLAVEDILRFIFDRNNCLLPAYFIANEIMRPFPYHWKLNRLMTDFVEEFRTTAQMVSIIGHASMLPIVEHFGYADHMMNSWRLDHNTLKFNFKGSLPYEPELLEEQKPLLRYVLEQPYSREMVSQMLNLQKHQKQRYNALEEQLVNLIVQAMEMTEANDATAGSGFNSSDEQITPYEWMWLHLSSQLIYFVLFQFVSFMHIVLALHEKLSKLELRKGRDQLMWILLQFISGSIQKNPITNFLPVFRLFDLLYPELEPLKLPDINKSSMVRHMAPICVWIHLMKKARVENMNITRPLPIALKNHYDFLQHLVTANTMMNMTLGNDFRIILICNAYSTNQEYFGRPMGLLLDALNGTSKSPNGGQIPAVTFSVTVLDSLTVHSKMSLIHSFVTQMLKQAQSKGQVPAAALLETYARLLVYTEIESLGIKGFLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRVQLLSLLHSLSSVPQTNKMQLNLCFESTALRLITSIGSAEFQPQFSRYFNDKSPGAVASNESEELNRVLILTLARSMHVHGGGDEMQGWCKDFLSNIIQHTPHSWPMHSLACFPPALNEYFTQNNQPPENKQQLKKAVEEEYRTWTSMTNENDIIAHFLRPTTNPLFLCLLFKIIWETENISPVAYKILEGISARALSTHLRKFCDYLVAEVASSSDGRDFIHKCVDTINNMIWKFNVVTIDRVVLCLALRTHEGNEAQVCFLIIQLLLLKASELRNRVQEFCKDNNPDHWKQSNWQDKHLSFHQKYPEKFALDESASQIPLPVYFSNVCLRFLPVLDVVVHRFIELTITNVHQILGFILDHLSILYKFHDRPITYLYNTLHYYERILRDRPALKKKLVGAITSAFSEIRPPNWSVSEPYKVYLQSQDSLWTPELSYYMSLIRRLADTISGKNVFYSTDWRFNEFPNAPTHALYVTCVELLGLPVAPPLVASNLIDVIVSGYAVIPQKDIHSYINAVGIVLAALPEPYWSGIYDRLQDMLNTPNMLNWTYRFNAFELFNFKTVREAMLEKTYAVVLAVAHSVFHHMGAFKLAAMTRYLKEKLKPCVRTEQQLLYLCHVFGPFLQRIELEKPNAVAGIAVLLYEILEIVDKHHGPKPLQYMDQICDFLYHIKYIHVGNIIKNESEAIIKRLRPLLQMRLRFITHLNLEDIHTEKINDNTSNNAITSQTQSPMQTQHQQQPQQPHQQQQQQQQQQQQQQQQQQQQQQMQQQQINAVQTTSVPLGSGGNLQQQQQINQQQQMYMQHMQQHQHMQNMRHN", "length": 1439, "header": "sp|Q9W1X7-1|MED23_DROME Isoform 1 of Mediator of RNA polymerase II transcription subunit 23 OS=Drosophila melanogaster OX=7227 GN=MED23 PE=1 SV=1 CANONICAL=Q9W1X7-1" }, "isoforms": [ { "isoform_ac": "Q9W1X7-1", "url": "", "sequence": { "sequence": "METQVIDTVNEFLKVDSLDEAFVSVIVFKPNTEQERATRFANDLVTAFGNVAQENREQVLRLYLLRAAGASGYHIKVLMAALVKLVDAHVITARMLCDKVLMCEKLDFEHRTFWIESFRLIKRVIVQVDYKGVREIMKVCRDKAQWFPLNVNVTYMPQLLAVEDILRFIFDRNNCLLPAYFIANEIMRPFPYHWKLNRLMTDFVEEFRTTAQMVSIIGHASMLPIVEHFGYADHMMNSWRLDHNTLKFNFKGSLPYEPELLEEQKPLLRYVLEQPYSREMVSQMLNLQKHQKQRYNALEEQLVNLIVQAMEMTEANDATAGSGFNSSDEQITPYEWMWLHLSSQLIYFVLFQFVSFMHIVLALHEKLSKLELRKGRDQLMWILLQFISGSIQKNPITNFLPVFRLFDLLYPELEPLKLPDINKSSMVRHMAPICVWIHLMKKARVENMNITRPLPIALKNHYDFLQHLVTANTMMNMTLGNDFRIILICNAYSTNQEYFGRPMGLLLDALNGTSKSPNGGQIPAVTFSVTVLDSLTVHSKMSLIHSFVTQMLKQAQSKGQVPAAALLETYARLLVYTEIESLGIKGFLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRVQLLSLLHSLSSVPQTNKMQLNLCFESTALRLITSIGSAEFQPQFSRYFNDKSPGAVASNESEELNRVLILTLARSMHVHGGGDEMQGWCKDFLSNIIQHTPHSWPMHSLACFPPALNEYFTQNNQPPENKQQLKKAVEEEYRTWTSMTNENDIIAHFLRPTTNPLFLCLLFKIIWETENISPVAYKILEGISARALSTHLRKFCDYLVAEVASSSDGRDFIHKCVDTINNMIWKFNVVTIDRVVLCLALRTHEGNEAQVCFLIIQLLLLKASELRNRVQEFCKDNNPDHWKQSNWQDKHLSFHQKYPEKFALDESASQIPLPVYFSNVCLRFLPVLDVVVHRFIELTITNVHQILGFILDHLSILYKFHDRPITYLYNTLHYYERILRDRPALKKKLVGAITSAFSEIRPPNWSVSEPYKVYLQSQDSLWTPELSYYMSLIRRLADTISGKNVFYSTDWRFNEFPNAPTHALYVTCVELLGLPVAPPLVASNLIDVIVSGYAVIPQKDIHSYINAVGIVLAALPEPYWSGIYDRLQDMLNTPNMLNWTYRFNAFELFNFKTVREAMLEKTYAVVLAVAHSVFHHMGAFKLAAMTRYLKEKLKPCVRTEQQLLYLCHVFGPFLQRIELEKPNAVAGIAVLLYEILEIVDKHHGPKPLQYMDQICDFLYHIKYIHVGNIIKNESEAIIKRLRPLLQMRLRFITHLNLEDIHTEKINDNTSNNAITSQTQSPMQTQHQQQPQQPHQQQQQQQQQQQQQQQQQQQQQQMQQQQINAVQTTSVPLGSGGNLQQQQQINQQQQMYMQHMQQHQHMQNMRHN", "length": 1439, "header": "sp|Q9W1X7-1|MED23_DROME Isoform 1 of Mediator of RNA polymerase II transcription subunit 23 OS=Drosophila melanogaster OX=7227 GN=MED23 PE=1 SV=1 CANONICAL=Q9W1X7-1" }, "locus": { "chromosome": "2R", "start_pos": 22894146, "end_pos": 22889014, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0071903", "url": "https://www.ensembl.org/id/FBtr0071903" }, { "database": "Ensembl Peptide", "id": "FBpp0071814", "url": "https://www.ensembl.org/id/FBpp0071814" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q9W1X7", "url": "https://www.uniprot.org/uniprot/Q9W1X7" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q9W1X7", "url": "https://www.uniprot.org/uniprot/Q9W1X7" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2004", "authors": "Kim J.M., Kim T.W., Song Y.-H., Kim Y.-J., Kim S.N., Kwon Y.-J.", "evidence": [ { "database": "UniProtKB", "id": "Q9W1X7", "url": "https://www.uniprot.org/uniprot/Q9W1X7" } ], "reference": [ { "type": "PubMed", "id": "15297616", "url": "https://glygen.org/publication/PubMed/15297616" } ] } ], "pathway": [ { "id": "dme:Dmel_CG3695", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG3695", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9ULK4-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 23", "gene_name": "MED23", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAMNSGSPAPQSNQVPVSLPVTQ", 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