{
    "uniprot_canonical_ac": "Q9VNE3-1",
    "uniprot_ac": "Q9VNE3",
    "uniprot_id": "Q9VNE3_DROME",
    "mass": {
        "chemical_mass": 53192.0,
        "monoisotopic_mass": 53192.0
    },
    "refseq": {
        "ac": "NP_996155",
        "name": "Sec synthetase, isoform D",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996155"
    },
    "gene_names": [
        {
            "name": "SecS",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q9VNE3",
            "id": "Q9VNE3"
        },
        {
            "name": "CG1427-RC",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9VNE3",
            "id": "Q9VNE3"
        },
        {
            "name": "CG1427; Dmel\\CG1427",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262290",
            "id": "NP_001262290"
        },
        {
            "name": "CG1427",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9VNE3",
            "id": "Q9VNE3"
        },
        {
            "name": "Dmel\\CG1427",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9VNE3",
            "id": "Q9VNE3"
        },
        {
            "name": "Dmel_CG1427",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9VNE3",
            "id": "Q9VNE3"
        },
        {
            "name": "SecS",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262290",
            "id": "NP_001262290"
        }
    ],
    "protein_names": [
        {
            "name": "O-phosphoseryl-tRNA(Sec) selenium transferase",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q9VNE3"
        },
        {
            "name": "2.9.1.2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9VNE3"
        },
        {
            "name": "CG1427-PC; SecS-PC",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649556",
            "id": "NP_649556"
        },
        {
            "name": "CG1427-PD; SecS-PD",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996155",
            "id": "NP_996155"
        },
        {
            "name": "CG1427-PE; SecS-PE",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262290",
            "id": "NP_001262290"
        },
        {
            "name": "Sec synthetase, isoform C",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649556",
            "id": "NP_649556"
        },
        {
            "name": "Sec synthetase, isoform D",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996155",
            "id": "NP_996155"
        },
        {
            "name": "Sec synthetase, isoform E",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262290",
            "id": "NP_001262290"
        },
        {
            "name": "Selenocysteine synthase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9VNE3"
        },
        {
            "name": "Selenocysteinyl-tRNA(Sec) synthase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9VNE3"
        },
        {
            "name": "Sep-tRNA:Sec-tRNA synthase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9VNE3"
        }
    ],
    "function": [
        {
            "annotation": "Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0C4DHG1",
                    "url": "https://www.uniprot.org/uniprot/A0A0C4DHG1#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "PIRNR017689",
                    "url": "https://www.uniprot.org/uniprot/PIRNR017689#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "ARBA00002552",
                    "url": "https://www.uniprot.org/uniprot/ARBA00002552#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9VNE3",
                    "url": "https://www.uniprot.org/uniprot/Q9VNE3#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0060270",
            "recommended_name": {
                "id": "DOID:0060270",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0060270",
                "name": "pontocerebellar hypoplasia type 2D",
                "description": "A pontocerebellar hypoplasia that is characterized by progressive microcephaly, profound intellectual disability, spasticity and seizure, has_material_basis_in autosomal recessive inheritance of mutation in the SEPSECS gene."
            },
            "synonyms": [
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "pontocerebellar hypoplasia type 2D",
                    "description": "Any non-syndromic pontocerebellar hypoplasia in which the cause of the disease is a mutation in the SEPSECS gene."
                },
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "SEPSECS non-syndromic pontocerebellar hypoplasia",
                    "description": ""
                },
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "non-syndromic pontocerebellar hypoplasia caused by mutation in SEPSECS",
                    "description": ""
                },
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "pontocerebellar hypoplasia type 2D",
                    "description": ""
                },
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "Cerebellocerebral atrophy, progressive",
                    "description": ""
                },
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "PCH2D",
                    "description": ""
                },
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "cerebello-cerebral atrophy, progressive",
                    "description": ""
                },
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "pontocerebellar hypoplasia, type 2D",
                    "description": ""
                },
                {
                    "id": "MIM:613811",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/613811",
                    "name": "Pontocerebellar hypoplasia 2D",
                    "description": "Pontocerebellar hypoplasia 2D"
                }
            ],
            "evidence": [
                {
                    "id": "0060270",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060270"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9VNE3",
                    "url": "https://www.uniprot.org/uniprot/Q9VNE3"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "gene": [
        {
            "name": "SecS",
            "url": "https://www.uniprot.org/uniprot/Q9VNE3",
            "locus": {
                "chromosome": "3R",
                "start_pos": 5603185,
                "end_pos": 5601433,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "FBgn0037347",
                        "url": "https://www.ensembl.org/id/FBgn0037347"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "FBgn0037347",
            "url": "https://bgee.org/?page=gene&gene_id=FBgn0037347",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "FBgn0037347",
            "url": "https://flybase.org/reports/FBgn0037347",
            "database": "FlyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "40681",
            "url": "https://www.ncbi.nlm.nih.gov/gene/40681",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q9VNE3",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9VNE3*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR008829",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008829",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015421",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015424",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019872",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019872",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "dme:Dmel_CG1427",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG1427",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "MSHANDY",
            "url": "https://omabrowser.org/oma/group/MSHANDY/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "121300at2759",
            "url": "http://www.orthodb.org/?query=121300at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12944",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12944",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12944:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12944:SF2",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF05889",
            "url": "http://pfam.xfam.org/family/PF05889",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_649556",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649556",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "25041",
            "url": "https://www.rhea-db.org/rhea/25041",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A0B4KF37",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KF37",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0B4KF37-1",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KF37-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0C4DHG1",
            "url": "https://www.uniprot.org/uniprot/A0A0C4DHG1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0C4DHG1-1",
            "url": "https://www.uniprot.org/uniprot/A0A0C4DHG1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9VNE3",
            "url": "https://www.uniprot.org/uniprot/Q9VNE3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9VNE3-1",
            "url": "https://www.uniprot.org/uniprot/Q9VNE3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MNFEQVNIPEKLVPDNYLQLGLAAQRSKQRSFKELLEKRKLPKNGWSDERIEELVHMLASLDSNNYPHKVGLGEREARIACKLVARRHYNFGHGIGRSGDLLEAQPKAAGSTLLARLTNALILDLIRGIGLPSCAGCFLVPMCTGMTLTLCLQSLRKRRPGARYVLWSRIDQKSCFKAITATGLVPVVIPCLIKGESLNTNVDLFREKIKSLGVDSILCLYTTTSCFAPRNSDDIAEVSKLSKQWQIPHLVNNAYGLQAKEIVNQLECANRVGRIDYFVQSSDKNLLVPVGSAIVASFNESVLHDVASTYAGRASGSQSLDVLMTLLSLGRNGFRLLFDQRGENFNYLRENLRKFAEPRGEIVIDSRFNSISLAITLATLAGDQMKSITKLGSMLHMRGVSGARVIVPGQNKTIDGHEFLDFGSHRSNLQVPYLTVAAGIGITREEIDKFFDIFNKCWNQIFQTKNEKIMSLLETTIK",
        "length": 478,
        "header": "tr|Q9VNE3-1|Q9VNE3_DROME Isoform 1 of O-phosphoseryl-tRNA(Sec) selenium transferase  OS=Drosophila melanogaster OX=7227 GN=SecS PE=2 SV=4 CANONICAL=Q9VNE3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0B4KF37-1",
            "url": "",
            "sequence": {
                "sequence": "MNFEQVNIPEKLVPDNYLQLGLAAQRSKQRSFKELLEKRKLPKNGWSDERIEELVHMLASLDSNNYPHKVGLGEREARIACNLETY",
                "length": 86,
                "header": "tr|A0A0B4KF37-1|Q9VNE3_DROME Computationally mapped isoform of O-phosphoseryl-tRNA(Sec) selenium transferase  OS=Drosophila melanogaster OX=7227 GN=SecS PE=2 SV=1 CANONICAL=Q9VNE3-1"
            },
            "locus": {
                "chromosome": "3R",
                "start_pos": 5601973,
                "end_pos": 5601556,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0333279",
                        "url": "https://www.ensembl.org/id/FBtr0333279"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0305477",
                        "url": "https://www.ensembl.org/id/FBpp0305477"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A0C4DHG1-1",
            "url": "",
            "sequence": {
                "sequence": "MNFEQVNIPEKLVPDNYLQLGLAAQRSKQRSFKELLEKLPKNGWSDERIEELVHMLASLDSNNYPHKVGLGEREARIACKLVARRHYNFGHGIGRSGDLLEAQPKAAGSTLLARLTNALILDLIRGIGLPSCAGCFLVPMCTGMTLTLCLQSLRKRRPGARYVLWSRIDQKSCFKAITATGLVPVVIPCLIKGESLNTNVDLFREKIKSLGVDSILCLYTTTSCFAPRNSDDIAEVSKLSKQWQIPHLVNNAYGLQAKEIVNQLECANRVGRIDYFVQSSDKNLLVPVGSAIVASFNESVLHDVASTYAGRASGSQSLDVLMTLLSLGRNGFRLLFDQRGENFNYLRENLRKFAEPRGEIVIDSRFNSISLAITLATLAGDQMKSITKLGSMLHMRGVSGARVIVPGQNKTIDGHEFLDFGSHRSNLQVPYLTVAAGIGITREEIDKFFDIFNKCWNQIFQTKNEKIMSLLETTIK",
                "length": 476,
                "header": "tr|A0A0C4DHG1-1|A0A0C4DHG1_DROME Computationally mapped isoform of O-phosphoseryl-tRNA(Sec) selenium transferase  OS=Drosophila melanogaster OX=7227 GN=SecS PE=3 SV=1 CANONICAL=Q9VNE3-1"
            },
            "locus": {
                "chromosome": "3R",
                "start_pos": 5603162,
                "end_pos": 5601556,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0333278",
                        "url": "https://www.ensembl.org/id/FBtr0333278"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0305476",
                        "url": "https://www.ensembl.org/id/FBpp0305476"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q9VNE3-1",
            "url": "",
            "sequence": {
                "sequence": "MNFEQVNIPEKLVPDNYLQLGLAAQRSKQRSFKELLEKRKLPKNGWSDERIEELVHMLASLDSNNYPHKVGLGEREARIACKLVARRHYNFGHGIGRSGDLLEAQPKAAGSTLLARLTNALILDLIRGIGLPSCAGCFLVPMCTGMTLTLCLQSLRKRRPGARYVLWSRIDQKSCFKAITATGLVPVVIPCLIKGESLNTNVDLFREKIKSLGVDSILCLYTTTSCFAPRNSDDIAEVSKLSKQWQIPHLVNNAYGLQAKEIVNQLECANRVGRIDYFVQSSDKNLLVPVGSAIVASFNESVLHDVASTYAGRASGSQSLDVLMTLLSLGRNGFRLLFDQRGENFNYLRENLRKFAEPRGEIVIDSRFNSISLAITLATLAGDQMKSITKLGSMLHMRGVSGARVIVPGQNKTIDGHEFLDFGSHRSNLQVPYLTVAAGIGITREEIDKFFDIFNKCWNQIFQTKNEKIMSLLETTIK",
                "length": 478,
                "header": "tr|Q9VNE3-1|Q9VNE3_DROME Isoform 1 of O-phosphoseryl-tRNA(Sec) selenium transferase  OS=Drosophila melanogaster OX=7227 GN=SecS PE=2 SV=4 CANONICAL=Q9VNE3-1"
            },
            "locus": {
                "chromosome": "3R",
                "start_pos": 5603162,
                "end_pos": 5601556,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0273377",
                        "url": "https://www.ensembl.org/id/FBtr0273377"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0271885",
                        "url": "https://www.ensembl.org/id/FBpp0271885"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "The genome sequence of Drosophila melanogaster.",
            "journal": "Science",
            "date": "2000",
            "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0B4KF37",
                    "url": "https://www.uniprot.org/uniprot/A0A0B4KF37"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9VNE3",
                    "url": "https://www.uniprot.org/uniprot/Q9VNE3"
                },
                {
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