{ "uniprot_canonical_ac": "Q9W060-1", "uniprot_ac": "Q9W060", "uniprot_id": "LYST_DROME", "mass": { "chemical_mass": 399853.0, "monoisotopic_mass": 399853.0 }, "refseq": { "ac": "NP_647681", "name": "mauve", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647681" }, "gene_names": [ { "name": "mv", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9W060", "id": "Q9W060" }, { "name": "CG11814; CG42863; CG5691; Dmel\\CG42863; fs(3)ros; ros", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647681", "id": "NP_647681" }, { "name": "CG11814", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W060", "id": "Q9W060" }, { "name": "CG42863", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W060", "id": "Q9W060" }, { "name": "CG5691", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9W060", "id": "Q9W060" }, { "name": "mv", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647681", "id": "NP_647681" } ], "protein_names": [ { "name": "Lysosomal-trafficking regulator", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9W060" }, { "name": "CG42863-PB; mv-PB; rosario", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647681", "id": "NP_647681" }, { "name": "Mauve protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9W060" }, { "name": "mauve", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647681", "id": "NP_647681" } ], "function": [ { "annotation": "Adapter protein that regulates intracellular membrane fusion reactions (By similarity) (PubMed:33725482). Regulates the fusion of lysosome-related organelles (PubMed:33725482). Promotes microtubules nucleation and centrosomal recruitment of microtubule nucleating proteins such as msps (PubMed:33725482). In syncytial embryos, during the formation of yolk granules, suppresses vesicle fusion events with lipid droplets, possibly via interaction with Rab5 (PubMed:33725482). In the eye, regulates pigment granules size (PubMed:22934826). In hemocytes, required for the late steps of bacteria phagocytosis (PubMed:22934826). In fat body, required for autophagosome maturation (PubMed:22934826).", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060#function" }, { "database": "UniProtKB", "id": "Q99698", "url": "https://www.uniprot.org/uniprot/Q99698#function" }, { "database": "PubMed", "id": "33725482", "url": "https://glygen.org/publication/PubMed/33725482" }, { "database": "PubMed", "id": "22934826", "url": "https://glygen.org/publication/PubMed/22934826" } ] } ], "disease": [ { "disease_id": "DOID:2935", "recommended_name": { "id": "DOID:2935", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2935", "name": "Chediak-Higashi syndrome", "description": "A syndrome characterized by oculocutaneous albinism, immune deficiency, coagulation deficiency and neuropathy and that has_material_basis_in homozygous or compound heterozygous mutation in the lysosomal trafficking regulator gene (LYST) on chromosome 1q42." }, "synonyms": [ { "id": "DOID:2935", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2935", "name": "CHS", "description": "" }, { "id": "DOID:2935", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2935", "name": "Chediak - Steinbrinck anomaly", "description": "" }, { "id": "MONDO:0008963", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008963", "name": "Chediak-Higashi syndrome", "description": "ChC)diak-Higashi syndrome (CHS) is a rare severe genetic disorder generally characterized by partial oculocutaneous albinism (OCA), severe immunodeficiency, mild bleeding, neurological dysfunction and lymphoproliferative disorder. A classic, early-onset form and an attenuated, later-onset form (Atypical CHS) have been described." }, { "id": "MONDO:0008963", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008963", "name": "CHS", "description": "" }, { "id": "MONDO:0008963", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008963", "name": "ChC)diak-Higashi disease", "description": "" }, { "id": "MONDO:0008963", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008963", "name": "ChC)diak-Higashi-Steinbrink syndrome", "description": "" }, { "id": "MONDO:0008963", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008963", "name": "Chediak - Steinbrinck anomaly", "description": "" }, { "id": "MONDO:0008963", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008963", "name": "Chediak-Higashi syndrome", "description": "" }, { "id": "MONDO:0008963", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008963", "name": "Chdiak-Higashi disease", "description": "" }, { "id": "MONDO:0008963", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008963", "name": "Chdiak-Higashi-Steinbrink syndrome", "description": "" }, { "id": "MONDO:0008963", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008963", "name": "Chediak Higashi syndrome", "description": "" }, { "id": "MONDO:0008963", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008963", "name": "Chdiak-Higashi syndrome", "description": "" }, { "id": "MIM:214500", "resource": "MIM", "url": "https://www.omim.org/entry/214500", "name": "Chediak-Higashi syndrome", "description": "Chediak-Higashi syndrome" } ], "evidence": [ { "id": "2935", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2935" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 2772, "end_pos": 3535, "sequence_org": "WKIMREVFCDKIVATPDQSKVIAITQQWREGLLTNWEYLMTLNQISGRTYNDLMQYPVFPWVLANYNSEVLDLREGHNFRRLGRPIAVQVEENEKHYISNYTYIDSTNTTMGSLILKPYHYSSHYSNSGTVLHFLVRVPPFTSYFLRYQDNDFDLPDRTFHALNTTWLLASRDSPTDVKELIPEFFCLPEMFENFERFKFGCRQNGERVEDVSLPPWSQRDSRLFVLIHRQALESELVRNQIHNWIDLIFGYKQSGESAVEAINVFHPATYAVFLDSEISDPIEREAVKTMVKTYGQMPRQLFKSPHPASKPLDYSLVGKPIVSTVRGLRWGVYVGSPQLKAPSWANIHKIPGTEHLVSFCNTNVVYALPGRASVMQGAEPDTYNVISWGYDDRIVRIQPLNKPQAKPKNLLHNGTFDDITACGCDVNSNQLWFGHKSGRISVYKCTGGLDSQQRASAKSRQSYARGFSLSYNSAFRKMTNKGIGGGGSERVDEAGNLHPTSSASSVNSSSISSGGDAFQRDGADLNWLGPTLLVRHTDEITCITLSVEFKIAVTAGRDGIAVIWDLNDWSYVRTIARPAEIHQSPITHVAISPTLGDIVTVHTLPQSCNTSTDPKPTAVATRPNSLNVADECFEVTEENLDDFVNVNVNPNGKSILRLHSVNARYVQHLVHEDRILAVCYSYIKEGVGVNVIATAVEGGFVRFWSSWNLSFVSELTTGTSPIRSICYSTHQHLVVLTRESHIQVWESEGLYGNAPKFPQIVYK", "sequence_mut": "", "comment": "Results in eye color defects caused by oversized pigment granules; when associated with 3160-W--K-3535.", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" }, { "database": "PubMed", "id": "22934826", "url": "https://glygen.org/publication/PubMed/22934826" } ] }, { "start_pos": 3160, "end_pos": 3535, "sequence_org": "WGYDDRIVRIQPLNKPQAKPKNLLHNGTFDDITACGCDVNSNQLWFGHKSGRISVYKCTGGLDSQQRASAKSRQSYARGFSLSYNSAFRKMTNKGIGGGGSERVDEAGNLHPTSSASSVNSSSISSGGDAFQRDGADLNWLGPTLLVRHTDEITCITLSVEFKIAVTAGRDGIAVIWDLNDWSYVRTIARPAEIHQSPITHVAISPTLGDIVTVHTLPQSCNTSTDPKPTAVATRPNSLNVADECFEVTEENLDDFVNVNVNPNGKSILRLHSVNARYVQHLVHEDRILAVCYSYIKEGVGVNVIATAVEGGFVRFWSSWNLSFVSELTTGTSPIRSICYSTHQHLVVLTRESHIQVWESEGLYGNAPKFPQIVYK", "sequence_mut": "", "comment": "Results in eye color defects caused by oversized pigment granules; when associated with 2772-W--K-3535.", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" }, { "database": "PubMed", "id": "22934826", "url": "https://glygen.org/publication/PubMed/22934826" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "mv", "url": "https://www.uniprot.org/uniprot/Q9W060", "locus": { "chromosome": "3L", "start_pos": 1950306, "end_pos": 1964178, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0288310", "url": "https://www.ensembl.org/id/FBgn0288310" } ] } } ], "crossref": [ { "id": "FBgn0265988", "url": "https://bgee.org/?page=gene&gene_id=FBgn0265988", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06071", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06071", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "FBgn0288310", "url": "https://flybase.org/reports/FBgn0288310", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "38259", "url": "https://www.ncbi.nlm.nih.gov/gene/38259", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9W060", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9W060*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023362", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023362", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG42863", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG42863", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RDFNMEQ", "url": "https://omabrowser.org/oma/group/RDFNMEQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "47483at2759", "url": "http://www.orthodb.org/?query=47483at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13743", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13743", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13743:SF147", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13743:SF147", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02138", "url": "http://pfam.xfam.org/family/PF02138", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9W060", "url": "http://purl.obolibrary.org/obo/PR_Q9W060", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_647681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647681", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9W060-1", "url": "https://www.uniprot.org/uniprot/Q9W060-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGMEVKEKEEQLLLDTLIGLWSQYLQASELEDASVKDHWLWLLLYNLQFLDDKNLQDAWLNSHFNLMPEELCSYLLEQVYQIISEAKRSQESSPTHEPEQQDKCIKQLRKQHNLAQLILSTPSDCNKILALRTFLTDKLGHHLLTFLLRVDIKLIASQKSLCHLCINLFPNCKWSASNEQLIPMTSIAQFIGSFYLNSQSKKLRRQQQPKSQLPNHISNPIKSSFEDFRGTTRSSDELALLLIQLLTRCVDAEQESQLSVTVHNFALGHLCSSSEQDASGNNDELIKFELLQLIAHCVNNFYVLEQQQPNVHDFNSNFGQLLYALTANRRSPLLAHGVLYIMFGTLHNLVDNGVRELNQIDVRNFDACFEVLQEAAKSTNFSTAIFLHIYKMLLRLTDNLSSQEQHLQSLMESSASTAMPKQQQHPRHKRQRSSQLHCLGATSLSCYFQGKLYHLLPSLEAELQEHSVRSLLRTGSCCCHYNVRNYATCLQLATQLSSSYQKCAYKFLHYNVLHTIFVKRNPQGCPGCEDKLKSPVFHMDLLNIYKDNYKALLNTPAMLLFLKHLKHIAYLLPYDLASGILAEVALPIFRRYKELIESGESKRKISKVTPLQLPSKLENYRALHECLSIFVMYLSDIRLVKAFYNEENIRYMQDLLIIPELQRGVCDLIKVGIDNIAFLGENSQEQITLSRRLIQLQLNSSDRASQLFQALLYKCSKHSRAKFWLDESSTPAKLEGHKPADILYITALQWTLNFELLKTSQLFYNEFAKIYSIPVEMLDDEDEDEVETPTSELLPGEKKLRHGDKNIFDILKLNYNALGCFLMLPKATMGPTTSSTATTPTAGICGSSSLETLVSQLPLAGSTSVSVTTAASSDYADSTLDYASVIGNYDSYSRDMATPSFLQQLLACEPDESTVLFDIRGSQSSKDNPSNSLILPSEEEGATADGIINKLFSIVGSLFGGSPGSGGSANSPTRANIDADFFCLYEPNGECKKLLLKLFEATMAICIKGFQNEEVEKMQKHLRKLRAIILSHATDNWSEHGEQHARDNAVIQTLQTLLKIAELSSTHQEPTGVVNSPSGDSQQPRPRARSFNSGSVELPRLQTVKLPAKNSLATPPTPRRRPNSSEANAGVDADYFSTRASLSCAADSELELSENEHEFYLTADEGYEADGEIADLSESECELNGGVLAANESTWTPFQPSSRYRSHIMHQGLSQLVVQMLAELSLLCIKQPNGWTESLTQLANRLFVIRDYLGGPLCLLKGFAPILSCSDPRLRELQQSILELVTHLNTPEVLQCYYSILASKQPPVDLLMRHMHHISSGSLRKAQPCMELDFPIITDGKIVVTSEPLVSEQIERVRLHHQQCQTNTLFTRAACIFPVTQTRLWQPDGLTLSLWLELRGQQMHRSSMQFNDDETRYSGEDLTKLHLLSLGTNQAMVSIYISNNMQLIFELVKPNEQLAPVRVEEQIEANADTASVISANTQAANGGTIRQALKQTKLALLNSFGQMHLLNGHQASADSTGGYFESSAVQLQHLRLPRHKWMHLVFGLQQQADSVEISIFLDGLEQHTMRLPFRNLRQLTRVHSFQLLALGEGQPTGRSPGSSSSSRSTLDGSTPRYALSNVILFKRRLVDPLLMMNLTAMGPDFTEFTQCQVANWKPNYGFVSLGKLSSSNFGNHLDCMRQLRQARVLVYTAQQPDLVMSYDASQELDMACYGQPHGHMLYGELQQHQAQTLQAATSLSGGLSTLLYLFARIVELTGNASTQALALDLLLQVAHSDAQLYTEFQRQDYLSLIGYVIKSEKCSKDVQLLRSIVNNACSQVLITRKGDSINVNDNTMATLVYPRLMLTVLQRYSDWHRSGATHSDVLDMLFRCILALTRDKHPQRDFNMEQLQKCGLLGALLNLCKVYVIESPSPVQISPYAAECFVQILAVFSGSPPDSSMLDEIMKLLLLLHKPSDCYVTHDRTHFYFLLTAQQPTKERSLVAANLSRVTTSLRRQLHPQPQELDPERAERIKKLRRLHASTSGYRKAVNEFEEHLDQMADCSNLNKSALRLLSPVEATRWRLKFKRRHPTSANSPKRSPLKIARRRIHPHLHLGKIWQPSGHSTPSSGQSSLPNRKTDFYDQLGIIRLQQRLLILLKDFLCLLPDSSVDVVTRHYVKLELLLVLANQRSCAVRQAIIQLVDVLTKRLPSGELNAATKLMHPLHLANQLTIHGCDVGMFEACLAWINGMHCSLTDIQSCDAPVRIRQRFGLPSLLAIAEGTEPQWVFKALLRLYLQNPDDQTCLIEAGLLQCSVKALYKIYSLRVGQSNADESVVELLATIGERAMRSVGQINLVWDILNLLSFYQDKQPQLIMRSFRTAQAQLQLEWLTKFFEPNSFRVAVTNDSSLSHSELRTRVELLIDRCTQFFTVGVGQTTGPNYVASSQELALFQLLVSYGISSNQRCNNFIAWGLQPSRPRDLRSYIVDALWRSQQDEFQRAIICDAKMIKALLWLSLLEDMPEPIENLKPLCDALGIKENDSSWNLVHELDRLDQNRNNMAAKQKTLLEKTVYRFEPLVQQCVESSMVTTRKVAELQNAERKALMCHMKVYDDTYTYTKWLEIIRRMTHEGAPWHSAERAECSWELDDTEGPSRVHTRLRRCHLDIDRRFFMNEYRPGQGHREDLEPYVRPLDYLIASYDQQLNISLNSQILYNFAAKFLPVDGEIEGEIIITDLKLYFLATYRCRYFNVNCDIANITEIWLKRYQHQETAFEILLDTNKSLFFSLQNADDWKIMREVFCDKIVATPDQSKVIAITQQWREGLLTNWEYLMTLNQISGRTYNDLMQYPVFPWVLANYNSEVLDLREGHNFRRLGRPIAVQVEENEKHYISNYTYIDSTNTTMGSLILKPYHYSSHYSNSGTVLHFLVRVPPFTSYFLRYQDNDFDLPDRTFHALNTTWLLASRDSPTDVKELIPEFFCLPEMFENFERFKFGCRQNGERVEDVSLPPWSQRDSRLFVLIHRQALESELVRNQIHNWIDLIFGYKQSGESAVEAINVFHPATYAVFLDSEISDPIEREAVKTMVKTYGQMPRQLFKSPHPASKPLDYSLVGKPIVSTVRGLRWGVYVGSPQLKAPSWANIHKIPGTEHLVSFCNTNVVYALPGRASVMQGAEPDTYNVISWGYDDRIVRIQPLNKPQAKPKNLLHNGTFDDITACGCDVNSNQLWFGHKSGRISVYKCTGGLDSQQRASAKSRQSYARGFSLSYNSAFRKMTNKGIGGGGSERVDEAGNLHPTSSASSVNSSSISSGGDAFQRDGADLNWLGPTLLVRHTDEITCITLSVEFKIAVTAGRDGIAVIWDLNDWSYVRTIARPAEIHQSPITHVAISPTLGDIVTVHTLPQSCNTSTDPKPTAVATRPNSLNVADECFEVTEENLDDFVNVNVNPNGKSILRLHSVNARYVQHLVHEDRILAVCYSYIKEGVGVNVIATAVEGGFVRFWSSWNLSFVSELTTGTSPIRSICYSTHQHLVVLTRESHIQVWESEGLYGNAPKFPQIVYK", "length": 3535, "header": "sp|Q9W060-1|LYST_DROME Isoform 1 of Lysosomal-trafficking regulator OS=Drosophila melanogaster OX=7227 GN=mv PE=1 SV=2 CANONICAL=Q9W060-1" }, "isoforms": [ { "isoform_ac": "Q9W060-1", "url": "", "sequence": { "sequence": 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"length": 3535, "header": "sp|Q9W060-1|LYST_DROME Isoform 1 of Lysosomal-trafficking regulator OS=Drosophila melanogaster OX=7227 GN=mv PE=1 SV=2 CANONICAL=Q9W060-1" }, "locus": { "chromosome": "3L", "start_pos": 1962913, "end_pos": 1950582, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0304060", "url": "https://www.ensembl.org/id/FBtr0304060" }, { "database": "Ensembl Peptide", "id": "FBpp0293022", "url": "https://www.ensembl.org/id/FBpp0293022" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "Drosophila mauve mutants reveal a role of LYST homologs late in the maturation of phagosomes and autophagosomes.", "journal": "Traffic", "date": "2012", "authors": "Rahman M, Haberman A, Tracy C, Ray S, Kramer H", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" } ], "reference": [ { "type": "PubMed", "id": "22934826", "url": "https://glygen.org/publication/PubMed/22934826" } ] }, { "title": "Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins.", "journal": "Dev. Cell", "date": "2021", "authors": "Glover D.M., Llamazares S., Rangone H., Lattao R.", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" } ], "reference": [ { "type": "PubMed", "id": "33725482", "url": "https://glygen.org/publication/PubMed/33725482" } ] } ], "pathway": [ { "id": "dme:Dmel_CG42863", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG42863", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" } ], "pmid": "" }, { "name": "vesicle", "id": "GO:0031982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031982", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" } ], "pmid": "" }, { "name": "phagocytosis", "id": "GO:0006909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" } ], "pmid": "" }, { "name": "positive regulation of microtubule nucleation", "id": "GO:0090063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090063", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" } ], "pmid": "" }, { "name": "negative regulation of vesicle fusion", "id": "GO:0031339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031339", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" } ], "pmid": "" }, { "name": "negative regulation of autophagosome size", "id": "GO:0045771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045771", "evidence": [ { "database": "UniProtKB", "id": "Q9W060", "url": "https://www.uniprot.org/uniprot/Q9W060" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1037, "end_pos": 1039, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1124, "end_pos": 1126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1192, "end_pos": 1194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1638, "end_pos": 1640, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1760, "end_pos": 1762, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1987, "end_pos": 1989, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2048, "end_pos": 2050, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2386, "end_pos": 2388, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2520, "end_pos": 2522, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2684, "end_pos": 2686, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2736, "end_pos": 2738, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2759, "end_pos": 2761, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2871, "end_pos": 2873, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2879, "end_pos": 2881, "annotation": "n_glycosylation_sequon" 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