{ "uniprot_canonical_ac": "Q9VE50-1", "uniprot_ac": "Q9VE50", "uniprot_id": "GOSR1_DROME", "mass": { "chemical_mass": 25562.0, "monoisotopic_mass": 25562.0 }, "refseq": { "ac": "NP_650739", "name": "golgi SNARE, 28 kDa", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650739" }, "gene_names": [ { "name": "Gos28", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9VE50", "id": "Q9VE50" }, { "name": "CG7700; dgos28; dGos28; Dmel\\CG7700; FSG28; gos28; GOS28", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650739", "id": "NP_650739" }, { "name": "CG7700", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9VE50", "id": "Q9VE50" }, { "name": "Gos28", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650739", "id": "NP_650739" } ], "protein_names": [ { "name": "Golgi SNAP receptor complex member 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9VE50" }, { "name": "CG7700-PA; Gos28-PA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650739", "id": "NP_650739" }, { "name": "Probable 28 kDa Golgi SNARE protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9VE50" }, { "name": "golgi SNARE, 28 kDa", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650739", "id": "NP_650739" } ], "function": [ { "annotation": "Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50#function" } ] } ], "disease": [ { "disease_id": "DOID:1289", "recommended_name": { "id": "DOID:1289", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1289", "name": "neurodegenerative disease", "description": "A central nervous system disease that results in the progressive deterioration of function or structure of neurons." }, "synonyms": [ { "id": "DOID:1289", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1289", "name": "degenerative disease", "description": "" } ], "evidence": [ { "id": "1289", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1289" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Gos28", "url": "https://www.uniprot.org/uniprot/Q9VE50", "locus": { "chromosome": "3R", "start_pos": 18665307, "end_pos": 18663738, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0044871", "url": "https://www.ensembl.org/id/FBgn0044871" } ] } } ], "crossref": [ { "id": "FBgn0044871", "url": "https://bgee.org/?page=gene&gene_id=FBgn0044871", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0044871", "url": "https://flybase.org/reports/FBgn0044871", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "248102", "url": "https://www.ncbi.nlm.nih.gov/gene/248102", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9VE50", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9VE50*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR023601", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023601", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG7700", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG7700", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RDYGSEY", "url": "https://omabrowser.org/oma/group/RDYGSEY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5396327at2759", "url": "http://www.orthodb.org/?query=5396327at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21094", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21094", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21094:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21094:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12352", "url": "http://pfam.xfam.org/family/PF12352", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9VE50", "url": "http://purl.obolibrary.org/obo/PR_Q9VE50", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DME-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6807878", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-6811438", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6811438", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_650739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650739", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9VE50-1", "url": "https://www.uniprot.org/uniprot/Q9VE50-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGSSYDVLRKQARSLENEIDLKLVAFSKIGAGSGGGGSGGLGGVDTSPLLGEHVFDSLSEEIEQMLEKLSSLNESMSDLPASGAAAMHTLQRHREILQGYRQEFNKICANHTMRIEREELLRGSGLATSSGSPSISGLNRREMYLKESGHLNSASHLVNDQINIAIETRDHLHAQRQAFKRLQTRFNDISNRFPLISSLIQRINIKKRRDSLILGAVIGFCVILLLLYAFN", "length": 232, "header": "sp|Q9VE50-1|GOSR1_DROME Isoform 1 of Golgi SNAP receptor complex member 1 OS=Drosophila melanogaster OX=7227 GN=Gos28 PE=2 SV=1 CANONICAL=Q9VE50-1" }, "isoforms": [ { "isoform_ac": "Q9VE50-1", "url": "", "sequence": { "sequence": "MGGSSYDVLRKQARSLENEIDLKLVAFSKIGAGSGGGGSGGLGGVDTSPLLGEHVFDSLSEEIEQMLEKLSSLNESMSDLPASGAAAMHTLQRHREILQGYRQEFNKICANHTMRIEREELLRGSGLATSSGSPSISGLNRREMYLKESGHLNSASHLVNDQINIAIETRDHLHAQRQAFKRLQTRFNDISNRFPLISSLIQRINIKKRRDSLILGAVIGFCVILLLLYAFN", "length": 232, "header": "sp|Q9VE50-1|GOSR1_DROME Isoform 1 of Golgi SNAP receptor complex member 1 OS=Drosophila melanogaster OX=7227 GN=Gos28 PE=2 SV=1 CANONICAL=Q9VE50-1" }, "locus": { "chromosome": "3R", "start_pos": 18665167, "end_pos": 18663796, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0083661", "url": "https://www.ensembl.org/id/FBtr0083661" }, { "database": "Ensembl Peptide", "id": "FBpp0083076", "url": "https://www.ensembl.org/id/FBpp0083076" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "A Drosophila full-length cDNA resource.", "journal": "Genome Biol.", "date": "2002", "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50" } ], "reference": [ { "type": "PubMed", "id": "12537569", "url": "https://glygen.org/publication/PubMed/12537569" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] } ], "pathway": [ { "id": "dme:Dmel_CG7700", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG7700", "resource": "KEGG Pathway" }, { "id": "R-DME-6807878", "name": "COPI-mediated anterograde transport", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" }, { "id": "R-DME-6811438", "name": "Intra-Golgi traffic", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6811438", "resource": "Reactome", "description": "Intra-Golgi traffic" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50" } ], "pmid": "" }, { "name": "Golgi medial cisterna", "id": "GO:0005797", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005797", "evidence": [ { "database": "UniProtKB", "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50" } ], "pmid": "" }, { "name": "cis-Golgi network", "id": "GO:0005801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005801", "evidence": [ { "database": "UniProtKB", "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50" } ], "pmid": "" }, { "name": "SNARE complex", "id": "GO:0031201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031201", "evidence": [ { "database": "UniProtKB", "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50" } ], "pmid": "" }, { "name": "Golgi trans cisterna", "id": "GO:0000138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000138", "evidence": [ { "database": "UniProtKB", "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50" } ], "pmid": "" }, { "name": "Golgi vesicle transport", "id": "GO:0048193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048193", "evidence": [ { "database": "UniProtKB", "id": "Q9VE50", "url": "https://www.uniprot.org/uniprot/Q9VE50" } ], "pmid": "" }, { "name": "vesicle fusion", "id": "GO:0006906", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006906", "evidence": [ { "database": 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"annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { 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