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"isoform_ac": "Q9VUJ1-1", "url": "", "sequence": { "sequence": "MDLDNARDLPRAGFNFDNCKRNATLLNRGFKPPTTTKTGTTIVGIIYKDGVILGADTRATEGPIVSDKNCAKIHYLAKNIYCCGAGTAADTEMTTDLISSQLELHRLQTDREVRVVAANTMLKQMLFRYQGHISAALVLGGVDKTGPHIYSIHPHGSSDKLPYATMGSGSLAAMTVFESRWKPDLSEEEGKKLVRDAIASGVFNDLGSGSNIDLCVIRKGSVEYLRNYELANKKGKRQLDYRFKTGTSTVLHTNIKDLLVTERVQAVPMEIS", "length": 272, "header": "tr|Q9VUJ1-1|Q9VUJ1_DROME Isoform 1 of Proteasome subunit beta OS=Drosophila melanogaster OX=7227 GN=Prosbeta2 PE=1 SV=1 CANONICAL=Q9VUJ1-1" }, "locus": { "chromosome": "3L", "start_pos": 15001218, "end_pos": 15000068, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0075629", "url": "https://www.ensembl.org/id/FBtr0075629" }, { "database": "Ensembl Peptide", "id": "FBpp0075382", "url": "https://www.ensembl.org/id/FBpp0075382" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.", "journal": "Cell", "date": "1999", "authors": "Methot N, Basler K", "evidence": [ { "database": "Reactome", "id": "R-DME-209360", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-209360" } ], "reference": [ { "type": "PubMed", "id": "10102270", "url": "https://glygen.org/publication/PubMed/10102270" } ] }, { "title": "Light-dependent sequestration of TIMELESS by CRYPTOCHROME.", "journal": "Science (New York, N.Y.)", "date": "1999", "authors": "Ceriani MF, Darlington TK, Staknis D, Mas P, Petti AA, Weitz CJ, Kay SA", "evidence": [ { "database": "Reactome", "id": "R-DME-432395", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-432395" } ], "reference": [ { "type": "PubMed", "id": "10417378", "url": "https://glygen.org/publication/PubMed/10417378" } ] }, { "title": "Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression.", "journal": "Cell", "date": "1999", "authors": "Chen CH, von Kessler DP, Park W, Wang B, Ma Y, Beachy PA", "evidence": [ { "database": "Reactome", "id": "R-DME-209360", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-209360" } ], "reference": [ { "type": "PubMed", "id": "10458606", "url": "https://glygen.org/publication/PubMed/10458606" } ] }, { "title": "A role for the proteasome in the light response of the timeless clock protein.", "journal": "Science (New York, N.Y.)", "date": "1999", "authors": "Naidoo N, Song W, Hunter-Ensor M, Sehgal A", "evidence": [ { "database": "Reactome", "id": "R-DME-432395", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-432395" } ], "reference": [ { "type": "PubMed", "id": "10481010", "url": "https://glygen.org/publication/PubMed/10481010" } ] }, { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q9VUJ1", "url": "https://www.uniprot.org/uniprot/Q9VUJ1" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Photic signaling by cryptochrome in the Drosophila circadian system.", "journal": "Molecular and cellular biology", "date": "2001", "authors": "Lin FJ, Song W, Meyer-Bernstein E, Naidoo N, Sehgal A", "evidence": [ { "database": "Reactome", "id": "R-DME-432395", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-432395" } ], "reference": [ { "type": "PubMed", "id": "11585911", "url": "https://glygen.org/publication/PubMed/11585911" } ] }, { "title": "Degrading Ci: who is Cul-pable?", "journal": "Genes & development", "date": "2002", "authors": "Jiang J", "evidence": [ { "database": "Reactome", "id": "R-DME-209360", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-209360" } ], "reference": [ { "type": "PubMed", "id": "12231619", "url": "https://glygen.org/publication/PubMed/12231619" } ] }, { "title": "The F-box protein slimb controls the levels of clock proteins period and timeless.", "journal": "Nature", "date": "2002", "authors": "Grima B, Lamouroux A, Chelot E, Papin C, Limbourg-Bouchon B, Rouyer F", "evidence": [ { "database": "Reactome", "id": "R-DME-432524", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-432524" } ], "reference": [ { "type": "PubMed", "id": "12432393", "url": "https://glygen.org/publication/PubMed/12432393" } ] }, { "title": "Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime.", "journal": "Nature", "date": "2002", "authors": "Ko HW, Jiang J, Edery I", "evidence": [ { "database": "Reactome", "id": "R-DME-432524", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-432524" } ], "reference": [ { "type": "PubMed", "id": "12442174", "url": "https://glygen.org/publication/PubMed/12442174" } ] }, { "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.", "journal": "Genome Biol.", "date": "2002", "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM", "evidence": [ { "database": "UniProtKB", "id": "Q9VUJ1", "url": "https://www.uniprot.org/uniprot/Q9VUJ1" } ], "reference": [ { "type": "PubMed", "id": "12537568", "url": "https://glygen.org/publication/PubMed/12537568" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q9VUJ1", "url": "https://www.uniprot.org/uniprot/Q9VUJ1" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.", "journal": "Genome Biol.", "date": "2002", "authors": "Kaminker JS, Bergman CM, Kronmiller B, Carlson J, Svirskas R, Patel S, Frise E, Wheeler DA, Lewis SE, Rubin GM, Ashburner M, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "Q9VUJ1", "url": "https://www.uniprot.org/uniprot/Q9VUJ1" } ], "reference": [ { "type": "PubMed", "id": "12537573", "url": "https://glygen.org/publication/PubMed/12537573" } ] }, { "title": "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.", "journal": "Genome Biol.", "date": "2002", "authors": "Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, Kaminker JS, Kennedy C, Mungall CJ, Sullivan BA, Sutton GG, Yasuhara JC, Wakimoto BT, Myers EW, Celniker SE, Rubin GM, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "Q9VUJ1", "url": "https://www.uniprot.org/uniprot/Q9VUJ1" } ], "reference": [ { "type": "PubMed", "id": "12537574", "url": "https://glygen.org/publication/PubMed/12537574" } ] }, { "title": "Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses.", "journal": "EMBO reports", "date": "2003", "authors": "Leulier F, Marchal C, Miletich I, Limbourg-Bouchon B, Benarous R, Lemaitre B", "evidence": [ { "database": "Reactome", "id": "R-DME-209406", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-209406" } ], "reference": [ { "type": "PubMed", "id": "12973300", "url": "https://glygen.org/publication/PubMed/12973300" } ] }, { "title": "Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception.", "journal": "Science (New York, N.Y.)", "date": "2004", "authors": "Busza A, Emery-Le M, Rosbash M, Emery P", "evidence": [ { "database": "Reactome", "id": "R-DME-432395", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-432395" } ], "reference": [ { "type": "PubMed", "id": "15178801", "url": "https://glygen.org/publication/PubMed/15178801" } ] }, { "title": "A constitutively active cryptochrome in Drosophila melanogaster.", "journal": "Nature neuroscience", "date": "2004", "authors": "Dissel S, Codd V, Fedic R, Garner KJ, Costa R, Kyriacou CP, Rosato E", "evidence": [ { "database": "Reactome", "id": "R-DME-432395", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-432395" } ], "reference": [ { "type": "PubMed", "id": "15258584", "url": "https://glygen.org/publication/PubMed/15258584" } ] }, { "title": "Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases.", "journal": "Molecular biology of the cell", "date": "2004", "authors": "Donaldson TD, Noureddine MA, Reynolds PJ, Bradford W, Duronio RJ", "evidence": [ { "database": "Reactome", "id": "R-DME-216167", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-216167" } ], "reference": [ { "type": "PubMed", "id": "15331761", "url": "https://glygen.org/publication/PubMed/15331761" } ] }, { "title": "Combined evidence annotation of transposable elements in genome sequences.", "journal": "PLoS Comput. Biol.", "date": "2005", "authors": "Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D", "evidence": [ { "database": "UniProtKB", "id": "Q9VUJ1", "url": "https://www.uniprot.org/uniprot/Q9VUJ1" } ], "reference": [ { "type": "PubMed", "id": "16110336", "url": "https://glygen.org/publication/PubMed/16110336" } ] }, { "title": "The circadian timekeeping system of Drosophila.", "journal": "Current biology : CB", "date": "2005", "authors": "Hardin PE", "evidence": [ { "database": "Reactome", "id": "R-DME-432626", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-432626" } ], "reference": [ { "type": "PubMed", "id": "16139204", "url": "https://glygen.org/publication/PubMed/16139204" } ] }, { "title": "A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-kappaB.", "journal": "Nature structural & molecular biology", "date": "2005", "authors": "Tian L, Holmgren RA, Matouschek A", "evidence": [ { "database": "Reactome", "id": "R-DME-209360", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-209360" } ], "reference": [ { "type": "PubMed", "id": "16299518", "url": "https://glygen.org/publication/PubMed/16299518" } ] }, { "title": "Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing.", "journal": "Developmental cell", "date": "2005", "authors": "Jia J, Zhang L, Zhang Q, Tong C, Wang B, Hou F, Amanai K, Jiang J", "evidence": [ { "database": "Reactome", "id": "R-DME-209360", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-209360" } ], "reference": [ { "type": "PubMed", "id": "16326393", "url": "https://glygen.org/publication/PubMed/16326393" } ] }, { "title": "Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb.", "journal": "Current biology : CB", "date": "2006", "authors": "Smelkinson MG, Kalderon 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"url": "https://www.reactome.org/PathwayBrowser/#R-DME-216167" } ], "reference": [ { "type": "PubMed", "id": "16740475", "url": "https://glygen.org/publication/PubMed/16740475" } ] }, { "title": "JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS.", "journal": "Science (New York, N.Y.)", "date": "2006", "authors": "Koh K, Zheng X, Sehgal A", "evidence": [ { "database": "Reactome", "id": "R-DME-432395", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-432395" } ], "reference": [ { "type": "PubMed", "id": "16794082", "url": "https://glygen.org/publication/PubMed/16794082" } ] }, { "title": "Regulation of Hh/Gli signaling by dual ubiquitin pathways.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2006", "authors": "Jiang J", "evidence": [ { "database": "Reactome", "id": "R-DME-216167", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-216167" } ], "reference": [ { "type": "PubMed", "id": "17102630", "url": "https://glygen.org/publication/PubMed/17102630" } ] }, { "title": "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Smith CD, Shu S, Mungall CJ, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "Q9VUJ1", "url": "https://www.uniprot.org/uniprot/Q9VUJ1" } ], "reference": [ { "type": "PubMed", "id": "17569856", "url": "https://glygen.org/publication/PubMed/17569856" } ] }, { "title": "Sequence finishing and mapping of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "Q9VUJ1", "url": "https://www.uniprot.org/uniprot/Q9VUJ1" } ], "reference": [ { "type": "PubMed", "id": "17569867", "url": "https://glygen.org/publication/PubMed/17569867" } ] }, { "title": 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